{"id":"https://openalex.org/W4388286341","doi":"https://doi.org/10.1371/journal.pone.0294042","title":"Maternal folic acid supplementation and the risk of ankyloglossia (tongue-tie) in infants; a systematic review","display_name":"Maternal folic acid supplementation and the risk of ankyloglossia (tongue-tie) in infants; a systematic review","publication_year":2023,"publication_date":"2023-11-03","ids":{"openalex":"https://openalex.org/W4388286341","doi":"https://doi.org/10.1371/journal.pone.0294042","pmid":"https://pubmed.ncbi.nlm.nih.gov/37922258","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10624271"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0294042","doi":"https://doi.org/10.1371/journal.pone.0294042","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0294042","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294042&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294042&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072746939","display_name":"Gal Rubin","orcid":"https://orcid.org/0000-0003-1467-8157","observed_orcids":["https://orcid.org/0000-0003-1467-8157"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gal Rubin","raw_affiliation_strings":["Minerva University: College of Natural Sciences, San Francisco, CA, United States America","UCL EGA Institute for Women's Health, Reproductive Health Research Dept, UCL, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-1467-8157","affiliations":[{"raw_affiliation_string":"Minerva University: College of Natural Sciences, San Francisco, CA, United States America","institution_ids":[]},{"raw_affiliation_string":"UCL EGA Institute for Women's Health, Reproductive Health Research Dept, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Catherine Stewart","orcid":"https://orcid.org/0000-0002-7204-7356","observed_orcids":["https://orcid.org/0000-0002-7204-7356"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine Stewart","raw_affiliation_strings":["UCL EGA Institute for Women's Health, Reproductive Health Research Dept, UCL, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-7204-7356","affiliations":[{"raw_affiliation_string":"UCL EGA Institute for Women's Health, Reproductive Health Research Dept, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030055222","display_name":"Laura J. McGowan","orcid":"https://orcid.org/0000-0003-3253-3226","observed_orcids":["https://orcid.org/0000-0003-3253-3226","https://orcid.org/0000-0002-4054-9300"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laura McGowan","raw_affiliation_strings":["Centre for Public Health, Institute for Global Food Security, Queen's University Belfast, Belfast, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Public Health, Institute for Global Food Security, Queen's University Belfast, Belfast, Ireland","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031466793","display_name":"Jayne V. Woodside","orcid":"https://orcid.org/0000-0002-5691-4659","observed_orcids":["https://orcid.org/0000-0002-5691-4659"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jayne V. Woodside","raw_affiliation_strings":["Centre for Public Health, Institute for Global Food Security, Queen's University Belfast, Belfast, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Public Health, Institute for Global Food Security, Queen's University Belfast, Belfast, Ireland","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041052709","display_name":"Geraldine Barrett","orcid":"https://orcid.org/0000-0002-9738-1051","observed_orcids":["https://orcid.org/0000-0002-9738-1051"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Geraldine Barrett","raw_affiliation_strings":["UCL EGA Institute for Women's Health, Reproductive Health Research Dept, UCL, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-9738-1051","affiliations":[{"raw_affiliation_string":"UCL EGA Institute for Women's Health, Reproductive Health Research Dept, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031184713","display_name":"Keith M. Godfrey","orcid":"https://orcid.org/0000-0002-4643-0618","observed_orcids":["https://orcid.org/0000-0002-4643-0618"]},"institutions":[{"id":"https://openalex.org/I2802965805","display_name":"University Hospital Southampton NHS Foundation Trust","ror":"https://ror.org/0485axj58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I4210118229","display_name":"NIHR Southampton Biomedical Research Centre","ror":"https://ror.org/01qqpzg67","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I43439940"]},{"id":"https://openalex.org/I4210148293","display_name":"MRC Lifecourse Epidemiology Unit","ror":"https://ror.org/04j4a6x59","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210148293","https://openalex.org/I43439940","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keith M. Godfrey","raw_affiliation_strings":["MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Lifecourse Epidemiology Centre and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom","institution_ids":["https://openalex.org/I2802965805","https://openalex.org/I4210118229","https://openalex.org/I4210148293","https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080891847","display_name":"Jennifer