{"id":"https://openalex.org/W4388288147","doi":"https://doi.org/10.26508/lsa.202302175","title":"Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation","display_name":"Clathrin light chains CLCa and CLCb have non-redundant roles in epithelial lumen formation","publication_year":2023,"publication_date":"2023-11-03","ids":{"openalex":"https://openalex.org/W4388288147","doi":"https://doi.org/10.26508/lsa.202302175","pmid":"https://pubmed.ncbi.nlm.nih.gov/37923360","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10624596"},"language":"en","primary_location":{"id":"doi:10.26508/lsa.202302175","doi":"https://doi.org/10.26508/lsa.202302175","is_oa":true,"landing_page_url":"https://doi.org/10.26508/lsa.202302175","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/1/e202302175.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.life-science-alliance.org/content/lsa/7/1/e202302175.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100402054","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0002-5765-6209","observed_orcids":["https://orcid.org/0000-0002-5765-6209"]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["Department of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom","Institute of Structural and Molecular Biology, Birkbeck and University College London, London WC1E 7HX, United Kingdom",", London, UK","Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK","Institute of Structural and Molecular Biology, Birkbeck and University College London"],"raw_orcid":"https://orcid.org/0000-0002-5765-6209","affiliations":[{"raw_affiliation_string":"Department of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck and University College London, London WC1E 7HX, United Kingdom","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"raw_affiliation_string":", London, UK","institution_ids":[]},{"raw_affiliation_string":"Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck and University College London","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025338947","display_name":"Kit Briant","orcid":"https://orcid.org/0000-0002-1368-6262","observed_orcids":["https://orcid.org/0000-0002-1368-6262"]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kit Briant","raw_affiliation_strings":["Department of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom","Institute of Structural and Molecular Biology, Birkbeck and University College London, London WC1E 7HX, United Kingdom",", London, UK","Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK","Institute of Structural and Molecular Biology, Birkbeck and University College London"],"raw_orcid":"https://orcid.org/0000-0002-1368-6262","affiliations":[{"raw_affiliation_string":"Department of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck and University College London, London WC1E 7HX, United Kingdom","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"raw_affiliation_string":", London, UK","institution_ids":[]},{"raw_affiliation_string":"Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck and University College London","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103876452","display_name":"Marine D. Camus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Marine D. Camus","raw_affiliation_strings":["Department of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom","Institute of Structural and Molecular Biology, Birkbeck and University College London, London WC1E 7HX, United Kingdom",", London, UK","Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK","Institute of Structural and Molecular Biology, Birkbeck and University College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck and University College London, London WC1E 7HX, United Kingdom","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"raw_affiliation_string":", London, UK","institution_ids":[]},{"raw_affiliation_string":"Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck and University College London","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033940715","display_name":"Frances M. Brodsky","orcid":"https://orcid.org/0000-0002-1334-9258","observed_orcids":["https://orcid.org/0000-0002-1334-9258"]},"institutions":[{"id":"https://openalex.org/I4210157240","display_name":"Institute of Structural and Molecular Biology","ror":"https://ror.org/05wsetc54","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I98259816","display_name":"Birkbeck, University of London","ror":"https://ror.org/02mb95055","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I98259816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Frances M. Brodsky","raw_affiliation_strings":["Department of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom","Institute of Structural and Molecular Biology, Birkbeck and University College London, London WC1E 7HX, United Kingdom",", London, UK","Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK","Institute of Structural and Molecular Biology, Birkbeck and University College London"],"raw_orcid":"https://orcid.org/0000-0002-1334-9258","affiliations":[{"raw_affiliation_string":"Department of Structural