{"id":"https://openalex.org/W4388295012","doi":"https://doi.org/10.1016/j.jep.2023.117313","title":"Mechanism of DaiTongXiao in the treatment of gouty arthritis through the NLRP3 signaling pathway","display_name":"Mechanism of DaiTongXiao in the treatment of gouty arthritis through the NLRP3 signaling pathway","publication_year":2023,"publication_date":"2023-11-03","ids":{"openalex":"https://openalex.org/W4388295012","doi":"https://doi.org/10.1016/j.jep.2023.117313","pmid":"https://pubmed.ncbi.nlm.nih.gov/37924998"},"language":"en","primary_location":{"id":"doi:10.1016/j.jep.2023.117313","doi":"https://doi.org/10.1016/j.jep.2023.117313","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jep.2023.117313","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.jep.2023.117313","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047059244","display_name":"Feifan Liu","orcid":"https://orcid.org/0000-0003-0881-6365","observed_orcids":["https://orcid.org/0000-0003-0881-6365","https://orcid.org/0000-0001-5349-7960"]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feifan Liu","raw_affiliation_strings":["College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: Lff13473656249@126.com","College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: Lff13473656249@126.com","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Fanyi Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanyi Shen","raw_affiliation_strings":["College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 1979862389@qq.com","College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 1979862389@qq.com","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063285493","display_name":"Yuanmei Bai","orcid":"https://orcid.org/0000-0003-1739-8011","observed_orcids":["https://orcid.org/0000-0003-1739-8011"]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanmei Bai","raw_affiliation_strings":["College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 846609106@qq.com","College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 846609106@qq.com","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Wan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wan","raw_affiliation_strings":["College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 2556882539@qq.com","College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 2556882539@qq.com","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101011565","display_name":"Lijie Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijie Zheng","raw_affiliation_strings":["College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 2367081903@qq.com","College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 2367081903@qq.com","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114096762","display_name":"Jinglin He","orcid":"https://orcid.org/0009-0007-4221-5447","observed_orcids":["https://orcid.org/0009-0007-4221-5447"]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jinglin He","raw_affiliation_strings":["College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 59968151@qq.com","College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: 59968151@qq.com","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuhuan Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuhuan Xie","raw_affiliation_strings":["College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: kmkamma@163.com","College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China. Electronic address: kmkamma@163.com","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044722489","display_name":"Peixin Guo","orcid":"https://orcid.org/0009-0002-7910-6416","observed_orcids":["https://orcid.org/0009-0002-7910-6416","https://orcid.org/0009-0009-7537-3171"]},"institutions":[{"id":"https://openalex.org/I46975222","display_name":"Yunnan University of Traditional Chinese Medicine","ror":"https://ror.org/04zap7912","country_code":"CN","type":"education","lineage":["https://openalex.org/I46975222"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Peixin Guo","raw_affiliation_strings":["College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China; Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, 650500, Yunnan, China. Electronic address: 13009@ynutcm.edu.cn","College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, 650500, Yunnan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China; Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, 650500, Yunnan, China. Electronic address: 13009@ynutcm.edu.cn","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"College of Ethnic Medicine, Yunnan University of Chinese Medicine, Yunnan, Kunming, 650500, China","institution_ids":["https://openalex.org/I46975222"]},{"raw_affiliation_string":"Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of Chinese Medicine, Kunming, 650500, Yunnan, China","institution_ids":["https://openalex.org/I46975222"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044722489","https://openalex.org/A5114096762"],"corresponding_institution_ids":["https://openalex.org/I46975222"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":1.508,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.82221354,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"319","issue":"Pt 3","first_page":"117313","last_page":"117313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gout","display_name":"gout","score":0.968999981880188},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9900000095367432},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.7250000238418579},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.609000027179718},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7960000038146973},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/asc","display_name":"ASC","score":0.5989999771118164},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7960000038146973},{"id":"https://openalex.org/keywords/j774a-1-macrophages","display_name":"J774A.1 macrophages","score":0.9079999923706055},{"id":"https://openalex.org/keywords/joint-swelling","display_name":"joint