Hall","orcid":"https://orcid.org/0000-0002-2084-9568","observed_orcids":["https://orcid.org/0000-0002-2084-9568"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jennifer Hall","raw_affiliation_strings":["UCL EGA Institute for Women's Health, Reproductive Health Research Dept, UCL, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2084-9568","affiliations":[{"raw_affiliation_string":"UCL EGA Institute for Women's Health, Reproductive Health Research Dept, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5080891847"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":1805,"currency":"USD","value_usd":1805},"apc_paid":{"value":1805,"currency":"USD","value_usd":1805},"fwci":0.3452,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.35215054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"18","issue":"11","first_page":"e0294042","last_page":"e0294042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13813","display_name":"Oral and Craniofacial Lesions","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13813","display_name":"Oral and Craniofacial Lesions","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-folic-acid-supplementation","display_name":"maternal folic acid supplementation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/ankyloglossia","display_name":"ankyloglossia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/infants","display_name":"infants","score":0.7110000252723694},{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.8149999976158142},{"id":"https://openalex.org/keywords/preconception-care","display_name":"preconception care","score":0.7850000262260437},{"id":"https://openalex.org/keywords/prenatal-care","display_name":"prenatal care","score":0.9139999747276306},{"id":"https://openalex.org/keywords/supplement-safety","display_name":"supplement safety","score":0.49900001287460327},{"id":"https://openalex.org/keywords/public-health-communication","display_name":"public health communication","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8302441835403442},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.6718541979789734},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.656549870967865},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.5489335060119629},{"id":"https://openalex.org/C2909565028","wikidata":"https://www.wikidata.org/wiki/Q2915477","display_name":"Folic acid supplementation","level":3,"score":0.5436798930168152},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.5342957377433777},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4886217713356018},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.4806860387325287},{"id":"https://openalex.org/C2992130864","wikidata":"https://www.wikidata.org/wiki/Q127060","display_name":"Folic acid","level":2,"score":0.46531012654304504},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4608660638332367},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4512256681919098},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.41636645793914795},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1875235140323639},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06328946352005005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072676","descriptor_name":"Ankyloglossia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014059","descriptor_name":"Tongue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pone.0294042","doi":"https://doi.org/10.1371/journal.pone.0294042","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0294042","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294042&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"doi:10.22541/au.168007870.09307215/v1","doi":"https://doi.org/10.22541/au.168007870.09307215/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.168007870.09307215/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.168007870.09307215","source":null,"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10624271","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10624271","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10624271/pdf/pone.0294042.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:37922258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37922258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Systematic Review"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/e3b670a3-cd8b-4b22-8097-47f5300d47bd","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/e3b670a3-cd8b-4b22-8097-47f5300d47bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rubin, G, Stewart, C, McGowan, L, Woodside, J V, Barrett, G, Godfrey, K M & Hall, J 2023, 'Maternal folic acid supplementation and the risk of ankyloglossia (tongue-tie) in infants; a systematic review', PLOS ONE, vol. 18, no. 11, e0294042. https://doi.org/10.1371/journal.pone.0294042","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.soton.ac.uk:483653","doi":null,"is_oa":false,"landing_page_url":"https://eprints.soton.ac.uk/id/eprint/483653/1/Maternal_FAS_and_the_risk_of_tongue_tie_plos_one_1_.docx","pdf_url":null,"source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10180727","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10180727/","pdf_url":"https://discovery.ucl.ac.uk/10180727/1/journal.pone.0294042.