{"id":"https://openalex.org/W4388033765","doi":"https://doi.org/10.1091/mbc.e23-02-0075","title":"Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells","display_name":"Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells","publication_year":2023,"publication_date":"2023-10-30","ids":{"openalex":"https://openalex.org/W4388033765","doi":"https://doi.org/10.1091/mbc.e23-02-0075","pmid":"https://pubmed.ncbi.nlm.nih.gov/37903222","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10848942"},"language":"en","primary_location":{"id":"doi:10.1091/mbc.e23-02-0075","doi":"https://doi.org/10.1091/mbc.e23-02-0075","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e23-02-0075","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2022/11/13/2022.11.11.516201.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036722354","display_name":"Olalekan H. Usman","orcid":"https://orcid.org/0009-0007-5756-325X","observed_orcids":["https://orcid.org/0009-0007-5756-325X"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olalekan H. Usman","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101569043","display_name":"Sampath Kumar","orcid":"https://orcid.org/0000-0003-2183-6731","observed_orcids":["https://orcid.org/0000-0003-2183-6731"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sampath Kumar","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056518737","display_name":"Reddick Russell Walker","orcid":"https://orcid.org/0000-0001-7021-3392","observed_orcids":["https://orcid.org/0000-0001-7021-3392"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reddick R. Walker","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101845137","display_name":"Gengqiang Xie","orcid":"https://orcid.org/0000-0002-2064-4757","observed_orcids":["https://orcid.org/0000-0002-2064-4757"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gengqiang Xie","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097026863","display_name":"Hyeje C. Sumajit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyeje C. Sumajit","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091598802","display_name":"AbdelAziz R. Jalil","orcid":"https://orcid.org/0000-0002-8031-7045","observed_orcids":["https://orcid.org/0000-0002-8031-7045"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"AbdelAziz R. Jalil","raw_affiliation_strings":["Physical Sciences Oncology Center at Penn, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Sciences Oncology Center at Penn, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003509758","display_name":"Subramanian Ramakrishnan","orcid":"https://orcid.org/0000-0001-5108-2198","observed_orcids":["https://orcid.org/0000-0001-5108-2198"]},"institutions":[{"id":"https://openalex.org/I1323276237","display_name":"Florida A&M University - Florida State University College of Engineering","ror":"https://ror.org/01v4tq883","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165","https://openalex.org/I1323276237","https://openalex.org/I8248082"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Subramanian Ramakrishnan","raw_affiliation_strings":["Department of Chemical and Biomedical Engineering, Florida A&M University-Florida State University College of Engineering, Tallahassee, FL 32310"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomedical Engineering, Florida A&M University-Florida State University College of Engineering, Tallahassee, FL 32310","institution_ids":["https://openalex.org/I1323276237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090377300","display_name":"Lawrence J. Dooling","orcid":"https://orcid.org/0000-0002-1688-2066","observed_orcids":["https://orcid.org/0000-0002-1688-2066"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence J. Dooling","raw_affiliation_strings":["Physical Sciences Oncology Center at Penn, University of Pennsylvania, Philadelphia, PA 19104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Sciences Oncology Center at Penn, University of Pennsylvania, Philadelphia, PA 19104","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043126694","display_name":"Yue Julia Wang","orcid":"https://orcid.org/0000-0003-2641-6904","observed_orcids":["https://orcid.org/0000-0003-2641-6904"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Julia Wang","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071622752","display_name":"Jerome Irianto","orcid":"https://orcid.org/0000-0002-4804-7225","observed_orcids":["https://orcid.org/0000-0002-4804-7225"]},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jerome Irianto","raw_affiliation_strings":["Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306"],"raw_orcid":"https://orcid.org/0000-0002-4804-7225","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL 32306","institution_ids":["https://openalex.org/I103163165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071622752"],"corresponding_institution_ids":["https://openalex.org/I103163165"],"apc_list":null,"apc_paid":null,"fwci":0.8497,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73319261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"34","issue":"13","first_page":"ar130","last_page":"ar130"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.5425000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.42089998722076416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/extracellular-matrix-proteins","display_name":"extracellular matrix proteins","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.8410000205039978},{"id":"https://openalex.org/keywords/metastatic-pancreatic-cancer","display_name":"metastatic