{"id":"https://openalex.org/W4388023910","doi":"https://doi.org/10.3390/pharmaceutics15112545","title":"Exploiting Pharma 4.0 Technologies in the Non-Biological Complex Drugs Manufacturing: Innovations and Implications","display_name":"Exploiting Pharma 4.0 Technologies in the Non-Biological Complex Drugs Manufacturing: Innovations and Implications","publication_year":2023,"publication_date":"2023-10-28","ids":{"openalex":"https://openalex.org/W4388023910","doi":"https://doi.org/10.3390/pharmaceutics15112545","pmid":"https://pubmed.ncbi.nlm.nih.gov/38004525","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10674941"},"language":"en","primary_location":{"id":"doi:10.3390/pharmaceutics15112545","doi":"https://doi.org/10.3390/pharmaceutics15112545","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15112545","pdf_url":"https://www.mdpi.com/1999-4923/15/11/2545/pdf?version=1698481684","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4923/15/11/2545/pdf?version=1698481684","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Vera Malheiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Vera Malheiro","raw_affiliation_strings":["Drug Development and Technology Laboratory, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development and Technology Laboratory, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063221433","display_name":"Joana Galv\u00e3o Duarte","orcid":"https://orcid.org/0000-0001-7092-0409","observed_orcids":["https://orcid.org/0000-0001-7092-0409"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Duarte","raw_affiliation_strings":["Drug Development and Technology Laboratory, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development and Technology Laboratory, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045596489","display_name":"Francisco Veiga","orcid":"https://orcid.org/0000-0002-1041-0068","observed_orcids":["https://orcid.org/0000-0002-1041-0068"]},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Francisco Veiga","raw_affiliation_strings":["Drug Development and Technology Laboratory, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal","LAQV, REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Development and Technology Laboratory, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"LAQV, REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006601703","display_name":"Filipa Mascarenhas\u2010Melo","orcid":"https://orcid.org/0000-0003-0786-6280","observed_orcids":["https://orcid.org/0000-0003-0786-6280"]},"institutions":[{"id":"https://openalex.org/I4210103026","display_name":"Universidade Polit\u00e9cnica da Guarda","ror":"https://ror.org/02463v873","country_code":"PT","type":"education","lineage":["https://openalex.org/I4210103026"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Filipa Mascarenhas-Melo","raw_affiliation_strings":["Drug Development and Technology Laboratory, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal","Higher School of Health, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-307 Guarda, Portugal","LAQV, REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"],"raw_orcid":"https://orcid.org/0000-0003-0786-6280","affiliations":[{"raw_affiliation_string":"Drug Development and Technology Laboratory, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Higher School of Health, Polytechnic Institute of Guarda, Rua da Cadeia, 6300-307 Guarda, Portugal","institution_ids":["https://openalex.org/I4210103026"]},{"raw_affiliation_string":"LAQV, REQUIMTE, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, P\u00f3lo das Ci\u00eancias da Sa\u00fade, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006601703"],"corresponding_institution_ids":["https://openalex.org/I4210103026","https://openalex.org/I76903346"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.8102,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.61452514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"15","issue":"11","first_page":"2545","last_page":"2545"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10763","display_name":"Digital Transformation in Industry","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10763","display_name":"Digital Transformation in Industry","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10783","display_name":"Additive Manufacturing and 3D Printing Technologies","score":0.06520000100135803,"subfield":{"id":"https://openalex.org/subfields/2209","display_name":"Industrial and Manufacturing Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharma-4-0","display_name":"Pharma 4.0","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmaceutical-manufacturing","display_name":"pharmaceutical manufacturing","score":0.6959999799728394},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.968999981880188},{"id":"https://openalex.org/keywords/in-silico-modeling","display_name":"in silico modeling","score":0.996999979019165},{"id":"https://openalex.org/keywords/3d-printing","display_name":"3D printing","score":0.9810000061988831},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/polymeric-micelles","display_name":"polymeric micelles","score":1.0},{"id":"https://openalex.org/keywords/glatiramer-acetate","display_name":"glatiramer acetate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nanocrystals","display_name":"nanocrystals","score":0.9139999747276306},{"id":"https://openalex.org/keywords/digital-twin","display_name":"digital twin","score":0.953000009059906},{"id":"https://openalex.org/keywords/regulatory-challenges","display_name":"regulatory challenges","score":0.8240000009536743},{"id":"https://openalex.org/keywords/production-process-optimization","display_name":"production process optimization","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.529374361038208},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5174875259399414},{"id":"https://openalex.org/C117671659","wikidata":"https://www.wikidata.org/wiki/Q11049265","display_name":"Manufacturing engineering","level":1,"score":0.48984643816947937},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.48303064703941345},{"id":"https://openalex.org/C207267971","wikidata":"https://www.wikidata.org/wiki/Q120208","display_name":"Emerging technologies","level":2,"score":0.4730355441570282},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.46159952878952026},{"id":"https://openalex.org/C77854861","wikidata":"https://www.wikidata.org/wiki/Q4686346","display_name":"Advanced manufacturing","level":2,"score":0.4603336751461029},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.45246267318725586},{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.43810755014419556},{"id":"https://openalex.org/C2778938233","wikidata":"https://www.wikidata.org/wiki/Q7180757","display_name":"Pharmaceutical