{"id":"https://openalex.org/W4388089889","doi":"https://doi.org/10.1136/ijgc-2023-004739","title":"The promise of combining CDK4/6 inhibition with hormonal therapy in the first-line treatment setting for metastatic or recurrent endometrial adenocarcinoma","display_name":"The promise of combining CDK4/6 inhibition with hormonal therapy in the first-line treatment setting for metastatic or recurrent endometrial adenocarcinoma","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388089889","doi":"https://doi.org/10.1136/ijgc-2023-004739","pmid":"https://pubmed.ncbi.nlm.nih.gov/37907262","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10804003"},"language":"en","primary_location":{"id":"doi:10.1136/ijgc-2023-004739","doi":"https://doi.org/10.1136/ijgc-2023-004739","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ijgc-2023-004739","pdf_url":"https://ijgc.bmj.com/content/ijgc/33/12/1943.full.pdf","source":{"id":"https://openalex.org/S41026820","display_name":"International Journal of Gynecological Cancer","issn_l":"1048-891X","issn":["1048-891X","1525-1438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Cancer","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ijgc.bmj.com/content/ijgc/33/12/1943.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073713547","display_name":"Isabelle Laure Ray-Coquard","orcid":"https://orcid.org/0000-0003-2472-8306","observed_orcids":["https://orcid.org/0000-0003-2472-8306","https://orcid.org/0000-0003-2857-3807"]},"institutions":[{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Ray-Coquard","raw_affiliation_strings":["Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire (GINECO), Centre Leon B\u00e8rard, Lyon, France"],"raw_orcid":"https://orcid.org/0000-0003-2472-8306","affiliations":[{"raw_affiliation_string":"Groupe d'Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire (GINECO), Centre Leon B\u00e8rard, Lyon, France","institution_ids":["https://openalex.org/I4210105738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014611244","display_name":"Bradley J. Monk","orcid":"https://orcid.org/0000-0001-6985-0159","observed_orcids":["https://orcid.org/0000-0001-6985-0159","https://orcid.org/0000-0002-0680-3184"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradley J Monk","raw_affiliation_strings":["Honor Health Research Institute, University of Arizona, Creighton University, Phoenix, Arizona, USA"],"raw_orcid":"https://orcid.org/0000-0001-6985-0159","affiliations":[{"raw_affiliation_string":"Honor Health Research Institute, University of Arizona, Creighton University, Phoenix, Arizona, USA","institution_ids":["https://openalex.org/I114493937","https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061939825","display_name":"Domenica Lorusso","orcid":"https://orcid.org/0000-0003-0981-0598","observed_orcids":["https://orcid.org/0000-0003-0981-0598"]},"institutions":[{"id":"https://openalex.org/I103320735","display_name":"Universit\u00e0 Cattolica del Sacro Cuore","ror":"https://ror.org/03h7r5v07","country_code":"IT","type":"education","lineage":["https://openalex.org/I103320735"]},{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenica Lorusso","raw_affiliation_strings":["Catholic University of Sacred Heart, Rome, Italy","Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catholic University of Sacred Heart, Rome, Italy","institution_ids":["https://openalex.org/I103320735"]},{"raw_affiliation_string":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089239939","display_name":"Haider Mahdi","orcid":"https://orcid.org/0000-0002-6343-5314","observed_orcids":["https://orcid.org/0000-0002-6343-5314"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haider Mahdi","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Women's Health Institute, Cleveland Clinic, Cleveland, Ohio, USA","Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Women's Health Institute, Cleveland Clinic, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016458162","display_name":"Vivek A. Upadhyay","orcid":"https://orcid.org/0000-0001-8730-1321","observed_orcids":["https://orcid.org/0000-0001-8730-1321"]},"institutions":[{"id":"https://openalex.org/I4405270745","display_name":"EQRx (United States)","ror":"https://ror.org/018f3ag52","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek Upadhyay","raw_affiliation_strings":["EQRx Inc, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EQRx Inc, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4405270745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026975662","display_name":"Regina Margaret Graul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270745","display_name":"EQRx (United States)","ror":"https://ror.org/018f3ag52","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Regina Graul","raw_affiliation_strings":["EQRx Inc, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EQRx