pancreatic cancer","score":0.7960000038146973},{"id":"https://openalex.org/keywords/primary-tumor-cells","display_name":"primary tumor cells","score":0.5740000009536743},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.8199999928474426},{"id":"https://openalex.org/keywords/gemcitabine-sensitivity","display_name":"gemcitabine sensitivity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.722000002861023},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9110000133514404},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.5690000057220459},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.7020000219345093},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.80290687084198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7511828541755676},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5955267548561096},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.576483964920044},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.571456253528595},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5389166474342346},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.52140212059021},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5039166808128357},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4934495985507965},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48643064498901367},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.452430784702301},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.44396671652793884},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4432287812232971},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36422860622406006},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3472740054130554},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3358769416809082},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24532079696655273},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.12072712182998657},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09062382578849792},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08126744627952576},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07534581422805786},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1091/mbc.e23-02-0075","doi":"https://doi.org/10.1091/mbc.e23-02-0075","is_oa":false,"landing_page_url":"https://doi.org/10.1091/mbc.e23-02-0075","pdf_url":null,"source":{"id":"https://openalex.org/S188085164","display_name":"Molecular Biology of the Cell","issn_l":"1059-1524","issn":["1059-1524","1939-4586"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319721","host_organization_name":"American Society for Cell Biology","host_organization_lineage":["https://openalex.org/P4310319721"],"host_organization_lineage_names":["American Society for Cell Biology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology of the Cell","raw_type":"journal-article"},{"id":"doi:10.1101/2022.11.11.516201","doi":"https://doi.org/10.1101/2022.11.11.516201","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.11.516201","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/11/13/2022.11.11.516201.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10848942","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10848942","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10848942/pdf/mbc-34-ar130.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Cell","raw_type":"Text"},{"id":"pmid:37903222","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37903222","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology of the cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2022.11.11.516201","doi":"https://doi.org/10.1101/2022.11.11.516201","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.11.11.516201","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/11/13/2022.11.11.516201.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3658484145","display_name":null,"funder_award_id":"1735968","funder_id":"https://openalex.org/F4320338075","funder_display_name":"Core Research for Evolutional Science and Technology"},{"id":"https://openalex.org/G3763452921","display_name":null,"funder_award_id":"1735968","funder_id":"https://openalex.org/F4320309360","funder_display_name":"Florida Department of Health"},{"id":"https://openalex.org/G5613623313","display_name":null,"funder_award_id":"CREST","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5968459809","display_name":"CREST   Center for Complex Materials Design for Multidimensional Additive Processing (CoManD)","funder_award_id":"1735968","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6203851445","display_name":null,"funder_award_id":"23L06","funder_id":"https://openalex.org/F4320309360","funder_display_name":"Florida Department of Health"},{"id":"https://openalex.org/G7248062449","display_name":null,"funder_award_id":"1735968","funder_id":"https://openalex.org/F4320316829","funder_display_name":"Florida Agricultural and Mechanical University"},{"id":"https://openalex.org/G7757980542","display_name":"Chromatin mobility in response to DNA damage","funder_award_id":"U01CA214282","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8900774153","display_name":null,"funder_award_id":"21B11","funder_id":"https://openalex.org/F4320309360","funder_display_name":"Florida Department of Health"},{"id":"https://openalex.org/G978970017","display_name":null,"funder_award_id":"1735968","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309170","display_name":"Florida State University","ror":"https://ror.org/05g3dte14"},{"id":"https://openalex.org/F4320309360","display_name":"Florida Department of Health","ror":"https://ror.org/03e1xkn26"},{"id":"https://openalex.org/F4320316829","display_name":"Florida Agricultural and Mechanical University","ror":"https://ror.org/00c4wc133"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388033765.pdf","grobid_xml":"https://content.openalex.org/works/W4388033765.