{"id":"https://openalex.org/W4388034088","doi":"https://doi.org/10.1042/bcj20230384","title":"Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma","display_name":"Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma","publication_year":2023,"publication_date":"2023-10-31","ids":{"openalex":"https://openalex.org/W4388034088","doi":"https://doi.org/10.1042/bcj20230384","pmid":"https://pubmed.ncbi.nlm.nih.gov/37905668","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10860161"},"language":"en","primary_location":{"id":"doi:10.1042/bcj20230384","doi":"https://doi.org/10.1042/bcj20230384","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20230384","pdf_url":"https://portlandpress.com/biochemj/article-pdf/doi/10.1042/BCJ20230384/951205/bcj-2023-0384.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://portlandpress.com/biochemj/article-pdf/doi/10.1042/BCJ20230384/951205/bcj-2023-0384.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029210441","display_name":"Tanner Wright","orcid":"https://orcid.org/0000-0002-4547-9663","observed_orcids":["https://orcid.org/0000-0002-4547-9663"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanner Wright","raw_affiliation_strings":["1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A","2MD Anderson UTHealth Houston, Graduate School of Biomedical Sciences, 6767 Bertner Ave, Houston, TX 77030, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"2MD Anderson UTHealth Houston, Graduate School of Biomedical Sciences, 6767 Bertner Ave, Houston, TX 77030, U.S.A","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100744974","display_name":"Yalong Wang","orcid":"https://orcid.org/0000-0002-9557-9101","observed_orcids":["https://orcid.org/0000-0002-9557-9101"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yalong Wang","raw_affiliation_strings":["1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070229901","display_name":"Sabrina A. Stratton","orcid":"https://orcid.org/0000-0002-5408-8242","observed_orcids":["https://orcid.org/0000-0002-5408-8242"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sabrina A. Stratton","raw_affiliation_strings":["1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025375045","display_name":"Manu M. Sebastian","orcid":"https://orcid.org/0000-0002-9229-8750","observed_orcids":["https://orcid.org/0000-0002-9229-8750"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manu Sebastian","raw_affiliation_strings":["3Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Veterinary Medicine and Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767367","display_name":"Bin Liu","orcid":"https://orcid.org/0000-0002-9113-9694","observed_orcids":["https://orcid.org/0000-0002-9113-9694","https://orcid.org/0009-0001-4292-4960","https://orcid.org/0009-0007-2607-500X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Liu","raw_affiliation_strings":["1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108748508","display_name":"David G. Johnson","orcid":"https://orcid.org/0000-0002-6223-1790","observed_orcids":["https://orcid.org/0000-0002-6223-1790"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David G. Johnson","raw_affiliation_strings":["1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001008905","display_name":"Mark T. Bedford","orcid":"https://orcid.org/0000-0002-8899-1050","observed_orcids":["https://orcid.org/0000-0002-8899-1050"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark T. Bedford","raw_affiliation_strings":["1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A"],"raw_orcid":"https://orcid.org/0000-0002-8899-1050","affiliations":[{"raw_affiliation_string":"1Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, U.S.A","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001008905"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":0.3169,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.45432993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"480","issue":"22","first_page":"1805","last_page":"1816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snd1","display_name":"SND1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tudor-domain","display_name":"Tudor domain","score":0.9919999837875366},{"id":"https://openalex.org/keywords/prmt5","display_name":"PRMT5","score":0.8410000205039978},{"id":"https://openalex.org/keywords/protein-arginine-methylation","display_name":"arginine methylation","score":0.847000002861023},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diethylnitrosamine-induced-liver-cancer","display_name":"diethylnitrosamine-induced liver cancer","score":0.824999988079071},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.5360000133514404},{"id":"https://openalex.org/keywords/acute-phase-proteins","display_name":"acute phase proteins","score":0.7789999842643738},{"id":"https://openalex.org/keywords/tumor-resistance","display_name":"tumor resistance","score":0.6449999809265137},{"id":"https://openalex.org/keywords/prmt5-inhibitors","display_name":"PRMT5 inhibitors","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5222856998443604},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4578820765018463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.45560163259506226},{"id":"https://openalex.org/C111819275","wikidata":"https://www.wikidata.org/wiki/Q18035368","display_name":"Protein arginine methyltransferase 5","level":5,"score":0.44730114936828613},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.38963136076927185},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.2587645947933197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21730348467826843},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21504440903663635},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18336406350135803}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bcj20230384","doi":"https://doi.org/10.1042/bcj20230384","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20230384","pdf_url":"https://portlandpress.com/biochemj/article-pdf/doi/10.1042/BCJ20230384/951205/bcj-2023-0384.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10860161","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10860161","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10860161/pdf/BCJ-480-1805.