{"id":"https://openalex.org/W4388199032","doi":"https://doi.org/10.1158/2767-9764.24442291","title":"FIGURE 2 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages","display_name":"FIGURE 2 from PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages","publication_year":2023,"publication_date":"2023-10-26","ids":{"openalex":"https://openalex.org/W4388199032","doi":"https://doi.org/10.1158/2767-9764.24442291"},"language":"en","primary_location":{"id":"doi:10.1158/2767-9764.24442291","doi":"https://doi.org/10.1158/2767-9764.24442291","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24442291","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/2767-9764.24442291","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019835767","display_name":"Kevin J. Kauffman","orcid":"https://orcid.org/0009-0004-3249-4671","observed_orcids":["https://orcid.org/0009-0004-3249-4671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Kauffman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-3249-4671","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083694544","display_name":"Denise J. Manfra","orcid":"https://orcid.org/0000-0002-1290-2437","observed_orcids":["https://orcid.org/0000-0002-1290-2437"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denise Manfra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1290-2437","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040337340","display_name":"Dominika Nowakowska","orcid":"https://orcid.org/0000-0001-8891-2714","observed_orcids":["https://orcid.org/0000-0001-8891-2714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dominika Nowakowska","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8891-2714","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050806329","display_name":"Mohammad R. Zafari","orcid":"https://orcid.org/0000-0002-0711-4612","observed_orcids":["https://orcid.org/0000-0002-0711-4612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Zafari","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0711-4612","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037622232","display_name":"Phuong A. Nguyen","orcid":"https://orcid.org/0000-0003-2393-1337","observed_orcids":["https://orcid.org/0000-0003-2393-1337"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Phuong A. Nguyen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2393-1337","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020513321","display_name":"Ryan Phennicie","orcid":"https://orcid.org/0000-0002-5105-7926","observed_orcids":["https://orcid.org/0000-0002-5105-7926"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan Phennicie","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5105-7926","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071966055","display_name":"Elisabeth H. Vollmann","orcid":"https://orcid.org/0000-0002-8569-515X","observed_orcids":["https://orcid.org/0000-0002-8569-515X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elisabeth H. Vollmann","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8569-515X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075038220","display_name":"Brian O\u2019Nuallain","orcid":"https://orcid.org/0009-0003-0464-6749","observed_orcids":["https://orcid.org/0009-0003-0464-6749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian O'Nuallain","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-0464-6749","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093042430","display_name":"Sara Basinski","orcid":"https://orcid.org/0009-0001-2832-3691","observed_orcids":["https://orcid.org/0009-0001-2832-3691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Basinski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-2832-3691","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011235186","display_name":"Veronica Komoroski","orcid":"https://orcid.org/0009-0001-5038-1660","observed_orcids":["https://orcid.org/0009-0001-5038-1660"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Veronica Komoroski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-5038-1660","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093042429","display_name":"Kate Rooney","orcid":"https://orcid.org/0000-0003-4901-9610","observed_orcids":["https://orcid.org/0000-0003-4901-9610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kate Rooney","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4901-9610","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079503076","display_name":"Elizabeth K. Culyba","orcid":"https://orcid.org/0000-0002-2812-764X","observed_orcids":["https://orcid.org/0000-0002-2812-764X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth K. Culyba","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2812-764X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079124110","display_name":"Joseph A. Wahle","orcid":"https://orcid.org/0009-0003-1432-6802","observed_orcids":["https://orcid.org/0009-0003-1432-6802"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph Wahle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-1432-6802","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031505278","display_name":"Carola Hermine Ries","orcid":"https://orcid.org/0000-0002-1855-8745","observed_orcids":["https://orcid.org/0000-0002-1855-8745"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carola Ries","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1855-8745","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023032912","display_name":"Michael A. Brehm","orcid":"https://orcid.org/0000-0001-6813-3262","observed_orcids":["https://orcid.org/0000-0001-6813-3262"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Brehm","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6813-3262","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031826057","display_name":"Steve