{"id":"https://openalex.org/W4388034828","doi":"https://doi.org/10.1080/19932820.2023.2275417","title":"Assessment of the anti-inflammatory and analgesic effects of Opuntia ficus indica L. Cladodes extract","display_name":"Assessment of the anti-inflammatory and analgesic effects of Opuntia ficus indica L. Cladodes extract","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388034828","doi":"https://doi.org/10.1080/19932820.2023.2275417","pmid":"https://pubmed.ncbi.nlm.nih.gov/37905304","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11018314"},"language":"en","primary_location":{"id":"doi:10.1080/19932820.2023.2275417","doi":"https://doi.org/10.1080/19932820.2023.2275417","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19932820.2023.2275417","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19932820.2023.2275417?needAccess=true","source":{"id":"https://openalex.org/S198684006","display_name":"Libyan Journal of Medicine","issn_l":"1819-6357","issn":["1819-6357","1993-2820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jpps-1","medline","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Libyan Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/19932820.2023.2275417?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110680579","display_name":"Abdelkader Ammam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148060","display_name":"Universit\u00e9 de Saida Dr Moulay Tahar","ror":"https://ror.org/03mwqca46","country_code":"DZ","type":"education","lineage":["https://openalex.org/I4210148060"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Abdelkader Ammam","raw_affiliation_strings":["Departement of biology, University Dr Moulay Tahar Saida city AADL Saida N 40, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departement of biology, University Dr Moulay Tahar Saida city AADL Saida N 40, Algeria","institution_ids":["https://openalex.org/I4210148060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092700246","display_name":"Hafidh Zemour","orcid":"https://orcid.org/0000-0002-9588-2530","observed_orcids":["https://orcid.org/0000-0002-9588-2530"]},"institutions":[{"id":"https://openalex.org/I4210106700","display_name":"Universit\u00e9 IBN Khaldoun Tiaret","ror":"https://ror.org/018jjaw76","country_code":"DZ","type":"education","lineage":["https://openalex.org/I4210106700"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Hafidh Zemour","raw_affiliation_strings":["Faculty of Natural and Life Sciences, Ibn Khaldoun University, Tiaret, BP, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Natural and Life Sciences, Ibn Khaldoun University, Tiaret, BP, Algeria","institution_ids":["https://openalex.org/I4210106700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091066240","display_name":"M\u2019hamed Kaid","orcid":"https://orcid.org/0000-0002-1558-901X","observed_orcids":["https://orcid.org/0000-0002-1558-901X"]},"institutions":[{"id":"https://openalex.org/I4210148060","display_name":"Universit\u00e9 de Saida Dr Moulay Tahar","ror":"https://ror.org/03mwqca46","country_code":"DZ","type":"education","lineage":["https://openalex.org/I4210148060"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"M\u2019hamed Kaid","raw_affiliation_strings":["Laboratoire des \u00e9tudes physico-chimiques. Facult\u00e9 des sciences.Universit\u00e9 de Sa\u00efda, BP, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire des \u00e9tudes physico-chimiques. Facult\u00e9 des sciences.Universit\u00e9 de Sa\u00efda, BP, Algeria","institution_ids":["https://openalex.org/I4210148060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035183914","display_name":"Didier Villemin","orcid":"https://orcid.org/0000-0002-6266-3817","observed_orcids":["https://orcid.org/0000-0002-6266-3817"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210126992","display_name":"Laboratoire de Chimie Mol\u00e9culaire et Thioorganique","ror":"https://ror.org/03q7p3t30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I194210350","https://openalex.org/I4210105918","https://openalex.org/I4210126992","https://openalex.org/I4210128300","https://openalex.org/I98702875"]},{"id":"https://openalex.org/I98702875","display_name":"Universit\u00e9 de Caen Normandie","ror":"https://ror.org/051kpcy16","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I98702875"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Didier Villemin","raw_affiliation_strings":["University of Caen, ISMRA, LCMT, UMR CNRS, Caen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Caen, ISMRA, LCMT, UMR CNRS, Caen, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210126992","https://openalex.org/I98702875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067422490","display_name":"Walid H. Soufan","orcid":"https://orcid.org/0000-0002-6273-2050","observed_orcids":["https://orcid.org/0000-0002-6273-2050"]},"institutions":[{"id":"https://openalex.org/I28022161","display_name":"King Saud University","ror":"https://ror.org/02f81g417","country_code":"SA","type":"education","lineage":["https://openalex.org/I28022161"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Walid Soufan","raw_affiliation_strings":["Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia","institution_ids":["https://openalex.org/I28022161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090167489","display_name":"Fathi Abdellatif