and Molecular Biology, Division of Biosciences, University College London, London WC1E 6BT, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck and University College London, London WC1E 7HX, United Kingdom","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]},{"raw_affiliation_string":", London, UK","institution_ids":[]},{"raw_affiliation_string":"Department of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Structural and Molecular Biology, Birkbeck and University College London","institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033940715"],"corresponding_institution_ids":["https://openalex.org/I4210157240","https://openalex.org/I45129253","https://openalex.org/I98259816"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":{"value":3500,"currency":"USD","value_usd":3500},"fwci":0.2954,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.40152614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"7","issue":"1","first_page":"e202302175","last_page":"e202302175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clathrin-light-chain","display_name":"clathrin light chain","score":0.9430000185966492},{"id":"https://openalex.org/keywords/uterine-glands","display_name":"endometrial glands","score":0.699999988079071},{"id":"https://openalex.org/keywords/epithelial-differentiation","display_name":"epithelial differentiation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/epithelial-cell-polarity","display_name":"epithelial polarity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cysts","display_name":"cysts","score":0.41600000858306885},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.574999988079071},{"id":"https://openalex.org/keywords/fertility","display_name":"fertility","score":0.42500001192092896},{"id":"https://openalex.org/keywords/neonatal-mortality","display_name":"neonatal mortality","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5752007961273193},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5326169729232788},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.5249100923538208},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4810933768749237},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4527462124824524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40106409788131714},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3968362808227539},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3272656798362732},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15344718098640442},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1517098844051361},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1401636302471161},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12387514114379883}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003560","descriptor_name":"Cysts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033941","descriptor_name":"Clathrin Light Chains","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D033941","descriptor_name":"Clathrin Light Chains","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055112","descriptor_name":"Pyometra","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.26508/lsa.202302175","doi":"https://doi.org/10.26508/lsa.202302175","is_oa":true,"landing_page_url":"https://doi.org/10.26508/lsa.202302175","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/1/e202302175.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},{"id":"doi:10.1101/2023.04.25.538235","doi":"https://doi.org/10.1101/2023.04.25.538235","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.04.25.538235","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/22/2023.04.25.538235.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10624596","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10624596","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10624596/pdf/LSA-2023-02175.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sci Alliance","raw_type":"Text"},{"id":"pmid:37923360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37923360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life science alliance","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10180848","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10180848/","pdf_url":"https://discovery.ucl.ac.uk/10180848/1/Chen-Briant-LSA-2023.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life Science Alliance , 7 (1) , Article e202302175. (2024)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:fd970d4a743144f297bbe0c742c05958","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fd970d4a743144f297bbe0c742c05958","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Life Science Alliance, Vol 7, Iss 1, p e202302175 (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.26508/lsa.202302175","doi":"https://doi.org/10.26508/lsa.202302175","is_oa":true,"landing_page_url":"https://doi.org/10.26508/lsa.202302175","pdf_url":"https://www.life-science-alliance.org/content/lsa/7/1/e202302175.full.pdf","source":{"id":"https://openalex.org/S4210202458","display_name":"Life Science Alliance","issn_l":"2575-1077","issn":["2575-1077"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-40","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Science Alliance","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4225719950","display_name":"REGULATION OF HUMAN GLUCOSE HOMEOSTASIS BY THE NOVEL CHC22 CLATHRIN ISOFORM","funder_award_id":"MR/S008144/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G6868616705","display_name":null,"funder_award_id":"/Z/15/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G896765999","display_name":"THE PHYSIOLOGICAL ROLE OF CLATHRIN LIGHT CHAIN DIVERSITY IN VERTEBRATES.","funder_award_id":"107858","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388288147.pdf","grobid_xml":"https://content.openalex.org/works/W4388288147.