{"id":"https://openalex.org/W4388300965","doi":"https://doi.org/10.1002/jsfa.13096","title":"l \u2010Theanine delays d \u2010galactose\u2010induced senescence by regulating the cell cycle and inhibiting apoptosis in rat intestinal cells","display_name":"l \u2010Theanine delays d \u2010galactose\u2010induced senescence by regulating the cell cycle and inhibiting apoptosis in rat intestinal cells","publication_year":2023,"publication_date":"2023-11-03","ids":{"openalex":"https://openalex.org/W4388300965","doi":"https://doi.org/10.1002/jsfa.13096","pmid":"https://pubmed.ncbi.nlm.nih.gov/37919877"},"language":"en","primary_location":{"id":"doi:10.1002/jsfa.13096","doi":"https://doi.org/10.1002/jsfa.13096","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jsfa.13096","pdf_url":null,"source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033575493","display_name":"Wei Xu","orcid":"https://orcid.org/0000-0001-8264-8561","observed_orcids":["https://orcid.org/0000-0001-8264-8561"]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Xu","raw_affiliation_strings":["Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100560579","display_name":"Xi Xiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Xiang","raw_affiliation_strings":["Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438678","display_name":"Ling Lin","orcid":"https://orcid.org/0000-0002-2437-8011","observed_orcids":["https://orcid.org/0000-0002-2437-8011"]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Lin","raw_affiliation_strings":["Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003910501","display_name":"Zhihua Gong","orcid":"https://orcid.org/0000-0002-9768-4626","observed_orcids":["https://orcid.org/0000-0002-9768-4626"]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi\u2010Hua Gong","raw_affiliation_strings":["Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015086222","display_name":"Wenjun Xiao","orcid":"https://orcid.org/0000-0002-6258-4414","observed_orcids":["https://orcid.org/0000-0002-6258-4414","https://orcid.org/0000-0002-3638-3061"]},"institutions":[{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wen\u2010Jun Xiao","raw_affiliation_strings":["Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China"],"raw_orcid":"https://orcid.org/0000-0002-6258-4414","affiliations":[{"raw_affiliation_string":"Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"Sino-Kenya Joint Laboratory of Tea Science, Hunan Agricultural University, Changsha, China","institution_ids":["https://openalex.org/I52180223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003910501","https://openalex.org/A5015086222"],"corresponding_institution_ids":["https://openalex.org/I52180223"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.7055,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60952308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"104","issue":"4","first_page":"2073","last_page":"2084"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.638700008392334,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13446","display_name":"Antioxidants, Aging, Portulaca oleracea","score":0.25760000944137573,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-theanine","display_name":"theanine","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9129999876022339},{"id":"https://openalex.org/keywords/d-galactose-induced-aging","display_name":"D-galactose-induced aging","score":0.8629999756813049},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.9490000009536743},{"id":"https://openalex.org/keywords/iec-6-cells","display_name":"IEC-6 cells","score":0.9589999914169312},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7889999747276306},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.9620000123977661},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.7850000262260437},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.996999979019165},{"id":"https://openalex.org/keywords/cdk4","display_name":"CDK4","score":0.902999997138977},{"id":"https://openalex.org/keywords/cdk6","display_name":"CDK6","score":0.996999979019165},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.6919999718666077},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.9900000095367432},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.6010000109672546},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6980850696563721},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.653679370880127},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5716444849967957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5422152280807495},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5082518458366394},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4641757011413574},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4319581091403961},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.42656418681144714},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.4133800268173218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2823464870452881},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2378692328929901},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22327104210853577},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.11202600598335266}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jsfa.13096","doi":"https://doi.org/10.1002/jsfa.13096","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jsfa.13096","pdf_url":null,"source":{"id":"https://openalex.org/S206298197","display_name":"Journal