{"id":"https://openalex.org/W4388185335","doi":"https://doi.org/10.1021/acsanm.3c03625","title":"Engineered Albumin Nanoparticles Targeting Inflammatory Neutrophils in Human Lungs Mitigate Endotoxemia-Induced Lung Injury","display_name":"Engineered Albumin Nanoparticles Targeting Inflammatory Neutrophils in Human Lungs Mitigate Endotoxemia-Induced Lung Injury","publication_year":2023,"publication_date":"2023-10-27","ids":{"openalex":"https://openalex.org/W4388185335","doi":"https://doi.org/10.1021/acsanm.3c03625"},"language":"en","primary_location":{"id":"doi:10.1021/acsanm.3c03625","doi":"https://doi.org/10.1021/acsanm.3c03625","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsanm.3c03625","pdf_url":null,"source":{"id":"https://openalex.org/S4210191493","display_name":"ACS Applied Nano Materials","issn_l":"2574-0970","issn":["2574-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Nano Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079941605","display_name":"Mazharul Maishan","orcid":"https://orcid.org/0000-0002-6374-7211","observed_orcids":["https://orcid.org/0000-0002-6374-7211"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mazharul Maishan","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States"],"raw_orcid":"https://orcid.org/0000-0002-6374-7211","affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047350328","display_name":"Andrew Stuart","orcid":"https://orcid.org/0000-0002-5389-8876","observed_orcids":["https://orcid.org/0000-0002-5389-8876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Stuart","raw_affiliation_strings":["Nano Biotherapeutics, 2201 W Campbell Park Drive, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nano Biotherapeutics, 2201 W Campbell Park Drive, Chicago, Illinois 60612, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022390052","display_name":"Kurt Bachmaier","orcid":"https://orcid.org/0000-0002-0299-2707","observed_orcids":["https://orcid.org/0000-0002-0299-2707"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kurt Bachmaier","raw_affiliation_strings":["Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016589324","display_name":"Shotaro Matsumoto","orcid":"https://orcid.org/0000-0002-4995-8442","observed_orcids":["https://orcid.org/0000-0002-4995-8442"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shotaro Matsumoto","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021063509","display_name":"Hiroki Taenaka","orcid":"https://orcid.org/0000-0002-8643-8702","observed_orcids":["https://orcid.org/0000-0002-8643-8702"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroki Taenaka","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073612351","display_name":"Abhalaxmi Singh","orcid":"https://orcid.org/0000-0003-0407-3154","observed_orcids":["https://orcid.org/0000-0003-0407-3154"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhalaxmi Singh","raw_affiliation_strings":["Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113036512","display_name":"Patricia Bucko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Bucko","raw_affiliation_strings":["Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336228","display_name":"Li Lily Wang","orcid":"https://orcid.org/0000-0002-3088-3022","observed_orcids":["https://orcid.org/0000-0002-3088-3022","https://orcid.org/0000-0003-3473-5833"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Wang","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052403695","display_name":"Lindsay R. Vivona","orcid":"https://orcid.org/0000-0003-2880-8899","observed_orcids":["https://orcid.org/0000-0003-2880-8899"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay R. Vivona","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051005374","display_name":"Wolfgang Michael Kuebler","orcid":"https://orcid.org/0000-0003-4100-2961","observed_orcids":["https://orcid.org/0000-0003-4100-2961"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang M. Kuebler","raw_affiliation_strings":["Institute of Physiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078424196","display_name":"Jalees Rehman","orcid":"https://orcid.org/0000-0002-2787-9292","observed_orcids":["https://orcid.org/0000-0002-2787-9292"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jalees Rehman","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011756238","display_name":"Asrar B. Malik","orcid":"https://orcid.org/0000-0002-8205-7128","observed_orcids":["https://orcid.org/0000-0002-8205-7128"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Asrar B. Malik","raw_affiliation_strings":["Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","Nano Biotherapeutics, 2201 W Campbell Park Drive, Chicago, Illinois 60612, United States"],"raw_orcid":"https://orcid.org/0000-0002-8205-7128","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, United States","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Nano Biotherapeutics, 2201 W Campbell Park Drive, Chicago, Illinois 60612, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Matthay","raw_affiliation_strings":["Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States","Department