{"id":"https://openalex.org/W4388048167","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0647","title":"647 PERIO-03: Pressure enabled intrapancreatic delivery of SD-101 with checkpoint blockade for locally advanced pancreatic adenocarcinoma \u2013 Initial safety and feasibility experience","display_name":"647 PERIO-03: Pressure enabled intrapancreatic delivery of SD-101 with checkpoint blockade for locally advanced pancreatic adenocarcinoma \u2013 Initial safety and feasibility experience","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388048167","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0647"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2023-sitc2023.0647","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0647","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0647","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/739.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/739.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088195904","display_name":"Michael S. Lee","orcid":"https://orcid.org/0000-0001-8407-3423","observed_orcids":["https://orcid.org/0000-0001-8407-3423"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael S Lee","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015116006","display_name":"Rahul A. Sheth","orcid":"https://orcid.org/0000-0001-9615-8985","observed_orcids":["https://orcid.org/0000-0001-9615-8985"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rahul Sheth","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030433015","display_name":"Joshua David Kuban","orcid":"https://orcid.org/0000-0003-0814-3375","observed_orcids":["https://orcid.org/0000-0003-0814-3375"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D Kuban","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026186757","display_name":"Ethan Bernard Ludmir","orcid":"https://orcid.org/0000-0002-5472-5344","observed_orcids":["https://orcid.org/0000-0002-5472-5344"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ethan Ludmir","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059325577","display_name":"Charla McMichael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charla McMichael","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069113364","display_name":"Jason P. LaPorte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802684491","display_name":"Westminster City Council","ror":"https://ror.org/01a35x275","country_code":"GB","type":"other","lineage":["https://openalex.org/I2802684491"]},{"id":"https://openalex.org/I3210091819","display_name":"City of Westminster College","ror":"https://ror.org/02mht3s70","country_code":"GB","type":"education","lineage":["https://openalex.org/I3210091819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jason LaPorte","raw_affiliation_strings":["TriSalus Life Sciences, Westminster, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TriSalus Life Sciences, Westminster, CO, USA","institution_ids":["https://openalex.org/I2802684491","https://openalex.org/I3210091819"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lindsay Laudal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802684491","display_name":"Westminster City Council","ror":"https://ror.org/01a35x275","country_code":"GB","type":"other","lineage":["https://openalex.org/I2802684491"]},{"id":"https://openalex.org/I3210091819","display_name":"City of Westminster College","ror":"https://ror.org/02mht3s70","country_code":"GB","type":"education","lineage":["https://openalex.org/I3210091819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lindsay Laudal","raw_affiliation_strings":["TriSalus Life Sciences, Westminster, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TriSalus Life Sciences, Westminster, CO, USA","institution_ids":["https://openalex.org/I2802684491","https://openalex.org/I3210091819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088764567","display_name":"Ann-Marie Hulstine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1305496451","display_name":"Phoenix Houses of New England","ror":"https://ror.org/04wkjxj31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305496451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann-Marie Hulstine","raw_affiliation_strings":["TriSalus Life Sciences, Phoenixville, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TriSalus Life Sciences, Phoenixville, PA, USA","institution_ids":["https://openalex.org/I1305496451"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040099847","display_name":"Steven