{"id":"https://openalex.org/W4388089596","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1053","title":"1053 Preclinical pharmacodynamic characterization of STK-026: a novel IL-12 partial agonist for cancer with maintained CD8 T cell activity, reduced NK-mediated toxicity and an improved therapeutic window","display_name":"1053 Preclinical pharmacodynamic characterization of STK-026: a novel IL-12 partial agonist for cancer with maintained CD8 T cell activity, reduced NK-mediated toxicity and an improved therapeutic window","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388089596","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1053"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2023-sitc2023.1053","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1053","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1136/jitc-2023-sitc2023.1053","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/A1160.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/A1160.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhenya Koliesnik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhenya Koliesnik","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081465331","display_name":"Michael Totagrande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Totagrande","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113033869","display_name":"Ryan Burgess","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Burgess","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508304","display_name":"Kim Q.T. Tran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kim Q Tran","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017522049","display_name":"Michele Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michele Bauer","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bharghavi Jayaraman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bharghavi Jayaraman","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088864649","display_name":"Cindy Buffone","orcid":"https://orcid.org/0000-0003-1286-7245","observed_orcids":["https://orcid.org/0000-0003-1286-7245"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy Buffone","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082026375","display_name":"Priyanka Balasubrahmanyam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Balasubrahmanyam","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012168959","display_name":"Jan Emmerich","orcid":"https://orcid.org/0000-0002-7216-2231","observed_orcids":["https://orcid.org/0000-0002-7216-2231"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Emmerich","raw_affiliation_strings":["Synthekine, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Germany","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058906822","display_name":"Deepti Chaturvedi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepti Chaturvedi","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001217519","display_name":"Deepti Rokkam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deepti Rokkam","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041768709","display_name":"Ren\u00e9 de Waal Malefyt","orcid":"https://orcid.org/0000-0002-2663-383X","observed_orcids":["https://orcid.org/0000-0002-2663-383X"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rene De Waal Malefyt","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023283844","display_name":"Heiko Greb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heiko Greb","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055737349","display_name":"Navneet P. Ratti","orcid":"https://orcid.org/0000-0002-5203-8989","observed_orcids":["https://orcid.org/0000-0002-5203-8989"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navneet Ratti","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000219144","display_name":"Sandro Vivona","orcid":"https://orcid.org/0000-0003-2340-3219","observed_orcids":["https://orcid.org/0000-0003-2340-3219"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandro Vivona","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018250332","display_name":"Robert Kastelein","orcid":"https://orcid.org/0000-0002-7318-6884","observed_orcids":["https://orcid.org/0000-0002-7318-6884"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Kastelein","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051487266","display_name":"Patrick J. Lupardus","orcid":"https://orcid.org/0000-0002-8662-074X","observed_orcids":["https://orcid.org/0000-0002-8662-074X"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Lupardus","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010745287","display_name":"Luis Alejandro Zuniga","orcid":"https://orcid.org/0000-0002-1832-122X","observed_orcids":["https://orcid.org/0000-0002-1832-122X"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis Zuniga","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103051827","display_name":"David Brian Rosen","orcid":"https://orcid.org/0000-0002-9856-7675","observed_orcids":["https://orcid.org/0000-0002-9856-7675"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B