{"id":"https://openalex.org/W4388178357","doi":"https://doi.org/10.61186/phypha.27.3.319","title":"The effect of calcium channels blockade on slow-wave distribution in the electrophysiological model of human gastric wall smooth muscle cells","display_name":"The effect of calcium channels blockade on slow-wave distribution in the electrophysiological model of human gastric wall smooth muscle cells","publication_year":2023,"publication_date":"2023-09-01","ids":{"openalex":"https://openalex.org/W4388178357","doi":"https://doi.org/10.61186/phypha.27.3.319"},"language":"en","primary_location":{"id":"doi:10.61186/phypha.27.3.319","doi":"https://doi.org/10.61186/phypha.27.3.319","is_oa":true,"landing_page_url":"http://dx.doi.org/10.61186/phypha.27.3.319","pdf_url":"http://ppj.phypha.ir/files/site1/user_files_d87f0d/fa_tabatabai-A-10-1659-1-b84ce19.pdf","source":{"id":"https://openalex.org/S2764399535","display_name":"Physiology and Pharmacology","issn_l":"1735-0581","issn":["1735-0581"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://ppj.phypha.ir/files/site1/user_files_d87f0d/fa_tabatabai-A-10-1659-1-b84ce19.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087272847","display_name":"Hossein Taghadosi","orcid":"https://orcid.org/0000-0002-7501-5552","observed_orcids":["https://orcid.org/0000-0002-7501-5552"]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I155419210","display_name":"Islamic Azad University, Science and Research Branch","ror":"https://ror.org/03187yj51","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hossein Taghadosi","raw_affiliation_strings":["Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103060960","display_name":"Farhad Tabatabai Ghomsheh","orcid":"https://orcid.org/0000-0001-6284-7053","observed_orcids":["https://orcid.org/0000-0001-6284-7053"]},"institutions":[{"id":"https://openalex.org/I4210166308","display_name":"University of Social Welfare and Rehabilitation Sciences","ror":"https://ror.org/05jme6y84","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210166308"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Farhad Tabatabai Ghomsheh","raw_affiliation_strings":["Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4210166308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060930366","display_name":"Aydin Farajidavar","orcid":"https://orcid.org/0000-0002-2073-0073","observed_orcids":["https://orcid.org/0000-0002-2073-0073"]},"institutions":[{"id":"https://openalex.org/I4210104314","display_name":"New York Institute of Technology","ror":"https://ror.org/01bghzb51","country_code":"US","type":"education","lineage":["https://openalex.org/I4210104314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aydin Farajidavar","raw_affiliation_strings":["Department of Electrical and Computer Engineering, New York Institute of Technology, Old Westbury, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, New York Institute of Technology, Old Westbury, New York, USA","institution_ids":["https://openalex.org/I4210104314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047955378","display_name":"Faezeh Khazaee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]},{"id":"https://openalex.org/I155419210","display_name":"Islamic Azad University, Science and Research Branch","ror":"https://ror.org/03187yj51","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Faezeh Khazaee","raw_affiliation_strings":["Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran","institution_ids":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088788732","display_name":"Fatemeh Hoseinpour","orcid":"https://orcid.org/0000-0002-3389-2880","observed_orcids":["https://orcid.org/0000-0002-3389-2880"]},"institutions":[{"id":"https://openalex.org/I4210154083","display_name":"Semnan University of Medical Sciences","ror":"https://ror.org/05y44as61","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210154083"]},{"id":"https://openalex.org/I928334797","display_name":"Semnan University","ror":"https://ror.org/029gksw03","country_code":"IR","type":"education","lineage":["https://openalex.org/I928334797"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Hoseinpour","raw_affiliation_strings":["Department of Occupational Therapy, Semnan University of Medical Science, Semnan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Occupational Therapy, Semnan University of Medical Science, Semnan, Iran","institution_ids":["https://openalex.org/I4210154083","https://openalex.org/I928334797"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.277265,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"3","first_page":"319","last_page":"330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.6284000277519226,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.35839998722076416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-channel-blockade","display_name":"calcium channel blockade","score":0.8700000047683716},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.9309999942779541},{"id":"https://openalex.org/keywords/t-type-calcium-channels","display_name":"T-type calcium channels","score":1.0},{"id":"https://openalex.org/keywords/gastric-smooth-muscle","display_name":"gastric smooth muscle","score":0.7940000295639038},{"id":"https://openalex.org/keywords/slow-waves","display_name":"slow waves","score":0.8920000195503235},{"id":"https://openalex.org/keywords/wavefront-propagation","display_name":"wavefront propagation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.9480000138282776},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.8970000147819519},{"id":"https://openalex.org/keywords/gastrointestinal-motility-disorders","display_name":"gastrointestinal motility disorders","score":0.7929999828338623},{"id":"https://openalex.org/keywords/electrophysiological-model","display_name":"electrophysiological