{"id":"https://openalex.org/W4388328568","doi":"https://doi.org/10.1038/s41598-023-45313-x","title":"Two novel phages PSPa and APPa inhibit planktonic, sessile and persister populations of Pseudomonas aeruginosa, and mitigate its virulence in Zebrafish model","display_name":"Two novel phages PSPa and APPa inhibit planktonic, sessile and persister populations of Pseudomonas aeruginosa, and mitigate its virulence in Zebrafish model","publication_year":2023,"publication_date":"2023-11-03","ids":{"openalex":"https://openalex.org/W4388328568","doi":"https://doi.org/10.1038/s41598-023-45313-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/37923820","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10624879"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-45313-x","doi":"https://doi.org/10.1038/s41598-023-45313-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-45313-x","pdf_url":"https://www.nature.com/articles/s41598-023-45313-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-45313-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112554145","display_name":"Chandrasekar Karthika","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandrasekar Karthika","raw_affiliation_strings":["Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085083360","display_name":"Nambiraman Malligarjunan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nambiraman Malligarjunan","raw_affiliation_strings":["Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112409209","display_name":"Ravi Jothi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ravi Jothi","raw_affiliation_strings":["Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037950306","display_name":"Thirupathi Kasthuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Thirupathi Kasthuri","raw_affiliation_strings":["Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008030495","display_name":"Rajaiah Alexpandi","orcid":"https://orcid.org/0000-0003-2076-5740","observed_orcids":["https://orcid.org/0000-0003-2076-5740"]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajaiah Alexpandi","raw_affiliation_strings":["Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034386729","display_name":"Arumugam Veera Ravi","orcid":"https://orcid.org/0000-0002-4768-8389","observed_orcids":["https://orcid.org/0000-0002-4768-8389"]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arumugam Veera Ravi","raw_affiliation_strings":["Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060964743","display_name":"Shunmugiah Karutha Pandian","orcid":"https://orcid.org/0000-0003-2925-0575","observed_orcids":["https://orcid.org/0000-0003-2925-0575"]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shunmugiah Karutha Pandian","raw_affiliation_strings":["Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India","institution_ids":["https://openalex.org/I131155284"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018158090","display_name":"Shanmugaraj Gowrishankar","orcid":"https://orcid.org/0000-0001-5728-6837","observed_orcids":["https://orcid.org/0000-0001-5728-6837"]},"institutions":[{"id":"https://openalex.org/I131155284","display_name":"Alagappa University","ror":"https://ror.org/04ec9cc06","country_code":"IN","type":"education","lineage":["https://openalex.org/I131155284"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Shanmugaraj Gowrishankar","raw_affiliation_strings":["Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India. gowrishankar.alu@gmail.com","Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India. gowrishankar.alu@gmail.com","institution_ids":["https://openalex.org/I131155284"]},{"raw_affiliation_string":"Department of Biotechnology, Science Campus, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India","institution_ids":["https://openalex.org/I131155284"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018158090"],"corresponding_institution_ids":["https://openalex.org/I131155284"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":2.745,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.90420876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"19033","last_page":"19033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13220","display_name":"Plant and Fungal Interactions Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.9139999747276306},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9470000267028809},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8240000009536743},{"id":"https://openalex.org/keywords/phage-genome","display_name":"phage genome","score":0.5799999833106995},{"id":"https://openalex.org/keywords/host-specificity","display_name":"host specificity","score":0.7450000047683716},{"id":"https://openalex.org/keywords/phage-bacteria-interactions","display_name":"phage-bacteria interactions","score":0.6050000190734863},{"id":"https://openalex.org/keywords/bacterial-persistence","display_name":"bacterial