{"id":"https://openalex.org/W4388034097","doi":"https://doi.org/10.1038/s41467-023-42707-3","title":"Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor","display_name":"Structural titration reveals Ca2+-dependent conformational landscape of the IP3 receptor","publication_year":2023,"publication_date":"2023-10-28","ids":{"openalex":"https://openalex.org/W4388034097","doi":"https://doi.org/10.1038/s41467-023-42707-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/37898605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10613215"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-42707-3","doi":"https://doi.org/10.1038/s41467-023-42707-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42707-3","pdf_url":"https://www.nature.com/articles/s41467-023-42707-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-42707-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022440884","display_name":"Navid Paknejad","orcid":"https://orcid.org/0000-0001-8914-7604","observed_orcids":["https://orcid.org/0000-0001-8914-7604"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navid Paknejad","raw_affiliation_strings":["Physiology, Biophysics, and Systems Biology (PBSB) Program, Weill Cornell Graduate School of Biomedical Sciences, 1300 York Avenue, New York, NY, 10065, USA","Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-8914-7604","affiliations":[{"raw_affiliation_string":"Physiology, Biophysics, and Systems Biology (PBSB) Program, Weill Cornell Graduate School of Biomedical Sciences, 1300 York Avenue, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037336402","display_name":"Vinay Sapuru","orcid":"https://orcid.org/0000-0002-9699-6126","observed_orcids":["https://orcid.org/0000-0002-9699-6126"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinay Sapuru","raw_affiliation_strings":["Physiology, Biophysics, and Systems Biology (PBSB) Program, Weill Cornell Graduate School of Biomedical Sciences, 1300 York Avenue, New York, NY, 10065, USA","Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-9699-6126","affiliations":[{"raw_affiliation_string":"Physiology, Biophysics, and Systems Biology (PBSB) Program, Weill Cornell Graduate School of Biomedical Sciences, 1300 York Avenue, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030566849","display_name":"Richard K. Hite","orcid":"https://orcid.org/0000-0003-0496-0669","observed_orcids":["https://orcid.org/0000-0003-0496-0669"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard K. Hite","raw_affiliation_strings":["Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. hiter@mskcc.org","Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-0496-0669","affiliations":[{"raw_affiliation_string":"Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. hiter@mskcc.org","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030566849"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":2.3945,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.90605358,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"6897","last_page":"6897"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.8970000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.04050000011920929,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.9520000219345093},{"id":"https://openalex.org/keywords/calcium-channels","display_name":"calcium channels","score":0.367000013589859},{"id":"https://openalex.org/keywords/conformational-landscape","display_name":"conformational landscape","score":0.7680000066757202},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.8939999938011169},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8299999833106995},{"id":"https://openalex.org/keywords/calcium-binding-sites","display_name":"calcium binding sites","score":0.7139999866485596},{"id":"https://openalex.org/keywords/channel-activation","display_name":"channel activation","score":0.5339999794960022},{"id":"https://openalex.org/keywords/channel-inhibition","display_name":"channel inhibition","score":0.7850000262260437},{"id":"https://openalex.org/keywords/resting-state","display_name":"resting state","score":0.746999979019165},{"id":"https://openalex.org/keywords/cryo-em-structure","display_name":"cryo-EM structure","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4809781312942505},{"id":"https://openalex.org/C184866935","wikidata":"https://www.wikidata.org/wiki/Q191010","display_name":"Titration","level":2,"score":0.44574180245399475},{"id":"https://openalex.org/C119621388","wikidata":"https://www.wikidata.org/wiki/Q5377166","display_name":"Energy landscape","level":2,"score":0.4288037121295929},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40203097462654114},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36425864696502686},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3302370309829712},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3087841272354126},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22020554542541504},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053496","descriptor_name":"Inositol 1,4,5-Trisphosphate Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41467-023-42707-3","doi":"https://doi.org/10.1038/s41467-023-42707-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42707-3","pdf_url":"https://www.nature.com/articles/s41467-023-42707-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2022.12.29.522241","doi":"https://doi.org/10.1101/2022.12.29.522241","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.12.29.522241","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/12/30/2022.12.29.522241.