{"id":"https://openalex.org/W4388245652","doi":"https://doi.org/10.1093/oso/9780195148503.003.0048","title":"Phage Therapy","display_name":"Phage Therapy","publication_year":2005,"publication_date":"2005-12-15","ids":{"openalex":"https://openalex.org/W4388245652","doi":"https://doi.org/10.1093/oso/9780195148503.003.0048"},"language":"en","primary_location":{"id":"doi:10.1093/oso/9780195148503.003.0048","doi":"https://doi.org/10.1093/oso/9780195148503.003.0048","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1093/oso/9780195148503.003.0048","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Bacteriophages","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4388245783","display_name":"The Bacteriophages"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111645688","display_name":"Carl R. Merril","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carl R Merril","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038136786","display_name":"Dean Scholl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dean Scholl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088321531","display_name":"Sankar L Adhya","orcid":"https://orcid.org/0000-0002-9970-9647","observed_orcids":["https://orcid.org/0000-0002-9970-9647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sankar Adhya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.43653032,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"725","last_page":"741"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phage-therapy","display_name":"phage therapy","score":0.8989999890327454},{"id":"https://openalex.org/keywords/bacteriophages","display_name":"bacteriophages","score":0.9150000214576721},{"id":"https://openalex.org/keywords/phage-purification","display_name":"phage purification","score":0.6480000019073486},{"id":"https://openalex.org/keywords/host-range","display_name":"host range","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2779256223","wikidata":"https://www.wikidata.org/wiki/Q611870","display_name":"Phage therapy","level":5,"score":0.8901467323303223},{"id":"https://openalex.org/C2776441376","wikidata":"https://www.wikidata.org/wiki/Q165028","display_name":"Bacteriophage","level":4,"score":0.6834574341773987},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5881029367446899},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5651520490646362},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5594980716705322},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.5221326947212219},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5171889066696167},{"id":"https://openalex.org/C19655278","wikidata":"https://www.wikidata.org/wiki/Q3293735","display_name":"Bacterial cell structure","level":3,"score":0.43854260444641113},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42238226532936096},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2791385054588318},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.14337849617004395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08470919728279114},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/oso/9780195148503.003.0048","doi":"https://doi.org/10.1093/oso/9780195148503.003.0048","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1093/oso/9780195148503.003.0048","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Bacteriophages","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2107557615","https://openalex.org/W7096802604","https://openalex.org/W4288056014","https://openalex.org/W4295227503","https://openalex.org/W2021288313","https://openalex.org/W7042633184","https://openalex.org/W4404455027","https://openalex.org/W4295021992","https://openalex.org/W3045035773","https://openalex.org/W4231940808"],"abstract_inverted_index":{"Abstract":[0],"The":[1,193],"ability":[2],"of":[3,13,29,35,47,53,59,69,72,88,103,105,111,159,166,173,197,201],"bacteriophage":[4],"(phage)":[5],"to":[6,116,140],"replicate":[7],"exponentially":[8],"and":[9,90,95,113,123],"lyse":[10],"pathogenic":[11],"strains":[12],"bacteria":[14,121],"suggests":[15],"that":[16,61,81,138,155],"they":[17,145,187],"should":[18],"play":[19],"a":[20,44,57,170,203],"vital":[21],"role":[22],"in":[23,33,43,79,93],"our":[24],"armamentarium":[25],"for":[26,66],"the":[27,50,70,86,106,157,163,189],"treatment":[28],"infectious":[30],"diseases.":[31],"However,":[32],"spite":[34],"an":[36,100,114],"initial":[37,101],"enthusiasm,":[38],"early":[39],"clinical":[40],"applications":[41],"resulted":[42],"negative":[45],"shift":[46],"opinion":[48],"concerning":[49],"therapeutic":[51,76],"potential":[52],"phage.":[54],"There":[55],"are":[56,146],"number":[58],"factors":[60,98],"may":[62],"have":[63],"been":[64],"responsible":[65],"this":[67],"rejection":[68],"use":[71],"phage":[73,112,118,142,160,198],"as":[74],"antibacterial":[75],"agents,":[77],"particularly":[78],"countries":[80],"require":[82],"certification":[83],"based":[84],"on":[85],"results":[87],"efficacy":[89],"pharmacokinetic":[91],"studies":[92],"animals":[94],"humans.":[96],"These":[97,125],"include":[99,129],"lack":[102],"understanding":[104],"relatively":[107],"narrow":[108,194],"host":[109,195],"range":[110,172,196],"inability":[115],"purify":[117],"preparations":[119,143],"from":[120],"products":[122],"debris.":[124],"contaminating":[126],"materials":[127],"often":[128,181],"bacterial":[130,135,174,191],"exoand":[131],"endotoxins":[132],"along":[133],"with":[134],"cellular":[136],"components":[137],"tend":[139],"inactivate":[141],"when":[144],"stored":[147],"without":[148],"further":[149],"purification":[150],"(60).":[151],"Another":[152],"major":[153],"factor":[154],"affected":[156],"development":[158],"therapy":[161],"was":[162],"successful":[164],"introduction":[165],"antibiotics":[167,178],"effective":[168],"against":[169],"broad":[171],"strains.":[175],"With":[176],"such":[177,202],"physicians":[179],"could":[180],"successfully":[182],"treat":[183],"infections":[184],"even":[185],"before":[186],"determined":[188],"causative":[190],"strain.":[192],"made":[199],"duplication":[200],"practice":[204],"questionable":[205],"at":[206],"best.":[207]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2023-11-03T00:00:00"}