Inc, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4405270745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110697296","display_name":"Amreen Husain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405270745","display_name":"EQRx (United States)","ror":"https://ror.org/018f3ag52","country_code":"US","type":"company","lineage":["https://openalex.org/I4405270745"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amreen Husain","raw_affiliation_strings":["EQRx Inc, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EQRx Inc, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I4405270745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079485962","display_name":"Mansoor Raza Mirza","orcid":"https://orcid.org/0000-0002-8085-1010","observed_orcids":["https://orcid.org/0000-0002-8085-1010"]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Mansoor Raza Mirza","raw_affiliation_strings":["Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8085-1010","affiliations":[{"raw_affiliation_string":"Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043064148","display_name":"Brian M. Slomovitz","orcid":"https://orcid.org/0000-0002-7241-3096","observed_orcids":["https://orcid.org/0000-0002-7241-3096"]},"institutions":[{"id":"https://openalex.org/I4210095266","display_name":"Mount Sinai Medical Center","ror":"https://ror.org/00wgjpw02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210095266"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian Slomovitz","raw_affiliation_strings":["Gynecologic Oncology, Mount Sinai Medical Center, Miami, Florida, USA bslomovitz@gog.org","Gynecologic Oncology, Mount Sinai Medical Center, Miami, FL 33140, USA"],"raw_orcid":"https://orcid.org/0000-0002-7241-3096","affiliations":[{"raw_affiliation_string":"Gynecologic Oncology, Mount Sinai Medical Center, Miami, Florida, USA bslomovitz@gog.org","institution_ids":["https://openalex.org/I4210095266"]},{"raw_affiliation_string":"Gynecologic Oncology, Mount Sinai Medical Center, Miami, FL 33140, USA","institution_ids":["https://openalex.org/I4210095266"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5043064148"],"corresponding_institution_ids":["https://openalex.org/I4210095266"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":{"value":3800,"currency":"USD","value_usd":3800},"fwci":0.9727,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.68631179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"33","issue":"12","first_page":"1943","last_page":"1949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endometrial-adenocarcinoma","display_name":"endometrial adenocarcinoma","score":0.9359999895095825},{"id":"https://openalex.org/keywords/endometrioid-carcinoma","display_name":"endometrioid carcinoma","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hormone-therapy","display_name":"hormone therapy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5929999947547913},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/metastatic-endometrial-cancer","display_name":"metastatic endometrial cancer","score":0.8539999723434448},{"id":"https://openalex.org/keywords/recurrent-endometrial-cancer","display_name":"recurrent endometrial cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endocrine-therapy","display_name":"endocrine therapy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/hormone-resistance","display_name":"hormone resistance","score":0.6259999871253967},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9268170595169067},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6364821791648865},{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.6155681610107422},{"id":"https://openalex.org/C2778311097","wikidata":"https://www.wikidata.org/wiki/Q5903784","display_name":"Hormonal therapy","level":4,"score":0.5870422124862671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5551721453666687},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5368021130561829},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.4719245433807373},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.43740618228912354},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4313387870788574},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.15912997722625732}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018269","descriptor_name":"Carcinoma, Endometrioid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051358","descriptor_name":"Cyclin-Dependent Kinase 4","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/ijgc-2023-004739","doi":"https://doi.org/10.1136/ijgc-2023-004739","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ijgc-2023-004739","pdf_url":"https://ijgc.bmj.com/content/ijgc/33/12/1943.full.pdf","source":{"id":"https://openalex.org/S41026820","display_name":"International Journal of Gynecological Cancer","issn_l":"1048-891X","issn":["1048-891X","1525-1438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10804003","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10804003","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10804003/pdf/ijgc-2023-004739.