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10613215","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10613215","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10613215/pdf/41467_2023_Article_42707.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:37898605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37898605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42707-3","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-42707-3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8d3dbc1232e647bebd996269938e7911","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8d3dbc1232e647bebd996269938e7911","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-42707-3","doi":"https://doi.org/10.1038/s41467-023-42707-3","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42707-3","pdf_url":"https://www.nature.com/articles/s41467-023-42707-3.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1391005062","display_name":null,"funder_award_id":"R01-GM13230704","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G2051006376","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320309468","funder_display_name":"Memorial Sloan-Kettering Cancer Center"},{"id":"https://openalex.org/G289723095","display_name":null,"funder_award_id":"P30\u00a0CA008748","funder_id":"https://openalex.org/F4320309468","funder_display_name":"Memorial Sloan-Kettering Cancer Center"},{"id":"https://openalex.org/G2911627494","display_name":null,"funder_award_id":"CA243235","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4102770861","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4983509971","display_name":"Molecular characterization of the multi-modal regulation of inositol 1,4,5-trisphosphate receptors","funder_award_id":"R01GM132307","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5602527752","display_name":null,"funder_award_id":"F31-CA243235","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G6555884451","display_name":"Molecular Mechanisms of Apoptosis Regulation Through IP3 Receptors","funder_award_id":"F31CA243235","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8068008632","display_name":null,"funder_award_id":"R01-GM13230704","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000003249","display_name":null,"funder_award_id":"CA008748","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320309468","display_name":"Memorial Sloan-Kettering Cancer Center","ror":"https://ror.org/02yrq0923"},{"id":"https://openalex.org/F4320314849","display_name":"Searle Scholars Program","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388034097.pdf","grobid_xml":"https://content.openalex.org/works/W4388034097.grobid-xml"},"referenced_works_count":124,"referenced_works":["https://openalex.org/W197633397","https://openalex.org/W1482354312","https://openalex.org/W1486474082","https://openalex.org/W1492343139","https://openalex.org/W1533480923","https://openalex.org/W1586746737","https://openalex.org/W1650401181","https://openalex.org/W1666469474","https://openalex.org/W1967205802","https://openalex.org/W1968177638","https://openalex.org/W1972772651","https://openalex.org/W1980730766","https://openalex.org/W1982704870","https://openalex.org/W1989709600","https://openalex.org/W1991820222","https://openalex.org/W1997778815","https://openalex.org/W1998143771","https://openalex.org/W2001907971","https://openalex.org/W2002287591","https://openalex.org/W2002291355","https://openalex.org/W2004589688","https://openalex.org/W2008906006","https://openalex.org/W2011665065","https://openalex.org/W2014668921","https://openalex.org/W2020828897","https://openalex.org/W2021847777","https://openalex.org/W2028656069","https://openalex.org/W2037842536","https://openalex.org/W2038780532","https://openalex.org/W2041200757","https://openalex.org/W2047663792","https://openalex.org/W2051435374","https://openalex.org/W2054972589","https://openalex.org/W2057264167","https://openalex.org/W2064883655","https://openalex.org/W2071095425","https://openalex.org/W2073706613","https://openalex.org/W2075470662","https://openalex.org/W2078941920","https://openalex.org/W2084742082","https://openalex.org/W2089788910","https://openalex.org/W2095236791","https://openalex.org/W2096199252","https://openalex.org/W2104234755","https://openalex.org/W2106114441","https://openalex.org/W2108411628","https://openalex.org/W2113904137","https://openalex.org/W2124026197","https://openalex.org/W2125511222","https://openalex.org/W2132629