{"id":"https://openalex.org/W4388127463","doi":"https://doi.org/10.21873/cdp.10264","title":"An Overview of Renal Cell Carcinoma Hallmarks, Drug Resistance, and Adjuvant Therapies","display_name":"An Overview of Renal Cell Carcinoma Hallmarks, Drug Resistance, and Adjuvant Therapies","publication_year":2023,"publication_date":"2023-11-01","ids":{"openalex":"https://openalex.org/W4388127463","doi":"https://doi.org/10.21873/cdp.10264","pmid":"https://pubmed.ncbi.nlm.nih.gov/37927802","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10619564"},"language":"en","primary_location":{"id":"doi:10.21873/cdp.10264","doi":"https://doi.org/10.21873/cdp.10264","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cdp.10264","pdf_url":"https://www.cancerdiagnosisprognosis.org/storage/cdp/3/6/cdp-3-616.pdf","source":{"id":"https://openalex.org/S4210192968","display_name":"Cancer Diagnosis & Prognosis","issn_l":"2732-7787","issn":["2732-7787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Diagnosis & Prognosis","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4388127463"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.cancerdiagnosisprognosis.org/storage/cdp/3/6/cdp-3-616.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"JOSIELE DA SILVA PRADE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"JOSIELE DA SILVA PRADE","raw_affiliation_strings":["Post-graduate Program in Health and Life Sciences, Franciscan University, Santa Maria, RS, Brazil","1614 Andradas Street, Santa Maria, RS, 97010-032, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Post-graduate Program in Health and Life Sciences, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]},{"raw_affiliation_string":"1614 Andradas Street, Santa Maria, RS, 97010-032, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109651329","display_name":"RUAN SOARES DE SOUZA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"RUAN SOARES DE SOUZA","raw_affiliation_strings":["Medicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108307968","display_name":"CAMILA MEDIANEIRA DA SILVA D\u2019\u00c1VILA","orcid":"https://orcid.org/0009-0004-8136-2413","observed_orcids":["https://orcid.org/0009-0004-8136-2413"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"CAMILA MEDIANEIRA DA SILVA D\u2019\u0391VILA","raw_affiliation_strings":["1614 Andradas Street, Santa Maria, RS, 97010-032, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1614 Andradas Street, Santa Maria, RS, 97010-032, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105940355","display_name":"THAYLINE CORREIA DA SILVA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"THAYLINE CORREIA DA SILVA","raw_affiliation_strings":["Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil","1614 Andradas Street, Santa Maria, RS, 97010-032, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]},{"raw_affiliation_string":"1614 Andradas Street, Santa Maria, RS, 97010-032, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"ISADORA CASSEL LIVINALLI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"ISADORA CASSEL LIVINALLI","raw_affiliation_strings":["Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108437305","display_name":"Ana Clara Zanini Bertoncelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"ANA CLARA ZANINI BERTONCELLI","raw_affiliation_strings":["Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]}]},{"author_position":"middle","author":{"id":null,"display_name":"FERNANDA KRAPF SACCOL","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"FERNANDA KRAPF SACCOL","raw_affiliation_strings":["Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113035408","display_name":"Tallys de Oliveira Mendes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"TALLYS DE OLIVEIRA MENDES","raw_affiliation_strings":["Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedicine Graduate Course, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111078988","display_name":"LARISSA GINDRI WENNING","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"LARISSA GINDRI WENNING","raw_affiliation_strings":["Pharmacy Graduate Course, Franciscan University, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy Graduate Course, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001011095","display_name":"Theodoro da Rosa Salles","orcid":"https://orcid.org/0000-0003-2157-2289","observed_orcids":["https://orcid.org/0000-0003-2157-2289"]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"THEODORO DA ROSA SALLES","raw_affiliation_strings":["Graduate Program in Nanosciences, Franciscan University, Santa Maria, RS, Brazil","Laboratory of Nanostructured Magnetic Materials - LaMMaN, Franciscan University, Santa Maria, RS, Brazil","1614 Andradas Street, Santa Maria, RS, 97010-032, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Nanosciences, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]},{"raw_affiliation_string":"Laboratory