persistence","score":0.652999997138977},{"id":"https://openalex.org/keywords/virulence-factor-inhibition","display_name":"virulence factor inhibition","score":0.6399999856948853},{"id":"https://openalex.org/keywords/zebrafish-infection-model","display_name":"zebrafish infection model","score":0.9380000233650208},{"id":"https://openalex.org/keywords/antibiotic-alternatives","display_name":"antibiotic alternatives","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8223442435264587},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7821749448776245},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.7242588996887207},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7076776027679443},{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.7041589021682739},{"id":"https://openalex.org/C2779256223","wikidata":"https://www.wikidata.org/wiki/Q611870","display_name":"Phage therapy","level":5,"score":0.5119436979293823},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.49466606974601746},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3809460401535034},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.33598992228507996},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30138373374938965},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.27064114809036255},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.26300615072250366},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.17220252752304077},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.16716116666793823}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001435","descriptor_name":"Bacteriophages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010933","descriptor_name":"Plankton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015226","descriptor_name":"Dinucleoside Phosphates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017105","descriptor_name":"Pseudomonas Phages","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41598-023-45313-x","doi":"https://doi.org/10.1038/s41598-023-45313-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-45313-x","pdf_url":"https://www.nature.com/articles/s41598-023-45313-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10624879","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10624879","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37923820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37923820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:92720ef687ad4930a54f7ff576959f7b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/92720ef687ad4930a54f7ff576959f7b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-45313-x","doi":"https://doi.org/10.1038/s41598-023-45313-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-45313-x","pdf_url":"https://www.nature.com/articles/s41598-023-45313-x.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G171728114","display_name":null,"funder_award_id":"F. 24-51/ 2014-U","funder_id":"https://openalex.org/F4320322724","funder_display_name":"Ministry of Education, India"},{"id":"https://openalex.org/G190219015","display_name":null,"funder_award_id":"F.24/51/2014-U","funder_id":"https://openalex.org/F4320337076","funder_display_name":"Rashtriya Uchchatar Shiksha Abhiyan"},{"id":"https://openalex.org/G3245260166","display_name":null,"funder_award_id":"SR/PURSE Phase 2/38","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G453353123","display_name":null,"funder_award_id":"F. 24\u201351/2014-U","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G5273709651","display_name":null,"funder_award_id":"24-51/2014-U","funder_id":"https://openalex.org/F4320337076","funder_display_name":"Rashtriya Uchchatar Shiksha Abhiyan"},{"id":"https://openalex.org/G6340081363","display_name":null,"funder_award_id":"BT/BI/25/012/2012","funder_id":"https://openalex.org/F4320320717","funder_display_name":"Department of Biotechnology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G644461714","display_name":null,"funder_award_id":"24-51/2014-U","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G6566578458","display_name":null,"funder_award_id":"SR/FST/LSI-639/2015","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G8353374239","display_name":null,"funder_award_id":"24-51/2014-U","funder_id":"https://openalex.org/F4320322724","funder_display_name":"Ministry of Education, India"},{"id":"https://openalex.org/G8660497242","display_name":null,"funder_award_id":"24-51/2014","funder_id":"https://openalex.org/F4320320719","funder_display_name":"Department of Science and Technology, Ministry of Science and Technology, India"},{"id":"https://openalex.org/G8740682185","display_name":null,"funder_award_id":"2014-U","funder_id":"https://openalex.org/F4320322724","funder_display_name":"Ministry of Education, India"}],"funders":[{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320337076","display_name":"Rashtriya Uchchatar Shiksha Abhiyan","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388328568.pdf","grobid_xml":"https://content.openalex.org/works/W4388328568.