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W124843545","https://openalex.org/W1968261842","https://openalex.org/W1970277398","https://openalex.org/W1973409593","https://openalex.org/W1976549834","https://openalex.org/W1982998571","https://openalex.org/W1996107769","https://openalex.org/W1997281741","https://openalex.org/W1999251929","https://openalex.org/W2000388340","https://openalex.org/W2030364983","https://openalex.org/W2034710119","https://openalex.org/W2043861102","https://openalex.org/W2044626246","https://openalex.org/W2051399235","https://openalex.org/W2058568944","https://openalex.org/W2068734008","https://openalex.org/W2070616723","https://openalex.org/W2073038040","https://openalex.org/W2077801296","https://openalex.org/W2080360085","https://openalex.org/W2088558790","https://openalex.org/W2092893350","https://openalex.org/W2124743484","https://openalex.org/W2127453466","https://openalex.org/W2131411890","https://openalex.org/W2134098725","https://openalex.org/W2140191008","https://openalex.org/W2144115944","https://openalex.org/W2148996569","https://openalex.org/W2305957222","https://openalex.org/W2517871575","https://openalex.org/W2519104534","https://openalex.org/W2566583131","https://openalex.org/W2765987013","https://openalex.org/W2770765554","https://openalex.org/W2789536221","https://openalex.org/W2792227155","https://openalex.org/W2793567263","https://openalex.org/W2804166135","https://openalex.org/W2809641528","https://openalex.org/W2890302226","https://openalex.org/W2897196381","https://openalex.org/W2898827836","https://openalex.org/W2901434239","https://openalex.org/W2937741430","https://openalex.org/W2944547583","https://openalex.org/W2945821563","https://openalex.org/W2982612361","https://openalex.org/W2989014418","https://openalex.org/W3033466435","https://openalex.org/W3081368827","https://openalex.org/W3084063384","https://openalex.org/W3131398442"],"related_works":["https://openalex.org/W4236587165","https://openalex.org/W123164916","https://openalex.org/W2013083005","https://openalex.org/W2920808998","https://openalex.org/W2103095881","https://openalex.org/W3016807328","https://openalex.org/W2167983900","https://openalex.org/W2739332878","https://openalex.org/W1970135176","https://openalex.org/W1765968760"],"abstract_inverted_index":{"To":[0],"identify":[1],"functional":[2],"differences":[3],"between":[4],"vertebrate":[5],"clathrin":[6],"light":[7],"chains":[8],"(CLCa":[9],"or":[10,61,109,119],"CLCb),":[11],"phenotypes":[12],"of":[13,36,66,77,88,103],"mice":[14,68],"lacking":[15,43,55,69],"genes":[16],"encoding":[17],"either":[18,117],"isoform":[19],"were":[20,113,121],"characterised.":[21],"Mice":[22,42],"without":[23],"CLCa":[24,56,70,118,128],"displayed":[25,45],"50%":[26],"neonatal":[27],"mortality,":[28],"reduced":[29,32,86],"body":[30],"weight,":[31],"fertility,":[33],"and":[34,57,82,84,101,152],"\u223c40%":[35],"aged":[37],"females":[38],"developed":[39,72],"uterine":[40,108],"pyometra.":[41],"CLCb":[44,120],"a":[46,85,163],"less":[47],"severe":[48,125],"weight":[49],"reduction":[50],"phenotype":[51],"compared":[52],"with":[53,123,162],"those":[54],"had":[58,135],"no":[59],"survival":[60],"reproductive":[62],"system":[63],"defects.":[64],"Analysis":[65],"female":[67],"that":[71],"pyometra":[73],"revealed":[74],"ectopic":[75],"expression":[76],"epithelial":[78,104,159],"differentiation":[79],"markers":[80],"(FOXA2":[81],"K14)":[83],"number":[87],"endometrial":[89],"glands,":[90],"indicating":[91],"defects":[92],"in":[93,98,145,158],"the":[94,132],"lumenal":[95],"epithelium.":[96],"Defects":[97],"lumen":[99,160],"formation":[100],"polarity":[102],"cysts":[105],"derived":[106],"from":[107,127],"gut":[110],"cell":[111],"lines":[112],"also":[114],"observed":[115],"when":[116],"depleted,":[122],"more":[124],"effects":[126],"depletion.":[129],"In":[130],"cysts,":[131],"CLC":[133,156],"isoforms":[134,157],"different":[136],"distributions":[137],"relative":[138],"to":[139],"each":[140],"other,":[141],"although":[142],"they":[143],"converge":[144],"tissue.":[146],"Together,":[147],"these":[148],"findings":[149],"suggest":[150],"differential":[151],"cooperative":[153],"roles":[154],"for":[155,166],"formation,":[161],"dominant":[164],"function":[165],"CLCa.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2023-11-04T00:00:00"}