of Nanostructured Magnetic Materials - LaMMaN, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]},{"raw_affiliation_string":"1614 Andradas Street, Santa Maria, RS, 97010-032, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016029887","display_name":"Cristiano Rodrigo Bohn Rhoden","orcid":"https://orcid.org/0000-0001-6171-4224","observed_orcids":["https://orcid.org/0000-0001-6171-4224"]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"CRISTIANO RODRIGO BOHN RHODEN","raw_affiliation_strings":["Graduate Program in Nanosciences, Franciscan University, Santa Maria, RS, Brazil","Laboratory of Nanostructured Magnetic Materials - LaMMaN, Franciscan University, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Nanosciences, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]},{"raw_affiliation_string":"Laboratory of Nanostructured Magnetic Materials - LaMMaN, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046859160","display_name":"Francine Carla Cadon\u00e1","orcid":"https://orcid.org/0000-0002-6761-9743","observed_orcids":["https://orcid.org/0000-0002-6761-9743"]},"institutions":[{"id":"https://openalex.org/I226123470","display_name":"Universidade Franciscana","ror":"https://ror.org/00wbge811","country_code":"BR","type":"education","lineage":["https://openalex.org/I226123470"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"FRANCINE CARLA CADONA","raw_affiliation_strings":["Post-graduate Program in Health and Life Sciences, Franciscan University, Santa Maria, RS, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Post-graduate Program in Health and Life Sciences, Franciscan University, Santa Maria, RS, Brazil","institution_ids":["https://openalex.org/I226123470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046859160"],"corresponding_institution_ids":["https://openalex.org/I226123470"],"apc_list":null,"apc_paid":null,"fwci":0.7099,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.62890855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"3","issue":"6","first_page":"616","last_page":"634"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.765999972820282},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.9879999756813049},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9269999861717224},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8500000238418579},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.625},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9359999895095825},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/resveratrol","display_name":"resveratrol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/englerin-a","display_name":"englerin A","score":0.9430000185966492},{"id":"https://openalex.org/keywords/honey","display_name":"honey","score":0.9120000004768372},{"id":"https://openalex.org/keywords/nanomedicine","display_name":"nanomedicine","score":0.8539999723434448},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6930000185966492},{"id":"https://openalex.org/keywords/vhl","display_name":"VHL","score":0.5550000071525574},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.753000020980835},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.6790000200271606},{"id":"https://openalex.org/keywords/bap1","display_name":"BAP1","score":0.578000009059906},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.7610756158828735},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7288557291030884},{"id":"https://openalex.org/C2781068499","wikidata":"https://www.wikidata.org/wiki/Q3242950","display_name":"Kidney cancer","level":3,"score":0.5673985481262207},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.557693600654602},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.48756808042526245},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.4851261079311371},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.46594274044036865},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.44984811544418335},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4173983335494995},{"id":"https://openalex.org/C2776539811","wikidata":"https://www.wikidata.org/wiki/Q4830631","display_name":"Axitinib","level":4,"score":0.41613683104515076},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41270118951797485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3977140784263611},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.37190598249435425},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36054688692092896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13157740235328674},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.09623968601226807},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21873/cdp.10264","doi":"https://doi.org/10.21873/cdp.10264","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cdp.10264","pdf_url":"https://www.cancerdiagnosisprognosis.org/storage/cdp/3/6/cdp-3-616.pdf","source":{"id":"https://openalex.org/S4210192968","display_name":"Cancer Diagnosis & Prognosis","issn_l":"2732-7787","issn":["2732-7787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Diagnosis & Prognosis","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10619564","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10619564","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10619564/pdf/cdp-3-616.