{"id":"https://openalex.org/W4388127705","doi":"https://doi.org/10.21873/anticanres.16682","title":"Cancer Stem Cells of Hepatocellular Carcinoma Are Suppressed by the Voltage-gated Calcium Channel Inhibitor Amlodipine","display_name":"Cancer Stem Cells of Hepatocellular Carcinoma Are Suppressed by the Voltage-gated Calcium Channel Inhibitor Amlodipine","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4388127705","doi":"https://doi.org/10.21873/anticanres.16682","pmid":"https://pubmed.ncbi.nlm.nih.gov/37909988"},"language":"en","primary_location":{"id":"doi:10.21873/anticanres.16682","doi":"https://doi.org/10.21873/anticanres.16682","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.16682","pdf_url":"https://ar.iiarjournals.org/content/anticanres/43/11/4855.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ar.iiarjournals.org/content/anticanres/43/11/4855.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017095541","display_name":"Atsushi Shiozaki","orcid":"https://orcid.org/0000-0003-3739-160X","observed_orcids":["https://orcid.org/0000-0003-3739-160X"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ATSUSHI SHIOZAKI","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan shiozaki@koto.kpu-m.ac.jp","Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan shiozaki@koto.kpu-m.ac.jp","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080455885","display_name":"Kento Kurashima","orcid":"https://orcid.org/0000-0002-3614-2559","observed_orcids":["https://orcid.org/0000-0002-3614-2559"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KENTO KURASHIMA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009571608","display_name":"Michihiro Kudou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MICHIHIRO KUDOU","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007258325","display_name":"Hiroki Shimizu","orcid":"https://orcid.org/0000-0002-6463-8498","observed_orcids":["https://orcid.org/0000-0002-6463-8498"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROKI SHIMIZU","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035643620","display_name":"Toshiyuki Kosuga","orcid":"https://orcid.org/0000-0002-1657-7272","observed_orcids":["https://orcid.org/0000-0002-1657-7272"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOSHIYUKI KOSUGA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033502162","display_name":"Kenichi Takemoto","orcid":"https://orcid.org/0000-0003-3610-0663","observed_orcids":["https://orcid.org/0000-0003-3610-0663"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KENICHI TAKEMOTO","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088541867","display_name":"Tomohiro Arita","orcid":"https://orcid.org/0000-0001-7127-6504","observed_orcids":["https://orcid.org/0000-0001-7127-6504"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOMOHIRO ARITA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020555893","display_name":"Hirotaka Konishi","orcid":"https://orcid.org/0000-0002-4899-8944","observed_orcids":["https://orcid.org/0000-0002-4899-8944"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROTAKA KONISHI","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017724039","display_name":"Yusuke Yamamoto","orcid":"https://orcid.org/0000-0002-8740-8468","observed_orcids":["https://orcid.org/0000-0002-8740-8468"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YUSUKE YAMAMOTO","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015703827","display_name":"Ryo Morimura","orcid":"https://orcid.org/0000-0002-5594-0943","observed_orcids":["https://orcid.org/0000-0002-5594-0943"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"RYO MORIMURA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016157097","display_name":"Shuhei Komatsu","orcid":"https://orcid.org/0000-0001-6074-7614","observed_orcids":["https://orcid.org/0000-0001-6074-7614"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHUHEI KOMATSU","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032001774","display_name":"Hisashi Ikoma","orcid":"https://orcid.org/0000-0002-2647-6854","observed_orcids":["https://orcid.org/0000-0002-2647-6854"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HISASHI IKOMA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010402266","display_name":"Takeshi Kubota","orcid":"https://orcid.org/0000-0002-2246-3028","observed_orcids":["https://orcid.org/0000-0002-2246-3028"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKESHI KUBOTA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032180784","display_name":"Hitoshi Fujiwara","orcid":"https://orcid.org/0000-0002-6507-4313","observed_orcids":["https://orcid.org/0000-0002-6507-4313"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HITOSHI FUJIWARA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041985650","display_name":"Eigo Otsuji","orcid":"https://orcid.org/0000-0002-3260-8155","observed_orcids":["https://orcid.org/0000-0002-3260-8155"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"EIGO OTSUJI","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":null,"apc_paid":null,"fwci":0.8422,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.70760367,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"43","issue":"11","first_page":"4855","last_page":"4864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9240000247955322},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":1.0},{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.9100000262260437},{"id":"https://openalex.org/keywords/aldh1a1","display_name":"ALDH1A1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-sphere-formation","display_name":"tumor sphere formation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.7354221343994141},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5969756841659546},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5340826511383057},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4904882609844208},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.459231972694397},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44302380084991455},{"id":"https://openalex.org/C25747580","wikidata":"https://www.wikidata.org/wiki/Q423792","display_name":"Aldehyde dehydrogenase","level":3,"score":0.43441537022590637},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.4326314330101013},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4107823669910431},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34534502029418945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20544421672821045},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11279690265655518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10453024506568909},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06426998972892761},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.21873/anticanres.16682","doi":"https://doi.org/10.21873/anticanres.16682","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.16682","pdf_url":"https://ar.iiarjournals.org/content/anticanres/43/11/4855.