{"id":"https://openalex.org/W4388310429","doi":"https://doi.org/10.1093/oso/9780199633647.003.0005","title":"Molecular methods","display_name":"Molecular methods","publication_year":1993,"publication_date":"1993-06-03","ids":{"openalex":"https://openalex.org/W4388310429","doi":"https://doi.org/10.1093/oso/9780199633647.003.0005"},"language":"en","primary_location":{"id":"doi:10.1093/oso/9780199633647.003.0005","doi":"https://doi.org/10.1093/oso/9780199633647.003.0005","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oso/9780199633647.003.0005","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histocompatibility Testing","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W566520753","display_name":"Histocompatibility Testing"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040775445","display_name":"David A. Savage","orcid":"https://orcid.org/0000-0002-2110-4023","observed_orcids":["https://orcid.org/0000-0002-2110-4023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Savage","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080362489","display_name":"Lee Ann Baxter\u2010Lowe","orcid":"https://orcid.org/0000-0002-6706-0273","observed_orcids":["https://orcid.org/0000-0002-6706-0273"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lee Ann Baxter-Lowe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103145736","display_name":"Jack Gorski","orcid":"https://orcid.org/0000-0002-0170-3782","observed_orcids":["https://orcid.org/0000-0002-0170-3782"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jack Gorski,","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072462908","display_name":"Derek Middleton","orcid":"https://orcid.org/0000-0002-6688-8642","observed_orcids":["https://orcid.org/0000-0002-6688-8642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derek Middleton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.95454545,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"107","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.22679999470710754,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.07289999723434448,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-class-ii-typing","display_name":"HLA class II typing","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hla-dr","display_name":"HLA-DR","score":0.7480000257492065},{"id":"https://openalex.org/keywords/hla-dq","display_name":"HLA-DQ","score":1.0},{"id":"https://openalex.org/keywords/hla-dw","display_name":"HLA-Dw","score":0.9660000205039978},{"id":"https://openalex.org/keywords/restriction-fragment-length-polymorphism","display_name":"restriction fragment length polymorphism","score":0.8769999742507935},{"id":"https://openalex.org/keywords/southern-blot","display_name":"Southern blot","score":0.746999979019165},{"id":"https://openalex.org/keywords/pcr","display_name":"PCR","score":0.9150000214576721},{"id":"https://openalex.org/keywords/dna-fingerprinting","display_name":"DNA fingerprinting","score":0.6240000128746033},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.7960000038146973}],"concepts":[{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.6310564279556274},{"id":"https://openalex.org/C2781209916","wikidata":"https://www.wikidata.org/wiki/Q3215756","display_name":"Typing","level":2,"score":0.6280443668365479},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6040319800376892},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.5674881935119629},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.5603816509246826},{"id":"https://openalex.org/C168007829","wikidata":"https://www.wikidata.org/wiki/Q857299","display_name":"Restriction fragment length polymorphism","level":4,"score":0.5582028031349182},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.541458785533905},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.5185307264328003},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4422064423561096},{"id":"https://openalex.org/C111824103","wikidata":"https://www.wikidata.org/wiki/Q7086828","display_name":"Oligomer restriction","level":4,"score":0.4336223900318146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41935068368911743},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3815559446811676},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.15818044543266296}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/oso/9780199633647.003.0005","doi":"https://doi.org/10.1093/oso/9780199633647.003.0005","is_oa":false,"landing_page_url":"https://doi.org/10.1093/oso/9780199633647.003.0005","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Histocompatibility Testing","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W182926708","https://openalex.org/W2029067691","https://openalex.org/W4388324504","https://openalex.org/W2406095105","https://openalex.org/W2253119326","https://openalex.org/W2009628982","https://openalex.org/W2091162925","https://openalex.org/W2085761331","https://openalex.org/W2084952943","https://openalex.org/W3128102275"],"abstract_inverted_index":{"Abstract":[0],"The":[1,22,58],"application":[2],"of":[3,25,31,40,61,68,72,86],"molecular":[4],"techniques":[5,35,102],"to":[6,11,95],"tissue":[7],"typing":[8,101],"has":[9],"led":[10],"a":[12],"fundamental":[13],"change":[14],"in":[15],"methodology":[16],"for":[17],"HLA":[18],"class":[19,74],"II":[20,75],"typing.":[21],"first":[23],"part":[24,60],"this":[26],"chapter":[27,63],"describes":[28,64],"the":[29,38,62,65,69,78,87],"use":[30],"Southern":[32],"blot":[33],"(1)":[34],"which":[36,46],"permit":[37],"identification":[39],"restriction":[41],"fragment":[42],"length":[43],"polymorphisms":[44],"(RFLPs)":[45],"correlate":[47],"with":[48,89],"known":[49],"serological":[50],"(HLA-DR/DQ)":[51],"and":[52,84],"cellular":[53],"(HLA-Dw)":[54],"defined":[55],"specificities":[56],"(2).":[57],"latter":[59],"enzymatic":[66],"amplification":[67],"second":[70],"exon":[71],"HLA-DR/DQ":[73],"genes":[76],"using":[77],"polymerase":[79],"chain":[80],"reaction":[81],"(PCR)":[82],"(3)":[83],"analysis":[85],"product":[88],"alleleand":[90],"sequence-specific":[91],"oligonucleotides":[92],"(4).":[93],"Compared":[94],"serotyping":[96],"(see":[97],"Chapter":[98],"3),":[99],"DNA":[100],"provide":[103],"more":[104],"information":[105],"on":[106],"genetic":[107],"variation.":[108],"Other":[109],"advantages":[110],"include:":[111],"\u2022":[112,124],"cell":[113,115,118],"type,":[114],"viability,":[116],"or":[117],"surface":[119],"expression":[120],"are":[121],"generally":[122],"unimportant":[123],"homozygosity":[125],"can":[126],"be":[127],"confirmed":[128]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-11-04T00:00:00"}
