{"id":"https://openalex.org/W4388300944","doi":"https://doi.org/10.1101/2023.10.31.564979","title":"Structural determinants of pure antiestrogenicity","display_name":"Structural determinants of pure antiestrogenicity","publication_year":2023,"publication_date":"2023-11-02","ids":{"openalex":"https://openalex.org/W4388300944","doi":"https://doi.org/10.1101/2023.10.31.564979"},"language":"en","primary_location":{"id":"doi:10.1101/2023.10.31.564979","doi":"https://doi.org/10.1101/2023.10.31.564979","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.10.31.564979","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/02/2023.10.31.564979.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"parent_works":[],"lineage":["https://openalex.org/W4388300944"],"child_works_count":0,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/02/2023.10.31.564979.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073591317","display_name":"Marine Diennet","orcid":"https://orcid.org/0000-0002-2888-937X","observed_orcids":["https://orcid.org/0000-0002-2888-937X"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Diennet","raw_affiliation_strings":["Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":null,"display_name":"F. Shaikh","orcid":"https://orcid.org/0000-0003-4664-2319","observed_orcids":["https://orcid.org/0000-0003-4664-2319"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F. Shaikh","raw_affiliation_strings":["Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":"https://orcid.org/0000-0003-4664-2319","affiliations":[{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019903925","display_name":"Mohamed El Ezzy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. El Ezzy","raw_affiliation_strings":["Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093007285","display_name":"Khady Thiombane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]},{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K. Thiombane","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of British Columbia, Vancouver BC, Canada","Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of British Columbia, Vancouver BC, Canada","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071048719","display_name":"Sandra Weber","orcid":"https://orcid.org/0009-0008-8449-6379","observed_orcids":["https://orcid.org/0009-0008-8449-6379","https://orcid.org/0000-0003-1100-4210"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"S. Weber","raw_affiliation_strings":["Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008154919","display_name":"Julien Poupart","orcid":"https://orcid.org/0000-0003-1164-5931","observed_orcids":["https://orcid.org/0000-0003-1164-5931"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Poupart","raw_affiliation_strings":["Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048317476","display_name":"Rodrigo Mendoza\u2010Sanchez","orcid":"https://orcid.org/0009-0007-6962-7505","observed_orcids":["https://orcid.org/0009-0007-6962-7505","https://orcid.org/0000-0002-6143-6620"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R. Mendoza-Sanchez","raw_affiliation_strings":["Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057948519","display_name":"Zu\u2010Hua Gao","orcid":"https://orcid.org/0000-0001-7232-0933","observed_orcids":["https://orcid.org/0000-0001-7232-0933"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Z. Gao","raw_affiliation_strings":["Chemistry Department, McGill University, Montreal QC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, McGill University, Montreal QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014290819","display_name":"James L. Gleason","orcid":"https://orcid.org/0000-0003-1687-3343","observed_orcids":["https://orcid.org/0000-0003-1687-3343"]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J. Gleason","raw_affiliation_strings":["Chemistry Department, McGill University, Montreal QC, Canada"],"raw_orcid":"https://orcid.org/0000-0003-1687-3343","affiliations":[{"raw_affiliation_string":"Chemistry Department, McGill University, Montreal QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050602211","display_name":"Doris A. Schuetz","orcid":"https://orcid.org/0000-0001-8615-9554","observed_orcids":["https://orcid.org/0000-0001-8615-9554"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"D.A. Schuetz","raw_affiliation_strings":["Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001039341","display_name":"Geoffrey L. Greene","orcid":"https://orcid.org/0000-0001-6894-8728","observed_orcids":["https://orcid.org/0000-0001-6894-8728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Greene","raw_affiliation_strings":["Ben May Department for Cancer Res, Chicago University, Chicago IL 60636, United States"],"raw_orcid":"https://orcid.org/0000-0001-6894-8728","affiliations":[{"raw_affiliation_string":"Ben May Department for Cancer Res, Chicago University, Chicago IL 60636, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006793350","display_name":"Anne Marinier","orcid":"https://orcid.org/0000-0002-0116-8345","observed_orcids":["https://orcid.org/0000-0002-0116-8345"]},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"A. Marinier","raw_affiliation_strings":["Chemistry Department, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemistry Department, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037945259","display_name":"Sean William Fanning","orcid":"https://orcid.org/0000-0002-9428-0060","observed_orcids":["https://orcid.org/0000-0002-9428-0060"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S.W. Fanning","raw_affiliation_strings":["Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, IL 