607","https://openalex.org/W2132926880","https://openalex.org/W2135032014","https://openalex.org/W2135548739","https://openalex.org/W2142161929","https://openalex.org/W2144553803","https://openalex.org/W2150792480","https://openalex.org/W2152032258","https://openalex.org/W2152888284","https://openalex.org/W2155044464","https://openalex.org/W2156675315","https://openalex.org/W2161260069","https://openalex.org/W2163248783","https://openalex.org/W2164829352","https://openalex.org/W2166691490","https://openalex.org/W2167279371","https://openalex.org/W2171437709","https://openalex.org/W2173669563","https://openalex.org/W2213499550","https://openalex.org/W2240467006","https://openalex.org/W2262709522","https://openalex.org/W2316911260","https://openalex.org/W2325421819","https://openalex.org/W2419423106","https://openalex.org/W2523333069","https://openalex.org/W2548833922","https://openalex.org/W2549436143","https://openalex.org/W2562383183","https://openalex.org/W2578653290","https://openalex.org/W2581941142","https://openalex.org/W2583770585","https://openalex.org/W2587625522","https://openalex.org/W2606631998","https://openalex.org/W2730689048","https://openalex.org/W2731784911","https://openalex.org/W2734356283","https://openalex.org/W2776568122","https://openalex.org/W2786390877","https://openalex.org/W2790336955","https://openalex.org/W2799315094","https://openalex.org/W2799449195","https://openalex.org/W2801376357","https://openalex.org/W2850305266","https://openalex.org/W2853874477","https://openalex.org/W2884580815","https://openalex.org/W2887001097","https://openalex.org/W2887263514","https://openalex.org/W2899714098","https://openalex.org/W2903222042","https://openalex.org/W2973457155","https://openalex.org/W2980690180","https://openalex.org/W2999920472","https://openalex.org/W3005655837","https://openalex.org/W3020440546","https://openalex.org/W3026130772","https://openalex.org/W3049001491","https://openalex.org/W3081241911","https://openalex.org/W3083406432","https://openalex.org/W3108495343","https://openalex.org/W3112596090","https://openalex.org/W3131760520","https://openalex.org/W3133734123","https://openalex.org/W3164574100","https://openalex.org/W3184532391","https://openalex.org/W3212755095","https://openalex.org/W4210907760","https://openalex.org/W4220675322","https://openalex.org/W4224980471","https://openalex.org/W4242816820","https://openalex.org/W4247052853","https://openalex.org/W4249299354","https://openalex.org/W4285390470","https://openalex.org/W4294748274","https://openalex.org/W4296458937","https://openalex.org/W4308963932"],"related_works":["https://openalex.org/W2850305266","https://openalex.org/W7130551356","https://openalex.org/W4220675322","https://openalex.org/W7170038317","https://openalex.org/W2150428929","https://openalex.org/W2108411628","https://openalex.org/W2046585597","https://openalex.org/W4296458937","https://openalex.org/W2727376491","https://openalex.org/W7165149718"],"abstract_inverted_index":{"Abstract":[0],"Inositol":[1],"1,4,5-trisphosphate":[2],"receptors":[3],"(IP3Rs)":[4],"are":[5,49],"endoplasmic":[6],"reticulum":[7],"Ca2+":[8,15,19,35,43,47,61,73,110,134,147],"channels":[9],"whose":[10],"biphasic":[11,42,159],"dependence":[12,44],"on":[13],"cytosolic":[14],"gives":[16],"rise":[17],"to":[18,118],"oscillations":[20,48],"that":[21,45,72,109],"regulate":[22],"fertilization,":[23],"cell":[24,27],"division":[25],"and":[26,93],"death.":[28],"Despite":[29],"the":[30,37,41,158],"critical":[31],"roles":[32],"of":[33,40,57,66,89,129,161],"IP3R-mediated":[34],"responses,":[36],"structural":[38],"underpinnings":[39],"underlies":[46],"incompletely":[50],"understood.":[51],"Here,":[52],"we":[53,107],"collect":[54],"cryo-EM":[55],"images":[56],"an":[58,127,139],"IP3R":[59,162],"with":[60],"concentrations":[62],"spanning":[63],"five":[64],"orders":[65],"magnitude.":[67],"Unbiased":[68],"image":[69],"analysis":[70],"reveals":[71],"binding":[74,111,148],"does":[75],"not":[76],"explicitly":[77],"induce":[78],"conformational":[79,86,104],"changes":[80],"but":[81],"rather":[82],"biases":[83],"a":[84,100,113,122,144,154],"complex":[85],"landscape":[87],"consisting":[88],"resting,":[90],"preactivated,":[91],"activated,":[92],"inhibited":[94,140],"states.":[95,131],"Using":[96],"particle":[97],"counts":[98],"as":[99],"proxy":[101],"for":[102,157],"relative":[103],"free":[105],"energy,":[106],"demonstrate":[108],"at":[112],"high-affinity":[114],"site":[115],"allows":[116],"IP3Rs":[117,136],"activate":[119],"by":[120,143],"escaping":[121],"low-energy":[123],"resting":[124],"state":[125,141],"through":[126],"ensemble":[128],"preactivated":[130],"At":[132],"high":[133],"concentrations,":[135],"preferentially":[137],"enter":[138],"stabilized":[142],"second,":[145],"low-affinity":[146],"site.":[149],"Together,":[150],"these":[151],"studies":[152],"provide":[153],"mechanistic":[155],"basis":[156],"Ca2+-dependence":[160],"channel":[163],"activity.":[164]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-01T00:00:00"}
