{"id":"https://openalex.org/W4388042258","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0442-q","title":"442-Q CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation","display_name":"442-Q CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388042258","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0442-q"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2023-sitc2023.0442-q","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0442-q","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0442-q","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_2/A1756.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts \u2013 Part 2","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/jitc/11/Suppl_2/A1756.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055665904","display_name":"Ji\u0159\u00ed Eitler","orcid":"https://orcid.org/0000-0002-3175-2438","observed_orcids":["https://orcid.org/0000-0002-3175-2438"]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]},{"id":"https://openalex.org/I4210162051","display_name":"University Hospital Carl Gustav Carus","ror":"https://ror.org/04za5zm41","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210162051"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jiri Eitler","raw_affiliation_strings":["Faculty of Medicine Carl Gustav Carus, Dresden, Germany","German Red Cross Blood Donation Service North-East, Dresden, Saxony, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Carl Gustav Carus, Dresden, Germany","institution_ids":["https://openalex.org/I4210162051"]},{"raw_affiliation_string":"German Red Cross Blood Donation Service North-East, Dresden, Saxony, Germany","institution_ids":["https://openalex.org/I2801931480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089919491","display_name":"Wiebke Rackwitz","orcid":"https://orcid.org/0009-0009-1482-7467","observed_orcids":["https://orcid.org/0009-0009-1482-7467"]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wiebke Rackwitz","raw_affiliation_strings":["Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Saxony, Germany","German Red Cross Blood Donation Service North-East, Dresden, Saxony, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Saxony, Germany","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"German Red Cross Blood Donation Service North-East, Dresden, Saxony, Germany","institution_ids":["https://openalex.org/I2801931480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076078234","display_name":"Natalie Wotschel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Natalie Wotschel","raw_affiliation_strings":["Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Saxony, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Saxony, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010151507","display_name":"Venugopal Gudipati","orcid":"https://orcid.org/0000-0001-6647-0708","observed_orcids":["https://orcid.org/0000-0001-6647-0708"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Venugopal Gudipati","raw_affiliation_strings":["Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010573724","display_name":"Johannes B. Huppa","orcid":"https://orcid.org/0000-0003-2634-8198","observed_orcids":["https://orcid.org/0000-0003-2634-8198"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Johannes Huppa","raw_affiliation_strings":["Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Hygiene and Applied Immunology, Medical University of Vienna, Vienna, Austria, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071124666","display_name":"Paola Ortiz Montero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Paola Ortiz Montero","raw_affiliation_strings":["Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Saxony, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Saxony, Germany","institution_ids":["https://openalex.org/I78650965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005060235","display_name":"Laurent Boissel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144466","display_name":"ImmunityBio (United States)","ror":"https://ror.org/04090g527","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurent Boissel","raw_affiliation_strings":["ImmunityBio Inc, Culver City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImmunityBio Inc, Culver City, CA, USA","institution_ids":["https://openalex.org/I4210144466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111951054","display_name":"Hans Klingemann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144466","display_name":"ImmunityBio (United States)","ror":"https://ror.org/04090g527","country_code":"US","type":"company","lineage":["https://openalex.org/I4210144466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans Klingemann","raw_affiliation_strings":["ImmunityBio Inc, Culver City, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ImmunityBio