of Anesthesiology, University of California, San Francisco, San Francisco, California 94143, United States","Department of Medicine, University of California, San Francisco, San Francisco, California 94143, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, United States","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Anesthesiology, University of California, San Francisco, San Francisco, California 94143, United States","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Medicine, University of California, San Francisco, San Francisco, California 94143, United States","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011756238","https://openalex.org/A5052576862"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I39422238"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.236,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.31582777,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"1","first_page":"92","last_page":"101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.030799999833106995,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/albumin-nanoparticles","display_name":"albumin nanoparticles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.7919999957084656},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.9570000171661377},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.9350000023841858},{"id":"https://openalex.org/keywords/piceatannol","display_name":"piceatannol","score":0.8410000205039978},{"id":"https://openalex.org/keywords/spleen-tyrosine-kinase-inhibitor","display_name":"spleen tyrosine kinase inhibitor","score":0.8830000162124634},{"id":"https://openalex.org/keywords/neutrophil-transmigration","display_name":"neutrophil transmigration","score":0.9100000262260437},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.6150000095367432},{"id":"https://openalex.org/keywords/pulmonary-edema","display_name":"pulmonary edema","score":0.9570000171661377},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.6399999856948853},{"id":"https://openalex.org/keywords/neutrophil-subsets","display_name":"neutrophil subsets","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.7231311798095703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7213358283042908},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.6427010297775269},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6093078255653381},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5809880495071411},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5327643752098083},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.474435955286026},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.46205249428749084},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4612174928188324},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.45534974336624146},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4516174793243408},{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.43308305740356445},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4213809072971344},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.17236655950546265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16131865978240967},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.14303264021873474},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsanm.3c03625","doi":"https://doi.org/10.1021/acsanm.3c03625","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsanm.3c03625","pdf_url":null,"source":{"id":"https://openalex.org/S4210191493","display_name":"ACS Applied Nano Materials","issn_l":"2574-0970","issn":["2574-0970"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Applied Nano Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4904248659","display_name":"Albumin Nanoparticles Incorporating Piceatannol (PANPs) for ALI/ARDS therapy","funder_award_id":"R42HL126456","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5548726810","display_name":"Nanoparticle Targeting of Neutrophil Subpopulations in Inflammatory Lung Injury","funder_award_id":"R01HL149300","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6041709380","display_name":"Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury","funder_award_id":"R01HL152515","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337582","display_name":"Department of Medicine, University of California, San