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W114564532","https://openalex.org/W1981239255","https://openalex.org/W1982939204","https://openalex.org/W1986270011","https://openalex.org/W2008472945","https://openalex.org/W2030382945","https://openalex.org/W2038575932","https://openalex.org/W2041350348","https://openalex.org/W2065204248","https://openalex.org/W2070861427","https://openalex.org/W2105439835","https://openalex.org/W2105508438","https://openalex.org/W2157529446","https://openalex.org/W2268518655","https://openalex.org/W2297966196","https://openalex.org/W2340155420","https://openalex.org/W2347102183","https://openalex.org/W2548742186","https://openalex.org/W2566866945","https://openalex.org/W2760090669","https://openalex.org/W2793753655","https://openalex.org/W2802696262","https://openalex.org/W2804007336","https://openalex.org/W2889689336","https://openalex.org/W2910846136","https://openalex.org/W2911255357","https://openalex.org/W2918903869","https://openalex.org/W2927414155","https://openalex.org/W2929294594","https://openalex.org/W2938621154","https://openalex.org/W2940026215","https://openalex.org/W2946864735","https://openalex.org/W2950891768","https://openalex.org/W2961017809","https://openalex.org/W2969434391","https://openalex.org/W2988892352","https://openalex.org/W3031591096","https://openalex.org/W3099789223","https://openalex.org/W3106692639","https://openalex.org/W3110415260","https://openalex.org/W3160285541","https://openalex.org/W3166197436","https://openalex.org/W3200554152","https://openalex.org/W3202083968","https://openalex.org/W3203182448","https://openalex.org/W3208184477","https://openalex.org/W4242318543","https://openalex.org/W4291964195","https://openalex.org/W4296708721","https://openalex.org/W4313273216","https://openalex.org/W4317716348"],"related_works":["https://openalex.org/W4366817130","https://openalex.org/W4311579384","https://openalex.org/W7161002306","https://openalex.org/W3199353805","https://openalex.org/W4411928167","https://openalex.org/W4385284621","https://openalex.org/W2110957778","https://openalex.org/W7118556224","https://openalex.org/W4404926043","https://openalex.org/W7140295223"],"abstract_inverted_index":{"The":[0,78,117,170],"present":[1],"study":[2,23],"explores":[3],"the":[4,46,52,70,106,111,146,156,160,193,199,204,213,220,224],"avenue":[5],"of":[6,49,62,75,91,97,105,129,135,158,188,216,223],"phage":[7,80,107,119,143],"therapy":[8],"as":[9],"an":[10],"alternative":[11],"antimicrobial":[12],"therapeutic":[13,47],"approach":[14],"to":[15,33,44,83,122,140,151],"counter":[16],"multidrug-resistant":[17],"(MDR)":[18],"Pseudomonas":[19,186],"aeruginosa":[20,232],"infection.":[21,233],"Our":[22],"investigated":[24],"two":[25],"novel":[26],"virulent":[27],"phages":[28,54,161,226],"PSPa":[29,79,175,207,227],"and":[30,66,94,110,132,145,168,176,208,228],"APPa,":[31],"specific":[32],"P.":[34,76,231],"aeruginosa,":[35],"in":[36,38,194],"which":[37,98,136],"vitro":[39],"evaluations":[40],"were":[41,100,114,138,149],"carried":[42],"out":[43],"assess":[45],"potential":[48,222],"phages.":[50],"Both":[51],"identified":[53],"exhibited":[55],"host":[56],"specificity":[57],"by":[58],"showing":[59],"antagonistic":[60],"activity":[61],"about":[63],"96.43%":[64],"(27/28)":[65],"92.85%":[67],"(26/28)":[68],"towards":[69],"28":[71],"MDR":[72],"clinical":[73],"isolates":[74],"aeruginosa.":[77],"was":[81,120],"found":[82,121,139,150],"have":[84,123,141],"linear":[85,124],"dsDNA":[86,125],"with":[87,126,183,206],"a":[88],"sequence":[89,181],"length":[90,131],"66,368":[92],"bp":[93,128],"92":[95],"ORFs,":[96,134],"32":[99],"encoded":[101],"for":[102,165],"known":[103,142],"functions":[104,144],"life":[108],"cycle":[109],"remaining":[112,147],"60":[113],"hypothetical":[115,153],"functions.":[116],"APPa":[118,177,209,229],"59,591":[127],"genome":[130,157],"79":[133],"15":[137],"64":[148],"be":[152],"proteins.":[154],"Notably,":[155],"both":[159],"lacks":[162],"genes":[163],"coding":[164],"tRNA,":[166],"rRNA,":[167],"tmRNA.":[169],"phylogenetic":[171],"analysis":[172],"revealed":[173,202],"that":[174,203],"share":[178],">":[179],"95%":[180],"similarity":[182],"previously":[184],"sequenced":[185],"viruses":[187],"their":[189],"respective":[190],"families.":[191],"Further,":[192],"vivo":[195],"efficacy":[196],"evaluation":[197],"using":[198],"zebrafish":[200],"model":[201],"treatment":[205],"has":[210],"remarkably":[211],"improved":[212],"survival":[214],"rate":[215],"bacterial-infected":[217],"zebrafish,":[218],"reinforcing":[219],"anti-infective":[221],"isolated":[225],"against":[230]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-04T00:00:00"}