60153, United States","Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, IL 0153, United States"],"raw_orcid":"https://orcid.org/0000-0002-9428-0060","affiliations":[{"raw_affiliation_string":"Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, IL 60153, United States","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"Department of Cancer Biology, Loyola University Chicago Stritch School of Medicine, IL 0153, United States","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020001679","display_name":"Sylvie Mader","orcid":"https://orcid.org/0000-0002-6423-627X","observed_orcids":["https://orcid.org/0000-0002-6423-627X"]},"institutions":[{"id":"https://openalex.org/I4210096154","display_name":"Institute for Research in Immunology and Cancer","ror":"https://ror.org/00wj6x496","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210096154"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"S Mader","raw_affiliation_strings":["Department of Biochemistry and Molecular Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","Department of Biochemistry and Molecular Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J Canada"],"raw_orcid":"https://orcid.org/0000-0002-6423-627X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"Institute for Research in Immunology and Cancer, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J7 Canada","institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Medicine, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al QC H3C3J Canada","institution_ids":["https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020001679"],"corresponding_institution_ids":["https://openalex.org/I4210096154","https://openalex.org/I70931966"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8460000157356262},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.8560000061988831},{"id":"https://openalex.org/keywords/sumoylation","display_name":"SUMOylation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/protacs","display_name":"PROTACs","score":0.6610000133514404},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.847000002861023},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/coactivator-recruitment","display_name":"coactivator recruitment","score":0.7429999709129333},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.7289999723434448},{"id":"https://openalex.org/keywords/ligand-binding-domain","display_name":"ligand-binding domain","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.8595295548439026},{"id":"https://openalex.org/C171350616","wikidata":"https://www.wikidata.org/wiki/Q61506","display_name":"SUMO protein","level":4,"score":0.7634938955307007},{"id":"https://openalex.org/C2780482068","wikidata":"https://www.wikidata.org/wiki/Q5508491","display_name":"Fulvestrant","level":5,"score":0.6794552206993103},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5834181904792786},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5341830253601074},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.5222421884536743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4042017161846161},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38959598541259766},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35594433546066284},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3513742983341217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2598131597042084},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22851356863975525},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16300204396247864},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12598639726638794},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.12033742666244507},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.11525237560272217},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08490738272666931}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2023.10.31.564979","doi":"https://doi.org/10.1101/2023.10.31.564979","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.10.31.564979","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/02/2023.10.31.564979.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2023.10.31.564979","doi":"https://doi.org/10.1101/2023.10.31.564979","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.10.31.564979","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/11/02/2023.10.31.564979.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G102163711","display_name":null,"funder_award_id":"DE\u2010 AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G107546177","display_name":null,"funder_award_id":"DE- AC02-06-CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G1313983767","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G1664757510","display_name":null,"funder_award_id":"AC02\u201306CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G2287611682","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G262962599","display_name":null,"funder_award_id":"AC02\u201006CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2857925935","display_name":null,"funder_award_id":"DEAC0206CH11357","funder_id":"https://openalex.org/F4320337509","funder_display_name":"Biological and Environmental Research"},{"id":"https://openalex.org/G3075337988","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320338284","funder_display_name":"Argonne National