{"id":"https://openalex.org/W4388048281","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0572","title":"572 PYX-102, an anti-KLRG1 antibody, enhances cytotoxic activity of CD8-T-cells from PBMC and human tumor samples by blocking the interaction between KLRG1 and cadherins","display_name":"572 PYX-102, an anti-KLRG1 antibody, enhances cytotoxic activity of CD8-T-cells from PBMC and human tumor samples by blocking the interaction between KLRG1 and cadherins","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388048281","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0572"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2023-sitc2023.0572","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0572","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0572","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/649.full.pdf","source":{"id":"https://openalex.org/S4363604233","display_name":"Regular and Young Investigator Award Abstracts","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/649.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050707000","display_name":"Kei Yasuda","orcid":"https://orcid.org/0000-0002-6791-4531","observed_orcids":["https://orcid.org/0000-0002-6791-4531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kei Yasuda","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113150263","display_name":"Liyang Diao","orcid":"https://orcid.org/0009-0001-4932-0916","observed_orcids":["https://orcid.org/0009-0001-4932-0916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liyang Diao","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianwen Feng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianwen Feng","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110341008","display_name":"Matthew Iovino","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Iovino","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061400491","display_name":"Sara L. Lewandowski","orcid":"https://orcid.org/0000-0002-5830-9962","observed_orcids":["https://orcid.org/0000-0002-5830-9962"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sara Lewandowski","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050796975","display_name":"Anthony B. Rodriguez","orcid":"https://orcid.org/0000-0001-6816-5870","observed_orcids":["https://orcid.org/0000-0001-6816-5870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony Rodriguez","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049048571","display_name":"Philipp Steiner","orcid":"https://orcid.org/0009-0007-5383-9714","observed_orcids":["https://orcid.org/0009-0007-5383-9714"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philipp Steiner","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dan Felitsky","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Felitsky","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101987129","display_name":"Ronald Herbst","orcid":"https://orcid.org/0000-0003-1702-7739","observed_orcids":["https://orcid.org/0000-0003-1702-7739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald Herbst","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ben Keller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ben Keller","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109650770","display_name":"Ona Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ona Miller","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014726634","display_name":"Alyssa Quigley","orcid":"https://orcid.org/0000-0003-4758-5387","observed_orcids":["https://orcid.org/0000-0003-4758-5387"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alyssa Quigley","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050064612","display_name":"Jan Pinkas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Pinkas","raw_affiliation_strings":["Pyxis Oncology, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pyxis Oncology, Boston, MA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A649","last_page":"A649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.7056000232696533,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.16060000658035278,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.09889999777078629,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klrg1","display_name":"KLRG1","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7580000162124634},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/e-cadherin","display_name":"E-cadherin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.699999988079071},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.6859999895095825},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.48399999737739563},{"id":"https://openalex.org/keywords/tumor-associated-neutrophils","display_name":"tumor-associated neutrophils","score":0.5440000295639038},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.4490000009536743},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.3499999940395355},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.5249999761581421},{"id":"https://openalex.org/keywords/bispecific-t-cell-engagers","display_name":"bispecific T-cell engagers","score":0.5910000205039978},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.5350000262260437}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.8202738165855408},{"id":"https://openalex.org/C129374314","wikidata":"https://www.wikidata.org/wiki/Q909381","display_name":"Interleukin 21","level":4,"score":0.6053853631019592},{"id":"https://openalex.org/C149532602","wikidata":"https://www.wikidata.org/wiki/Q2409681","display_name":"Interleukin 12","level":4,"score":0.5308958888053894},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5090200901031494},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.47674569487571716},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47451868653297424},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.46862295269966125},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.45566290616989136},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.4412979483604431},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.389398455619812},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3551862835884094},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34805718064308167},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32473647594451904},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2740892767906189},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20884373784065247},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09490761160850525}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2023-sitc2023.0572","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0572","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0572","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/649.full.pdf","source":{"id":"https://openalex.org/S4363604233","display_name":"Regular