swelling","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.5545875430107117},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.522418737411499},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5143898129463196},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.5131743550300598},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.5017225742340088},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.45518654584884644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4282359778881073},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.41804203391075134},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40408068895339966},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.392183393239975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34900128841400146},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.24291318655014038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2220197319984436}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004487","descriptor_name":"Edema","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015210","descriptor_name":"Arthritis, Gouty","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jep.2023.117313","doi":"https://doi.org/10.1016/j.jep.2023.117313","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jep.2023.117313","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4542556","doi":"https://doi.org/10.2139/ssrn.4542556","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4542556","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:37924998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37924998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of ethnopharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jep.2023.117313","doi":"https://doi.org/10.1016/j.jep.2023.117313","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jep.2023.117313","pdf_url":null,"source":{"id":"https://openalex.org/S29564236","display_name":"Journal of Ethnopharmacology","issn_l":"0378-8741","issn":["0378-8741","1872-7573"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Ethnopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1985538633","https://openalex.org/W1998704430","https://openalex.org/W2033605168","https://openalex.org/W2044246578","https://openalex.org/W2063033429","https://openalex.org/W2073239633","https://openalex.org/W2079882002","https://openalex.org/W2126384811","https://openalex.org/W2137444266","https://openalex.org/W2190735152","https://openalex.org/W2359142600","https://openalex.org/W2566506390","https://openalex.org/W2609743202","https://openalex.org/W2772365261","https://openalex.org/W2790644231","https://openalex.org/W2899132793","https://openalex.org/W2941488156","https://openalex.org/W2943293743","https://openalex.org/W2944136715","https://openalex.org/W2961112538","https://openalex.org/W2998728526","https://openalex.org/W3035364992","https://openalex.org/W3080901962","https://openalex.org/W3094578730","https://openalex.org/W3166867667","https://openalex.org/W3178243456","https://openalex.org/W3211959642","https://openalex.org/W4281676404"],"related_works":["https://openalex.org/W2991463032","https://openalex.org/W4401039484","https://openalex.org/W4412697047","https://openalex.org/W4319063699","https://openalex.org/W4416968331","https://openalex.org/W4401384762","https://openalex.org/W2155299920","https://openalex.org/W4361011348","https://openalex.org/W3203351443","https://openalex.org/W4402657978"],"abstract_inverted_index":{"ETHNOPHARMACOLOGICAL":[0],"RELEVANCE:":[1],"DaiTongXiao":[2],"(DTX)":[3],"is":[4,27],"a":[5,195,270,312],"traditional":[6],"Chinese":[7],"Dai":[8],"folk":[9],"formulation":[10],"utilized":[11],"for":[12],"gouty":[13,49,324],"arthritis":[14,50,273,325],"treatment,":[15],"with":[16,77,87,275],"substantial":[17],"evidence":[18],"supporting":[19],"its":[20,53,276],"anti-inflammatory":[21],"properties.":[22],"The":[23,60,105,170],"NLRP3":[24,283],"inflammasome":[25],"disorder":[26],"tightly":[28,279],"linked":[29,280],"to":[30,128,154,281,311],"the":[31,43,97,130,156,204,241,264,282,315],"development":[32],"of":[33,46,84,107,132,161,172,207,245,317],"many":[34],"inflammatory":[35,284],"diseases.":[36],"AIM":[37],"OF":[38],"THE":[39],"STUDY:":[40],"To":[41],"elucidate":[42],"therapeutic":[44],"efficacy":[45],"DTX":[47,65,184,201,217,238,255,268],"in":[48,64,100,111,142,167,190,197,226,251,263,308,314],"and":[51,71,92,96,115,137,145,165,176,213,223,231,249,260,296,303,320],"reveal":[52],"potential":[54],"underlying":[55],"mechanism.":[56],"MATERIALS":[57],"AND":[58],"METHODS:":[59],"primary":[61],"active":[62],"constituents":[63],"were":[66,118],"determined":[67],"through":[68,120],"ultraviolet":[69],"spectrophotometry":[70],"gas":[72],"chromatography.":[73],"Rats":[74],"underwent":[75],"induction":[76,95,212],"monosodium":[78],"urate":[79],"(MSU),":[80],"followed":[81],"by":[82,180,194,292,298],"treatment":[83],"J774A.1":[85,168,208,252],"cells":[86,209],"adenosine":[88],"triphosphate":[89],"(ATP)":[90],"activation":[91],"lipopolysaccharide":[93],"(LPS)":[94],"subsequent":[98],"culture":[99,229],"Dulbecco's":[101],"modified":[102],"Eagle's":[103],"medium.":[104],"degree":[106],"foot":[108],"joint":[109,188,198,265],"swelling":[110,189],"rats":[112],"was":[113,126,152,178],"assessed,":[114],"ankle":[116],"joints":[117],"evaluated":[119],"H&E":[121],"staining.":[122],"Enzyme-linked":[123],"immunosorbent":[124],"assay":[125],"performed":[127,153],"measure":[129],"levels":[131,160,225,244],"interleukin":[133],"(IL)-1\u03b2,":[134],"IL-6,":[135,221,318],"IL-8,":[136,222,319],"tumor":[138],"necrosis":[139],"factor":[140],"(TNF)-\u03b1":[141],"both":[143,227],"serum":[144],"cells.":[146,253],"Reverse":[147],"transcription-polymerase":[148],"chain":[149],"reaction":[150],"(RT-PCR)":[151],"determine":[155],"relative":[157],"mRNA":[158,242],"expression":[159,171,243,262],"NLRP3,":[162,173,246,257,300],"ASC,":[163,174,247,258,301],"Caspase-1,":[164,175,248,302],"NF-\u03baB":[166,177,250,304],"macrophages.":[169],"examined":[179],"western":[181],"blotting.":[182],"RESULTS:":[183],"could":[185],"alleviate":[186],"MSU-induced":[187],"rats,":[191],"as":[192],"evidenced":[193],"reduction":[196,313],"inflammation.":[199],"Moreover,":[200],"effectively":[202],"enhanced":[203],"survival":[205],"rate":[206],"following":[210],"LPS":[211],"ATP":[214],"activation.":[215],"Furthermore,":[216],"significantly":[218],"reduced":[219],"IL-1\u03b2,":[220],"TNF-\u03b1":[224],"cell":[228],"medium":[230],"rat":[232],"serum.":[233],"RT-PCR":[234],"results":[235],"revealed":[236],"that":[237],"notably":[239],"downregulated":[240,256],"Additionally,":[254],"NF-\u03baB,":[259],"Caspase-1":[261],"tissue.":[266],"CONCLUSIONS:":[267],"exerts":[269],"significant":[271],"anti-gouty":[272],"effect,":[274],"mechanism":[277],"being":[278],"signaling":[285],"pathway.":[286],"This":[287],"pathway":[288],"may":[289],"be":[290],"modulated":[291],"inhibiting":[293],"IL-1\u03b2":[294],"differentiation":[295],"maturation":[297],"downregulating":[299],"protein":[305],"expression.":[306],"This,":[307],"turn,":[309],"leads":[310],"release":[316],"TNF-\u03b1,":[321],"ultimately":[322],"impeding":[323],"progression.":[326]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-11-04T00:00:00"}
