{"id":"https://openalex.org/W4388049569","doi":"https://doi.org/10.1177/1934578x231210413","title":"PD-1/PD-L1 Interaction Upregulates YAP1 Expression in HepG2 Cells Through MAPK/ERK Pathway","display_name":"PD-1/PD-L1 Interaction Upregulates YAP1 Expression in HepG2 Cells Through MAPK/ERK Pathway","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4388049569","doi":"https://doi.org/10.1177/1934578x231210413"},"language":"en","primary_location":{"id":"doi:10.1177/1934578x231210413","doi":"https://doi.org/10.1177/1934578x231210413","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x231210413","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1177/1934578x231210413","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101953092","display_name":"Shenghao Li","orcid":"https://orcid.org/0000-0002-8968-7333","observed_orcids":["https://orcid.org/0000-0002-8968-7333"]},"institutions":[{"id":"https://openalex.org/I4210098384","display_name":"Fifth Hospital of Shijiazhuang","ror":"https://ror.org/00rd5z074","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098384"]},{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shenghao Li","raw_affiliation_strings":["Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang, Hebei Province, P.R. China","Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang, Hebei Province, P.R. China","institution_ids":["https://openalex.org/I4210098384"]},{"raw_affiliation_string":"Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110418788","display_name":"Muwei Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106405","display_name":"Fourth Hospital of Hebei Medical University","ror":"https://ror.org/01mdjbm03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106405"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Muwei Dai","raw_affiliation_strings":["Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, P.R. China","institution_ids":["https://openalex.org/I4210106405"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023232293","display_name":"Fang Wang","orcid":"https://orcid.org/0009-0005-8933-7666","observed_orcids":["https://orcid.org/0009-0005-8933-7666"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fang Wang","raw_affiliation_strings":["School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, P.R. China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076424492","display_name":"Liyuan Hao","orcid":"https://orcid.org/0000-0001-9429-5134","observed_orcids":["https://orcid.org/0000-0001-9429-5134"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyuan Hao","raw_affiliation_strings":["Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China"],"raw_orcid":"https://orcid.org/0000-0001-9429-5134","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104329609","display_name":"Caixia Feng","orcid":"https://orcid.org/0000-0001-6082-9863","observed_orcids":["https://orcid.org/0000-0001-6082-9863"]},"institutions":[{"id":"https://openalex.org/I4210098384","display_name":"Fifth Hospital of Shijiazhuang","ror":"https://ror.org/00rd5z074","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098384"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Caixia Feng","raw_affiliation_strings":["Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang, Hebei Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang, Hebei Province, P.R. China","institution_ids":["https://openalex.org/I4210098384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083428853","display_name":"Yansheng Jia","orcid":"https://orcid.org/0000-0002-2922-2075","observed_orcids":["https://orcid.org/0000-0002-2922-2075"]},"institutions":[{"id":"https://openalex.org/I4210098384","display_name":"Fifth Hospital of Shijiazhuang","ror":"https://ror.org/00rd5z074","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098384"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yansheng Jia","raw_affiliation_strings":["Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang, Hebei Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang, Hebei Province, P.R. China","institution_ids":["https://openalex.org/I4210098384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026037173","display_name":"Yaoqi Li","orcid":"https://orcid.org/0000-0001-6540-395X","observed_orcids":["https://orcid.org/0000-0001-6540-395X"]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaoqi Li","raw_affiliation_strings":["School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, P.R. China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xichun Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111381250","display_name":"Hebei Medical University","ror":"https://ror.org/04eymdx19","country_code":"CN","type":"education","lineage":["https://openalex.org/I111381250"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xichun