Rosen","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021268908","display_name":"Martin Oft","orcid":"https://orcid.org/0000-0001-9833-2326","observed_orcids":["https://orcid.org/0000-0001-9833-2326"]},"institutions":[{"id":"https://openalex.org/I4387152537","display_name":"Synthekine","ror":"https://ror.org/01j84fh13","country_code":"US","type":"company","lineage":["https://openalex.org/I4387152537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Oft","raw_affiliation_strings":["Synthekine, Menlo Park, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Synthekine, Menlo Park, CA, USA","institution_ids":["https://openalex.org/I4387152537"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4387152537"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A1160","last_page":"A1160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4894999861717224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.4894999861717224,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.1785999983549118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.07760000228881836,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8730000257492065},{"id":"https://openalex.org/keywords/il-12-receptor-beta-1","display_name":"IL-12 receptor beta 1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cd8-t-cell-activation","display_name":"CD8+ T cell activation","score":0.906000018119812},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6890000104904175},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7480000257492065},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.9929999709129333},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"therapeutic index","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-bearing-mice","display_name":"tumor-bearing mice","score":0.39399999380111694},{"id":"https://openalex.org/keywords/cynomolgus-macaques","display_name":"cynomolgus macaques","score":0.9079999923706055},{"id":"https://openalex.org/keywords/myeloid-cell-activation","display_name":"myeloid cell activation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.63138747215271},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6076893210411072},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.555977463722229},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.519321084022522},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5099698305130005},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5059308409690857},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.49912428855895996},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4664095640182495},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.44230759143829346},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.42221611738204956},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4165942668914795},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4048180878162384},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.38920414447784424},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3887048363685608},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3764968514442444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37097638845443726},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19173851609230042},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.18574270606040955},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16490063071250916},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07457628846168518}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2023-sitc2023.1053","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1053","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1136/jitc-2023-sitc2023.1053","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/A1160.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:3e0b02efc0da4cb49b22cd8ab1e23832","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3e0b02efc0da4cb49b22cd8ab1e23832","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2023-sitc2023.1053","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1053","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1136/jitc-2023-sitc2023.1053","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/A1160.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388089596.pdf","grobid_xml":"https://content.openalex.org/works/W4388089596.