{"id":"https://openalex.org/W4388077245","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0835","title":"835 Heterologous prime boost viral vector vaccination provides protection against intracranial syngeneic murine glioblastoma","display_name":"835 Heterologous prime boost viral vector vaccination provides protection against intracranial syngeneic murine glioblastoma","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388077245","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0835"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2023-sitc2023.0835","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0835","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0835","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/A933.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/A933.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057564591","display_name":"Emily E Steffke","orcid":"https://orcid.org/0000-0003-3350-9818","observed_orcids":["https://orcid.org/0000-0003-3350-9818"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Emily E Steffke","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003675455","display_name":"Taijun Hana","orcid":"https://orcid.org/0000-0001-7649-3305","observed_orcids":["https://orcid.org/0000-0001-7649-3305"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taijun Hana","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114592260","display_name":"Laila Latifi","orcid":"https://orcid.org/0009-0008-0088-1465","observed_orcids":["https://orcid.org/0009-0008-0088-1465"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laila Latifi","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009760683","display_name":"Vinnycius Pereira Almeida","orcid":"https://orcid.org/0000-0002-3635-7787","observed_orcids":["https://orcid.org/0000-0002-3635-7787"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vinnycius Pereira Almeida","raw_affiliation_strings":["University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030027454","display_name":"James McAuliffe","orcid":"https://orcid.org/0000-0002-4858-3191","observed_orcids":["https://orcid.org/0000-0002-4858-3191","https://orcid.org/0000-0002-5471-8638"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James McAuliffe","raw_affiliation_strings":["University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072482751","display_name":"Amanda Wicki","orcid":"https://orcid.org/0009-0001-7779-932X","observed_orcids":["https://orcid.org/0009-0001-7779-932X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amanda Wicki","raw_affiliation_strings":["University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054550606","display_name":"Laurine Noblecourt","orcid":"https://orcid.org/0009-0002-8710-6846","observed_orcids":["https://orcid.org/0009-0002-8710-6846"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laurine Noblecourt","raw_affiliation_strings":["University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111065165","display_name":"Morgan Coombs","orcid":"https://orcid.org/0009-0009-4371-4832","observed_orcids":["https://orcid.org/0009-0009-4371-4832"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Coombs","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112984733","display_name":"Nargis Malik","orcid":"https://orcid.org/0000-0003-1294-1660","observed_orcids":["https://orcid.org/0000-0003-1294-1660"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nargis Malik","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100637184","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0001-7673-1924","observed_orcids":["https://orcid.org/0000-0001-7673-1924"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100696943","display_name":"Meili Zhang","orcid":"https://orcid.org/0000-0001-9515-0420","observed_orcids":["https://orcid.org/0000-0001-9515-0420"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meili Zhang","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022068070","display_name":"Hua Song","orcid":"https://orcid.org/0000-0002-8525-7061","observed_orcids":["https://orcid.org/0000-0002-8525-7061","https://orcid.org/0000-0002-2791-1723"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Song","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087243296","display_name":"Dionne L. Davis","orcid":"https://orcid.org/0000-0003-2880-8952","observed_orcids":["https://orcid.org/0000-0003-2880-8952"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dionne Davis","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032032046","display_name":"Nicole Briceno","orcid":"https://orcid.org/0000-0003-0816-2410","observed_orcids":["https://orcid.org/0000-0003-0816-2410"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Briceno","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mark Gilbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Gilbert","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022169733","display_name":"Gary Kohanbash","orcid":"https://orcid.org/0000-0002-3953-8022","observed_orcids":["https://orcid.org/0000-0002-3953-8022"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary Kohanbash","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058793243","display_name":"Hideho