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One , 18 (11) , Article e0294042. (2023)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:c9f5786bf23043859abe391df9baa1b9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/c9f5786bf23043859abe391df9baa1b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 18, Iss 11, p e0294042 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0294042","doi":"https://doi.org/10.1371/journal.pone.0294042","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0294042","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0294042&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[{"id":"https://openalex.org/G466435702","display_name":"NIHR Senior Investigator Award","funder_award_id":"NIHR200286","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388286341.pdf","grobid_xml":"https://content.openalex.org/works/W4388286341.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1805403428","https://openalex.org/W1961533318","https://openalex.org/W1984043725","https://openalex.org/W2006181515","https://openalex.org/W2034641962","https://openalex.org/W2053880670","https://openalex.org/W2072008636","https://openalex.org/W2099564906","https://openalex.org/W2115609680","https://openalex.org/W2120935789","https://openalex.org/W2140900388","https://openalex.org/W2145773499","https://openalex.org/W2153488855","https://openalex.org/W2338473884","https://openalex.org/W2575440932","https://openalex.org/W2767306601","https://openalex.org/W2892815296","https://openalex.org/W2962978838","https://openalex.org/W2979477346","https://openalex.org/W2989263474","https://openalex.org/W3000196268","https://openalex.org/W3015349381","https://openalex.org/W3029665503","https://openalex.org/W3042009865","https://openalex.org/W3112462794","https://openalex.org/W3118615836","https://openalex.org/W3200906280","https://openalex.org/W3205368765"],"related_works":["https://openalex.org/W4414698711","https://openalex.org/W2989263474","https://openalex.org/W4406616040","https://openalex.org/W2747672997","https://openalex.org/W7098097102","https://openalex.org/W7099776423","https://openalex.org/W1971726758","https://openalex.org/W2330601853","https://openalex.org/W7162872702","https://openalex.org/W2278610362"],"abstract_inverted_index":{"BACKGROUND:":[0],"Maternal":[1],"folic":[2,29,54,71,111,170,182,217,226],"acid":[3,30,55,72,112,171,183,218,227],"supplementation":[4,73,113,172,219,228],"is":[5],"protective":[6],"against":[7],"the":[8,34,67,79,88,107,119,167,205,223,231],"development":[9],"of":[10,81,109,121,181,225],"neural":[11],"tube":[12],"defects":[13],"(NTDs)":[14],"in":[15,40,83,123,159,187],"babies.":[16],"However,":[17,193],"recent":[18],"public-facing":[19],"communications":[20,43],"have":[21],"raised":[22],"concerns":[23],"about":[24],"a":[25,161,214],"causal":[26],"relationship":[27,168,215],"between":[28,69,169,216],"supplementation,":[31,56],"particularly":[32],"after":[33],"first":[35],"trimester,":[36],"and":[37,78,94,100,103,145,148,173,202,220,245],"ankyloglossia":[38,82,122],"(tongue-tie)":[39],"infants.":[41,84],"Non-evidence-based":[42],"are":[44],"potentially":[45],"harmful":[46],"because":[47],"they":[48],"could":[49],"adversely":[50],"affect":[51],"adherence":[52],"to":[53,63,238],"increasing":[57],"NTD":[58],"occurrence.":[59],"This":[60,175,233],"study":[61,163,176,195],"aimed":[62],"review":[64],"evidence":[65,211],"on":[66,118,129,131],"relationships":[68],"maternal":[70,110],"during":[74,114,243],"preconception":[75,115,244],"and/or":[76],"pregnancy":[77,117],"risk":[80],"METHODS:":[85],"We":[86,96],"searched":[87,97],"databases":[89],"MEDLINE,":[90],"EMBASE,":[91],"Cochrane":[92],"CENTRAL,":[93],"Scopus.":[95],"for":[98,157,213],"observational,":[99],"interventional":[101],"studies,":[102],"systematic":[104],"reviews":[105],"investigating":[106],"effect":[108],"or":[116],"occurrence":[120],"offspring.":[124],"The":[125,136],"search":[126],"was":[127,154,185],"registered":[128],"PROSPERO":[130],"01/12/2022,":[132],"ID:":[133],"CRD42022375862.":[134],"RESULTS:":[135],"database":[137],"searches":[138],"yielded":[139],"93":[140],"articles.":[141],"After":[142],"removing":[143],"duplicates":[144],"screening":[146],"titles":[147],"abstracts,":[149],"26":[150],"remained.":[151],"One":[152],"article":[153],"judged":[155],"relevant":[156],"inclusion":[158],"analyses;":[160],"case-control":[162],"that":[164,178],"directly":[165],"mentions":[166],"ankyloglossia.":[174,192,221],"reported":[177],"regular":[179],"intake":[180],"supplements":[184],"higher":[186],"women":[188],"with":[189,191],"infants":[190],"this":[194],"has":[196],"limitations":[197],"regarding":[198],"design,":[199],"selection":[200],"bias,":[201],"confounding,":[203],"calling":[204],"findings":[206],"into":[207],"question.":[208],"CONCLUSIONS:":[209],"Insufficient":[210],"exists":[212],"Currently,":[222],"benefits":[224],"far":[229],"outweigh":[230],"risks.":[232],"must":[234],"be":[235],"clearly":[236],"communicated":[237],"patients":[239],"by":[240],"their":[241],"clinicians":[242],"antenatal":[246],"care.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-04T00:00:00"}