Kang","raw_affiliation_strings":["School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, P.R. China","institution_ids":["https://openalex.org/I111381250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060090382","display_name":"Xiaoyu Hu","orcid":"https://orcid.org/0000-0001-8129-7085","observed_orcids":["https://orcid.org/0000-0001-8129-7085"]},"institutions":[{"id":"https://openalex.org/I53411278","display_name":"Chengdu University of Traditional Chinese Medicine","ror":"https://ror.org/00pcrz470","country_code":"CN","type":"education","lineage":["https://openalex.org/I53411278"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyu Hu","raw_affiliation_strings":["Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China"],"raw_orcid":"https://orcid.org/0000-0001-8129-7085","affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, P.R. China","institution_ids":["https://openalex.org/I53411278"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001220614","display_name":"Huimin Yan","orcid":"https://orcid.org/0000-0003-3158-2536","observed_orcids":["https://orcid.org/0000-0003-3158-2536"]},"institutions":[{"id":"https://openalex.org/I4210098384","display_name":"Fifth Hospital of Shijiazhuang","ror":"https://ror.org/00rd5z074","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098384"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huimin Yan","raw_affiliation_strings":["Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang, Hebei Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Shijiazhuang Fifth Hospital, Shijiazhuang, Hebei Province, P.R. China","institution_ids":["https://openalex.org/I4210098384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001220614","https://openalex.org/A5060090382"],"corresponding_institution_ids":["https://openalex.org/I4210098384","https://openalex.org/I53411278"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":{"value":2000,"currency":"USD","value_usd":2000},"fwci":0.7219,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.67406005,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"18","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pd-1-pd-l1-interaction","display_name":"PD-1/PD-L1 interaction","score":0.9279999732971191},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mapk-erk-pathway","display_name":"MAPK/ERK pathway","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.890999972820282},{"id":"https://openalex.org/keywords/nivolumab","display_name":"nivolumab","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.9039999842643738},{"id":"https://openalex.org/keywords/erk-inhibition","display_name":"ERK inhibition","score":0.6940000057220459},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.43799999356269836}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.8451550602912903},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.5671374797821045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5108556151390076},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.5086008310317993},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47806623578071594},{"id":"https://openalex.org/C2780219982","wikidata":"https://www.wikidata.org/wiki/Q17544238","display_name":"YAP1","level":4,"score":0.47094500064849854},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44989556074142456},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42817291617393494},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.425437867641449},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4146266281604767},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.368569940328598},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.326617032289505},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2647396922111511},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22995999455451965},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14642232656478882},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0652676522731781},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1177/1934578x231210413","doi":"https://doi.org/10.1177/1934578x231210413","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x231210413","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b1e3527053354915b5995b711d3285a9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b1e3527053354915b5995b711d3285a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Natural Product Communications, Vol 18 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1177/1934578x231210413","doi":"https://doi.org/10.1177/1934578x231210413","is_oa":true,"landing_page_url":"https://doi.org/10.1177/1934578x231210413","pdf_url":null,"source":{"id":"https://openalex.org/S124250138","display_name":"Natural Product Communications","issn_l":"1555-9475","issn":["1555-9475","1934-578X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","norway-1","oarl","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Natural