{"id":"https://openalex.org/W4388026558","doi":"https://doi.org/10.51847/vafvsv35cl","title":"Effects of Dimethyl Sulfoxide on Hippocampal Activity in a Rotenone-Induced Rat Model of Parkinson\u2019s Disease","display_name":"Effects of Dimethyl Sulfoxide on Hippocampal Activity in a Rotenone-Induced Rat Model of Parkinson\u2019s Disease","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4388026558","doi":"https://doi.org/10.51847/vafvsv35cl","pmid":"https://pubmed.ncbi.nlm.nih.gov/37522774"},"language":"en","primary_location":{"id":"doi:10.51847/vafvsv35cl","doi":"https://doi.org/10.51847/vafvsv35cl","is_oa":true,"landing_page_url":"http://dx.doi.org/10.51847/vafvsv35cl","pdf_url":"https://pharmacophorejournal.com/storage/files/article/97e8f5de-fbf7-46ab-8bfd-c3204c5d9e8d-RdAHwNACoqwIuWRG/OjNxurW40Vv192w.pdf","source":{"id":"https://openalex.org/S4210195344","display_name":"Pharmacophore","issn_l":"2229-5402","issn":["2229-5402"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacophore","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pharmacophorejournal.com/storage/files/article/97e8f5de-fbf7-46ab-8bfd-c3204c5d9e8d-RdAHwNACoqwIuWRG/OjNxurW40Vv192w.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030711731","display_name":"Lilit Darbinyan","orcid":"https://orcid.org/0000-0002-5364-2838","observed_orcids":["https://orcid.org/0000-0002-5364-2838"]},"institutions":[{"id":"https://openalex.org/I4210115086","display_name":"L. A. Orbeli Institute of Physiology NAS RA","ror":"https://ror.org/02gse4n09","country_code":"AM","type":"education","lineage":["https://openalex.org/I4210115086","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Lilit Darbinyan","raw_affiliation_strings":[". Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia","institution_ids":["https://openalex.org/I4210115086","https://openalex.org/I99064381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Karen Simonyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115086","display_name":"L. A. Orbeli Institute of Physiology NAS RA","ror":"https://ror.org/02gse4n09","country_code":"AM","type":"education","lineage":["https://openalex.org/I4210115086","https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":true,"raw_author_name":"Karen Simonyan","raw_affiliation_strings":[". Neuroendocrine Relationships Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Neuroendocrine Relationships Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia","institution_ids":["https://openalex.org/I4210115086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028385628","display_name":"Larisa Manukyan","orcid":"https://orcid.org/0009-0007-7605-5189","observed_orcids":["https://orcid.org/0009-0007-7605-5189"]},"institutions":[{"id":"https://openalex.org/I4210115086","display_name":"L. A. Orbeli Institute of Physiology NAS RA","ror":"https://ror.org/02gse4n09","country_code":"AM","type":"education","lineage":["https://openalex.org/I4210115086","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Larisa Manukyan","raw_affiliation_strings":[". Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia","institution_ids":["https://openalex.org/I4210115086","https://openalex.org/I99064381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022561141","display_name":"L. E. Hambardzumyan","orcid":"https://orcid.org/0000-0002-3694-4068","observed_orcids":["https://orcid.org/0000-0002-3694-4068"]},"institutions":[{"id":"https://openalex.org/I4210115086","display_name":"L. A. Orbeli Institute of Physiology NAS RA","ror":"https://ror.org/02gse4n09","country_code":"AM","type":"education","lineage":["https://openalex.org/I4210115086","https://openalex.org/I99064381"]},{"id":"https://openalex.org/I99064381","display_name":"National Academy of Sciences of Armenia","ror":"https://ror.org/04mczx267","country_code":"AM","type":"government","lineage":["https://openalex.org/I99064381"]}],"countries":["AM"],"is_corresponding":false,"raw_author_name":"Lilia Hambardzumyan","raw_affiliation_strings":[". Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia","Neuroendocrine Relationships Lab , Orbeli Institute of Physiology NAS RA , Yerevan , 0028 , Armenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":". Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, 0028, Armenia","institution_ids":["https://openalex.org/I4210115086","https://openalex.org/I99064381"]},{"raw_affiliation_string":"Neuroendocrine Relationships Lab , Orbeli Institute of Physiology NAS RA , Yerevan , 0028 , Armenia","institution_ids":["https://openalex.org/I4210115086"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210115086"],"apc_list":null,"apc_paid":null,"fwci":0.4849,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58167521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"14","issue":"5","first_page":"18","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimethyl-sulfoxide","display_name":"dimethyl sulfoxide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.902999997138977},{"id":"https://openalex.org/keywords/pyramidal-neurons","display_name":"pyramidal neurons","score":0.718999981880188},{"id":"https://openalex.org/keywords/nissl-bodies","display_name":"Nissl bodies","score":0.777999997138977},{"id":"https://openalex.org/keywords/ca1","display_name":"CA1","score":0.5920000076293945},{"id":"https://openalex.org/keywords/ca3","display_name":"CA3","score":0.996999979019165},{"id":"https://openalex.org/keywords/tremor","display_name":"tremor","score":0.4050000011920929},{"id":"https://openalex.org/keywords/dyskinesia","display_name":"dyskinesia","score":0.6159999966621399},{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"entorhinal cortex","score":0.8500000238418579},{"id":"https://openalex.org/keywords/high-frequency-stimulation","display_name":"high-frequency stimulation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6430000066757202},{"id":"https://openalex.org/keywords/drug-penetration","display_name":"drug penetration","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C2778389096","wikidata":"https://www.wikidata.org/wiki/Q412388","display_name":"Rotenone","level":3,"score":0.8291365504264832},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6644922494888306},{"id":"https://openalex.org/C2778452553","wikidata":"https://www.wikidata.org/wiki/Q407927","display_name":"Dimethyl sulfoxide","level":2,"score":0.6268661618232727},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6017624735832214},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42324966192245483},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3876839876174927},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3609667122364044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3447258472442627},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33300164341926575},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29759055376052856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2506880760192871},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22389617562294006},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.07709941267967224},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0699426531791687}],"mesh":[{"descriptor_ui":"D004121","descriptor_name":"Dimethyl Sulfoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012402","descriptor_name":"Rotenone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.51847/vafvsv35cl","doi":"https://doi.org/10.51847/vafvsv35cl","is_oa":true,"landing_page_url":"http://dx.doi.org/10.51847/vafvsv35cl","pdf_url":"https://pharmacophorejournal.com/storage/files/article/97e8f5de-fbf7-46ab-8bfd-c3204c5d9e8d-RdAHwNACoqwIuWRG/OjNxurW40Vv192w.pdf","source":{"id":"https://openalex.org/S4210195344","display_name":"Pharmacophore","issn_l":"2229-5402","issn":["2229-5402"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacophore","raw_type":"journal-article"},{"id":"pmid:37522774","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37522774","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Georgian medical news","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.51847/vafvsv35cl","doi":"https://doi.org/10.51847/vafvsv35cl","is_oa":true,"landing_page_url":"http://dx.doi.org/10.51847/vafvsv35cl","pdf_url":"https://pharmacophorejournal.com/storage/files/article/97e8f5de-fbf7-46ab-8bfd-c3204c5d9e8d-RdAHwNACoqwIuWRG/OjNxurW40Vv192w.pdf","source":{"id":"https://openalex.org/S4210195344","display_name":"Pharmacophore","issn_l":"2229-5402","issn":["2229-5402"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacophore","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388026558.pdf","grobid_xml":"https://content.openalex.org/works/W4388026558.