{"id":"https://openalex.org/W4388047731","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1170","title":"1170 Development of a fusion protein bispecific for a CMV-specific TCR and CD19 which selectively activates and expands CMV-specific CTLs and redirects them to eliminate B cell leukemia cells","display_name":"1170 Development of a fusion protein bispecific for a CMV-specific TCR and CD19 which selectively activates and expands CMV-specific CTLs and redirects them to eliminate B cell leukemia cells","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388047731","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1170"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2023-sitc2023.1170","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1170","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1136/jitc-2023-sitc2023.1170","pdf_url":"https://jitc.bmj.com/content/11/Suppl_1/A1289.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/11/Suppl_1/A1289.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Christopher R Hiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R Hiner","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076308820","display_name":"S. Garforth","orcid":"https://orcid.org/0000-0001-6281-4833","observed_orcids":["https://orcid.org/0000-0001-6281-4833"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Garforth","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006013523","display_name":"Steven C. Almo","orcid":"https://orcid.org/0000-0003-2591-5234","observed_orcids":["https://orcid.org/0000-0003-2591-5234"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Almo","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089011676","display_name":"Harris Goldstein","orcid":"https://orcid.org/0000-0003-0543-6025","observed_orcids":["https://orcid.org/0000-0003-0543-6025"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harris Goldstein","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY, USA","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A1289","last_page":"A1290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.7724999785423279,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.13670000433921814,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bispecific-fusion-protein","display_name":"bispecific fusion protein","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.746999979019165},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.7059999704360962},{"id":"https://openalex.org/keywords/peptide-mhc-complex","display_name":"peptide-MHC complex","score":0.6299999952316284},{"id":"https://openalex.org/keywords/single-chain-variable-fragment","display_name":"scFv","score":0.6539999842643738},{"id":"https://openalex.org/keywords/b-cell-leukemia","display_name":"B-cell leukemia","score":0.5389999747276306},{"id":"https://openalex.org/keywords/nalm-6-cells","display_name":"Nalm-6 cells","score":0.7940000295639038},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.5370000004768372},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/fc-fusion-protein","display_name":"Fc fusion protein","score":0.6740000247955322},{"id":"https://openalex.org/keywords/hla-a2","display_name":"HLA-A2","score":0.7590000033378601},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.597000002861023},{"id":"https://openalex.org/keywords/nsg-mice","display_name":"NSG