{"id":"https://openalex.org/W4388048389","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1148","title":"1148 A listeriolysin O-CD47 protein-antibody conjugate triggers cGAS-STING activation in solid tumor malignancies","display_name":"1148 A listeriolysin O-CD47 protein-antibody conjugate triggers cGAS-STING activation in solid tumor malignancies","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388048389","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1148"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2023-sitc2023.1148","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1148","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.1148","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/1264.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/1264.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070712895","display_name":"Abin Antony","orcid":"https://orcid.org/0000-0001-8907-1056","observed_orcids":["https://orcid.org/0000-0001-8907-1056"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abin Antony","raw_affiliation_strings":["UT MD Anderson Cancer Center, Missouri City, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UT MD Anderson Cancer Center, Missouri City, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041156272","display_name":"Benjamin R. Schrank","orcid":"https://orcid.org/0000-0001-8138-4250","observed_orcids":["https://orcid.org/0000-0001-8138-4250"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin R Schrank","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398535","display_name":"Yifan Wang","orcid":"https://orcid.org/0000-0001-7387-0654","observed_orcids":["https://orcid.org/0000-0001-7387-0654"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yifan Wang","raw_affiliation_strings":["The University of Texas Southwestern Medical Center, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas Southwestern Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090210760","display_name":"Wen Jiang","orcid":"https://orcid.org/0000-0001-9154-633X","observed_orcids":["https://orcid.org/0000-0001-9154-633X","https://orcid.org/0000-0003-0612-2917","https://orcid.org/0000-0002-6073-3260","https://orcid.org/0000-0001-6858-2666"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wen Jiang","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A1264","last_page":"A1264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.15199999511241913,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/listeriolysin-o","display_name":"listeriolysin O","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cd47","display_name":"CD47","score":0.9769999980926514},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.9660000205039978},{"id":"https://openalex.org/keywords/macrophage-phagocytosis","display_name":"macrophage phagocytosis","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.6100000143051147},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.5830000042915344},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.8999999761581421},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.4749999940395355},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.46299999952316284},{"id":"https://openalex.org/keywords/anti-cd47-monoclonal-antibody","display_name":"anti-CD47 monoclonal antibody","score":0.7429999709129333},{"id":"https://openalex.org/keywords/sirpalpha","display_name":"SIRP\u03b1","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2781275251","wikidata":"https://www.wikidata.org/wiki/Q17146593","display_name":"Listeriolysin O","level":5,"score":0.7998918294906616},{"id":"https://openalex.org/C2780104668","wikidata":"https://www.wikidata.org/wiki/Q21108354","display_name":"CD47","level":3,"score":0.704994261264801},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5776394009590149},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.5374062657356262},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4551212787628174},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44617775082588196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.425618052482605},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3971029222011566},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36267223954200745},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24010437726974487},{"id":"https://openalex.org/C2781350384","wikidata":"https://www.wikidata.org/wiki/Q292015","display_name":"Listeria