Francisco","ror":"https://ror.org/043mz5j54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1515006217","https://openalex.org/W1520680917","https://openalex.org/W1521262588","https://openalex.org/W1924609456","https://openalex.org/W1960747206","https://openalex.org/W1979143111","https://openalex.org/W1981754471","https://openalex.org/W1990819855","https://openalex.org/W2001328992","https://openalex.org/W2020397881","https://openalex.org/W2029844302","https://openalex.org/W2033358607","https://openalex.org/W2040721257","https://openalex.org/W2050069950","https://openalex.org/W2053003162","https://openalex.org/W2058682780","https://openalex.org/W2061628196","https://openalex.org/W2067500754","https://openalex.org/W2068725361","https://openalex.org/W2078923098","https://openalex.org/W2088951348","https://openalex.org/W2095076310","https://openalex.org/W2096908366","https://openalex.org/W2104149109","https://openalex.org/W2106601033","https://openalex.org/W2108664926","https://openalex.org/W2115144902","https://openalex.org/W2127618101","https://openalex.org/W2131993766","https://openalex.org/W2133110080","https://openalex.org/W2137820694","https://openalex.org/W2146981918","https://openalex.org/W2150014711","https://openalex.org/W2154134195","https://openalex.org/W2159545496","https://openalex.org/W2161762223","https://openalex.org/W2266423912","https://openalex.org/W2301690523","https://openalex.org/W2340033765","https://openalex.org/W2373352946","https://openalex.org/W2403588784","https://openalex.org/W2516481767","https://openalex.org/W2570947205","https://openalex.org/W2608651137","https://openalex.org/W2742556528","https://openalex.org/W2784579142","https://openalex.org/W2791578198","https://openalex.org/W2793327795","https://openalex.org/W2793793105","https://openalex.org/W2885071016","https://openalex.org/W2889894889","https://openalex.org/W2912970743","https://openalex.org/W2915419329","https://openalex.org/W2948697630","https://openalex.org/W2966314303","https://openalex.org/W2976615680","https://openalex.org/W2985512580","https://openalex.org/W3017334852","https://openalex.org/W3033969504","https://openalex.org/W3060019369","https://openalex.org/W3085242789","https://openalex.org/W3093133909","https://openalex.org/W3106444534","https://openalex.org/W3112489274","https://openalex.org/W3128688942","https://openalex.org/W3131631532","https://openalex.org/W3138919762","https://openalex.org/W3157841475","https://openalex.org/W3199800273","https://openalex.org/W4211250103","https://openalex.org/W4214641830","https://openalex.org/W4214884821","https://openalex.org/W4385191078"],"related_works":["https://openalex.org/W4214641830","https://openalex.org/W3039566993","https://openalex.org/W4414162507","https://openalex.org/W4407485155","https://openalex.org/W4367604615","https://openalex.org/W4415760621","https://openalex.org/W4396815459","https://openalex.org/W2067500754","https://openalex.org/W2078544167","https://openalex.org/W2732198862"],"abstract_inverted_index":{"Dysregulated":[0],"neutrophil":[1,33],"infiltration":[2,167],"and":[3,23,47,82,135,156,181,194],"activity":[4],"in":[5,25,132,185,200,215,242],"lung":[6,44,137,201,218],"tissues":[7],"are":[8],"pathogenic":[9],"features":[10],"of":[11,21,31,130,159,177,183,226,230,240],"sepsis-induced":[12],"acute":[13],"respiratory":[14],"distress":[15],"syndrome":[16],"(ARDS),":[17],"an":[18,51,236],"important":[19,52],"cause":[20],"morbidity":[22],"mortality":[24],"critically":[26],"ill":[27],"patients.":[28,244],"Therapeutic":[29],"reduction":[30,199],"excessive":[32],"transmigration":[34,180],"from":[35,213],"the":[36,39,98,110,140,169,172,186,224],"vasculature":[37],"into":[38,63,168],"distal":[40],"airspaces":[41],"to":[42,77,86,90,161],"mitigate":[43,126],"tissue":[45],"damage":[46],"improve":[48],"survival":[49],"is":[50],"objective.":[53],"Human":[54],"peripheral":[55],"blood":[56,152],"polymorphonuclear":[57],"neutrophils":[58],"(PMNs)":[59],"can":[60],"be":[61],"separated":[62],"two":[64],"subsets":[65],"as":[66,78,91,188],"recently":[67],"described:":[68],"one":[69],"that":[70,84,100,121],"readily":[71],"endocytoses":[72],"albumin":[73,231],"nanoparticles":[74,232],"(ANPs)":[75],"referred":[76,89],"ANP":[79,92,102],"high":[80,103],"PMN":[81,166],"another":[83],"fails":[85],"endocytose":[87],"ANPs":[88,107],"low":[93],"PMN.":[94],"Here,":[95],"we":[96],"tested":[97],"hypothesis":[99],"targeting":[101,235],"human":[104,133,143,154,217],"PMNs":[105,131,155,184,241],"with":[106,109,149],"loaded":[108],"drug":[111,228],"piceatannol":[112],"(PANPs),":[113],"a":[114,204],"selective":[115],"spleen":[116],"tyrosine":[117],"kinase":[118],"(Syk)":[119],"inhibitor":[120],"inhibits":[122],"\u03b22-integrin":[123],"signaling,":[124],"would":[125],"lipopolysaccharide":[127],"(LPS)-induced":[128],"accumulation":[129,182],"lungs":[134,144,187],"reduce":[136],"edema.":[138],"In":[139],"present":[141],"study,":[142],"were":[145],"perfused":[146],"ex":[147],"vivo":[148],"fresh":[150],"whole":[151],"containing":[153],"6":[157],"mg":[158],"LPS":[160,173],"induce":[162],"injury":[163,219],"accompanied":[164],"by":[165,190],"lungs.":[170],"Following":[171],"exposure,":[174],"intravenous":[175],"injection":[176],"PANPs":[178],"reduced":[179],"determined":[189],"bronchoalveolar":[191],"lavage":[192],"counts":[193],"histologic":[195],"scoring.":[196],"A":[197],"parallel":[198],"weight":[202],"gain,":[203],"surrogate":[205],"for":[206,234],"pulmonary":[207],"edema":[208,214],"fluid":[209],"accumulation,":[210],"suggested":[211],"protection":[212],"this":[216],"model.":[220],"The":[221],"results":[222],"demonstrate":[223],"potential":[225],"therapeutic":[227],"loading":[229],"(PANPs)":[233],"injurious,":[237],"inflammation-inducing":[238],"population":[239],"ARDS":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-02T00:00:00"}
