{"id":"https://openalex.org/W4388049068","doi":"https://doi.org/10.4084/mjhid.2023.059","title":"NOVEL MUTATIONS IN THE NON-STRUCTURE PROTEIN 2 OF SARS-CoV-2: Sequence analysis NSP2 of SARS-CoV-2","display_name":"NOVEL MUTATIONS IN THE NON-STRUCTURE PROTEIN 2 OF SARS-CoV-2: Sequence analysis NSP2 of SARS-CoV-2","publication_year":2023,"publication_date":"2023-10-16","ids":{"openalex":"https://openalex.org/W4388049068","doi":"https://doi.org/10.4084/mjhid.2023.059","pmid":"https://pubmed.ncbi.nlm.nih.gov/38028396","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10631707"},"language":"en","primary_location":{"id":"doi:10.4084/mjhid.2023.059","doi":"https://doi.org/10.4084/mjhid.2023.059","is_oa":true,"landing_page_url":"https://doi.org/10.4084/mjhid.2023.059","pdf_url":"https://www.mjhid.org/index.php/mjhid/article/download/5404/4420","source":{"id":"https://openalex.org/S159911762","display_name":"Mediterranean Journal of Hematology and Infectious Diseases","issn_l":"2035-3006","issn":["2035-3006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Hematology and Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mjhid.org/index.php/mjhid/article/download/5404/4420","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Mohsen Nakhaei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I235686326","display_name":"Kerman University of Medical Sciences","ror":"https://ror.org/02kxbqc24","country_code":"IR","type":"education","lineage":["https://openalex.org/I235686326"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohsen Nakhaei","raw_affiliation_strings":["Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran","Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran","institution_ids":["https://openalex.org/I235686326"]},{"raw_affiliation_string":"Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran","institution_ids":["https://openalex.org/I235686326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005152511","display_name":"Zohreh\u2010al\u2010sadat Ghoreshi","orcid":"https://orcid.org/0000-0002-0556-3000","observed_orcids":["https://orcid.org/0000-0002-0556-3000"]},"institutions":[{"id":"https://openalex.org/I1280764379","display_name":"University of Jiroft","ror":"https://ror.org/00mz6ad23","country_code":"IR","type":"education","lineage":["https://openalex.org/I1280764379"]},{"id":"https://openalex.org/I4405281540","display_name":"Jiroft University of Medical Sciences","ror":"https://ror.org/04gy83161","country_code":"IR","type":"education","lineage":["https://openalex.org/I4405281540"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zohreh-Al-Sadat Ghoreshi","raw_affiliation_strings":["School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran","Student Research Committee Jiroft University of Medical Sciences, Jiroft, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran","institution_ids":["https://openalex.org/I1280764379","https://openalex.org/I4405281540"]},{"raw_affiliation_string":"Student Research Committee Jiroft University of Medical Sciences, Jiroft, Iran","institution_ids":["https://openalex.org/I1280764379","https://openalex.org/I4405281540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036606011","display_name":"Mohammad Rezaei Zadeh Rukerd","orcid":"https://orcid.org/0000-0001-8390-4344","observed_orcids":["https://orcid.org/0000-0001-8390-4344"]},"institutions":[{"id":"https://openalex.org/I235686326","display_name":"Kerman University of Medical Sciences","ror":"https://ror.org/02kxbqc24","country_code":"IR","type":"education","lineage":["https://openalex.org/I235686326"]},{"id":"https://openalex.org/I4210105474","display_name":"Universal Scientific Education and Research Network","ror":"https://ror.org/01n71v551","country_code":"IR","type":"nonprofit","lineage":["https://openalex.org/I4210105474"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Rezaei Zadeh Rukerd","raw_affiliation_strings":["Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran","Universal Scientific Education and Research Network (USERN), Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran","institution_ids":["https://openalex.org/I235686326"]},{"raw_affiliation_string":"Universal Scientific Education and Research Network (USERN), Tehran, Iran","institution_ids":["https://openalex.org/I4210105474"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039339110","display_name":"Hedyeh Askarpour","orcid":"https://orcid.org/0000-0003-0047-1702","observed_orcids":["https://orcid.org/0000-0003-0047-1702"]},"institutions":[{"id":"https://openalex.org/I1280764379","display_name":"University of Jiroft","ror":"https://ror.org/00mz6ad23","country_code":"IR","type":"education","lineage":["https://openalex.org/I1280764379"]},{"id":"https://openalex.org/I4405281540","display_name":"Jiroft University of Medical Sciences","ror":"https://ror.org/04gy83161","country_code":"IR","type":"education","lineage":["https://openalex.org/I4405281540"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hedyeh Askarpour","raw_affiliation_strings":["School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran","institution_ids":["https://openalex.org/I1280764379","https://openalex.org/I4405281540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104705257","display_name":"Nasir --","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1280764379","display_name":"University