Inc, Culver City, CA, USA","institution_ids":["https://openalex.org/I4210144466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059562009","display_name":"Winfried S. Wels","orcid":"https://orcid.org/0000-0001-9858-3643","observed_orcids":["https://orcid.org/0000-0001-9858-3643"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210161239","display_name":"Frankfurt Cancer Institute","ror":"https://ror.org/05bx21r34","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4210161239"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Winfried Wels","raw_affiliation_strings":["Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Hesse, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frankfurt Cancer Institute, Goethe University, Frankfurt am Main, Hesse, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210161239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050893255","display_name":"Torsten Tonn","orcid":"https://orcid.org/0000-0001-9580-2193","observed_orcids":["https://orcid.org/0000-0001-9580-2193"]},"institutions":[{"id":"https://openalex.org/I2801931480","display_name":"German Red Cross","ror":"https://ror.org/02y3dtg29","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801931480"]},{"id":"https://openalex.org/I78650965","display_name":"Technische Universit\u00e4t Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Torsten Tonn","raw_affiliation_strings":["Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Saxony, Germany","German Red Cross Blood Donation Service North-East, Dresden, Saxony, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Saxony, Germany","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"German Red Cross Blood Donation Service North-East, Dresden, Saxony, Germany","institution_ids":["https://openalex.org/I2801931480"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A1801","last_page":"A1801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lfa-1","display_name":"LFA-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.7559999823570251},{"id":"https://openalex.org/keywords/car-nk-cells","display_name":"CAR-NK cells","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antibody-dependent-cellular-cytotoxicity","display_name":"antibody-dependent cellular cytotoxicity","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-immune-evasion","display_name":"tumor immune evasion","score":0.7459999918937683},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7490000128746033},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9819999933242798},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nkg2a","display_name":"NKG2A","score":0.9039999842643738},{"id":"https://openalex.org/keywords/immunological-synapse","display_name":"immunological synapse","score":0.8050000071525574},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/fcgammariiia","display_name":"Fc\u03b3RIIIa","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8063945770263672},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6235436201095581},{"id":"https://openalex.org/C185946421","wikidata":"https://www.wikidata.org/wiki/Q3146527","display_name":"ICAM-1","level":3,"score":0.5267602205276489},{"id":"https://openalex.org/C3018558359","wikidata":"https://www.wikidata.org/wiki/Q1660157","display_name":"Immune escape","level":3,"score":0.4852859675884247},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3888033926486969},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35963642597198486},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3302549719810486},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2776114344596863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24476966261863708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14288821816444397},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0621909499168396},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04220235347747803}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2023-sitc2023.0442-q","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0442-q","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0442-q","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_2/A1756.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts \u2013 Part 2","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:6631a9096b6341f49cfecf75a7de5933","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6631a9096b6341f49cfecf75a7de5933","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2023-sitc2023.0442-q","doi":"https://doi.org/10.1136/jitc-2023-sitc2023.0442-q","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2023-sitc2023.0442-q","pdf_url":"https://jitc.bmj.com/content/jitc/11/Suppl_2/A1756.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts \u2013 Part 2","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388042258.pdf","grobid_xml":"https://content.openalex.org/works/W4388042258.