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W1568495307","https://openalex.org/W2100510996"],"related_works":["https://openalex.org/W4404052992","https://openalex.org/W4417501649","https://openalex.org/W4404053142","https://openalex.org/W4362595098","https://openalex.org/W3179235861","https://openalex.org/W4214915804","https://openalex.org/W4282963087","https://openalex.org/W4388075386","https://openalex.org/W4411236862","https://openalex.org/W7104179027"],"abstract_inverted_index":{"Background":[0],"Interleukin-12":[1],"(IL-12)":[2],"is":[3,58,363],"a":[4,68,123,167,223,364,417,450],"pro-inflammatory":[5],"cytokine":[6,186],"composed":[7],"of":[8,40,101,112,119,128,152,166,171,231,239,244,324,330,342,352,392],"p35":[9],"and":[10,25,97,137,143,149,181,188,198,209,242,254,275,294,304,312,328,348,438,441,455],"p40":[11],"subunits":[12],"produced":[13],"by":[14,50,60,449],"antigen-presenting":[15],"cells":[16,103,233],"to":[17,78,83,98,284,356,371],"stimulate":[18],"Th1":[19],"cells,":[20,24,90,107],"cytotoxic":[21],"CD8":[22,250,314],"T":[23,89,106,251,315],"NK":[26,61,102,190,201,232,291,326,343,421],"cells.":[27,422],"IL-12":[28,43,56,71,130,175,241,383],"has":[29],"potent":[30],"anti-tumor":[31,214,237,320,373],"properties":[32],"in":[33,141,157,216,290,301,345,398,433,444,470],"multiple":[34],"preclinical":[35,117],"models,":[36],"however":[37,220],"clinical":[38],"applications":[39],"wild":[41,172],"type":[42,173],"(IL-12wt)":[44],"or":[45,104,281,458],"IL-12wt-Fc":[46],"fusions":[47],"are":[48],"hampered":[49],"severe":[51,331],"dose-limiting":[52],"toxicities.":[53],"1":[54],"Preclinically,":[55],"toxicity":[57],"mediated":[59],"cell":[62,191,202,252,256,292],"activation.2":[63],"Here":[64],"we":[65,121],"report":[66],"on":[67],"novel":[69,365],"human":[70,153,261,337,395],"partial":[72,131],"agonist":[73,132],"(STK-026)":[74],"with":[75,183,205,248,334,368,382,400,435,472],"diminished":[76],"binding":[77],"IL-12Rb1.":[79],"STK-026":[80,154,262,286,338,362],"was":[81,195,246,267],"designed":[82],"increase":[84],"selectivity":[85],"towards":[86],"antigen":[87],"activated":[88],"which":[91,108],"strongly":[92],"upregulate":[93],"IL-12Rb1":[94],"upon":[95],"activation,":[96],"reduce":[99],"stimulation":[100],"resting":[105],"express":[109],"modest":[110],"levels":[111],"IL-12Rb1.Methods":[113],"To":[114],"understand":[115],"the":[116,129,369],"pharmacology":[118],"STK-026,":[120],"generated":[122],"half-life":[124,168],"extended":[125,169],"mouse":[126,174],"surrogate":[127],"(mSTK-026)":[133],"for":[134,420],"pharmacokinetic":[135],"(PK)":[136],"pharmacodynamic":[138],"(PD)":[139],"assessment":[140],"healthy":[142,158],"tumor":[144,218],"bearing":[145],"mice.":[146],"Further,":[147],"PK":[148],"PD":[150],"parameters":[151],"were":[155,430,447,468],"analyzed":[156],"cynomolgus":[159,259,346],"macaques.Results":[160],"At":[161],"efficacious":[162],"doses,":[163],"systemic":[164,189,279,295,353,413],"administration":[165],"version":[170],"(mIL-12wt-Fc)":[176],"induced":[177,276],"significant":[178],"weight":[179],"loss":[180],"lethality":[182],"early":[184,288,325,340],"proinflammatory":[185],"release":[187],"activation.":[192,257],"Conversely,":[193],"mSTK-026":[194,208,221,245,318],"well":[196],"tolerated,":[197],"avoided":[199,287,339],"rapid":[200],"activation":[203,253,300,327],"seen":[204,333],"mIL-12wt-Fc.":[206,229,335],"Both":[207],"mIL-12wt-Fc":[210],"showed":[211,349],"robust":[212],"single-agent":[213],"efficacy":[215,238,243,321,374],"syngeneic":[217],"models":[219],"demonstrated":[222,263],">10-fold":[224],"higher":[225],"therapeutic":[226],"index":[227],"than":[228],"Depletion":[230],"did":[234],"not":[235],"diminish":[236],"either":[240],"associated":[247,381],"intratumoral":[249],"myeloid":[255],"In":[258],"macaques,":[260],"antibody":[264],"like":[265],"PK,":[266],"well-tolerated":[268],"at":[269,308],"all":[270],"doses":[271,309],"tested":[272],"(highest:":[273],"5mg/kg),":[274],"no":[277],"detectable":[278],"IL-6":[280],"TNF\u03b1.":[282],"Compared":[283],"hIL-12wt-Fc,":[285],"spikes":[289,323,341],"activity":[293,344],"chemokine":[296],"levels,":[297],"reduced":[298,305,350],"lymphocyte":[299],"peripheral":[302],"tissues,":[303],"ALT/AST":[306],"induction":[307,329],"activating":[310],"effector":[311],"memory":[313],"cells.Conclusions":[316],"Overall,":[317],"retained":[319],"without":[322],"toxicities":[332,354,379],"Similarly,":[336],"macaques":[347],"signs":[351],"compared":[355],"hIL-12wt-Fc.":[357],"These":[358],"data":[359],"suggest":[360],"that":[361],"immunotherapy":[366],"approach":[367],"potential":[370],"maintain":[372],"while":[375],"avoiding":[376],"dose":[377],"limiting":[378],"classically":[380],"therapy.References":[384],"Atkins":[385],"M,":[386],"et":[387,408],"al.":[388,409],"Phase":[389],"I":[390],"evaluation":[391],"intravenous":[393],"recombinant":[394],"interleukin":[396],"12":[397],"patients":[399],"advanced":[401],"malignancies.":[402],"Clinical":[403],"Cancer":[404],"Research.":[405],"1997;3(3):409\u201317.Carson":[406],"W,":[407],"A":[410],"fatal":[411],"cytokine-induced":[412],"inflammatory":[414],"response":[415],"reveals":[416],"critical":[418],"role":[419],"J":[423],"Immunology.":[424],"1999;162(8):4943\u20134951.Ethics":[425],"Approval":[426],"All":[427,443,466],"animal":[428],"experiments":[429],"carried":[431],"out":[432],"accordance":[434,471],"local":[436,451,473],"government":[437],"institutional":[439],"guidelines":[440],"regulations.":[442,474],"vivo":[445],"protocols":[446],"approved":[448],"Institutional":[452],"Animal":[453],"Care":[454],"Use":[456],"Committee,":[457],"other":[459],"appropriate":[460],"review":[461],"board,":[462],"before":[463],"study":[464],"execution.":[465],"animals":[467],"housed":[469]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2023-11-01T00:00:00"}