and Young Investigator Award Abstracts","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:d58746e935aa484e91284e907bc0b59c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d58746e935aa484e91284e907bc0b59c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2023-sitc2023.0572","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0572","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0572","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/649.full.pdf","source":{"id":"https://openalex.org/S4363604233","display_name":"Regular and Young Investigator Award Abstracts","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388048281.pdf","grobid_xml":"https://content.openalex.org/works/W4388048281.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4244249577","https://openalex.org/W4393090922","https://openalex.org/W4393094102","https://openalex.org/W4310104766","https://openalex.org/W2912602334","https://openalex.org/W7152371111","https://openalex.org/W7154461707","https://openalex.org/W1504591313","https://openalex.org/W2125224862","https://openalex.org/W2104412491"],"abstract_inverted_index":{"Background":[0],"KLRG1":[1,13,45,197,210],"is":[2,14,42,46,62],"an":[3,77,175,271],"inhibitory":[4],"receptor":[5],"expressed":[6,15,198,248],"on":[7,16,379],"T":[8,22,26,89],"and":[9,23,37,90,113,167,234,273,360,386,398],"NK-cells.":[10],"On":[11],"CD8-T-cells,":[12,391],"highly":[17],"differentiated":[18],"antigen-specific":[19,350],"effector":[20],"memory":[21,25],"CD45RA-effector":[24],"cells.":[27,117,172,348],"These":[28],"cells":[29,132,201,225,255,316],"display":[30],"strong":[31],"anti-tumor":[32],"cytotoxicity":[33],"by":[34,48,101,106,111,283,319],"releasing":[35],"IFNg":[36,126,268,279],"TNFa,":[38],"however":[39],"this":[40,396],"process":[41],"inhibited":[43],"when":[44,285],"engaged":[47],"various":[49],"tumor-expressed":[50],"cadherins.":[51],"The":[52],"percentage":[53],"of":[54,87,103,263,343,390,395],"KLRG1+CD8-T-cells":[55,73,136,257,351],"increases":[56],"with":[57,72,135,190,256,270,297],"age,":[58],"suggesting":[59],"why":[60],"age":[61],"a":[63,184,218],"risk":[64],"factor":[65],"for":[66,373],"cancer.":[67],"We":[68],"hypothesized":[69],"that":[70],"patients":[71,145],"may":[74],"benefit":[75],"from":[76,138,140,147,183,220,238,258,288,309],"antagonistic":[78],"antibody":[79],"blocking":[80],"KLRG1-cadherin":[81,384],"interactions,":[82],"thereby":[83],"restoring":[84],"the":[85,261,300,371,383],"function":[86],"cytotoxic":[88],"NK-cells,":[91],"resulting":[92],"in":[93,199,332,354],"broad":[94],"tumor-killing":[95],"activity.":[96],"Methods":[97],"Antibodies":[98],"were":[99,317,352],"generated":[100],"immunization":[102,189],"mice":[104],"followed":[105],"humanization.":[107],"Binding":[108,192,204],"was":[109,119,153,181,202,211,280],"measured":[110],"Octet":[112],"FACS":[114],"using":[115,121,304,322],"KLRG1-overexpressing":[116],"Blocking":[118],"studied":[120],"labelled":[122],"KLRG1-tetramers.":[123],"Assays":[124],"measuring":[125],"or":[127,143,146,169,208,213,326,336,345],"TNFa":[128,274],"used":[129,154],"artificial":[130],"antigen-presenting":[131],"(aAPC)":[133],"mixed":[134,296],"isolated":[137,182,237,308],"PBMCs":[139,291],"healthy":[141,259],"donors":[142],"cancer":[144,289],"dissociated":[148,311],"tumors.":[149],"A":[150],"human":[151,179,196,239],"IgG4-antibody":[152,176],"as":[155],"negative":[156],"control.":[157],"Cytotoxic":[158],"assays":[159],"employed":[160],"BiTE":[161,323],"molecules":[162,324],"binding":[163,221,230],"to":[164,195,205,222,231,328,334,366,388],"CD3-expressing":[165],"T-cells":[166],"CD19-":[168,335],"HER2-expressing":[170,337],"target":[171,338,347],"Results":[173],"PYX-102,":[174,380],"which":[177,246,363,381],"targets":[178],"KLRG1,":[180],"wild-type":[185],"mouse":[186,209],"hybridoma":[187],"after":[188],"hKLRG1-Fc.":[191],"affinity":[193],"(EC50)":[194],"ExpiCHO":[200],"1.0nM.":[203],"cynomolgus":[206],"monkey":[207],"weak":[212],"not":[214],"detected.":[215],"PYX-102":[216,228,264,284,340],"blocked":[217],"hKLRG1-tetramer":[219],"E-cadherin-overexpressing":[223],"K562":[224],"(EC50=1.1nM).":[226],"Furthermore,":[227],"demonstrated":[229],"CD8-T-cells":[232,331],"(2.3nM)":[233],"CD56+NK-cells":[235],"(1.4nM)":[236],"PBMCs.":[240],"Functionally,":[241],"we":[242],"utilized":[243],"E-cadherin-expressing":[244],"aAPC":[245],"also":[247,281],"TCR-activating":[249],"ligands":[250],"(TCR-CHO-K1-cells).":[251],"When":[252],"co-culturing":[253],"these":[254],"donors,":[260],"addition":[262],"induced":[265,282],"pro-inflammatory":[266],"cytokines":[267],"(1,243pg/mL":[269],"EC50=0.29nM)":[272],"(206pg/mL,":[275],"EC50=0.32":[276],"nM).":[277],"Importantly,":[278],"utilizing":[286],"CCR7-CD8+T-cells":[287],"patient":[290],"(1":[292],"prostate,":[293],"2":[294,310],"kidney)":[295],"TCR-CHO-K1-cells.":[298],"In":[299],"same":[301],"assay":[302],"but":[303],"CD8+tumor-infiltrating":[305],"lymphocytes":[306],"(TIL)":[307],"kidney":[312],"cancers,":[313],"IFNg-producing":[314],"CD8+TIL":[315],"increased":[318],"PYX-102.":[320],"Lastly,":[321],"(CD3xCD19":[325],"CD3xHER2)":[327],"bring":[329],"KLRG1-enriched":[330],"proximity":[333],"cells,":[339],"reduced":[341],"viability":[342],"HEK-CD19-E-cadherin":[344],"HCC2935-HER2-E-cadherin":[346],"Tumor":[349],"observed":[353],"breast,":[355],"lung,":[356],"kidney,":[357],"ovarian,":[358],"esophageal":[359],"colorectal":[361],"tumors":[362],"are":[364],"known":[365],"express":[367],"cadherins,":[368],"strongly":[369],"supporting":[370],"rational":[372],"targeting":[374],"KLRG1+CD8-T-cells.":[375],"Conclusions":[376],"Our":[377],"data":[378],"blocks":[382],"interaction":[385],"leads":[387],"activation":[389],"supports":[392],"further":[393],"development":[394],"promising":[397],"innovative":[399],"anti-cancer":[400],"experimental":[401],"therapeutic.":[402]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-11-01T00:00:00"}
