{"id":"https://openalex.org/W4388048650","doi":"https://doi.org/10.3390/jpm13111566","title":"Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride","display_name":"Food Administration and Not Genetic Variants Causes Pharmacokinetic Variability of Tadalafil and Finasteride","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388048650","doi":"https://doi.org/10.3390/jpm13111566","pmid":"https://pubmed.ncbi.nlm.nih.gov/38003881","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10672114"},"language":"en","primary_location":{"id":"doi:10.3390/jpm13111566","doi":"https://doi.org/10.3390/jpm13111566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jpm13111566","pdf_url":"https://www.mdpi.com/2075-4426/13/11/1566/pdf?version=1698759706","source":{"id":"https://openalex.org/S2736780684","display_name":"Journal of Personalized Medicine","issn_l":"2075-4426","issn":["2075-4426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","erih-plus","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Personalized Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2075-4426/13/11/1566/pdf?version=1698759706","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010008926","display_name":"Gonzalo Villapalos\u2010Garc\u00eda","orcid":"https://orcid.org/0000-0002-4849-3268","observed_orcids":["https://orcid.org/0000-0002-4849-3268"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gonzalo Villapalos-Garc\u00eda","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-4849-3268","affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026681178","display_name":"Pablo Zubiaur","orcid":"https://orcid.org/0000-0002-6150-4320","observed_orcids":["https://orcid.org/0000-0002-6150-4320"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Pablo Zubiaur","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-6150-4320","affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cristina Mari\u00e1n-Revilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Mari\u00e1n-Revilla","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023070833","display_name":"Paula Soria\u2010Chacartegui","orcid":"https://orcid.org/0000-0002-1951-2626","observed_orcids":["https://orcid.org/0000-0002-1951-2626"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Soria-Chacartegui","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056454945","display_name":"Marcos Navares\u2010G\u00f3mez","orcid":"https://orcid.org/0000-0003-2501-6845","observed_orcids":["https://orcid.org/0000-0003-2501-6845"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marcos Navares-G\u00f3mez","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047342267","display_name":"Gina Paola Mej\u00eda-Abril","orcid":"https://orcid.org/0000-0002-8689-7941","observed_orcids":["https://orcid.org/0000-0002-8689-7941"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gina Mej\u00eda-Abril","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8689-7941","affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102659611","display_name":"Andrea Rodr\u00edguez\u2010Lopez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Andrea Rodr\u00edguez-Lopez","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010238011","display_name":"Eva Gonz\u00e1lez\u2010Iglesias","orcid":"https://orcid.org/0000-0003-4875-6141","observed_orcids":["https://orcid.org/0000-0003-4875-6141"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eva Gonz\u00e1lez-Iglesias","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078396638","display_name":"Samuel Mart\u00edn\u2010V\u00edlchez","orcid":"https://orcid.org/0000-0003-0557-7653","observed_orcids":["https://orcid.org/0000-0003-0557-7653"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Samuel Mart\u00edn-V\u00edlchez","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107990871","display_name":"Manuel Casal Rom\u00e1n","orcid":"https://orcid.org/0000-0002-7562-9845","observed_orcids":["https://orcid.org/0000-0002-7562-9845"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel Rom\u00e1n","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111421362","display_name":"Dolores Ochoa","orcid":"https://orcid.org/0000-0002-1265-6600","observed_orcids":["https://orcid.org/0000-0002-1265-6600"]},"institutions":[{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Dolores Ochoa","raw_affiliation_strings":["Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010358276","display_name":"Francisco Abad\u2010Santos","orcid":"https://orcid.org/0000-0002-6519-8885","observed_orcids":["https://orcid.org/0000-0002-6519-8885","https://orcid.org/0009-0002-9221-717X"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210130498","display_name":"Hospital Universitario de La Princesa","ror":"https://ror.org/03cg5md32","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130498","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210132431","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas","ror":"https://ror.org/03cn6tr16","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132431"]},{"id":"https://openalex.org/I4405259965","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Universitario de La Princesa","ror":"https://ror.org/02zx68e15","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4405259965"]},{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Francisco Abad-Santos","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain","Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-6519-8885","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210132431"]},{"raw_affiliation_string":"Clinical Pharmacology Department, School of Medicine, Hospital Universitario de La Princesa, Instituto Te\u00f3filo Hernando, Instituto de Investigaci\u00f3n Sanitaria La Princesa (IP), Universidad Aut\u00f3noma de Madrid, 28006 