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},{"id":"pmid:37909988","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37909988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/anticanres.16682","doi":"https://doi.org/10.21873/anticanres.16682","is_oa":true,"landing_page_url":"https://doi.org/10.21873/anticanres.16682","pdf_url":"https://ar.iiarjournals.org/content/anticanres/43/11/4855.full.pdf","source":{"id":"https://openalex.org/S157347057","display_name":"Anticancer Research","issn_l":"0250-7005","issn":["0250-7005","1791-7530"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4320800545","host_organization_name":"International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts","host_organization_lineage":["https://openalex.org/P4320800545"],"host_organization_lineage_names":["International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3677127723","display_name":"The development of targeterd therapies for Intra-mitochondrial calcium ion dinamics in colorectal cancer stem cells","funder_award_id":"23K06654","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4402282697","display_name":"Development of novel therapeutics against ion transporters expressed in cancer-associated fibroblast","funder_award_id":"22K16518","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5491259739","display_name":"The development of hypoosmotic therapy targeting volume-activated anion channels for peritoneal dissemination of colorectal cancer.","funder_award_id":"23K08115","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6097495749","display_name":"The development of novel targeted therapies to over-expressed ion transporters in cancer stem cells of esophagogastric junctional and esophageal adenocarcinoma.","funder_award_id":"23K08218","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6254256138","display_name":"The development of cancer-stem cells-targeted hypotoic therapies  under the regulation of calsium ion tranporter","funder_award_id":"20K17659","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7695425090","display_name":"Development of novel hypotonic intraperitoneal chemotherapy based on the expression level of SLCO2A1 in gastric cancer","funder_award_id":"22K08832","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G8964858640","display_name":"Functional analysis of voltage-gated potassium channels in pancreatic cancer stem cells","funder_award_id":"21K08689","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388127705.pdf","grobid_xml":"https://content.openalex.org/works/W4388127705.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1999356404","https://openalex.org/W2088497927","https://openalex.org/W2090577904","https://openalex.org/W2141297251","https://openalex.org/W2300340985","https://openalex.org/W2516577703","https://openalex.org/W2586020508","https://openalex.org/W2604605313","https://openalex.org/W2633470271","https://openalex.org/W2743448946","https://openalex.org/W2909536530","https://openalex.org/W2923366951","https://openalex.org/W3021610682","https://openalex.org/W3110212829","https://openalex.org/W3126165107","https://openalex.org/W3133852210","https://openalex.org/W3188778556","https://openalex.org/W3190598238","https://openalex.org/W3195190884","https://openalex.org/W3198035303","https://openalex.org/W3201780258","https://openalex.org/W4210774372","https://openalex.org/W4302022990","https://openalex.org/W4311161651"],"related_works":["https://openalex.org/W3126165107","https://openalex.org/W4313198542","https://openalex.org/W2061664346","https://openalex.org/W4386533689","https://openalex.org/W2909536530","https://openalex.org/W3188778556","https://openalex.org/W2604605313","https://openalex.org/W4315566271","https://openalex.org/W2074715643","https://openalex.org/W2034615970"],"abstract_inverted_index":{"BACKGROUND/AIM:":[0],"The":[1,21,110,139,163],"membrane":[2],"transporters":[3],"activated":[4],"in":[5,31,76,93,96,151,154,185],"cancer":[6,15],"stem":[7],"cells":[8,168],"(CSCs)":[9],"are":[10],"the":[11,25,69,106,113,119,142,159],"target":[12],"of":[13,28,33,71,112,116,122,141,161],"novel":[14],"therapies":[16],"for":[17],"hepatocellular":[18],"carcinoma":[19],"(HCC).":[20],"present":[22],"investigation":[23],"demonstrated":[24],"expression":[26,74,121],"profiles":[27,75],"ion":[29,127],"channels":[30],"CSCs":[32,64,77,94,99,117,152],"HCC.":[34,200],"MATERIALS":[35],"AND":[36],"METHODS:":[37],"Cells":[38],"that":[39,169],"highly":[40,170],"expressed":[41,171],"aldehyde":[42],"dehydrogenase":[43],"1":[44],"family":[45],"member":[46],"A1":[47],"(ALDH1A1)":[48],"were":[49,65,78],"separated":[50],"from":[51],"HepG2":[52,85,167],"cells,":[53,86],"a":[54,183,195],"human":[55],"HCC":[56],"cell":[57,61,164],"line,":[58],"by":[59,177],"fluorescence-activated":[60],"sorting,":[62],"and":[63,104,156,188],"identified":[66],"based":[67],"on":[68],"formation":[70],"tumorspheres.":[72,162],"Gene":[73],"investigated":[79],"using":[80],"microarray":[81,114],"analysis.":[82],"RESULTS:":[83],"Among":[84],"ALDH1A1":[87,172],"messenger":[88],"RNA":[89],"level":[90],"was":[91,146,173],"higher":[92,147],"than":[95,153],"non-CSCs.":[97],"Furthermore,":[98],"exhibited":[100],"resistance":[101],"to":[102,108,126],"cisplatin":[103],"had":[105],"capacity":[107],"redifferentiate.":[109],"results":[111],"analysis":[115],"showed":[118],"up-regulated":[120],"several":[123],"genes":[124],"related":[125],"channels,":[128],"such":[129],"as":[130],"calcium":[131],"voltage-gated":[132],"channel":[133],"auxiliary":[134],"subunit":[135],"gamma":[136],"4":[137],"(CACNG4).":[138],"cytotoxicity":[140],"CACNG4":[143,181],"inhibitor":[144],"amlodipine":[145],"at":[148],"lower":[149],"concentrations":[150],"non-CSCs,":[155],"markedly":[157],"decreased":[158],"number":[160],"population":[165],"among":[166],"also":[174],"significantly":[175],"reduced":[176],"this":[178],"inhibitor.":[179],"CONCLUSION:":[180],"plays":[182],"role":[184],"maintaining":[186],"CSCs,":[187],"its":[189],"inhibitor,":[190],"amlodipine,":[191],"could":[192],"potentially":[193],"be":[194],"targeted":[196],"therapeutic":[197],"agent":[198],"against":[199]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-02T00:00:00"}