C. Katz","orcid":"https://orcid.org/0000-0002-6030-9312","observed_orcids":["https://orcid.org/0000-0002-6030-9312"]},"institutions":[{"id":"https://openalex.org/I2802684491","display_name":"Westminster City Council","ror":"https://ror.org/01a35x275","country_code":"GB","type":"other","lineage":["https://openalex.org/I2802684491"]},{"id":"https://openalex.org/I3210091819","display_name":"City of Westminster College","ror":"https://ror.org/02mht3s70","country_code":"GB","type":"education","lineage":["https://openalex.org/I3210091819"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven Katz","raw_affiliation_strings":["TriSalus Life Sciences, Westminster, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TriSalus Life Sciences, Westminster, CO, USA","institution_ids":["https://openalex.org/I2802684491","https://openalex.org/I3210091819"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084349853","display_name":"Shubham Pant","orcid":"https://orcid.org/0000-0001-9281-480X","observed_orcids":["https://orcid.org/0000-0001-9281-480X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shubham Pant","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A739","last_page":"A739"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sd-101","display_name":"SD-101","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tlr9-agonist","display_name":"TLR9 agonist","score":0.8450000286102295},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.7490000128746033},{"id":"https://openalex.org/keywords/portal-vein-infusion","display_name":"portal vein infusion","score":0.5720000267028809},{"id":"https://openalex.org/keywords/desmoplastic-stroma","display_name":"desmoplastic stroma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.593999981880188},{"id":"https://openalex.org/keywords/safety-and-feasibility","display_name":"feasibility and safety","score":0.5509999990463257},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.831526517868042},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5505858659744263},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.44681620597839355},{"id":"https://openalex.org/C2780333324","wikidata":"https://www.wikidata.org/wiki/Q707326","display_name":"Splenic artery","level":2,"score":0.4242575466632843},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.41751986742019653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41076046228408813},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37614521384239197},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3556745648384094},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.35130566358566284},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3491690158843994}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2023-sitc2023.0647","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0647","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0647","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/739.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:8ef94102aec24529b45c654adb1bd41c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8ef94102aec24529b45c654adb1bd41c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2023-sitc2023.0647","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0647","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0647","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_1/739.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388048167.pdf","grobid_xml":"https://content.openalex.org/works/W4388048167.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4321781913","https://openalex.org/W4317891437","https://openalex.org/W4281690697","https://openalex.org/W3004966470","https://openalex.org/W3004685364","https://openalex.org/W3039325621","https://openalex.org/W3104936688","https://openalex.org/W4362596030","https://openalex.org/W4392009992","https://openalex.org/W7154695775"],"abstract_inverted_index":{"Background":[0],"Immune":[1],"checkpoint":[2],"inhibitors":[3],"(ICI)":[4],"have":[5],"not":[6],"demonstrated":[7,314],"clinical":[8,408],"benefit":[9],"in":[10,56,300,316,327,347,368,381,430],"the":[11,66,144,157,165,192,241,254,369,382,413,431],"majority":[12],"of":[13,35,69,87,122,302,312,337,349],"pancreatic":[14,78,167],"ductal":[15],"adenocarcinomas":[16],"(PDAC).":[17],"Drug":[18,46],"delivery":[19,71],"challenges":[20,68],"due":[21,225],"to":[22,84,116,226,240,428],"a":[23,37,43,76,276],"high-pressure":[24],"desmoplastic":[25],"stroma":[26],