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4398193515","https://openalex.org/W4388085746","https://openalex.org/W2039609199","https://openalex.org/W3176412723","https://openalex.org/W2626558431","https://openalex.org/W1961144161","https://openalex.org/W3012490010","https://openalex.org/W2327409939","https://openalex.org/W2525626375","https://openalex.org/W1788305820"],"abstract_inverted_index":{"Background":[0],"Antitumor":[1],"activity":[2],"of":[3,35,58,64,132,145,194,202,227,237,261,287,313,350],"natural":[4,62],"killer":[5],"(NK)":[6],"cells":[7,66,88,96,109,117,138,199,206,219,232,246,254,304,319,331,360],"can":[8,41],"be":[9,345],"enhanced":[10],"by":[11,76,192,281],"specific":[12],"targeting":[13],"with":[14,26,48,103,119,123,166,252],"therapeutic":[15],"antibodies":[16],"that":[17,244,255],"trigger":[18],"antibody-dependent":[19],"cell-mediated":[20,180],"cytotoxicity":[21,63,84,181],"(ADCC)":[22],"or":[23,44,105,121,200],"genetic":[24],"engineering":[25],"chimeric":[27],"antigen":[28],"receptors":[29],"(CARs).":[30],"Nevertheless,":[31],"despite":[32],"continued":[33],"presence":[34],"the":[36,49,56,77,124,130,146,228,259,288,348,367],"target":[37,198],"antigen,":[38],"some":[39],"tumors":[40],"escape":[42,325],"antibody":[43,80],"CAR-NK":[45,179,231,245,303,330],"cell":[46,141,151,175,291,301],"treatment,":[47],"underlying":[50],"mechanisms":[51],"only":[52,306],"poorly":[53],"understood.":[54],"While":[55],"importance":[57],"ICAM-1/LFA-1":[59,147,186],"interaction":[60,148],"for":[61,347],"NK":[65,116,140,174,205,218,290,300,353],"has":[67,89],"been":[68,92],"previously":[69],"shown,":[70],"its":[71],"impact":[72],"on":[73,135,139,185,197,204,316],"ADCC":[74,158,269],"induced":[75,169,233],"ErbB2":[78],"(HER2)-specific":[79],"trastuzumab":[81,104,120,212],"and":[82,153,172,188,298],"ErbB2-CAR-mediated":[83],"against":[85,159],"breast":[86,136,161,317],"cancer":[87,137,162,318,355],"not":[90,183,190,215,264],"yet":[91],"investigated.":[93],"Methods":[94],"NK-92":[95,108],"expressing":[97],"high-affinity":[98],"Fc\u03b3RIIIa":[99],"(haNK)":[100],"in":[101,230,273],"combination":[102],"ErbB2-CAR":[106,125,229],"engineered":[107],"(NK-92/5.28.z)":[110],"as":[111,113,320,338,340],"well":[112,339],"primary":[114],"human":[115],"combined":[118],"modified":[122],"were":[126,305,332,364],"employed":[127],"to":[128,334],"investigate":[129],"effects":[131],"ICAM-1":[133,170,195,262,314],"downregulation":[134,312],"cytotoxicity.":[142],"Results":[143],"Blockade":[144],"significantly":[149],"reduced":[150,296],"killing":[152],"cytokine":[154],"release":[155],"during":[156,268],"trastuzumab-mediated":[157],"ErbB2-positive":[160],"cells,":[163],"while":[164,225,285],"pretreatment":[165],"5-aza-2\u2019-deoxycytidine":[167],"(5AZA)":[168],"upregulation":[171],"reversed":[173],"resistance.":[176],"In":[177,209],"contrast,":[178],"did":[182,214,263],"rely":[184],"interaction,":[187],"was":[189,279],"impaired":[191],"reduction":[193],"expression":[196,315],"blockade":[201],"LFA-1":[203,223],"(figure":[207],"1).":[208],"degranulation":[210,235],"experiments,":[211],"alone":[213],"sufficiently":[216],"activate":[217],"but":[220,270],"required":[221],"additional":[222],"stimulation,":[224],"activation":[226],"efficient":[234],"independent":[236],"LFA-1.":[238],"TIRF":[239],"single":[240],"molecule":[241,293],"imaging":[242],"revealed":[243],"formed":[247],"an":[248,375],"irregular":[249],"immunological":[250],"synapse":[251],"tumor":[253],"excluded":[256],"ICAM-1.":[257],"Mechanistically,":[258],"absence":[260],"affect":[265],"cell-cell":[266],"adhesion":[267],"rather":[271],"resulted":[272],"decreased":[274],"signaling":[275],"via":[276],"Pyk2,":[277],"which":[278,343],"restored":[280],"CAR-mediated":[282],"targeting.":[283],"Furthermore,":[284],"stimulation":[286],"inhibitory":[289],"checkpoint":[292],"NKG2A":[294],"markedly":[295],"trastuzumab-":[297],"ICAM-1-mediated":[299],"activation,":[302],"marginally":[307],"affected.":[308],"Conclusions":[309],"We":[310],"identified":[311],"a":[321],"critical":[322],"mechanism":[323],"mediating":[324],"from":[326,361,366],"trastuzumab-triggered":[327],"ADCC.":[328],"Importantly,":[329],"able":[333],"overcome":[335],"ICAM-1-based":[336],"resistance":[337],"NKG2A-mediated":[341],"inhibition,":[342],"may":[344],"relevant":[346],"development":[349],"more":[351],"effective":[352],"cell-based":[354],"immunotherapies.":[356],"Ethics":[357,376],"Approval":[358],"Primary":[359],"healthy":[362],"donors":[363],"obtained":[365],"German":[368],"Red":[369],"Cross":[370],"Blood":[371],"Donation":[372],"Service":[373],"under":[374],"Review":[377],"Board-approved":[378],"protocol":[379],"number":[380],"EK138042014.":[381]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2023-11-01T00:00:00"}
