{"id":"https://openalex.org/W4388069600","doi":"https://doi.org/10.1016/j.jtho.2023.09.228","title":"MA15.11 A Phase I/II Study of TQ-B2450 plus Anlotinib in EGFR+ Advanced NSCLC Patients Failed to Prior EGFR TKI Therapies: Phase II Results Updates","display_name":"MA15.11 A Phase I/II Study of TQ-B2450 plus Anlotinib in EGFR+ Advanced NSCLC Patients Failed to Prior EGFR TKI Therapies: Phase II Results Updates","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388069600","doi":"https://doi.org/10.1016/j.jtho.2023.09.228"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtho.2023.09.228","doi":"https://doi.org/10.1016/j.jtho.2023.09.228","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2023.09.228","pdf_url":"http://www.jto.org/article/S1556086423010304/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jto.org/article/S1556086423010304/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M. Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"M. Shi","raw_affiliation_strings":["1Jiangsu Cancer Hospital, Nanjing, Jiangsu Province/CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Jiangsu Cancer Hospital, Nanjing, Jiangsu Province/CN","institution_ids":["https://openalex.org/I4210128482"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124597","display_name":"Wuhu No 1 People's Hospital","ror":"https://ror.org/02xae6c61","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124597"]},{"id":"https://openalex.org/I4405254154","display_name":"The No. 2 People's Hospital of Lanzhou","ror":"https://ror.org/01fxcka27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4405254154"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"P. Chen","raw_affiliation_strings":["2YanCheng NO.1 People\u2019s Hospital, YanCheng/CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2YanCheng NO.1 People\u2019s Hospital, YanCheng/CN","institution_ids":["https://openalex.org/I4210124597","https://openalex.org/I4405254154"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090920","display_name":"Zhangqiu City People's Hospital","ror":"https://ror.org/00fts7a69","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090920"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"L. Cui","raw_affiliation_strings":["3Zhangqiu People\u2019s Hospital, Zhangqiu/CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Zhangqiu People\u2019s Hospital, Zhangqiu/CN","institution_ids":["https://openalex.org/I4210090920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966852","display_name":"Yung-mae M. Yao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y. Yao","raw_affiliation_strings":["4The Affiliated Hospital of Xuzhou Medical University, Xuzhou/CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4The Affiliated Hospital of Xuzhou Medical University, Xuzhou/CN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378537","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-5398-0802","observed_orcids":["https://orcid.org/0000-0002-5398-0802","https://orcid.org/0000-0001-5412-9860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Wang","raw_affiliation_strings":["5Hanzhong 3201 Hospital, Hanzhong/CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Hanzhong 3201 Hospital, Hanzhong/CN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071054719","display_name":"Ting Zhou","orcid":"https://orcid.org/0000-0003-4349-2036","observed_orcids":["https://orcid.org/0000-0003-4349-2036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Zhou","raw_affiliation_strings":["6Changzhou Cancer Hospital, Changzhou/CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Changzhou Cancer Hospital, Changzhou/CN","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023020157","display_name":"Jian Feng","orcid":"https://orcid.org/0000-0003-4248-4237","observed_orcids":["https://orcid.org/0000-0003-4248-4237"]},"institutions":[{"id":"https://openalex.org/I4210128482","display_name":"Jiangsu Cancer Hospital","ror":"https://ror.org/03108sf43","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"J. Feng","raw_affiliation_strings":["1Jiangsu Cancer Hospital, Nanjing, Jiangsu Province/CN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Jiangsu Cancer Hospital, Nanjing, Jiangsu Province/CN","institution_ids":["https://openalex.org/I4210128482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25875828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"11","first_page":"S157","last_page":"S157"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anlotinib","display_name":"anlotinib","score":0.9670000076293945},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.9290000200271606},{"id":"https://openalex.org/keywords/egfr-tki-resistance","display_name":"EGFR tyrosine kinase inhibitor resistance","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pd-l1-blockade","display_name":"PD-L1 blockade","score":0.7490000128746033},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.503000020980835},{"id":"https://openalex.org/keywords/impower150","display_name":"IMpower150","score":0.7179999947547913},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.8730000257492065},{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.8270000219345093},{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9500539302825928},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.7642130851745605},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.6916956901550293},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6783730983734131},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6376211047172546},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5103139281272888},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.47159919142723083},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.4472886323928833},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.3545854091644287},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.18571114540100098},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1845027506351471},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.10462683439254761}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jtho.2023.09.228","doi":"https://doi.org/10.1016/j.jtho.2023.09.228","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2023.09.228","pdf_url":"http://www.jto.org/article/S1556086423010304/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jtho.2023.09.228","doi":"https://doi.org/10.1016/j.jtho.2023.09.228","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2023.09.228","pdf_url":"http://www.jto.org/article/S1556086423010304/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388069600.pdf","grobid_xml":"https://content.openalex.org/works/W4388069600.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3143402436","https://openalex.org/W3167265661","https://openalex.org/W4310753426","https://openalex.org/W3186228900","https://openalex.org/W4310923305","https://openalex.org/W4281710949","https://openalex.org/W4389262606","https://openalex.org/W4296009479","https://openalex.org/W3088374074","https://openalex.org/W4362586345"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-11-01T00:00:00"}