Madrid, Spain","institution_ids":["https://openalex.org/I4210130498","https://openalex.org/I4405259965","https://openalex.org/I63634437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5010358276","https://openalex.org/A5026681178"],"corresponding_institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210130498","https://openalex.org/I4210132431","https://openalex.org/I4405259965","https://openalex.org/I63634437"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2224},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2224},"fwci":0.6003,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5607054,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"11","first_page":"1566","last_page":"1566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tadalafil","display_name":"tadalafil","score":1.0},{"id":"https://openalex.org/keywords/finasteride","display_name":"finasteride","score":1.0},{"id":"https://openalex.org/keywords/pharmacokinetic-variability","display_name":"pharmacokinetic variability","score":0.9610000252723694},{"id":"https://openalex.org/keywords/pharmacogenes","display_name":"drug metabolism genes","score":0.7760000228881836},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.6470000147819519},{"id":"https://openalex.org/keywords/benign-prostatic-hyperplasia","display_name":"benign prostatic hyperplasia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.45399999618530273},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.6330000162124634},{"id":"https://openalex.org/keywords/abcc3","display_name":"ABCC3","score":0.843999981880188},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.996999979019165},{"id":"https://openalex.org/keywords/carboxylesterase-1","display_name":"CES1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nudt15","display_name":"NUDT15","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ugt2b10","display_name":"UGT2B10","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4860000014305115},{"id":"https://openalex.org/keywords/drug-transport","display_name":"drug transport","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2775874879","wikidata":"https://www.wikidata.org/wiki/Q424167","display_name":"Finasteride","level":4,"score":0.901671826839447},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8734838366508484},{"id":"https://openalex.org/C2780816001","wikidata":"https://www.wikidata.org/wiki/Q424156","display_name":"Tadalafil","level":3,"score":0.861008882522583},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.8298743367195129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7373395562171936},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5968598127365112},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.5903512239456177},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5142859816551208},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3544219732284546},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3273055851459503},{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.203226238489151},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.053293049335479736},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/jpm13111566","doi":"https://doi.org/10.3390/jpm13111566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jpm13111566","pdf_url":"https://www.mdpi.com/2075-4426/13/11/1566/pdf?version=1698759706","source":{"id":"https://openalex.org/S2736780684","display_name":"Journal of Personalized Medicine","issn_l":"2075-4426","issn":["2075-4426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","erih-plus","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Personalized Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10672114","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10672114","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10672114/pdf/jpm-13-01566.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Pers Med","raw_type":"Text"},{"id":"pmid:38003881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38003881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of personalized medicine","raw_type":"Journal Article"},{"id":"pmh:oai:hispana.mcu.es:59516032","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10486/719327","pdf_url":null,"source":{"id":"https://openalex.org/S4377196108","display_name":"Hispana","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"},{"id":"pmh:oai:repositorio.uam.es:10486/719327","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10486/719327","pdf_url":null,"source":{"id":"https://openalex.org/S4306400964","display_name":"Biblos-e Archivo (Universidad Aut\u00f3noma de Madrid)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I63634437","host_organization_name":"Universidad Aut\u00f3noma de Madrid","host_organization_lineage":["https://openalex.org/I63634437"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"research article"}],"best_oa_location":{"id":"doi:10.3390/jpm13111566","doi":"https://doi.org/10.3390/jpm13111566","is_oa":true,"landing_page_url":"https://doi.org/10.3390/jpm13111566","pdf_url":"https://www.mdpi.com/2075-4426/13/11/1566/pdf?version=1698759706","source":{"id":"https://openalex.org/S2736780684","display_name":"Journal of Personalized Medicine","issn_l":"2075-4426","issn":["2075-4426"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","erih-plus","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Personalized Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1479653444","display_name":null,"funder_award_id":"FPI-UAM 2021","funder_id":"https://openalex.org/F4320322755","funder_display_name":"Universidad Aut\u00f3noma de Madrid"},{"id":"https://openalex.org/G2818817098","display_name":null,"funder_award_id":"2022-C23.I01.P03.S0020-0000031","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3632859828","display_name":"Ensayo cl\u00ednico aleatorizado para evaluar la utilidad del genotipado de CYP2D6 para mejorar la eficacia y la seguridad del tramadol en el tratamiento del dolor postoperatorio agudo","funder_award_id":"ICI20/00131","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4118085173","display_name":null,"funder_award_id":"09-PIN1-00015.6/2022","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4938108364","display_name":null,"funder_award_id":"FI20/00090","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G983329318","display_name":null,"funder_award_id":"FPI-UAM, 2021","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320322755","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388048650.pdf","grobid_xml":"https://content.openalex.org/works/W4388048650.