Sazinsky","orcid":"https://orcid.org/0009-0009-1936-8490","observed_orcids":["https://orcid.org/0009-0009-1936-8490"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve Sazinsky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-1936-8490","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088825252","display_name":"Igor Feldman","orcid":"https://orcid.org/0009-0004-5340-0128","observed_orcids":["https://orcid.org/0009-0004-5340-0128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Feldman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0004-5340-0128","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019685125","display_name":"Tatiana I. Novobrantseva","orcid":"https://orcid.org/0000-0001-8070-403X","observed_orcids":["https://orcid.org/0000-0001-8070-403X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tatiana I. Novobrantseva","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8070-403X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psgl-1","display_name":"PSGL-1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9300000071525574},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.828000009059906},{"id":"https://openalex.org/keywords/macrophage-differentiation","display_name":"macrophage differentiation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.8669999837875366},{"id":"https://openalex.org/keywords/lipid-nanoparticles","display_name":"lipid nanoparticles","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cd163","display_name":"CD163","score":0.8569999933242798},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cd16","display_name":"CD16","score":0.9490000009536743},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.640999972820282},{"id":"https://openalex.org/keywords/peripheral-blood-monocytes","display_name":"peripheral blood monocytes","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.7557988166809082},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.6807492971420288},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.619938313961029},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6151635050773621},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5343890190124512},{"id":"https://openalex.org/C2781462264","wikidata":"https://www.wikidata.org/wiki/Q78482053","display_name":"CD16","level":5,"score":0.44971194863319397},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.4382268190383911},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4337038993835449},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.42787501215934753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35581862926483154},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3244929015636444},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2898280620574951},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24496346712112427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2212957739830017},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10736176371574402},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.10654816031455994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09089434146881104},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/2767-9764.24442291","doi":"https://doi.org/10.1158/2767-9764.24442291","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24442291","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/2767-9764.24442291.v1","doi":"https://doi.org/10.1158/2767-9764.24442291.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/2767-9764.24442291.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/2767-9764.24442291","doi":"https://doi.org/10.1158/2767-9764.24442291","is_oa":true,"landing_page_url":"https://doi.org/10.1158/2767-9764.24442291","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388203826","https://openalex.org/W4388202484","https://openalex.org/W3029384960","https://openalex.org/W4388198745","https://openalex.org/W4388203854","https://openalex.org/W3104969488","https://openalex.org/W4387528475","https://openalex.org/W4362545890","https://openalex.org/W3212090075","https://openalex.org/W4200002633"],"abstract_inverted_index":{"PSGL-1":[0,25,53,61,75],"is":[1,44],"expressed":[2],"on":[3,27,64,82],"human":[4,20],"M2-like":[5],"macrophages.":[6,32],"A,":[7],"Schematic":[8],"of":[9,46,52,101,140],"M1,":[10],"M0,":[11,28],"and":[12,16,30,43,67,72,77,90,106,148],"M2c":[13,55,102,114],"macrophage":[14,142],"differentiation":[15,71],"polarization":[17,73],"conditions":[18,143],"using":[19,129],"peripheral":[21],"blood":[22],"monocytes.":[23],"B,":[24],"expression":[26],"M2c,":[29],"M1-like":[31],"Data":[33],"are":[34],"presented":[35],"as":[36,108],"an":[37],"average":[38],"MFI":[39],"across":[40],"4":[41,96],"donors":[42],"representative":[45],"six":[47],"experiments.":[48],"C,":[49],"siRNA":[50,62,118,146],"knockdown":[51,147],"in":[54,113,133],"macrophages":[56,115],"transfected":[57],"with":[58,117,124],"25":[59],"nmol/L":[60],"LNPs":[63,119],"days":[65],"1":[66],"3":[68],"during":[69],"the":[70],"period.":[74],"mRNA":[76],"protein":[78],"levels":[79],"were":[80],"measured":[81,128],"day":[83],"8":[84],"by":[85,110],"branched":[86],"chain":[87],"DNA":[88],"analysis":[89],"flow":[91,111],"cytometry,":[92],"respectively":[93],"(n":[94],"=":[95],"donors).":[97],"D,":[98],"Fold":[99],"change":[100,150],"markers":[103],"CD16,":[104],"CD163,":[105],"CD206":[107],"determined":[109],"cytometry":[112],"treated":[116,123],"relative":[120],"to":[121],"those":[122],"Luciferase":[125],"siRNA.":[126],"Significance":[127],"Student":[130],"t":[131],"test":[132],"Graph":[134],"Prism":[135],"software":[136],"for":[137],"each":[138],"pair":[139],"phenotypic":[141,149],"(B)":[144],"or":[145],"(C,":[151],"D).":[152]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-11-02T00:00:00"}