mice","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.55833899974823},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5345688462257385},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46947965025901794},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.459708034992218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4318808913230896},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.40788283944129944},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3754376471042633},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35266584157943726},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.35197770595550537},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30324316024780273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0752595067024231}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2023-sitc2023.1170","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1170","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1136/jitc-2023-sitc2023.1170","pdf_url":"https://jitc.bmj.com/content/11/Suppl_1/A1289.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:8efb06b8ead147f1a7d91340f55c5509","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8efb06b8ead147f1a7d91340f55c5509","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2023-sitc2023.1170","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.1170","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1136/jitc-2023-sitc2023.1170","pdf_url":"https://jitc.bmj.com/content/11/Suppl_1/A1289.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388047731.pdf","grobid_xml":"https://content.openalex.org/works/W4388047731.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W3205280723"],"related_works":["https://openalex.org/W4388047673","https://openalex.org/W2585869380","https://openalex.org/W4412161974","https://openalex.org/W2132713837","https://openalex.org/W2770412068","https://openalex.org/W627930738","https://openalex.org/W3097929068","https://openalex.org/W1452327051","https://openalex.org/W2155575072","https://openalex.org/W2966112968"],"abstract_inverted_index":{"Background":[0],"We":[1,107,355,401],"constructed":[2],"RediTac,":[3,282,903],"novel":[4,387],"biologics":[5],"designed":[6,532,546],"to":[7,20,32,38,50,65,97,131,146,152,211,233,293,329,350,362,390,404,533,629,865,929,1031],"selectively":[8,56],"activate":[9],"and":[10,17,55,116,128,148,161,195,304,312,345,364,370,383,394,409,418,456,475,583,593,703,727,733,773,829,895,1019,1021,1029],"expand":[11,147,363],"virus-specific":[12,58,63,367,380],"CD8":[13],"T":[14,368,447,458,578,754],"cells":[15,23,177,182,217,260,306,369,393,634,638,642,755,888,985,1034,1057],"(CTL)":[16],"redirect":[18,149,365,534],"them":[19],"eliminate":[21,66,153,351,391,866],"cancer":[22,67,392,540,565,591],"(figure":[24,41,218,236,252,297,338],"1A).":[25],"RediTac":[26,74,139,189,224,244,265,341,359,421,550,604,609,627,650,653,670,699,720,789,802,860,906,912,1010],"utilize":[27],"an":[28,34,294,395,555,655,658,662,746,908],"Fc-fusion":[29],"protein":[30],"scaffold":[31],"dimerize":[33],"HLA-A2":[35],"pMHC":[36,44,77,94,291],"linked":[37,96,292],"cancer-targeting":[39],"scFvs":[40],"1B).":[42],"The":[43,60,137],"presents":[45],"a":[46,70,76,79,98,132,155,202,267,285,290,330,335,386,665,838,890,914,948,977,1003,1012,1040],"tethered":[47],"virus":[48],"peptide":[49,296],"target":[51,371],"its":[52,144],"cognate":[53],"TCR":[54],"stimulate":[57],"CTL.":[59],"scFv":[61,100,118,287,656,918],"redirects":[62,346,861],"CTLs":[64,87,127,151,172,227,251,255,303,344,702,795,864],"cells.":[68,354,541,619,814,869],"As":[69],"proof-of-concept,":[71],"we":[72],"developed":[73],"with":[75,88,169,175,180,241,263,280,289,374,480,645,654,664,711,717,792,798,843,872,883,898,907,953,965,981,1051],"presenting":[78],"CMV-derived":[80],"peptide,":[81],"NLV,":[82],"capable":[83,101],"of":[84,102,112,125,185,214,258,488,504,520,548,586,595,601,616,625,632,647,682,693,706,751,762,811,824,831,941,989,1008,1055],"expanding":[85],"CMV-specific":[86,150,343,457,701],"potent":[89],"cytotoxic":[90,348,587],"activity.":[91],"1":[92,899,1004],"This":[93,495],"was":[95,140,199,208,276,314,323,478,497,514,672,743,778,817,924],"CD19-specific":[99,117],"targeting":[103,286,657,915],"malignant":[104],"B":[105],"cells.Methods":[106],"first":[108],"confirmed":[109],