of Jiroft","ror":"https://ror.org/00mz6ad23","country_code":"IR","type":"education","lineage":["https://openalex.org/I1280764379"]},{"id":"https://openalex.org/I4405281540","display_name":"Jiroft University of Medical Sciences","ror":"https://ror.org/04gy83161","country_code":"IR","type":"education","lineage":["https://openalex.org/I4405281540"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nasir","raw_affiliation_strings":["a:1:{s:5:\"en_US\";s:71:\"School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran\";}","a:1:{s:5:\"en_US\"","s:71:\"School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran\""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a:1:{s:5:\"en_US\";s:71:\"School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran\";}","institution_ids":["https://openalex.org/I1280764379","https://openalex.org/I4405281540"]},{"raw_affiliation_string":"a:1:{s:5:\"en_US\"","institution_ids":[]},{"raw_affiliation_string":"s:71:\"School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran\"","institution_ids":["https://openalex.org/I1280764379","https://openalex.org/I4405281540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":600,"currency":"EUR","value_usd":647},"apc_paid":{"value":600,"currency":"EUR","value_usd":647},"fwci":0.963,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70686116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"15","issue":"1","first_page":"e2023059","last_page":"e2023059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/nsp2","display_name":"NSP2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/viral-mutations","display_name":"viral mutations","score":0.7250000238418579},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.9729999899864197},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.777999997138977},{"id":"https://openalex.org/keywords/homology-modeling","display_name":"homology modeling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.7730000019073486},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8019999861717224},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.8100000023841858},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8230000138282776},{"id":"https://openalex.org/keywords/wuhan-hu-1","display_name":"Wuhan-Hu-1","score":0.777999997138977},{"id":"https://openalex.org/keywords/sars-cov-2-genome-sequencing","display_name":"SARS-CoV-2 genome sequencing","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.8692171573638916},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.7618846893310547},{"id":"https://openalex.org/C165525559","wikidata":"https://www.wikidata.org/wiki/Q224180","display_name":"Homology (biology)","level":3,"score":0.50678950548172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.502183198928833},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.49809861183166504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4952971041202545},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4676256775856018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40678074955940247},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37055253982543945}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4084/mjhid.2023.059","doi":"https://doi.org/10.4084/mjhid.2023.059","is_oa":true,"landing_page_url":"https://doi.org/10.4084/mjhid.2023.059","pdf_url":"https://www.mjhid.org/index.php/mjhid/article/download/5404/4420","source":{"id":"https://openalex.org/S159911762","display_name":"Mediterranean Journal of Hematology and Infectious Diseases","issn_l":"2035-3006","issn":["2035-3006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Hematology and Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10631707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10631707","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10631707/pdf/mjhid-15-1-e2023059.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterr J Hematol Infect Dis","raw_type":"Text"},{"id":"pmid:38028396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38028396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean journal of hematology and infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:04c8447c7da9426abab221a957d7a616","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/04c8447c7da9426abab221a957d7a616","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mediterranean Journal of Hematology and Infectious Diseases, Vol 15, Iss 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4084/mjhid.2023.059","doi":"https://doi.org/10.4084/mjhid.2023.059","is_oa":true,"landing_page_url":"https://doi.org/10.4084/mjhid.2023.059","pdf_url":"https://www.mjhid.org/index.php/mjhid/article/download/5404/4420","source":{"id":"https://openalex.org/S159911762","display_name":"Mediterranean Journal of Hematology and Infectious Diseases","issn_l":"2035-3006","issn":["2035-3006"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319913","host_organization_name":"PAGEPress (Italy)","host_organization_lineage":["https://openalex.org/P4310319913"],"host_organization_lineage_names":["PAGEPress (Italy)"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mediterranean Journal of Hematology and Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322776","display_name":"Kerman University of Medical Sciences","ror":"https://ror.org/02kxbqc24"},{"id":"https://openalex.org/F4320337173","display_name":"Student Research Committee, Tabriz University of Medical Sciences","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388049068.pdf","grobid_xml":"https://content.openalex.org/works/W4388049068.