Okada","orcid":"https://orcid.org/0000-0003-0076-9920","observed_orcids":["https://orcid.org/0000-0003-0076-9920"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hideho Okada","raw_affiliation_strings":["University of California, San Francisco, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, San Francisco, CA, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075138707","display_name":"Carol Sze Ki Leung","orcid":"https://orcid.org/0000-0002-1545-7228","observed_orcids":["https://orcid.org/0000-0002-1545-7228"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carol Leung","raw_affiliation_strings":["University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110511175","display_name":"Benoit J. Van den Eynde","orcid":"https://orcid.org/0000-0002-4995-3270","observed_orcids":["https://orcid.org/0000-0002-4995-3270"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Benoit Van den Eynde","raw_affiliation_strings":["University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101822595","display_name":"Masaki Terabe","orcid":"https://orcid.org/0000-0002-1777-0189","observed_orcids":["https://orcid.org/0000-0002-1777-0189"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masaki Terabe","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health, Bethesda, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A933","last_page":"A933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/heterologous-prime-boost-vaccination","display_name":"heterologous prime-boost","score":0.9210000038146973},{"id":"https://openalex.org/keywords/viral-vector-vaccines","display_name":"viral vector vaccines","score":0.734000027179718},{"id":"https://openalex.org/keywords/modified-vaccinia-ankara","display_name":"modified vaccinia Ankara","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8230000138282776},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7620000243186951},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.9409999847412109},{"id":"https://openalex.org/keywords/prophylactic-vaccination","display_name":"prophylactic vaccination","score":0.7540000081062317},{"id":"https://openalex.org/keywords/intracranial-tumors","display_name":"intracranial tumors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.5989999771118164},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.699999988079071},{"id":"https://openalex.org/keywords/syngeneic-murine-model","display_name":"syngeneic murine model","score":0.734000027179718},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.6539999842643738},{"id":"https://openalex.org/keywords/tumor-immunogenicity","display_name":"tumor immunogenicity","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.741604745388031},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.602148175239563},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5010509490966797},{"id":"https://openalex.org/C2778378633","wikidata":"https://www.wikidata.org/wiki/Q2378309","display_name":"Cancer vaccine","level":4,"score":0.4825517535209656},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48244816064834595},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47728243470191956},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4734206795692444},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.46274498105049133},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.4615260660648346},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.4498139023780823},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.42208653688430786},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4132431149482727},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3432295024394989},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3003428280353546},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.11661246418952942},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2023-sitc2023.0835","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0835","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0835","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/A933.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:38cc5e5c367b49da8bd48f9b5fad5c53","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/38cc5e5c367b49da8bd48f9b5fad5c53","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2023-sitc2023.0835","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0835","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0835","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/A933.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388077245.pdf","grobid_xml":"https://content.openalex.org/works/W4388077245.