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Diagn Progn","raw_type":"Text"},{"id":"pmid:37927802","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37927802","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer diagnosis & prognosis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21873/cdp.10264","doi":"https://doi.org/10.21873/cdp.10264","is_oa":true,"landing_page_url":"https://doi.org/10.21873/cdp.10264","pdf_url":"https://www.cancerdiagnosisprognosis.org/storage/cdp/3/6/cdp-3-616.pdf","source":{"id":"https://openalex.org/S4210192968","display_name":"Cancer Diagnosis & Prognosis","issn_l":"2732-7787","issn":["2732-7787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Diagnosis & Prognosis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388127463.pdf","grobid_xml":"https://content.openalex.org/works/W4388127463.grobid-xml"},"referenced_works_count":151,"referenced_works":["https://openalex.org/W1173721425","https://openalex.org/W1507573241","https://openalex.org/W1606420139","https://openalex.org/W1757407923","https://openalex.org/W1834622946","https://openalex.org/W1845242231","https://openalex.org/W1966034643","https://openalex.org/W1966055645","https://openalex.org/W1968657935","https://openalex.org/W1973234749","https://openalex.org/W1979812712","https://openalex.org/W1981801486","https://openalex.org/W1985213644","https://openalex.org/W1988581394","https://openalex.org/W1994812075","https://openalex.org/W1995197723","https://openalex.org/W2002803408","https://openalex.org/W2004151829","https://openalex.org/W2006434892","https://openalex.org/W2010991736","https://openalex.org/W2013484447","https://openalex.org/W2015266394","https://openalex.org/W2017322644","https://openalex.org/W2023952988","https://openalex.org/W2030869361","https://openalex.org/W2034932355","https://openalex.org/W2037358612","https://openalex.org/W2042494748","https://openalex.org/W2044510096","https://openalex.org/W2060070314","https://openalex.org/W2060157525","https://openalex.org/W2061270171","https://openalex.org/W2066604995","https://openalex.org/W2066671159","https://openalex.org/W2068555261","https://openalex.org/W2079891600","https://openalex.org/W2082331198","https://openalex.org/W2090960951","https://openalex.org/W2094159831","https://openalex.org/W2096172976","https://openalex.org/W2102401417","https://openalex.org/W2103514232","https://openalex.org/W2109706412","https://openalex.org/W2111261591","https://openalex.org/W2111867681","https://openalex.org/W2115494288","https://openalex.org/W2116293130","https://openalex.org/W2116949558","https://openalex.org/W2117365333","https://openalex.org/W2117866050","https://openalex.org/W2119113195","https://openalex.org/W2124254699","https://openalex.org/W2127385754","https://openalex.org/W2130261635","https://openalex.org/W2135647551","https://openalex.org/W2136109165","https://openalex.org/W2139248078","https://openalex.org/W2139731402","https://openalex.org/W2143254802","https://openalex.org/W2143772132","https://openalex.org/W2144390074","https://openalex.org/W2144520999","https://openalex.org/W2146315158","https://openalex.org/W2149456801","https://openalex.org/W2157076786","https://openalex.org/W2161609794","https://openalex.org/W2165630767","https://openalex.org/W2167514745","https://openalex.org/W2170102327","https://openalex.org/W2170552969","https://openalex.org/W2171369497","https://openalex.org/W2222086386","https://openalex.org/W2237254160","https://openalex.org/W2296338206","https://openalex.org/W2315383551","https://openalex.org/W2322384230","https://openalex.org/W2335012284","https://openalex.org/W2507163473","https://openalex.org/W2519678626","https://openalex.org/W2526795449","https://openalex.org/W2554620156","https://openalex.org/W2558408743","https://openalex.org/W2560367415","https://openalex.org/W2573152477","https://openalex.org/W2579143428","https://openalex.org/W2597872842","https://openalex.org/W2606089517","https://openalex.org/W2614257677","https://openalex.org/W2616238336","https://openalex.org/W2616761213","https://openalex.org/W2620229194","https://openalex.org/W2726542547","https://openalex.org/W2736535396","https://openalex.org/W2738614225","https://openalex.org/W2741550370","https://openalex.org/W2753840075","https://openalex.org/W2766202733","https://openalex.org/W2768600953","https://openalex.org/W2772643547","https://openalex.org/W2780379277","https://openalex.org/W2782183686","https://openalex.org/W2791618536","https://openalex.org/W2793285294","https://openalex