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W107210901","https://openalex.org/W850981696","https://openalex.org/W1489169544","https://openalex.org/W1901755736","https://openalex.org/W1965934593","https://openalex.org/W1975119053","https://openalex.org/W1975157264","https://openalex.org/W1979725554","https://openalex.org/W1986566323","https://openalex.org/W1988910337","https://openalex.org/W1994414216","https://openalex.org/W2015746645","https://openalex.org/W2028292035","https://openalex.org/W2033139608","https://openalex.org/W2039470011","https://openalex.org/W2045412406","https://openalex.org/W2066602810","https://openalex.org/W2066759626","https://openalex.org/W2081597080","https://openalex.org/W2088525052","https://openalex.org/W2118905420","https://openalex.org/W2125867389","https://openalex.org/W2138509705","https://openalex.org/W2173732482","https://openalex.org/W2299367035","https://openalex.org/W2407495396","https://openalex.org/W2466547779","https://openalex.org/W2511011293","https://openalex.org/W2527682840","https://openalex.org/W2606471894","https://openalex.org/W2737877120","https://openalex.org/W2770862842","https://openalex.org/W2900673338","https://openalex.org/W2917080169","https://openalex.org/W2923904006","https://openalex.org/W2937367049","https://openalex.org/W2945323630","https://openalex.org/W2990348714","https://openalex.org/W3095158159","https://openalex.org/W3167268391","https://openalex.org/W3175801695","https://openalex.org/W3194343284","https://openalex.org/W3204659292","https://openalex.org/W4205713819","https://openalex.org/W4207040466","https://openalex.org/W4213127162","https://openalex.org/W4220771491","https://openalex.org/W4223504984","https://openalex.org/W4245421692","https://openalex.org/W4251855550","https://openalex.org/W4293633679","https://openalex.org/W4299795893"],"related_works":["https://openalex.org/W1987244221","https://openalex.org/W3194343284","https://openalex.org/W3205427784","https://openalex.org/W4388093643","https://openalex.org/W7162809451","https://openalex.org/W3033825601","https://openalex.org/W4387706517","https://openalex.org/W4408161674","https://openalex.org/W1975119053","https://openalex.org/W2015281966"],"abstract_inverted_index":{"Tadalafil":[0],"and":[1,23,41,63,109,139,155,169,182,217,242],"finasteride":[2,28,166,193,216,243],"are":[3,226],"used":[4],"in":[5,17,20,56,73,117,130,176,190],"combination":[6],"for":[7,201],"the":[8,21,52,59,131,213,230],"management":[9],"of":[10,25,46,54,61,90,215,232],"benign":[11],"prostatic":[12],"hyperplasia":[13],"(BPH).":[14],"Genetic":[15,204],"variations":[16],"genes":[18,75],"involved":[19],"metabolism":[22],"transport":[24],"tadalafil":[26,62,113,191,241],"or":[27,97,238],"(i.e.,":[29],"pharmacogenes)":[30],"could":[31],"affect":[32],"their":[33,37],"pharmacokinetic":[34,188],"processes":[35],"altering":[36],"drug":[38],"exposure,":[39],"efficacy,":[40],"toxicity.":[42],"The":[43],"main":[44],"objective":[45],"this":[47],"study":[48,69,103],"was":[49,76,104],"to":[50,141,146,158,172,209,228],"investigate":[51],"effects":[53],"variants":[55,72],"pharmacogenes":[57],"on":[58,212,240],"pharmacokinetics":[60,214],"finasteride.":[64],"An":[65],"exploratory":[66],"candidate":[67],"gene":[68],"involving":[70],"120":[71],"33":[74],"performed":[77],"with":[78,106,187,222],"66":[79],"male":[80,108,149],"healthy":[81],"volunteers":[82,111,126,150,163],"from":[83],"two":[84],"bioequivalence":[85,120],"clinical":[86,121],"trials":[87],"after":[88,199],"administration":[89],"tadalafil/finasteride":[91],"5":[92],"mg/5":[93],"mg":[94,115],"under":[95],"fed":[96,125,162],"fasting":[98,147,173],"conditions.":[99],"Afterwards,":[100],"a":[101],"confirmatory":[102],"conducted":[105],"189":[107],"female":[110,159],"receiving":[112],"20":[114],"formulations":[116],"seven":[118],"additional":[119,220],"trials.":[122],"Regarding":[123],"tadalafil,":[124],"showed":[127,152],"higher":[128,153,165],"area":[129],"time-concentration":[132],"curve":[133],"(AUC\u221e),":[134],"maximum":[135],"plasma":[136],"concentration":[137],"(Cmax),":[138],"time":[140],"reach":[142],"Cmax":[143,156,168],"(tmax)":[144],"compared":[145,157,171],"volunteers;":[148],"also":[151],"AUC\u221e":[154],"volunteers.":[160],"Furthermore,":[161],"presented":[164],"AUC\u221e,":[167],"tmax":[170],"individuals.":[174],"Variants":[175],"ABCC3,":[177],"CYP1A2,":[178],"CES1,":[179],"NUDT15,":[180],"SLC22A1/A2":[181],"UGT2B10":[183],"were":[184],"nominally":[185],"associated":[186],"variation":[189,205],"and/or":[192],"but":[194],"did":[195,206],"not":[196,207],"remain":[197],"significant":[198],"correction":[200],"multiple":[202],"comparisons.":[203],"demonstrate":[208],"clinically":[210],"impact":[211],"tadalafil;":[218],"however,":[219],"studies":[221],"larger":[223],"sample":[224],"sizes":[225],"needed":[227],"assess":[229],"effect":[231],"rare":[233],"variants,":[234],"such":[235],"as":[236],"CYP3A4*20":[237],"*22,":[239],"pharmacokinetics.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-11-01T00:00:00"}