Belhouadjeb","orcid":"https://orcid.org/0000-0001-7624-4878","observed_orcids":["https://orcid.org/0000-0001-7624-4878"]},"institutions":[{"id":"https://openalex.org/I4401726906","display_name":"Centre de recherche en Agropastoralisme (CRAPast)","ror":"https://ror.org/043vfk764","country_code":"DZ","type":"facility","lineage":["https://openalex.org/I4401726906"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Fathi Abdellatif Belhouadjeb","raw_affiliation_strings":["Centre de Recherche en Agropastoralisme (CRAPAST), Djelfa, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche en Agropastoralisme (CRAPAST), Djelfa, Algeria","institution_ids":["https://openalex.org/I4401726906"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5067422490","https://openalex.org/A5110680579"],"corresponding_institution_ids":["https://openalex.org/I28022161","https://openalex.org/I4210148060"],"apc_list":{"value":1625,"currency":"GBP","value_usd":1993},"apc_paid":{"value":1625,"currency":"GBP","value_usd":1993},"fwci":1.4798,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78060404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"18","issue":"1","first_page":"2275417","last_page":"2275417"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12330","display_name":"Botanical Research and Applications","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12330","display_name":"Botanical Research and Applications","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opuntia-ficus-indica","display_name":"Opuntia ficus-indica","score":1.0},{"id":"https://openalex.org/keywords/cladode-extract","display_name":"cladode extract","score":0.9020000100135803},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.8450000286102295},{"id":"https://openalex.org/keywords/analgesic-activity","display_name":"analgesic activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/methanol-extract","display_name":"methanol extract","score":0.7900000214576721},{"id":"https://openalex.org/keywords/carrageenan-induced-paw-edema","display_name":"carrageenan-induced paw edema","score":0.8769999742507935},{"id":"https://openalex.org/keywords/acetic-acid-writhing-test","display_name":"acetic acid-induced writhing","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.9829999804496765},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8500000238418579},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.6610000133514404},{"id":"https://openalex.org/keywords/natural-remedies","display_name":"natural remedies","score":0.4480000138282776},{"id":"https://openalex.org/keywords/nsaid-alternatives","display_name":"NSAID alternatives","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2778998652","wikidata":"https://www.wikidata.org/wiki/Q10748947","display_name":"Cladodes","level":3,"score":0.9631433486938477},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.7481694221496582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6947817802429199},{"id":"https://openalex.org/C2779362140","wikidata":"https://www.wikidata.org/wiki/Q1938846","display_name":"Ficus","level":2,"score":0.586524248123169},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.549847424030304},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3125326633453369},{"id":"https://openalex.org/C2780106946","wikidata":"https://www.wikidata.org/wiki/Q14560","display_name":"Cactus","level":2,"score":0.26598215103149414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1936807632446289},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1417228877544403}],"mesh":[{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011794","descriptor_name":"Quercetin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D029747","descriptor_name":"Opuntia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/19932820.2023.2275417","doi":"https://doi.org/10.1080/19932820.2023.2275417","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19932820.2023.2275417","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19932820.2023.2275417?needAccess=true","source":{"id":"https://openalex.org/S198684006","display_name":"Libyan Journal of Medicine","issn_l":"1819-6357","issn":["1819-6357","1993-2820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jpps-1","medline","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Libyan Journal of Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11018314","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11018314","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11018314/pdf/ZLJM_18_2275417.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Libyan J Med","raw_type":"Text"},{"id":"pmid:37905304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37905304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Libyan journal of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2551ca29fcbf4ed9a7399d39d3a74820","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2551ca29fcbf4ed9a7399d39d3a74820","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Libyan Journal of Medicine, Vol 18, Iss 1 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/19932820.2023.2275417","doi":"https://doi.org/10.1080/19932820.2023.2275417","is_oa":true,"landing_page_url":"https://doi.org/10.1080/19932820.2023.2275417","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/19932820.2023.2275417?needAccess=true","source":{"id":"https://openalex.org/S198684006","display_name":"Libyan