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Gynecol Cancer","raw_type":"Text"},{"id":"pmid:37907262","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37907262","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of gynecological cancer : official journal of the International Gynecological Cancer Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/ijgc-2023-004739","doi":"https://doi.org/10.1136/ijgc-2023-004739","is_oa":true,"landing_page_url":"https://doi.org/10.1136/ijgc-2023-004739","pdf_url":"https://ijgc.bmj.com/content/ijgc/33/12/1943.full.pdf","source":{"id":"https://openalex.org/S41026820","display_name":"International Journal of Gynecological Cancer","issn_l":"1048-891X","issn":["1048-891X","1525-1438"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Gynecological Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319279","display_name":"EQRx","ror":"https://ror.org/018f3ag52"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388089889.pdf","grobid_xml":"https://content.openalex.org/works/W4388089889.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1576770999","https://openalex.org/W1969255091","https://openalex.org/W2003929214","https://openalex.org/W2004000621","https://openalex.org/W2061451800","https://openalex.org/W2119874496","https://openalex.org/W2136158663","https://openalex.org/W2144790402","https://openalex.org/W2158294624","https://openalex.org/W2590528754","https://openalex.org/W2601079093","https://openalex.org/W2617437931","https://openalex.org/W2783457746","https://openalex.org/W2908699784","https://openalex.org/W2910972034","https://openalex.org/W2944706951","https://openalex.org/W2976415870","https://openalex.org/W3004504895","https://openalex.org/W3010330135","https://openalex.org/W3021358214","https://openalex.org/W3045712044","https://openalex.org/W3083198770","https://openalex.org/W3088846126","https://openalex.org/W3096728494","https://openalex.org/W3112490627","https://openalex.org/W3114074286","https://openalex.org/W3133909149","https://openalex.org/W3207557929","https://openalex.org/W3207579801","https://openalex.org/W4200057475","https://openalex.org/W4200069316","https://openalex.org/W4205741581","https://openalex.org/W4210989197","https://openalex.org/W4220709633","https://openalex.org/W4221085715","https://openalex.org/W4280523559","https://openalex.org/W4281678049","https://openalex.org/W4297990023","https://openalex.org/W4386948757","https://openalex.org/W6642477732","https://openalex.org/W6803117150"],"related_works":["https://openalex.org/W4388495871","https://openalex.org/W4408462484","https://openalex.org/W4387135519","https://openalex.org/W4414650369","https://openalex.org/W4408695657","https://openalex.org/W4399380739","https://openalex.org/W4327568701","https://openalex.org/W2895682835","https://openalex.org/W4306180599","https://openalex.org/W2985351007"],"abstract_inverted_index":{"Metastatic":[0],"or":[1,142],"recurrent":[2,73,143],"endometrioid":[3,32],"adenocarcinoma":[4],"of":[5,56,62,118],"the":[6,54,68,111,116,125,133],"uterine":[7],"corpus":[8],"is":[9,34,59,100],"often":[10,18,51],"incurable":[11],"with":[12,89,139],"limited":[13],"treatment":[14,17,65,135],"options.":[15],"First-line":[16],"includes":[19],"cytotoxic":[20],"chemotherapy,":[21],"which":[22],"incurs":[23],"significant":[24],"toxicities":[25],"for":[26,71,137],"many":[27],"patients.":[28],"Endometrial":[29],"cancer,":[30,33],"specifically":[31],"a":[35,60],"hormone-sensitive":[36],"disease":[37],"and,":[38],"while":[39],"single-agent":[40],"hormonal":[41,85,122],"therapies":[42],"have":[43],"demonstrated":[44],"clinical":[45,79,112],"benefit,":[46],"resistance":[47],"to":[48,53,127,132],"these":[49],"agents":[50],"leads":[52],"use":[55],"chemotherapy.":[57],"There":[58],"lack":[61],"approved":[63],"endocrine":[64],"options":[66,136],"in":[67,87,105],"metastatic":[69],"setting":[70],"most":[72],"endometrial":[74,144],"cancers,":[75],"representing":[76],"an":[77,129],"unmet":[78],"need.":[80],"Emerging":[81],"evidence":[82,113],"suggests":[83],"that":[84,115],"therapy":[86,123],"combination":[88,117],"other":[90],"targeted":[91],"treatments,":[92],"such":[93],"as":[94],"cyclin":[95],"dependent":[96],"kinase":[97],"(CDK)4/6":[98],"inhibitors,":[99],"well":[101],"tolerated":[102],"and":[103,121],"effective":[104],"select":[106],"patient":[107],"populations.":[108],"We":[109],"discuss":[110],"suggesting":[114],"CDK4/6":[119],"inhibitors":[120],"has":[124],"potential":[126],"represent":[128],"important":[130],"addition":[131],"first-line":[134],"patients":[138],"low-grade":[140],"advanced":[141],"cancer.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-01T00:00:00"}