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1504584187","https://openalex.org/W1964370830","https://openalex.org/W1976566509","https://openalex.org/W1977116908","https://openalex.org/W1993027122","https://openalex.org/W1997252714","https://openalex.org/W2001877436","https://openalex.org/W2005104343","https://openalex.org/W2010268515","https://openalex.org/W2015435658","https://openalex.org/W2017088002","https://openalex.org/W2026858268","https://openalex.org/W2029503022","https://openalex.org/W2045350003","https://openalex.org/W2045698094","https://openalex.org/W2056527946","https://openalex.org/W2076416015","https://openalex.org/W2085019002","https://openalex.org/W2117878495","https://openalex.org/W2123890403","https://openalex.org/W2124405216","https://openalex.org/W2148237460","https://openalex.org/W2150363205","https://openalex.org/W2162155268","https://openalex.org/W2532882443","https://openalex.org/W2580475495","https://openalex.org/W2735170571","https://openalex.org/W2971903447","https://openalex.org/W3145025631","https://openalex.org/W4307550142","https://openalex.org/W4308972786","https://openalex.org/W4310376614","https://openalex.org/W4310672723","https://openalex.org/W4315498124","https://openalex.org/W4317907766","https://openalex.org/W4323312602","https://openalex.org/W4362633066","https://openalex.org/W4365515035","https://openalex.org/W4382657053"],"related_works":["https://openalex.org/W7211900490","https://openalex.org/W2580475495","https://openalex.org/W3205567776","https://openalex.org/W2888160169","https://openalex.org/W2499061153","https://openalex.org/W2000696636","https://openalex.org/W2746887613","https://openalex.org/W2279397902","https://openalex.org/W3043249417","https://openalex.org/W4210410640"],"abstract_inverted_index":{"Parkinson's":[0,31],"disease":[1,10,32],"(PD)":[2],"is":[3],"the":[4,20,42,49,71,92,133,147],"second":[5],"most":[6],"common":[7],"age-related":[8],"neurodegenerative":[9],"worldwide.":[11],"The":[12,127],"goal":[13],"of":[14,22,30,44,73,98,146],"this":[15],"study":[16],"was":[17],"to":[18,37,40,137],"examine":[19],"effects":[21,131],"dimethyl":[23],"sulfoxide":[24],"(DMSO)":[25],"in":[26,58,70,91,132,135],"a":[27,112,123],"rat":[28],"model":[29],"caused":[33],"by":[34],"rotenone.":[35],"Due":[36],"its":[38],"capacity":[39],"increase":[41],"penetration":[43],"potential":[45],"water-insoluble":[46],"drugs":[47],"into":[48],"central":[50],"nervous":[51],"system,":[52],"DMSO":[53,76,105,117],"has":[54],"been":[55],"widely":[56],"used":[57],"preclinical":[59],"and":[60,64,88,95,110],"clinical":[61],"studies.":[62],"Background":[63],"evoked":[65],"spike":[66],"activities":[67],"were":[68],"recorded":[69],"hippocampus":[72,134],"rats":[74,99],"administered":[75,100],"(1":[77],"ml/kg":[78],"i.p.":[79],"for":[80,143],"3":[81],"weeks).":[82],"We":[83],"showed":[84],"that":[85],"pyramidal":[86],"cells":[87],"Nissl":[89],"bodies":[90],"hippocampal":[93],"CA1":[94],"CA3":[96],"areas":[97],"rotenone":[101],"dramatically":[102],"improved":[103],"after":[104],"treatment.":[106],"Rotenone":[107],"enhanced":[108,119],"TP":[109,120],"induced":[111,122],"milder":[113],"TD":[114,125],"effect,":[115],"while":[116],"also":[118],"but":[121],"stronger":[124],"effect.":[126],"analysis":[128],"revealed":[129],"inhibitory":[130],"response":[136],"high-frequency":[138],"stimulation":[139],"(HFS;":[140],"100":[141],"Hz":[142],"1":[144],"s)":[145],"ipsilateral":[148],"entorhinal":[149],"cortex.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-11-01T00:00:00"}