of the Science of Food and Agriculture","issn_l":"0022-5142","issn":["0022-5142","1097-0010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Science of Food and Agriculture","raw_type":"journal-article"},{"id":"pmid:37919877","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37919877","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the science of food and agriculture","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320330206","display_name":"Science and Technology Program of Hunan Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W927818589","https://openalex.org/W1578451589","https://openalex.org/W2000242745","https://openalex.org/W2008530148","https://openalex.org/W2011726623","https://openalex.org/W2013287222","https://openalex.org/W2097588734","https://openalex.org/W2161551178","https://openalex.org/W2460913867","https://openalex.org/W2754828366","https://openalex.org/W2767927459","https://openalex.org/W2768033029","https://openalex.org/W2793517230","https://openalex.org/W2796948084","https://openalex.org/W2801928995","https://openalex.org/W2905039795","https://openalex.org/W2913976105","https://openalex.org/W2952366443","https://openalex.org/W2968702366","https://openalex.org/W2974795043","https://openalex.org/W2982995500","https://openalex.org/W2992558821","https://openalex.org/W2994783539","https://openalex.org/W2997939147","https://openalex.org/W2998046159","https://openalex.org/W3011764854","https://openalex.org/W3036142100","https://openalex.org/W3087617819","https://openalex.org/W3092681649","https://openalex.org/W3093572772","https://openalex.org/W3106899554","https://openalex.org/W3131607388","https://openalex.org/W3134651853","https://openalex.org/W3158277220","https://openalex.org/W3162806658","https://openalex.org/W3163529259","https://openalex.org/W3165324754","https://openalex.org/W3168314397","https://openalex.org/W3171736372","https://openalex.org/W3176904497","https://openalex.org/W3203104501","https://openalex.org/W3212567029","https://openalex.org/W3216735480","https://openalex.org/W4206503963","https://openalex.org/W4210290601","https://openalex.org/W4211008136","https://openalex.org/W4282943275","https://openalex.org/W4285178043","https://openalex.org/W4289028880","https://openalex.org/W4293783808","https://openalex.org/W4313531093","https://openalex.org/W4323294708","https://openalex.org/W6772305331"],"related_works":["https://openalex.org/W4392877199","https://openalex.org/W7168750539","https://openalex.org/W2997939147","https://openalex.org/W4414587822","https://openalex.org/W2783239189","https://openalex.org/W4396699039","https://openalex.org/W4412489226","https://openalex.org/W7171622525","https://openalex.org/W565599071","https://openalex.org/W7160861001"],"abstract_inverted_index":{"BACKGROUND:":[0],"Intestinal":[1],"senescence":[2,31,40,188],"is":[3],"associated":[4],"with":[5,56,74,118],"several":[6],"aging-related":[7],"diseases.":[8],"l-Theanine":[9],"(LTA)":[10],"has":[11],"demonstrated":[12],"strong":[13],"potential":[14],"as":[15],"an":[16,33],"antioxidant":[17,96],"and":[18,80,86,98,107,115,133,139,142,171,176,197],"antisenescence":[19],"agent.":[20],"This":[21],"study":[22],"investigated":[23],"the":[24,42,65,69,87,95,100,108,123,137,162,165,174,194],"regulatory":[25],"effect":[26],"of":[27,37,53,68,89,111,164,167,203],"LTA":[28,78,121,148,184],"on":[29],"cellular":[30],"using":[32],"in":[34,41,64,189],"vitro":[35],"model":[36],"d-galactose":[38],"(D-Gal)-induced":[39],"rat":[43],"epithelial":[44],"cell":[45,71,84,125,195],"line,":[46],"intestinal":[47],"epithelioid":[48],"cell-6":[49],"(IEC-6).":[50],"RESULTS:":[51],"Treatment":[52],"IEC-6":[54,190],"cells":[55,191],"40":[57],"mg/mL":[58],"D-Gal":[59,75],"for":[60],"48":[61],"h":[62],"resulted":[63],"successful":[66],"development":[67],"senescent":[70,112],"model.":[72],"Compared":[73],"alone,":[76],"both":[77],"preventive":[79,149],"delayed":[81,116,158],"intervention":[82,117,150,159,185],"increased":[83,94],"viability":[85],"ratio":[88],"JC-1":[90],"monomers":[91],"to":[92,153],"aggregates,":[93],"capacity,":[97],"decreased":[99],"advanced":[101],"glycation":[102],"end":[103],"product":[104],"(AGE)":[105],"levels":[106],"overall":[109],"number":[110],"cells.":[113],"Preventive":[114],"1000":[119],"\u03bcM":[120],"alleviated":[122],"D-Gal-induced":[124],"cycle":[126,196],"arrest":[127],"by":[128,160,192],"regulating":[129,193],"p38,":[130],"p53,":[131],"CDK4,":[132],"CDK6":[134],"expression":[135,163],"at":[136,173],"mRNA":[138,175],"protein":[140,177],"levels,":[141],"further":[143],"induced":[144],"CycD1":[145],"proteins.":[146],"Moreover,":[147],"reduced":[151],"apoptosis":[152],"a":[154],"greater":[155],"degree":[156],"than":[157],"upregulating":[161],"receptors":[166],"AGEs,":[168],"Bax,":[169],"Bcl-2,":[170],"NF-\u03baB":[172],"levels.":[178],"CONCLUSION:":[179],"Our":[180],"findings":[181],"indicate":[182],"that":[183],"could":[186],"attenuate":[187],"inhibiting":[198],"apoptosis.":[199],"\u00a9":[200],"2023":[201],"Society":[202],"Chemical":[204],"Industry.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-04T00:00:00"}