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:37905668","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37905668","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-1242","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/241","pdf_url":null,"source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1042/bcj20230384","doi":"https://doi.org/10.1042/bcj20230384","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bcj20230384","pdf_url":"https://portlandpress.com/biochemj/article-pdf/doi/10.1042/BCJ20230384/951205/bcj-2023-0384.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2533282170","display_name":null,"funder_award_id":"P50 CA217674","funder_id":"https://openalex.org/F4320332521","funder_display_name":"University of Texas MD Anderson Cancer Center"},{"id":"https://openalex.org/G5515608451","display_name":"The Functional Analysis of the Coactivator CARM1","funder_award_id":"R01GM126421","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6956264640","display_name":"The University of Texas MD Anderson Cancer Center SPORE in Hepatocellular Carcinoma","funder_award_id":"P50CA217674","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8700591257","display_name":"The E2F1 Post-Translational Modification Code","funder_award_id":"R01CA214723","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000899146","display_name":"Mechanisms of action and therapeutic targeting of the CARM1-NFIB axis in small cell lung cancer","funder_award_id":"R01CA272843","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388034088.pdf","grobid_xml":"https://content.openalex.org/works/W4388034088.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1480123369","https://openalex.org/W1571534017","https://openalex.org/W1987872465","https://openalex.org/W1998607186","https://openalex.org/W2013151542","https://openalex.org/W2021590347","https://openalex.org/W2025277638","https://openalex.org/W2033141278","https://openalex.org/W2052077233","https://openalex.org/W2057968019","https://openalex.org/W2066050590","https://openalex.org/W2076142854","https://openalex.org/W2089774164","https://openalex.org/W2096967258","https://openalex.org/W2097511227","https://openalex.org/W2113655009","https://openalex.org/W2157746712","https://openalex.org/W2222401609","https://openalex.org/W2266018744","https://openalex.org/W2317184793","https://openalex.org/W2570732803","https://openalex.org/W2605899767","https://openalex.org/W2830806864","https://openalex.org/W2890767432","https://openalex.org/W2897617954","https://openalex.org/W2905301889","https://openalex.org/W2915527866","https://openalex.org/W2942698941","https://openalex.org/W2949815414","https://openalex.org/W2953863996","https://openalex.org/W3039455661","https://openalex.org/W3042556996","https://openalex.org/W3091529259","https://openalex.org/W3118966797","https://openalex.org/W3131202762","https://openalex.org/W3198999861","https://openalex.org/W4210774372","https://openalex.org/W4211183069","https://openalex.org/W4296023056","https://openalex.org/W4296077873","https://openalex.org/W4306182126","https://openalex.org/W4320495511","https://openalex.org/W4362521091","https://openalex.org/W4366256335","https://openalex.org/W4382182035","https://openalex.org/W4385876743"],"related_works":["https://openalex.org/W7015401822","https://openalex.org/W2771131579","https://openalex.org/W3118966797","https://openalex.org/W2492457904","https://openalex.org/W2605899767","https://openalex.org/W2830806864","https://openalex.org/W1998364925","https://openalex.org/W2008359831","https://openalex.org/W2318304207","https://openalex.org/W2060539562"],"abstract_inverted_index":{"Staphylococcal":[0],"nuclease":[1],"Tudor":[2,17,51,68,91,122,219],"domain":[3,52,69,123,220],"containing":[4],"1":[5],"(SND1)":[6],"protein":[7,26],"is":[8,32,46,53],"an":[9,83,89],"oncogene":[10],"that":[11,150,187,215],"'reads'":[12],"methylarginine":[13,104],"marks":[14,23],"through":[15],"its":[16],"domain.":[18],"Specifically,":[19],"it":[20,45],"recognizes":[21],"methylation":[22],"deposited":[24],"by":[25,75],"arginine":[27],"methyltransferase":[28],"5":[29],"(PRMT5),":[30],"which":[31,135],"also":[33],"known":[34],"to":[35,55,60,204],"promote":[36,56],"tumorigenesis.":[37],"Although":[38],"SND1":[39,50,67,80,98,121,141,154,176,218],"can":[40,99],"drive":[41],"hepatocellular":[42],"carcinoma":[43],"(HCC),":[44],"unclear":[47],"whether":[48],"the":[49,62,66,120,126,156,161,170,181,209,217,222],"needed":[54],"HCC.":[57,166,184,232],"We":[58,185],"sought":[59],"identify":[61],"biological":[63],"role":[64,118],"of":[65,109,128,153,163,173,183,211,224],"in":[70,124,143,155],"normal":[71],"and":[72,88,112,175,191],"tumorigenic":[73],"settings":[74],"developing":[76],"two":[77],"genetically":[78],"engineered":[79],"mouse":[81,157],"models,":[82],"Snd1":[84,90,189,192],"knockout":[85],"(Snd1":[86,93],"KO)":[87],"domain-mutated":[92],"KI)":[94],"mouse,":[95],"whose":[96],"mutant":[97],"no":[100],"longer":[101],"recognize":[102],"PRMT5-catalyzed":[103],"marks.":[105],"Quantitative":[106],"PCR":[107],"analysis":[108],"normal,":[110],"KO,":[111],"KI":[113,193],"liver":[114,158],"samples":[115],"revealed":[116],"a":[117,144],"for":[119,231],"regulating":[125],"expression":[127],"genes":[129],"encoding":[130],"major":[131],"acute":[132],"phase":[133],"proteins,":[134],"could":[136],"provide":[137],"mechanistic":[138],"insight":[139],"into":[140],"function":[142],"tumor":[145,200],"setting.":[146],"Prior":[147],"studies":[148],"indicated":[149],"ectopic":[151],"overexpression":[152],"dramatically":[159],"accelerates":[160],"development":[162,182,201,210],"diethylnitrosamine":[164],"(DEN)-induced":[165],"Thus,":[167],"we":[168],"tested":[169],"combined":[171],"effects":[172],"DEN":[174],"loss":[177],"or":[178,221],"mutation":[179],"on":[180],"found":[186],"both":[188],"KO":[190],"mice":[194],"were":[195],"partially":[196],"protected":[197],"against":[198],"malignant":[199],"following":[202],"exposure":[203],"DEN.":[205],"These":[206],"results":[207],"support":[208],"small":[212],"molecule":[213],"inhibitors":[214],"target":[216],"use":[223],"upstream":[225],"PRMT5":[226],"inhibitors,":[227],"as":[228],"novel":[229],"treatments":[230]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-11-01T00:00:00"}