model","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.8420913815498352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5202816128730774},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4464280307292938},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.44636791944503784},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33073943853378296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20425045490264893},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06412991881370544}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.61186/phypha.27.3.319","doi":"https://doi.org/10.61186/phypha.27.3.319","is_oa":true,"landing_page_url":"http://dx.doi.org/10.61186/phypha.27.3.319","pdf_url":"http://ppj.phypha.ir/files/site1/user_files_d87f0d/fa_tabatabai-A-10-1659-1-b84ce19.pdf","source":{"id":"https://openalex.org/S2764399535","display_name":"Physiology and Pharmacology","issn_l":"1735-0581","issn":["1735-0581"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology and Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.61186/phypha.27.3.319","doi":"https://doi.org/10.61186/phypha.27.3.319","is_oa":true,"landing_page_url":"http://dx.doi.org/10.61186/phypha.27.3.319","pdf_url":"http://ppj.phypha.ir/files/site1/user_files_d87f0d/fa_tabatabai-A-10-1659-1-b84ce19.pdf","source":{"id":"https://openalex.org/S2764399535","display_name":"Physiology and Pharmacology","issn_l":"1735-0581","issn":["1735-0581"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology and Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388178357.pdf","grobid_xml":"https://content.openalex.org/works/W4388178357.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1566552624","https://openalex.org/W1841062557","https://openalex.org/W1973049754","https://openalex.org/W1977151187","https://openalex.org/W1985940938","https://openalex.org/W1988441324","https://openalex.org/W1993382504","https://openalex.org/W2002647328","https://openalex.org/W2008451599","https://openalex.org/W2010614186","https://openalex.org/W2010682403","https://openalex.org/W2020823084","https://openalex.org/W2026380166","https://openalex.org/W2031355590","https://openalex.org/W2041249812","https://openalex.org/W2045266411","https://openalex.org/W2053581580","https://openalex.org/W2069255677","https://openalex.org/W2086376981","https://openalex.org/W2087480838","https://openalex.org/W2106860892","https://openalex.org/W2113316793","https://openalex.org/W2118004060","https://openalex.org/W2143733452","https://openalex.org/W2147814677","https://openalex.org/W2163228087","https://openalex.org/W2167708320","https://openalex.org/W2171425687","https://openalex.org/W2314528136","https://openalex.org/W2586496736","https://openalex.org/W2782736278","https://openalex.org/W2802791866","https://openalex.org/W2808106200","https://openalex.org/W2890979861","https://openalex.org/W2909463618","https://openalex.org/W2988009946","https://openalex.org/W2999220255","https://openalex.org/W3007670977","https://openalex.org/W3012491811","https://openalex.org/W3106660416","https://openalex.org/W3188071960","https://openalex.org/W4230663201","https://openalex.org/W4312380043"],"related_works":["https://openalex.org/W2243544604","https://openalex.org/W3188071960","https://openalex.org/W2016323578","https://openalex.org/W2092723726","https://openalex.org/W4312380043","https://openalex.org/W2416135645","https://openalex.org/W1996276415","https://openalex.org/W1587489391","https://openalex.org/W1873745381","https://openalex.org/W2008451599"],"abstract_inverted_index":{"Introduction:":[0],"Two":[1],"of":[2,43,53,61,68,102,111,164],"the":[3,9,50,54,59,75,95,100,103,116,120,130,142,156,181],"most":[4,96],"important":[5],"ion":[6,185],"channels":[7,20,30,73,166,186],"in":[8,33,79,115,187],"smooth":[10,24,51,83,199],"muscle":[11,25,52,84,152,177,200],"membrane":[12,35,117,134,170],"are":[13,21,31],"L-type":[14,69,104,143],"and":[15,66,70,113,122,132,138,175,198],"T-type":[16,28,71,126,157],"calcium":[17,19,29,72,105,127,144,158,165],"channels.L-type":[18],"responsible":[22],"for":[23],"contraction,":[26,178],"while":[27],"involved":[32],"cell":[34],"depolarization.Methods:":[36],"In":[37],"this":[38],"study,":[39],"a":[40,109,147],"model":[41],"consisting":[42],"1200":[44],"cells":[45],"was":[46],"used":[47],"to":[48,108,155,168,180],"simulate":[49],"gastric":[55,81],"wall.The":[56],"paper":[57],"explores":[58],"effects":[60],"blocking":[62],"10%,":[63],"50%,":[64],"90%,":[65],"100%":[67],"on":[74,99,150],"spatiotemporal":[76],"wavefront":[77],"propagation":[78],"human":[80],"wall":[82],"cells,":[85],"simulated":[86],"separately.":[87],"Results:The":[88],"results":[89],"showed":[90],"that":[91,161],"complete":[92],"blockage":[93,163],"had":[94],"significant":[97],"effect":[98],"slow-wave.Blockage":[101],"channel":[106,128,145],"led":[107,167],"reduction":[110],"-3.4%":[112],"-0.8%":[114],"potential":[118,135,171],"during":[119,172],"spike":[121,131],"plateau":[123],"phases,":[124],"respectively.The":[125],"reduced":[129,176],"resting":[133],"by":[136],"-1.8%":[137],"-0.9%,":[139],"respectively.In":[140],"addition,":[141],"exhibited":[146],"greater":[148],"impact":[149],"reducing":[151],"contraction":[153],"compared":[154,179],"channel.This":[159],"suggests":[160],"higher":[162],"decreased":[169],"slow-wave":[173],"phases":[174],"physiological":[182],"state.Conclusion:":[183],"Blocking":[184],"electrophysiological":[188],"models":[189],"can":[190],"potentially":[191],"help":[192],"control":[193],"gastrointestinal":[194],"tract":[195],"motility":[196],"disorders":[197],"contraction.":[201],"www.phypha.ir/ppj":[202]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-02T00:00:00"}