monocytogenes","level":3,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C2778682378","wikidata":"https://www.wikidata.org/wiki/Q746209","display_name":"Listeria","level":4,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2023-sitc2023.1148","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1148","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.1148","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/1264.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:a2f8c4136b774151ba7481d3c12da188","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a2f8c4136b774151ba7481d3c12da188","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2023-sitc2023.1148","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1148","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.1148","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/1264.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388048389.pdf","grobid_xml":"https://content.openalex.org/works/W4388048389.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W1966217032","https://openalex.org/W2011865356","https://openalex.org/W2966261467"],"related_works":["https://openalex.org/W4307297259","https://openalex.org/W4387208129","https://openalex.org/W4393072846","https://openalex.org/W3200579739","https://openalex.org/W4407922316","https://openalex.org/W4416412035","https://openalex.org/W2400479672","https://openalex.org/W4394615419","https://openalex.org/W4408870197","https://openalex.org/W3003989858"],"abstract_inverted_index":{"Background":[0],"Tumor":[1,182],"DNA":[2,76,382],"is":[3,12,90,493],"a":[4,91,100,209,331,494],"potent":[5],"activator":[6],"of":[7,38,57,74,111,164,172,184,193,202,228,258,264,273,289,293,324,531],"the":[8,28,54,67,72,119,126,133,141,162,170,286,294,322,385],"cGAS-STING":[9,81,301,386],"pathway.1":[10],"CD47":[11],"expressed":[13],"on":[14,315],"various":[15],"tumor":[16,42,75,86,156,174,206,262,278,306],"types":[17],"including":[18],"breast,":[19],"prostate,":[20],"glioblastoma,":[21],"non-Hodgkin":[22],"lymphoma,":[23],"and":[24,40,51,85,104,140,166,179,195,204,233,253,305,326,353,361,390,535,540],"hepatocellular":[25],"carcinoma.":[26],"Interrupting":[27],"CD47-SIRP":[29],"alpha":[30,490],"axis":[31],"by":[32,106,355,384,538],"monoclonal":[33],"antibodies":[34],"fosters":[35],"macrophage-mediated":[36],"phagocytosis":[37,201],"solid":[39,499],"hematopoietic":[41],"cells.2":[43],"The":[44,109,271,486],"pore-forming":[45],"protein":[46,296,489],"listeriolysin":[47,532],"O":[48,533],"(LLO)":[49],"polymerizes":[50],"activates":[52],"in":[53,118,161,208,281,318,364,388],"acidic":[55],"vacuoles":[56],"antigen":[58,83,180,234,303],"presenting":[59],"cells.3":[60],"We":[61],"hypothesize":[62],"that":[63,94,213],"LLO":[64,98,295],"conjugation":[65],"to":[66,97,114,168,237,269,297,341],"anti-CD47":[68,96,115,167,194,221,238,298],"mAb":[69],"(anti-CD47)":[70],"enhances":[71,299],"release":[73],"within":[77],"macrophages":[78,152,280,320],"thereby":[79],"augmenting":[80],"activation,":[82,178,302],"presentation,":[84,304],"phagocytosis.":[87,308],"Methods":[88],"LLO-CD47":[89,112,165,198,223,259,311],"protein-antibody":[92,312],"conjugate":[93,313],"joins":[95],"using":[99],"water-soluble":[101],"SPDP":[102],"crosslinker":[103],"purified":[105],"affinity":[107],"chromatography.":[108],"cytotoxicity":[110],"relative":[113,236,268],"was":[116,188,214],"tested":[117],"mouse":[120,134,149],"breast":[121,128],"cancer":[122,129,136],"cell":[123,130,137,145,157,175,251,307],"line":[124,131,138,146],"E0771,":[125],"human":[127,142,498],"MDA-MB-468,":[132],"lung":[135],"LLC,":[139],"leukemia":[143],"monocytic":[144],"THP-1.":[147],"C57B6":[148],"bone":[150],"marrow-derived":[151],"(BMDM)":[153],"co-cultured":[154],"with":[155,220,243,336,366],"lines