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W57953669","https://openalex.org/W1576773659","https://openalex.org/W1903224084","https://openalex.org/W1907686361","https://openalex.org/W1951333968","https://openalex.org/W1965498876","https://openalex.org/W1968812902","https://openalex.org/W1972135632","https://openalex.org/W1982204629","https://openalex.org/W1983375889","https://openalex.org/W1994408107","https://openalex.org/W2002603913","https://openalex.org/W2018049139","https://openalex.org/W2022784273","https://openalex.org/W2023026872","https://openalex.org/W2024302667","https://openalex.org/W2030615035","https://openalex.org/W2031484321","https://openalex.org/W2049017382","https://openalex.org/W2051330448","https://openalex.org/W2066254965","https://openalex.org/W2070050178","https://openalex.org/W2078448804","https://openalex.org/W2094007386","https://openalex.org/W2099540110","https://openalex.org/W2100303404","https://openalex.org/W2101244168","https://openalex.org/W2105183595","https://openalex.org/W2108861663","https://openalex.org/W2111895881","https://openalex.org/W2114125159","https://openalex.org/W2122038069","https://openalex.org/W2131070390","https://openalex.org/W2131162243","https://openalex.org/W2146078095","https://openalex.org/W2147213735","https://openalex.org/W2150163671","https://openalex.org/W2158288339","https://openalex.org/W2159695799","https://openalex.org/W2160254610","https://openalex.org/W2168992025","https://openalex.org/W2169456326","https://openalex.org/W2169895148","https://openalex.org/W2179438025","https://openalex.org/W2183902741","https://openalex.org/W2220944543","https://openalex.org/W2312604219","https://openalex.org/W2326081342","https://openalex.org/W2342949264","https://openalex.org/W2425011738","https://openalex.org/W2476542314","https://openalex.org/W2513294073","https://openalex.org/W2552754421","https://openalex.org/W2564267981","https://openalex.org/W2572707648","https://openalex.org/W2576896693","https://openalex.org/W2619683448","https://openalex.org/W2726164542","https://openalex.org/W2756562465","https://openalex.org/W2769094265","https://openalex.org/W2802799856","https://openalex.org/W2807088563","https://openalex.org/W2901606464","https://openalex.org/W2911188335","https://openalex.org/W2943229766","https://openalex.org/W2947998101","https://openalex.org/W2957594695","https://openalex.org/W2971483070","https://openalex.org/W3090067576","https://openalex.org/W3097574028","https://openalex.org/W3133734054","https://openalex.org/W3137355934","https://openalex.org/W3181438909","https://openalex.org/W3201764306","https://openalex.org/W3207717279","https://openalex.org/W4211181525","https://openalex.org/W4224231300","https://openalex.org/W4244578979","https://openalex.org/W4248792436","https://openalex.org/W4312052647","https://openalex.org/W4386099719"],"related_works":["https://openalex.org/W4293778265","https://openalex.org/W2971483070","https://openalex.org/W2895614576","https://openalex.org/W7135218168","https://openalex.org/W7135070768","https://openalex.org/W4309463303","https://openalex.org/W2278409975","https://openalex.org/W2566706463","https://openalex.org/W2076921551","https://openalex.org/W3201764306"],"abstract_inverted_index":{"Pancreatic":[0],"ductal":[1],"adenocarcinoma":[2],"(PDAC)":[3],"is":[4,20,38],"reported":[5],"to":[6,114],"be":[7],"the":[8,16,33,62,65,85,95,115,123,127,131,139,147,158,173],"third":[9],"highest":[10],"cause":[11],"of":[12,26,32,41,64,130,146,160,175],"cancer-related":[13],"deaths":[14],"in":[15],"United":[17],"States.":[18],"PDAC":[19,68,106,134,141,150],"known":[21],"for":[22,30,182],"its":[23],"high":[24],"proportion":[25],"stroma,":[27],"which":[28,99],"accounts":[29],"90%":[31],"tumor":[34,133,149],"mass.":[35],"The":[36],"stroma":[37],"made":[39],"up":[40],"extracellular":[42],"matrix":[43],"(ECM)":[44],"and":[45,54,56,126,169],"nonmalignant":[46],"cells":[47,73,151],"such":[48,163],"as":[49,164],"inflammatory":[50],"cells,":[51],"cancer-associated":[52],"fibroblasts,":[53],"lymphatic":[55],"blood":[57],"vessels.":[58],"Here,":[59],"we":[60],"decoupled":[61],"effects":[63],"ECM":[66,79,96,117,120,155,183],"on":[67,74,94,98,153],"cell":[69,88,135,165],"lines":[70,89],"by":[71],"culturing":[72],"surfaces":[75],"coated":[76],"with":[77,112],"different":[78,91,116,154],"proteins.":[80,118],"Our":[81],"data":[82],"show":[83],"that":[84,179],"primary":[86,132,148],"tumor-derived":[87],"have":[90],"morphology":[92,108],"depending":[93],"proteins":[97,121,156],"they":[100],"are":[101,180],"cultured,":[102],"while":[103],"metastatic":[104,140],"lesion-derived":[105],"lines'":[107],"does":[109],"not":[110,138],"change":[111],"respect":[113],"Similarly,":[119],"modulate":[122],"proliferation":[124],"rate":[125],"gemcitabine":[128],"sensitivity":[129],"lines,":[136],"but":[137],"lines.":[142],"Lastly,":[143],"transcriptomics":[144],"analysis":[145],"cultured":[152],"reveals":[157],"regulation":[159,174],"various":[161],"pathways,":[162],"cycle,":[166],"cell-adhesion":[167],"molecules,":[168],"focal":[170],"adhesion,":[171],"including":[172],"several":[176],"integrin":[177],"genes":[178],"essential":[181],"recognition.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-11-01T00:00:00"}