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3197958750"],"related_works":["https://openalex.org/W4385687165","https://openalex.org/W4388080102","https://openalex.org/W4415900259","https://openalex.org/W4416446130","https://openalex.org/W4362524503","https://openalex.org/W7165487062","https://openalex.org/W7148788508","https://openalex.org/W4409733228","https://openalex.org/W2969270137","https://openalex.org/W7098811379"],"abstract_inverted_index":{"Background":[0],"Glioblastomas":[1],"are":[2,287,359],"immunologically":[3],"\u2018cold\u2019":[4],"tumors":[5,212,278,322],"with":[6,37,77,180,195,215,219,386,466,500],"sparse":[7],"cytotoxic":[8],"T-cell":[9,424],"infiltration.":[10],"Therefore,":[11,69],"viral":[12],"vector":[13],"vaccines":[14,81,216,332,379],"may":[15,373],"be":[16,90,328,362],"a":[17,49,189,234,243,265,305,335],"promising":[18],"approach":[19],"to":[20,72,110,280,327,338,361,376,383],"boost":[21],"the":[22,93,173,206,250,255,259,271,282,289,296,317,344,349,352,448,467,470,483,501],"induction":[23],"of":[24,52,67,162,237,252,254,274,291,308,319,346,351,450,469,503],"glioblastoma-targeted":[25],"T":[26,54,240,311],"cells.":[27],"It":[28,325],"has":[29],"been":[30],"previously":[31],"shown":[32],"that":[33,313],"heterologous":[34,230,301],"prime-boost":[35,231,302,417],"vaccination":[36,232,263,293,347,418],"chimpanzee-derived":[38],"adenovirus":[39],"ChAdOx1":[40,78,141,181,227],"and":[41,60,79,86,95,120,142,153,182,228,343,355,370,426,454,458,479,489,492],"modified":[42],"vaccinia":[43],"Ankara":[44],"(MVA)":[45],"vectors":[46,144,184],"can":[47,333],"induce":[48],"high":[50,235,306],"magnitude":[51,236,307],"CD8+":[53,239,310],"cells":[55,169,241,312],"specific":[56],"for":[57],"cancer-associated":[58],"antigens":[59,85,88,119,148,187,256,421],"have":[61],"therapeutic":[62,96,207,297,336],"effects":[63,345],"against":[64,98,242,316],"mouse":[65],"models":[66,372],"cancer.1":[68],"we":[70,154,248],"aimed":[71],"evaluate":[73],"whether":[74,330],"treating":[75],"mice":[76,177,209,275,339],"MVA":[80,143,183,229],"targeting":[82,264,419],"model":[83,112,146,190,200,244,266],"tumor":[84,147,175,191,224,245,267,353,371,423],"endogenous":[87,117,150,186],"could":[89],"beneficial":[91],"in":[92,124,217,295,323,464,498],"prophylactic":[94,174],"settings":[97],"syngeneic,":[99],"intracranial":[100,197,211,277,341],"murine":[101,125],"glioblastoma.":[102,387],"Methods":[103],"Murine":[104],"glioblastoma":[105,126,321],"cell":[106],"lines":[107,127],"were":[108,122,178,213,461,495],"developed":[109],"express":[111,281],"tumour":[113],"antigens.":[114],"In":[115,172,205],"addition,":[116],"tumor-associated":[118],"neoantigens":[121],"identified":[123,257],"using":[128,367],"our":[129,368],"novel":[130],"Mouse":[131],"nEoanTigen":[132],"pRedictOr":[133],"(METRO)":[134],"antigen":[135,151,201,268],"discovery":[136],"pipeline.":[137,261],"We":[138],"then":[139,193],"created":[140],"expressing":[145,185,202],"or":[149,170,188,199,481],"candidates,":[152],"confirmed":[155,249],"their":[156],"immunogenicity":[157,251],"via":[158],"intracellular":[159],"cytokine":[160],"staining":[161],"ex":[163],"vivo":[164],"stimulated":[165],"peripheral":[166],"blood":[167],"mononuclear":[168],"splenocytes.":[171],"setting,":[176,208],"vaccinated":[179],"antigen,":[192],"challenged":[194],"syngeneic":[196],"wild-type":[198],"tumors,":[203,342],"respectively.":[204],"bearing":[210,276,340],"treated":[214],"combination":[218],"checkpoint":[220,428],"inhibitors":[221],"after":[222],"confirming":[223],"formation.":[225],"Results":[226],"generated":[233,366],"antigen-specific":[238,309],"antigen.":[246,284],"Furthermore,":[247],"some":[253],"by":[258,446,482],"METRO":[260],"Prophylactic":[262],"significantly":[269],"increased":[270],"survival":[272],"time":[273],"engineered":[279],"same":[283],"Ongoing":[285],"studies":[286],"investigating":[288],"efficacy":[290],"this":[292],"strategy":[294,303],"setting.":[298],"Conclusions":[299],"Our":[300],"generates":[304],"provide":[314,334,374],"protection":[315],"development":[318],"orthotopic":[320],"mice.":[324],"remains":[326],"seen":[329],"these":[331,378],"benefit":[337],"on":[348],"remodeling":[350],"microenvironment":[354],"tumor-draining":[356],"lymph":[357],"nodes":[358],"yet":[360],"determined.":[363],"Preclinical":[364],"data":[365],"vaccine":[369],"proof-of-concept":[375],"move":[377],"into":[380],"clinical":[381],"trials":[382],"treat":[384],"patients":[385],"Reference":[388],"1.":[389],"McAuliffe":[390],"J,":[391],"Chan":[392],"HF,":[393],"Noblecourt":[394],"L,":[395],"Ramirez-Valdez":[396],"RA,":[397],"Pereira-Almeida":[398],"V,":[399],"Zhou":[400],"Y,":[401],"Pollock":[402],"E,":[403],"Cappuccini":[404],"F,":[405],"Redchenko":[406],"I,":[407],"Hill":[408],"AV,":[409],"Leung":[410],"CSK,":[411],"Van":[412],"den":[413],"Eynde":[414],"BJ.":[415],"Heterologous":[416],"MAGE-type":[420],"promotes":[422],"infiltration":[425],"improves":[427],"blockade":[429],"therapy.":[430],"J":[431],"Immunother":[432],"Cancer":[433,485],".":[434],"2021":[435],"Sep;":[436],"9":[437],"(9):e003218.":[438],"Ethics":[439],"Approval":[440],"All":[441],"animal":[442],"work":[443],"was":[444],"approved":[445],"either":[447],"University":[449],"Oxford":[451],"Animal":[452,487],"Care":[453,488],"Ethical":[455],"Review":[456],"Committee":[457,491],"experimental":[459,493],"procedures":[460,494],"carried":[462,496],"out":[463,497],"accordance":[465,499],"terms":[468,502],"UK":[471],"Animals":[472],"(Scientific":[473],"Procedures)":[474],"Act":[475],"Project":[476],"Licenses":[477],"P0D369534":[478],"PB050649E;":[480],"National":[484],"Institute-Bethesda":[486],"Use":[490],"Protocol":[504],"NOB-024.":[505]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-01T00:00:00"}