":[158],"were":[159,349],"analyzed":[160],"presence":[163],"determine":[169],"efficiency":[171],"BMDM":[173,200,226],"phagocytosis,":[176],"STING":[177],"presentation.":[181],"growth":[183,263],"E0771-bearing":[185,265,282],"wildtype":[186,266],"mice":[187,267],"measured":[189],"following":[190],"intratumoral":[191,256],"injection":[192,257],"LLO-CD47.":[196,290],"Results":[197],"enhanced":[199],"LLC":[203],"E0771":[205],"cells":[207,218,276],"dose":[210],"dependent":[211],"manner":[212],"significantly":[215,224,260,284],"higher":[216],"than":[217],"treated":[219],"alone.":[222],"increased":[225],"levels":[227],"phosphorylated":[229],"STING,":[230],"interferon-stimulated":[231],"genes,":[232],"presentation":[235],"treatment.":[239],"At":[240],"doses":[241],"compatible":[242],"preserved":[244],"animal":[245,369],"total":[246],"body":[247],"weight,":[248],"red":[249],"blood":[250],"counts,":[252,255],"lymphocyte":[254],"suppressed":[261],"anti-CD47.":[270],"elimination":[272],"CD8+":[274],"T":[275],"or":[277,339],"associated":[279],"animals":[283,348],"abrogated":[285],"antitumor":[287],"effect":[288],"Conclusions":[291],"Conjugation":[292],"macrophage":[300],"This":[309],"novel":[310],"builds":[314],"clinical":[316],"interest":[317],"targeting":[319],"for":[321,334,497],"treatment":[323],"malignancy":[325],"may":[327],"be":[328],"studied":[329],"as":[330],"supplemental":[332],"therapy":[333],"patients":[335],"tumors":[337],"resistant":[338],"refractory":[340],"checkpoint":[342],"therapy.":[343],"Ethics":[344],"Approval":[345],"Studies":[346],"involving":[347],"submitted":[350],"to,":[351],"reviewed,":[352],"approved":[354],"MD":[356],"Anderson\u2019s":[357],"Institutional":[358],"Animal":[359],"Care":[360],"Use":[362],"Committee":[363],"accordance":[365],"all":[367],"applicable":[368],"welfare":[370],"regulations;":[371],"protocol":[372],"number":[373],"00002163-RN00.":[374],"References":[375],"Motwani":[376],"M,":[377,453,475,512,514,516,520,527],"Pesiridis":[378],"S,":[379,459],"Fitzgerald":[380],"KA.":[381],"sensing":[383],"pathway":[387],"health":[389],"disease.":[391],"Nat":[392],"Rev":[393],"Genet.":[394],"2019;20(11):657\u2013674.":[395],"Willingham":[396],"SB,":[397],"Volkmer":[398,426],"JP,":[399],"Gentles":[400],"AJ,":[401],"Sahoo":[402],"D,":[403,451,457],"Dalerba":[404],"P,":[405,417,445],"Mitra":[406],"SS,":[407],"Wang":[408],"J,":[409],"Contreras-Trujillo":[410],"H,":[411],"Martin":[412],"R,":[413,469],"Cohen":[414],"JD,":[415],"Lovelace":[416],"Scheeren":[418],"FA,":[419],"Chao":[420],"MP,":[421],"Weiskopf":[422],"K,":[423],"Tang":[424],"C,":[425],"AK,":[427],"Naik":[428],"TJ,":[429],"Storm":[430],"TA,":[431],"Mosley":[432],"AR,":[433],"Edris":[434],"B,":[435],"Schmid":[436],"SM,":[437],"Sun":[438],"CK,":[439],"Chua":[440],"MS,":[441],"Murillo":[442],"O,":[443],"Rajendran":[444],"Cha":[446],"AC,":[447],"Chin":[448],"RK,":[449],"Kim":[450],"Adorno":[452],"Raveh":[454],"T,":[455],"Tseng":[456],"Jaiswal":[458],"Enger":[460],"P\u00d8,":[461],"Steinberg":[462],"GK,":[463],"Li":[464],"G,":[465],"So":[466],"SK,":[467],"Majeti":[468],"Harsh":[470],"GR,":[471],"van":[472],"de":[473],"Rijn":[474],"Teng":[476],"NN,":[477],"Sunwoo":[478],"JB,":[479],"Alizadeh":[480],"AA,":[481],"Clarke":[482],"MF,":[483],"Weissman":[484],"IL.":[485],"CD47-signal":[487],"regulatory":[488],"(SIRPa)":[491],"interaction":[492],"therapeutic":[495],"target":[496],"tumors.":[500],"Proc":[501],"Natl":[502],"Acad":[503],"Sci":[504,544,553],"U":[505],"S":[506],"A.":[507],"2012":[508],"Apr":[509,547],"24;109(17):6662\u20137.":[510],"Podobnik":[511],"Marchioretto":[513],"Zanetti":[515],"Bavdek":[517],"A,":[518],"Kisovec":[519],"Cajnko":[521],"MM,":[522],"Lunelli":[523],"L,":[524],"Dalla":[525],"Serra":[526],"Anderluh":[528],"G.":[529],"Plasticity":[530],"pores":[534],"its":[536],"regulation":[537],"pH":[539],"unique":[541],"histidine":[542],"[corrected].":[543],"Rep.":[545,554],"2015":[546],"8;5:9623.":[548],"doi:":[549],"10.1038/srep09623.":[550],"Erratum":[551],"in:":[552],"2015;5:15690.":[555]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-11-01T00:00:00"}