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W132286244","https://openalex.org/W1031578623","https://openalex.org/W2059598052","https://openalex.org/W2073875193","https://openalex.org/W2098391569","https://openalex.org/W2121719851","https://openalex.org/W2136513422","https://openalex.org/W2154551219","https://openalex.org/W2266909178","https://openalex.org/W2938574745","https://openalex.org/W2947881281","https://openalex.org/W2954896633","https://openalex.org/W2999535351","https://openalex.org/W3006645647","https://openalex.org/W3010956505","https://openalex.org/W3014910618","https://openalex.org/W3015103596","https://openalex.org/W3016636971","https://openalex.org/W3022285953","https://openalex.org/W3022687324","https://openalex.org/W3038958209","https://openalex.org/W3039177096","https://openalex.org/W3047668048","https://openalex.org/W3092296275","https://openalex.org/W3093900830","https://openalex.org/W3104285666","https://openalex.org/W3108269660","https://openalex.org/W3131467665","https://openalex.org/W3143532022","https://openalex.org/W3174633538","https://openalex.org/W4206405158","https://openalex.org/W4224321626","https://openalex.org/W4281723774","https://openalex.org/W4283155713","https://openalex.org/W4283215039","https://openalex.org/W4283654132","https://openalex.org/W4287838589","https://openalex.org/W4291017825","https://openalex.org/W4294917736","https://openalex.org/W4317871225","https://openalex.org/W4317932799","https://openalex.org/W4318823037","https://openalex.org/W4366525449","https://openalex.org/W4380423291","https://openalex.org/W4381309652","https://openalex.org/W4381481061","https://openalex.org/W4384154806","https://openalex.org/W4395002359"],"related_works":["https://openalex.org/W3202880756","https://openalex.org/W6920697395","https://openalex.org/W4405390587","https://openalex.org/W4378965227","https://openalex.org/W3091996264","https://openalex.org/W3127437500","https://openalex.org/W3093085773","https://openalex.org/W4200116634","https://openalex.org/W4383998802","https://openalex.org/W4280609023"],"abstract_inverted_index":{"Background:":[0,103],"Mutation":[1,104],"in":[2,11,29,105,114,132,233,322],"the":[3,25,30,58,84,106,128,133,161,187,213,247,256,261,264,272,279,302,336,345,350,353,361,368],"genome":[4,107],"of":[5,17,86,92,108,120,189,195,212,263,281,301,352,370],"SARS-CoV-2":[6,109],"may":[7,110],"play":[8,111],"a":[9,112],"role":[10,113],"immune":[12,115],"evasion,":[13,116],"pathogenicity":[14,117],"and":[15,33,63,118,136,166,224,241,276,283,290,313,330,365,372,379],"speed":[16,119],"its":[18,121],"transmission.":[19,122],"Our":[20,123,268,357],"investigation":[21,124],"aimed":[22,125],"to":[23,82,126,185,260,349],"evaluate":[24,127],"mutations":[26,87,129,190,216,238,273,305,327,362],"that":[27,130,210,255,271,299,344,360],"exist":[28,131],"nsp2.":[31,134,234,323],"Materials":[32,135],"Method:":[34,137],"RNA":[35,138],"was":[36,46,80,139,149,183,205,230,319],"extracted":[37,140],"from":[38,41,141,144],"nasopharyngeal":[39,142],"swabs":[40,143],"100":[42,145],"COVID-19":[43,146],"patients.":[44,147],"RT-PCR":[45,148],"performed":[47,150],"on":[48,88,151,191],"all":[49,152],"samples":[50,153],"using":[51,65,154,168],"nsp2":[52,155,215,236,282,304,325,371],"specific":[53,156],"primers.":[54,157],"Following":[55,158],"gel":[56,159],"electrophoresis,":[57,160],"bands":[59,162],"were":[60,163,226,258,315,347],"cut,":[61,164],"purified,":[62,165],"sequenced":[64,167],"Sanger":[66,169],"method.":[67,170],"After":[68,171],"sequencing,":[69,172],"90":[70,173],"sequences":[71,174,262,351],"could":[72,175],"be":[73,176,288,377],"used":[74,177],"for":[75,178],"further":[76,179],"analysis.":[77,180],"Bioinformatics":[78,181],"analysis":[79,182],"conducted":[81,184],"investigate":[83,186],"effect":[85,188],"protein":[89,192],"structure,":[90,193],"prediction":[91,194],"homology":[93,196],"models,":[94,197],"phylogeny":[95,198],"tree.":[96,199],"Results:":[97,200],"The":[98,201,207,251,296,340],"patients'":[99,202],"mean":[100,203],"age":[101,204],"wa":[102],"51.08.":[206,295],"results":[208,297],"revealed":[209,298],"8":[211,300],"17":[214,303],"(R207C,":[217,306],"T224I,":[218,307],"G262V,":[219,308],"T265I,":[220,309],"K337D,":[221,310],"N348S,":[222,311],"G392D,":[223,312],"I431M)":[225,314],"missense.":[227,316],"One":[228,317],"deletion":[229,318],"also":[231,320],"found":[232,321],"Among":[235,324],"missense":[237,326],"studied,":[239,328],"K337D":[240,275,329,364],"G392D":[242,277,331,366],"increased":[243,332],"structural":[244,333],"stability":[245,280,334,369],"while":[246,335],"others":[248,337],"decreased":[249,338],"it.":[250,339],"homology-designed":[252,341],"models":[253,342],"demonstrated":[254,343],"homologies":[257,346],"comparable":[259,348],"Wuhan-HU-1":[265,354],"virus.":[266,355],"Conclusion:":[267,356],"study":[269,358],"suggested":[270,359],"as":[274,363],"modulate":[278,367],"tracking":[284,373],"viral":[285,374],"evolution":[286,375],"should":[287,376],"implemented":[289,378],"vaccine":[291,380],"development":[292,381],"updated.":[293,382],"s":[294]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-11-01T00:00:00"}