Laboratory"},{"id":"https://openalex.org/G498139845","display_name":null,"funder_award_id":"DE-AC02","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G6848031779","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G6918803902","display_name":null,"funder_award_id":"06CH11357","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"},{"id":"https://openalex.org/G969889393","display_name":null,"funder_award_id":"DE-AC02-","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G993149817","display_name":null,"funder_award_id":"DE-AC02-06CH11357 ","funder_id":"https://openalex.org/F4320332359","funder_display_name":"Office of Science"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320306141","display_name":"Susan G. Komen for the Cure","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320332359","display_name":"Office of Science","ror":"https://ror.org/00mmn6b08"},{"id":"https://openalex.org/F4320337509","display_name":"Biological and Environmental Research","ror":"https://ror.org/0114b2m14"},{"id":"https://openalex.org/F4320338284","display_name":"Argonne National Laboratory","ror":"https://ror.org/05gvnxz63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388300944.pdf","grobid_xml":"https://content.openalex.org/works/W4388300944.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W1565310327","https://openalex.org/W1967021280","https://openalex.org/W1985341596","https://openalex.org/W1985588649","https://openalex.org/W1989954597","https://openalex.org/W2013809140","https://openalex.org/W2019311111","https://openalex.org/W2019989294","https://openalex.org/W2021145743","https://openalex.org/W2022784397","https://openalex.org/W2023586989","https://openalex.org/W2024903228","https://openalex.org/W2027044981","https://openalex.org/W2036487394","https://openalex.org/W2039871782","https://openalex.org/W2045389096","https://openalex.org/W2056155028","https://openalex.org/W2073367400","https://openalex.org/W2088932561","https://openalex.org/W2096690893","https://openalex.org/W2108681406","https://openalex.org/W2113249646","https://openalex.org/W2118369585","https://openalex.org/W2125695596","https://openalex.org/W2134427809","https://openalex.org/W2142274316","https://openalex.org/W2146505166","https://openalex.org/W2151084507","https://openalex.org/W2154911204","https://openalex.org/W2159206513","https://openalex.org/W2177855755","https://openalex.org/W2258559299","https://openalex.org/W2415372857","https://openalex.org/W2514824518","https://openalex.org/W2530784802","https://openalex.org/W2565707423","https://openalex.org/W2604928956","https://openalex.org/W2791787748","https://openalex.org/W2801333278","https://openalex.org/W2802285866","https://openalex.org/W2808671332","https://openalex.org/W2890830469","https://openalex.org/W2913168907","https://openalex.org/W2949512680","https://openalex.org/W2964142306","https://openalex.org/W2975211683","https://openalex.org/W3005469775","https://openalex.org/W3015634062","https://openalex.org/W3092710734","https://openalex.org/W3126771999","https://openalex.org/W3145363169","https://openalex.org/W3162472509","https://openalex.org/W3163477359","https://openalex.org/W3186188353","https://openalex.org/W4211005384","https://openalex.org/W4256087015","https://openalex.org/W4280516872","https://openalex.org/W4310553410"],"related_works":["https://openalex.org/W4387361950","https://openalex.org/W7039725109","https://openalex.org/W2134427809","https://openalex.org/W7166072140","https://openalex.org/W4310553410","https://openalex.org/W2890830469","https://openalex.org/W4403148444","https://openalex.org/W6983513687","https://openalex.org/W4403586749","https://openalex.org/W4280516872"],"abstract_inverted_index":{"Abstract":[0],"Inhibitory":[1],"activities":[2],"of":[3,36,45,57,71,74,98,129,144],"antiestrogens":[4],"on":[5,68],"estrogen":[6],"receptor":[7],"alpha":[8],"(ER\u03b1)":[9],"range":[10],"from":[11],"mixed":[12],"antagonism/agonism":[13],"(selective":[14,26],"ER":[15,27],"modulators;":[16],"SERMs)":[17],"to":[18,105,140],"complete":[19,51,142],"antiestrogenicity":[20],"associated":[21],"with":[22,94,117],"accelerated":[23,61],"ER\u03b1":[24,46,62,65,102,119,145],"turnover":[25],"degraders;":[28],"SERDs).":[29],"Here,":[30],"we":[31],"show":[32,135],"using":[33],"a":[34,40],"panel":[35],"SERMs,":[37],"SERDs":[38],"and":[39,108,125,147],"PROTAC":[41],"that":[42,136],"efficient":[43],"induction":[44],"SUMOylation":[47,66,93,138],"better":[48],"accounts":[49],"for":[50],"transcriptional":[52],"repression":[53],"than":[54],"increased":[55],"suppression":[56,143],"coactivator":[58],"recruitment":[59],"or":[60],"degradation.":[63],"Antiestrogen-induced":[64],"depends":[67],"the":[69,99,122,127,141],"hydrophobicity":[70],"N-terminal":[72],"residues":[73],"ligand":[75],"binding":[76],"domain":[77],"(LBD)":[78],"helix":[79],"12":[80],"(H12).":[81],"L536":[82,130],"mutations,":[83],"including":[84],"those":[85],"occurring":[86],"in":[87,121],"endocrine":[88],"therapy-resistant":[89],"breast":[90],"cancer,":[91],"abolished":[92],"all":[95],"antiestrogens.":[96],"Structures":[97],"L536S":[100],"human":[101],"LBD":[103],"bound":[104],"fulvestrant":[106],"analogs":[107],"molecular":[109],"dynamics":[110],"simulations":[111],"predict":[112],"dynamic":[113],"side":[114],"chain":[115],"interactions":[116],"wild-type":[118],"H12":[120],"coactivator-binding":[123],"groove":[124],"model":[126],"impact":[128],"mutations.":[131],"Together,":[132],"our":[133],"results":[134],"induced":[137],"contributes":[139],"activity":[146],"provide":[148],"insights":[149],"into":[150],"its":[151],"structural":[152],"determinants.":[153]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-11-04T00:00:00"}