"the":[110,113,212,317,321,358,420,484,500,517,545,564,590,596,602,614,623,630,749,807,987,1052],"functionality":[111],"NLV-pMHC":[114],"domain":[115,119],"by":[120,229,248,325,483,499,516,1035],"demonstrating":[121],"NLV-CD19":[122,138,188,207,223,243,264,313,340,649,694,719,788,801,902,1009],"RediTac-mediated":[123,379],"expansion":[124,382,460,742],"NLV-specific":[126,171,226,794,863,873,966],"selective":[129,452],"binding":[130,210,628,671],"CD19":[133,612,1030],"on":[134,613,734,1048],"cells,":[135,1050],"respectively.":[136],"then":[141],"evaluated":[142],"for":[143,204,398,413,622,713,878,971,1025,1044],"capacity":[145],"NALM6,":[154],"CD19-expressing":[156],"leukemia":[157,353,618,868],"cell-line,":[158],"in":[159,162,320,416,453,461,567,748,806],"vitro":[160],"vivo.":[163],"To":[164],"do":[165],"this,":[166],"donor":[167,765],"PBMC":[168,473,710,791,836,871,946,964,998],"expanded":[170,228,250,302,793,862,877,970],"were":[173,193,307,643,715,725,757,796,876,881,896,969,974,1017,1023],"cocultured":[174,882],"NALM6":[176,181,196,216,259,273,305,318,352,617,637,813,867,887,933,984,1033,1056],"or":[178,190,288,334,639,651,721,737,803,809,920,1011],"coinjected":[179,308,975],"into":[183,309,986],"spleens":[184,322],"NSG":[186,310,991],"mice.":[187,463,992],"control":[191,281,332,337],"treatments":[192],"administered":[194,315],"cell":[197,274,448,459,566,579,592,934],"elimination":[198,275],"measured":[200],"as":[201,231,385,745,768],"readout":[203],"functional":[205],"activity.Results":[206],"detected":[209,673],"surface":[213,615,631],"CD19+":[215,636,812,983],"2A,B).":[219],"Twelve":[220],"days":[221,300,735,820,880,928,973],"after":[222,301,926],"treatment,":[225,790],">40-fold":[230],"compared":[232,328],"untreated":[234,805],"controls":[235],"3A).":[237],"After":[238],"expansion,":[239],"treatment":[240,333,730,823],"fresh":[242,800,901],"induced":[245],"IFN\u03b3":[246],"secretion":[247,705],"these":[249],"3B).":[253],"Expanded":[254],"eliminated":[256],"~60%":[257],"when":[261,278,327],"treated":[262,279,716,797,897],"during":[266],"two-day":[268],"coculture,":[269],"but":[270],"no":[271,996],"significant":[272],"observed":[277],"either":[283,648],"without":[284,913],"irrelevant":[295,659,909],"4A).":[298],"Five":[299],"mice":[311,994,1046],"intravenously,":[316],"population":[319],"reduced":[324],">99%":[326],"vehicle":[331,1014],"no-effector-cell":[336],"4B).Conclusions":[339],"expands":[342,700],"their":[347,414],"activity":[349,537,588],"can":[356,610],"use":[357,513,524],"modular":[360],"design":[361],"other":[366,372],"cancers":[373],"scFvs.":[375],"These":[376,574],"results":[377],"support":[378],"CTL":[381,536],"redirection":[384,585],"immunotherapy":[388],"strategy":[389],"effective":[396],"platform":[397],"future":[399],"treatments.Acknowledgements":[400],"would":[402],"like":[403],"acknowledge":[405],"Dr.":[406,410],"Steve":[407],"Almo":[408,443],"Scott":[411],"Garforth":[412,425],"work":[415,477],"conceiving":[417],"developing":[419],"technology.Reference":[422],"Li":[423],"M,":[424],"SJ,":[426],"O\u2019Connor":[427],"KE,":[428],"Su":[429],"H,":[430],"Lee":[431],"DM,":[432],"Celikgil":[433],"A,":[434],"Chaparro":[435],"RJ,":[436],"Seidel":[437],"RD,":[438],"Jones":[439],"RB,":[440],"Arav-Boger":[441],"R,":[442],"SC,":[444],"Goldstein":[445],"H.":[446],"receptor-targeted":[449],"immunotherapeutics":[450],"drive":[451],"vivo":[454],"HIV-":[455],"humanized":[462],"J":[464],"Clin":[465],"Invest.":[466],"2021":[467],"Dec":[468],"1;131(23):e141051Ethics":[469],"Approval":[470],"All":[471,490],"human":[472,1026],"samples":[474,766],"animal":[476,523],"done":[479],"ethics":[481],"approval":[482,509],"Albert":[485,501],"Einstein":[486,502],"College":[487,503],"Medicine.":[489],"participants":[491],"gave":[492],"informed":[493],"consent.":[494],"study":[496],"approved":[498