.org/W2810166643","https://openalex.org/W2889435856","https://openalex.org/W2889646458","https://openalex.org/W2892128860","https://openalex.org/W2892325025","https://openalex.org/W2898712541","https://openalex.org/W2902733146","https://openalex.org/W2917524635","https://openalex.org/W2920648489","https://openalex.org/W2938933772","https://openalex.org/W2943591849","https://openalex.org/W2948149251","https://openalex.org/W2962747911","https://openalex.org/W2967335509","https://openalex.org/W2986598926","https://openalex.org/W2994822278","https://openalex.org/W2997242469","https://openalex.org/W3003976945","https://openalex.org/W3006533361","https://openalex.org/W3008405960","https://openalex.org/W3010196076","https://openalex.org/W3092025866","https://openalex.org/W3119005666","https://openalex.org/W3119379403","https://openalex.org/W3126722884","https://openalex.org/W3131135251","https://openalex.org/W3193941256","https://openalex.org/W3195382359","https://openalex.org/W4205580461","https://openalex.org/W4205818685","https://openalex.org/W4207029235","https://openalex.org/W4214735702","https://openalex.org/W4220993642","https://openalex.org/W4225565073","https://openalex.org/W4232130103","https://openalex.org/W4249722343","https://openalex.org/W4252851641","https://openalex.org/W4280543024","https://openalex.org/W4284899546","https://openalex.org/W4285096993","https://openalex.org/W4293765840","https://openalex.org/W4296161658","https://openalex.org/W4297236708","https://openalex.org/W4306765021","https://openalex.org/W4307690171","https://openalex.org/W4316810391","https://openalex.org/W4362634704","https://openalex.org/W6922416790"],"related_works":["https://openalex.org/W3179596048","https://openalex.org/W4282038076","https://openalex.org/W2782189286","https://openalex.org/W4386055576","https://openalex.org/W4229452974","https://openalex.org/W4404812523","https://openalex.org/W7135018045","https://openalex.org/W2419646292","https://openalex.org/W2324288276"],"abstract_inverted_index":{"Renal":[0,14],"neoplasms":[1],"are":[2,46,79,124],"highlighted":[3],"as":[4,44,111,113,134],"one":[5],"of":[6,12,23,32,170,172,183,199,214,217,225],"the":[7,19,27,35,159,164,215,223],"10":[8],"most":[9,20,29,39],"common":[10,21,30],"types":[11],"cancer.":[13],"cell":[15],"carcinoma":[16],"(RCC)":[17],"is":[18,150,204],"type":[22,31],"renal":[24],"cancer,":[25],"considered":[26],"seventh":[28],"cancer":[33],"in":[34,66,166,240],"Western":[36],"world.":[37],"The":[38],"frequently":[40,86],"altered":[41,45],"genes":[42],"described":[43],"VHL,":[47],"PBRM1,":[48],"SETD2,":[49],"KDM5C,":[50],"PTEN,":[51],"BAP1,":[52],"mTOR,":[53],"TP53,":[54],"TCEB1":[55],"(ELOC),":[56],"SMARCA4,":[57],"ARID1A,":[58],"and":[59,74,91,140,157,168,192,209,229,234],"PIK3CA.":[60],"RCC":[61,155,188,203,227],"therapies":[62,117],"can":[63,237],"be":[64,238],"classified":[65],"three":[67],"groups:":[68],"monoclonal":[69],"antibodies,":[70],"tyrosine":[71],"kinase":[72],"inhibitors,":[73],"mTOR":[75],"inhibitors.":[76],"Besides,":[77],"there":[78],"targeted":[80],"agents":[81],"to":[82,103,153,163,219],"treat":[83],"RCC.":[84,147],"However,":[85],"patients":[87],"present":[88],"side":[89,122,160],"effects":[90,123,161],"resistance.":[92],"Even":[93],"though":[94],"many":[95],"multidrug":[96],"resistance":[97,218],"mechanisms":[98],"already":[99],"have":[100],"been":[101],"reported":[102,129,201],"RCC,":[104],"studies":[105,128,200],"focused":[106],"on":[107,187],"revealing":[108],"new":[109],"biomarkers":[110],"well":[112],"more":[114],"effective":[115],"antitumor":[116,144],"with":[118],"no":[119],"or":[120],"low":[121],"very":[125],"important.":[126],"Some":[127],"that":[130,202],"natural":[131,235],"products,":[132],"such":[133],"honey,":[135],"epigallocatechin-3-gallate":[136],"(EGCG),":[137],"curcumin,":[138],"resveratrol,":[139],"englerin":[141],"A":[142],"showed":[143],"activity":[145],"against":[146],"Moreover,":[148],"nanoscience":[149,233],"another":[151],"strategy":[152],"improve":[154],"treatment":[156,228],"reduce":[158],"due":[162],"improvement":[165],"pharmacokinetics":[167],"reduction":[169],"toxicities":[171],"chemotherapies.":[173],"Taking":[174],"this":[175],"into":[176],"account,":[177],"we":[178],"conducted":[179],"a":[180,197],"systemic":[181],"review":[182],"recent":[184],"research":[185],"findings":[186],"hallmarks,":[189],"drug":[190],"resistance,":[191],"adjuvant":[193],"therapies.":[194,221],"In":[195],"conclusion,":[196],"range":[198],"characterized":[205],"by":[206],"high":[207],"incidence":[208],"increased":[210],"mortality":[211],"rates":[212],"because":[213],"development":[216],"standard":[220],"Given":[222],"importance":[224],"improving":[226],"reducing":[230],"adverse":[231],"effects,":[232],"products":[236],"included":[239],"therapeutic":[241],"strategies.":[242]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2023-11-02T00:00:00"}