Product Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4005990155","display_name":null,"funder_award_id":"No. 81973840","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5035494206","display_name":null,"funder_award_id":"No. 81273748","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1969791922","https://openalex.org/W1994193851","https://openalex.org/W1994302891","https://openalex.org/W2039123767","https://openalex.org/W2045410587","https://openalex.org/W2054735475","https://openalex.org/W2146774792","https://openalex.org/W2150544967","https://openalex.org/W2160004726","https://openalex.org/W2606367731","https://openalex.org/W2737207041","https://openalex.org/W2755693293","https://openalex.org/W2760106390","https://openalex.org/W2766852052","https://openalex.org/W2768434280","https://openalex.org/W2773816511","https://openalex.org/W2790897054","https://openalex.org/W2886242604","https://openalex.org/W2886777384","https://openalex.org/W2890371056","https://openalex.org/W2892711895","https://openalex.org/W2897214742","https://openalex.org/W2921032123","https://openalex.org/W2938360122","https://openalex.org/W2947270765","https://openalex.org/W3006810429","https://openalex.org/W3009977304","https://openalex.org/W3011009916","https://openalex.org/W3022800246","https://openalex.org/W3036531881","https://openalex.org/W3047048186","https://openalex.org/W3133105567","https://openalex.org/W3133440540","https://openalex.org/W3181394750","https://openalex.org/W3198238214","https://openalex.org/W4200333307","https://openalex.org/W4210774372","https://openalex.org/W4283393993","https://openalex.org/W4309233024"],"related_works":["https://openalex.org/W4313237594","https://openalex.org/W2904726397","https://openalex.org/W2868809607","https://openalex.org/W2890158083","https://openalex.org/W2950414295","https://openalex.org/W2737207041","https://openalex.org/W3094534381","https://openalex.org/W3011009916","https://openalex.org/W3129071125","https://openalex.org/W3134264738"],"abstract_inverted_index":{"Background":[0],"Antibodies,":[1],"which":[2],"target":[3],"programmed":[4,12],"cell":[5],"death":[6,13],"protein-1":[7],"(PD-1)":[8],"or":[9,79,221,251],"its":[10],"ligand":[11],"ligand-1":[14],"(PD-L1),":[15],"can":[16],"rescue":[17],"T":[18],"cells":[19,45,61,66,137,217,244],"from":[20],"an":[21,48],"exhausted":[22],"state":[23],"and":[24,88,100,102,106,118,123,176,192,233],"resume":[25],"their":[26],"immune":[27,44],"response":[28],"to":[29,42,46,93,112,210],"cancer":[30],"cells.":[31,180,197],"Clinically,":[32],"the":[33,37,52,95,114,144,155,172,188,200,206,229,247,256],"purpose":[34],"of":[35,54,116,146,158,174,190,202,208,215,231,249,258],"blocking":[36,58,185],"PD-1/PD-L1":[38,56,161,240,259],"signaling":[39],"pathway":[40],"is":[41],"induce":[43],"play":[47],"anti-tumor":[49],"role.":[50],"However,":[51],"effect":[53,157],"intertumor":[55],"signal":[57],"on":[59,160],"tumor":[60,243],"remains":[62],"unclear.":[63],"Methods":[64],"HepG2":[65,136,179,196,216],"were":[67,91,138],"treated":[68,139],"with":[69,133,140,218,224],"DHA,":[70],"IFN-\u03b3,":[71],"BSA,":[72],"DDP,":[73],"PD-1-Fc":[74,167],"(1":[75],"\u03bcg/ml),":[76],"IgG-Fc,":[77],"nivolumab,":[78],"human":[80],"IgG":[81],"for":[82],"24":[83],"h,":[84],"respectively.":[85],"GEPIA,":[86,121],"cBioPortal,":[87,122],"TIMER":[89,124],"databases":[90,125],"used":[92,111],"analyze":[94],"correlation":[96],"between":[97,242],"YAP1,":[98],"PD-1,":[99],"PD-L1":[101],"ERK,":[103],"ERK-5,":[104],"JNK,":[105],"p38.":[107],"Western":[108],"blot":[109],"was":[110,130,148],"detect":[113],"expression":[115,145,173,189,207,230,248],"YAP1":[117,129,147,177,193,252],"p-ERK.":[119],"Results":[120],"analysis":[126],"showed":[127],"that":[128,166,239],"positively":[131],"correlated":[132],"ERK.":[134],"After":[135],"PD98059":[141,159],"(ERK":[142],"inhibitor),":[143],"decreased.":[149],"In":[150,181,198],"this":[151],"study,":[152],"we":[153],"investigated":[154],"inhibitory":[156],"signaling.":[162],"Our":[163],"study":[164],"found":[165],"(PD-1":[168,184],"fusion":[169],"protein)":[170],"promoted":[171],"p-ERK/ERK":[175,191,209,232],"in":[178,194],"contrast,":[182],"nivolumab":[183],"antibody)":[186],"reduced":[187],"IFN-\u03b3-pretreated":[195],"addition,":[199],"application":[201],"DHA":[203,219,222],"also":[204],"inhibited":[205,228],"inhibit":[211],"YAP1.":[212,234],"Furthermore,":[213],"treatment":[214],"alone":[220],"combined":[223],"cisplatin":[225],"(DDP)":[226],"both":[227],"Conclusions":[235],"These":[236],"results":[237],"suggested":[238],"interactions":[241],"could":[245,260],"promote":[246],"ERK":[250,264],"within":[253],"tumors.":[254],"Moreover,":[255],"conduction":[257],"be":[261],"reversed":[262],"using":[263],"inhibitors.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2023-11-01T00:00:00"}