,515],"Medicine":[505],"institution\u2019s":[506],"Ethics":[507],"Board;":[508],"number":[510,526],"2017\u20138116.":[511],"Animal":[512,521],"AECOM":[518],"Institute":[519],"Studies":[522],"protocol":[525],"00001105.Abstract":[527],"1170":[528,606,696,857],"Figure":[529,607,697,858],"1RediTac":[530],"is":[531,1039],"antigen-specific":[535,577],"against":[538,589],"labeled":[539],"(A)":[542,620,708,870],"Graphic":[543],"depicting":[544],"function":[547],"RediTac.":[549],"binds":[551],"cancer-associated":[552],"antigen":[553],"via":[554],"antibody-derived":[556],"single":[557,839,949],"chain":[558],"variable":[559],"fragment":[560],"(scFv),":[561],"which":[562],"coats":[563],"bivalent":[568],"peptide-major":[569],"histocompatibility":[570],"complex":[571],"(pMHC)":[572],"modules.":[573],"modules":[575],"trigger":[576],"receptor":[580],"(TCR)":[581],"activation":[582],"facilitate":[584],"proliferation":[594],"effector":[597,997],"cell.":[598],"(B)":[599,635,783,963],"Components":[600],"complete":[603],"dimer.Abstract":[605],"2NLV-CD19":[608],"bind":[611],"Methodology":[621],"detection":[624],"scFv-mediated":[626],"antigen-expressing":[633],"CD19-":[640],"Jurkat":[641],"incubated":[644],"80nM":[646],"NLV-gp120":[652],"antigen.":[660],"Following":[661],"incubation":[663],"fluorochrome-conjugated":[666],"anti-His-Tag":[667],"secondary":[668,822],"antibody,":[669],"using":[674,689,835,945],"flow":[675,1036],"cytometry.":[676,1037],"Representative":[677],"dot":[678,1042],"plots":[679],"depict":[680],"one":[681],"four":[683],"replicates":[684,834,944],"from":[685,837,947],"two":[686,690,819,927],"independent":[687],"experiments":[688],"different":[691,764],"batches":[692],"RediTac.Abstract":[695],"3NLV-CD19":[698],"activates":[704],"IFNy.":[707],"Donor-derived":[709],"memory":[712],"CMV":[714],"1nM":[718,904,911],"left":[722,804],"untreated.":[723],"Cells":[724],"collected":[726],"stained":[728,1024],"before":[729],"(Day":[731],"0)":[732],"7":[736],"12":[738],"following":[739,787,821],"treatment.":[740],"Selective":[741],"determined":[744],"increase":[747],"percentage":[750],"live":[752,931],"CD8+":[753],"that":[756,875,968],"NLV-tetramer+.":[758],"Data":[759,826,938,1038],"represents":[760,827],"mean":[761,828,940,1053],"N=4":[763],"depicted":[767],"unique":[769],"shapes.":[770],"Two-way":[771],"ANOVA":[772,842,952],"Sidak\u2019s":[774],"multiple":[775,845,955],"comparison":[776],"test":[777,847,957],"performed.":[779,848,958],"**":[780,959],"=":[781,850,854,960],"p>0.01.":[782],"On":[784],"day":[785],"14":[786],"5nM":[799],"presence":[808],"absence":[810],"IFNy":[815],"ELISpot":[816],"performed":[818,925],"PBMC.":[825],"SD":[830],"n=3":[832,942],"technical":[833,943],"donor.":[840,950],"One-way":[841,951],"Tukey\u2019s":[844],"comparisons":[846,956],"***":[849],"p>":[851,855,961],"0.001,":[852],"****":[853],"0.0001.Abstract":[856],"4NLV-CD19":[859],"CTIs":[874,967],"seven":[879],"PKH26":[884],"membrane":[885],"dyed":[886],"at":[889,976],"1:1":[891,978],"Effector:Target":[892],"(E:T)":[893],"ratio":[894,980],"nM":[900],"SL9-CD19":[905],"pMHC,":[910],"scFV":[916],"(NLV-no":[917],"RediTac),":[919],"nothing.":[921],"Flow":[922],"cytometry":[923],"detect":[930,1032],"PKH26+":[932],"count":[935,1054],"per":[936],"well.":[937],"depicts":[939],"Dunnett\u2019s":[954],"0.01.":[962],"twelve":[972],"E:T":[979],"CD24+":[982],"spleen":[988],"immunocompromised":[990],"Some":[993],"received":[995,1002],"(0:1":[999],"E:T).":[1000],"Mice":[1001],"mg/kg":[1005],"retro-orbital":[1006],"injection":[1007],"PBS":[1013],"control.":[1015],"Spleens":[1016],"harvested":[1018],"processed":[1020],"splenocytes":[1022],"CD3,":[1027],"CD24,":[1028],"representative":[1041],"plot":[1043],"n=2":[1045],"gated":[1047],"CD3-":[1049],"depicted.":[1058]},"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2023-11-01T00:00:00"}