"and":[27,161,171,181,206,263,296,324,330,339,357,384,394],"myeloid":[28],"driven":[29],"immunosuppression":[30],"are":[31,98,174,179,201],"therapeutic":[32],"barriers.":[33],"Delivery":[34,47],"SD-101,":[36],"class":[38],"C":[39],"TLR9":[40],"agonist":[41],"via":[42],"Pressure":[44],"Enabled":[45],"(PEDD)":[48],"system,":[49,160],"has":[50],"been":[51],"associated":[52,318,351,375],"with":[53,58,96,110,126,143,222,235,253,279,319,363,376,390,397],"encouraging":[54],"outcomes":[55],"patients":[57,190,200,218,245,284,304,423],"hepatic":[59,62],"tumors":[60],"using":[61,140],"artery":[63],"infusion.":[64],"Given":[65],"anatomic":[67],"intra-arterial":[70],"for":[72,89,100],"PDAC,":[73],"we":[74],"developed":[75],"novel":[77],"retrograde":[79],"venous":[80,159],"infusion":[81,152,341],"(PRVI)":[82],"approach":[83],"enable":[85],"PEDD":[86,148,151,364],"SD-101":[88,113,123,128,183,196,294,360],"locally":[90],"advanced":[91],"PDAC":[92,342],"(LA-PDAC).":[93],"Methods":[94],"Patients":[95],"LA-PDAC":[97],"eligible":[99],"enrollment.":[101],"Oligometastatic":[102],"disease":[103],"is":[104,114,129,154],"permitted.":[105],"A":[106],"phase":[107,120],"1":[108],"dose-escalation":[109],"single":[111,277],"agent":[112],"underway,":[115],"be":[117],"followed":[118],"by":[119,290],"1b":[121],"PRVI":[124,138,230,361],"combined":[125],"ICI.":[127],"delivered":[130],"over":[131],"2":[132,301],"cycles":[133],"(1":[134],"dose/cycle),":[135],"during":[136],"outpatient":[137],"procedures":[139,231],"transhepatic":[141],"access":[142],"TriSalus":[145],"Infusion":[146],"SystemTM":[147],"device.":[149],"The":[150,176,208,269],"system":[153],"inserted":[155],"into":[156,164],"portal":[158],"then":[162],"tracked":[163],"target":[166],"vein.":[168],"Serial":[169],"blood":[170],"tumor":[172,210,343],"biopsies":[173],"collected.":[175],"primary":[177],"endpoints":[178],"safety":[180,237],"optimal":[182],"dose":[184,392],"determination.":[185],"Results":[186],"We":[187],"enrolled":[188],"3":[189,199,244,281,303,371],"at":[191,247],"lowest":[193],"(0.5":[194],"mg)":[195],"dose.":[197],"All":[198,229,243,422],"male":[202],"(ages":[203],"57,":[204],"63,":[205],"66).":[207],"average":[209],"size":[211],"was":[212,275],"2.6":[213],"cm":[214],"(range":[215],"1.9\u20133.6).":[216],"Two":[217,283],"remain":[219],"on":[220],"study,":[221],"one":[223,249],"discontinuing":[224],"extra-pancreatic":[227],"progression.":[228],"were":[232,334,365,374],"successfully":[233],"completed,":[234],"no":[236],"events":[238],"related":[239],"infusions.":[242],"experienced":[246],"least":[248],"adverse":[250],"event":[251],"(AE),":[252],"most":[255],"common":[256],"being":[257],"fatigue,":[258],"liver":[259],"function":[260],"test":[261],"increases,":[262],"decreased":[264,286],"platelet":[265],"count":[266],"(all":[267],"minor).":[268],"only":[270],"grade":[271,280],"3\u20134":[272],"AE":[273],"noted":[274],"subject":[278],"hypertension.":[282],"had":[285],"circulating":[287,306],"monocytic":[288],"MDSCs":[289],"flow":[291],"cytometry":[292],"following":[293],"infusion,":[295],"LAG-3":[297],"expression":[298,333,348],"increased":[299],"among":[305],"CD8+":[307],"T":[308],"cells.":[309],"Nanostring":[310],"analysis":[311],"PBMCs":[313],"decreases":[315,346],"genes":[317,352],"MDSCs,":[320],"including":[321,353],"NOS2,":[322,356],"IL10,":[323],"IDO1.":[325],"Increases":[326],"IL2,":[328],"IL12,":[329],"IL15":[331],"gene":[332],"noted.":[335],"Comparison":[336],"pre-":[338],"post-SD-101":[340],"specimens":[344],"revealed":[345],"MDSC":[350],"TGFb,":[354],"ARG1,":[355],"IL10.":[358],"Conclusions":[359],"infusions":[362],"well":[366],"tolerated":[367],"initial":[370],"patients.":[372],"Infusions":[373],"potentially":[377],"favorable":[378],"immune":[379],"changes":[380],"periphery":[383],"tumors.":[385],"These":[386],"findings":[387],"support":[388],"continuing":[389],"single-agent":[391],"escalation":[393],"subsequent":[395],"combination":[396],"systemic":[398],"CPI.":[399],"Trial":[400],"Registration":[401],"ClinicalTrials.gov":[402],"Identifier:":[403],"NCT05607953":[404],"Ethics":[405],"Approval":[406],"This":[407],"trial":[409],"obtained":[410],"approval":[411],"from":[412],"WCG":[414],"institutional":[415],"review":[416],"board":[417],"(IRB":[418],"Tracking":[419],"ID:":[420],"20221967).":[421],"provided":[424],"informed":[425],"consent":[426],"prior":[427],"participating":[429],"trial.":[432]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2023-11-01T00:00:00"}