Journal of Medicine","issn_l":"1819-6357","issn":["1819-6357","1993-2820"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jpps-1","medline","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Libyan Journal of Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2293653017","display_name":null,"funder_award_id":"RSP2023R390","funder_id":"https://openalex.org/F4320321145","funder_display_name":"King Saud University"}],"funders":[{"id":"https://openalex.org/F4320313948","display_name":"Minist\u00e8re de l\u2019Enseignement Sup\u00e9rieur et de la Recherche Scientifique","ror":"https://ror.org/05v1m8q81"},{"id":"https://openalex.org/F4320321145","display_name":"King Saud University","ror":"https://ror.org/02f81g417"},{"id":"https://openalex.org/F4320321424","display_name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche Scientifique","ror":"https://ror.org/01ejfgc23"},{"id":"https://openalex.org/F4320322890","display_name":"Minist\u00e8re de l'Enseignement Sup\u00e9rieur et de la Recherche","ror":"https://ror.org/03sjk9a61"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388034828.pdf","grobid_xml":"https://content.openalex.org/works/W4388034828.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1971093836","https://openalex.org/W1998007929","https://openalex.org/W2002531479","https://openalex.org/W2002629348","https://openalex.org/W2030519220","https://openalex.org/W2034063916","https://openalex.org/W2049701947","https://openalex.org/W2053424727","https://openalex.org/W2069903202","https://openalex.org/W2080191633","https://openalex.org/W2092763906","https://openalex.org/W2108931588","https://openalex.org/W2117055554","https://openalex.org/W2127733313","https://openalex.org/W2130782827","https://openalex.org/W2134850531","https://openalex.org/W2157009156","https://openalex.org/W2167226997","https://openalex.org/W2185550536","https://openalex.org/W2271511571","https://openalex.org/W2470316029","https://openalex.org/W2953793082","https://openalex.org/W3194642955","https://openalex.org/W4400432906"],"related_works":["https://openalex.org/W2428395806","https://openalex.org/W2064743497","https://openalex.org/W7100430958","https://openalex.org/W2788849763","https://openalex.org/W2602035587","https://openalex.org/W4406999435","https://openalex.org/W4408534586","https://openalex.org/W2806220174","https://openalex.org/W2368910742","https://openalex.org/W2773867056"],"abstract_inverted_index":{"This":[0],"study":[1,64],"aimed":[2],"to":[3,55,69,216,233],"evaluate":[4],"the":[5,11,34,71,74,84,102,123,127,207,217,226],"anti-inflammatory":[6,38,105],"and":[7,23,97,116,137,168,184,191,195,223],"analgesic":[8,81],"properties":[9],"of":[10,14,36,73,83,126,209,225,229],"methanolic":[12],"extract":[13,103,178],"Opuntia":[15,174],"ficus":[16,175],"indica":[17,176],"L.":[18,177],"in":[19,91,112,193,238],"small":[20,239],"animal":[21,240],"(rats":[22],"mice":[24,196],"model).":[25],"The":[26,63,76,133,198],"current":[27],"treatment":[28],"for":[29,189],"febrile":[30],"conditions":[31],"often":[32],"involves":[33],"use":[35],"non-steroidal":[37],"drugs":[39],"(NSAIDs),":[40],"which":[41,213],"can":[42],"have":[43],"adverse":[44],"effects,":[45,106],"particularly":[46],"gastrointestinal":[47],"ulcers.":[48],"Therefore,":[49],"there":[50],"is":[51],"a":[52,79,89,110],"growing":[53],"need":[54],"explore":[56],"natural":[57,187],"alternatives":[58],"with":[59],"fewer":[60],"side":[61],"effects.":[62,220],"utilized":[65],"various":[66,210],"experimental":[67],"models":[68],"assess":[70],"effects":[72],"extract.":[75],"results":[77],"demonstrated":[78],"significant":[80],"effect":[82],"extract,":[85,128],"as":[86,107,181],"evidenced":[87],"by":[88,94,109],"reduction":[90],"pain":[92,190],"induced":[93],"acetic":[95],"acid":[96],"hot":[98],"plate":[99],"tests.":[100],"Additionally,":[101],"exhibited":[104],"indicated":[108],"decrease":[111],"carrageenan-induced":[113],"paw":[114],"edema":[115],"dextran-induced":[117],"inflammation.":[118],"To":[119],"gain":[120],"insights":[121,205],"into":[122,206],"chemical":[124,200],"composition":[125,201],"HPLC":[129],"analysis":[130,134,202],"was":[131],"conducted.":[132],"successfully":[135],"identified":[136],"quantified":[138],"20":[139],"compounds,":[140,212],"including":[141],"luteolin,":[142],"galangin,":[143],"catechin,":[144],"thymol,":[145],"methylated":[146],"quercetin,":[147,148],"rutin,":[149],"acacetin,":[150],"hesperidin,":[151],"apigenin,":[152],"kaempferol,":[153],"pinocembrin,":[154],"chrysin,":[155],"gallic":[156],"acid,":[157,159,161,163,165,167],"caffeic":[158],"ascorbic":[160],"ferulic":[162],"m-coumaric":[164],"rosmarinic":[166],"trans-cinnamic":[169],"acid.The":[170],"findings":[171],"suggest":[172],"that":[173],"holds":[179],"promise":[180],"an":[182],"effective":[183],"reasonably":[185],"priced":[186],"remedy":[188],"inflammation":[192],"rats":[194],"model.":[197],"comprehensive":[199],"provided":[203],"valuable":[204],"presence":[208],"bioactive":[211],"may":[214],"contribute":[215],"observed":[218],"therapeutic":[219],"Further":[221],"research":[222],"exploration":[224],"extract\u2019s":[227],"mechanisms":[228],"action":[230],"are":[231],"warranted":[232],"fully":[234],"understand":[235],"its":[236],"potential":[237],"healthcare.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-11-01T00:00:00"}