manufacturing","level":2,"score":0.43260499835014343},{"id":"https://openalex.org/C195094911","wikidata":"https://www.wikidata.org/wiki/Q14167904","display_name":"Process management","level":1,"score":0.39065858721733093},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3750472664833069},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.22164061665534973},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12994876503944397},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.09746435284614563},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.08419293165206909},{"id":"https://openalex.org/C19351080","wikidata":"https://www.wikidata.org/wiki/Q1395034","display_name":"New product development","level":2,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/pharmaceutics15112545","doi":"https://doi.org/10.3390/pharmaceutics15112545","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15112545","pdf_url":"https://www.mdpi.com/1999-4923/15/11/2545/pdf?version=1698481684","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10674941","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10674941","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10674941/pdf/pharmaceutics-15-02545.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Text"},{"id":"pmid:38004525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38004525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3ff1e2ad6448434fa2cad581019d5d04","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3ff1e2ad6448434fa2cad581019d5d04","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceutics, Vol 15, Iss 11, p 2545 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/pharmaceutics15112545","doi":"https://doi.org/10.3390/pharmaceutics15112545","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pharmaceutics15112545","pdf_url":"https://www.mdpi.com/1999-4923/15/11/2545/pdf?version=1698481684","source":{"id":"https://openalex.org/S30283931","display_name":"Pharmaceutics","issn_l":"1999-4923","issn":["1999-4923"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.5378999710083008,"display_name":"Industry, innovation and infrastructure"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4388023910.pdf","grobid_xml":"https://content.openalex.org/works/W4388023910.grobid-xml"},"referenced_works_count":116,"referenced_works":["https://openalex.org/W830547093","https://openalex.org/W1973673666","https://openalex.org/W1987612487","https://openalex.org/W1990469304","https://openalex.org/W1992577925","https://openalex.org/W2000617311","https://openalex.org/W2011553445","https://openalex.org/W2026930707","https://openalex.org/W2027891488","https://openalex.org/W2029677759","https://openalex.org/W2055888564","https://openalex.org/W2060609416","https://openalex.org/W2065466552","https://openalex.org/W2085496520","https://openalex.org/W2086438722","https://openalex.org/W2097603366","https://openalex.org/W2118800477","https://openalex.org/W2123020477","https://openalex.org/W2276769347","https://openalex.org/W2289560656","https://openalex.org/W2335355012","https://openalex.org/W2343106452","https://openalex.org/W2402512029","https://openalex.org/W2409885204","https://openalex.org/W2528942521","https://openalex.org/W2576896112","https://openalex.org/W2579811554","https://openalex.org/W2581549798","https://openalex.org/W2589045496","https://openalex.org/W2600313485","https://openalex.org/W2742033145","https://openalex.org/W2765383527","https://openalex.org/W2766735954","https://openalex.org/W2791526401","https://openalex.org/W2807245343","https://openalex.org/W2868238225","https://openalex.org/W2886482292","https://openalex.org/W2886693580","https://openalex.org/W2900950982","https://openalex.org/W2901411193","https://openalex.org/W2905301874","https://openalex.org/W2921200631","https://openalex.org/W2925207909","https://openalex.org/W2926780735","https://openalex.org/W2928516672","https://openalex.org/W2955377836","https://openalex.org/W2964630594","https://openalex.org/W2969296462","https://openalex.org/W2986446268","https://openalex.org/W2990091358","https://openalex.org/W2995891886","https://openalex.org/W3001177047","https://openalex.org/W3007852328","https://openalex.org/W3010308608","https://openalex.org/W3013269370","https://openalex.org/W3019531250","https://openalex.org/W3029200316","https://openalex.org/W3044908416","https://openalex.org/W3047574894","https://openalex.org/W3082942458","https://openalex.org/W3088981963","https://openalex.org/W3094492244","https://openalex.org/W3110441277","https://openalex.org/W3132635904","https://openalex.org/W3134531697","https://openalex.org/W3138409295","https://openalex.org/W3144396085","https://openalex.org/W3145485668","https://openalex.org/W3151708782","https://openalex.org/W3153418506","https://openalex.org/W3158919441","https://openalex.org/W3161581468","https://openalex.org/W3163549795","https://openalex.org/W3163880690","https://openalex.org/W3169176357","https://openalex.org/W3171579459","https://openalex.org/W3175913239","https://openalex.org/W3185994191","https://openalex.org/W3189555047","https://openalex.org/W3195421105","https://openalex.org/W3200098781","https://openalex.org/W3203359277","https://openalex.org/W3203496628","https://openalex.org/W3209231500","https://openalex.org/W3211856256","https://openalex.org/W3214760545","https://openalex.org/W3215237506","https://openalex.org/W4206620032","https://openalex.org/W4211200711","https://openalex.org/W4220825322","https://openalex.org/W4224881243","https://openalex.org/W4281687812","https://openalex.org/W4288457668","https://openalex.org/W4293087938","https://openalex.org/W4293199734","https://openalex.org/W4294713295","https://openalex.org/W4295959876","https://openalex.org/W4296035977","https://openalex.org/W4296050340","https://openalex.org/W4303961744","https://openalex.org/W4306758945","https://openalex.org/W4307657928","https://openalex.org/W4308922189","https://openalex.org/W4309099316","https://openalex.org/W4309269387","https://openalex.org/W4310433441","https://openalex.org/W4311141815","https://openalex.org/W4311281815","https://openalex.org/W4323928609","https://openalex.org/W4361278975","https://openalex.org/W4366000610","https://openalex.org/W4367669572","https://openalex.org/W4376274616","https://openalex.org/W4379623241","https://openalex.org/W6745293756","https://openalex.org/W6803624722"],"related_works":["https://openalex.org/W1918888157","https://openalex.org/W2504512426","https://openalex.org/W4288457668","https://openalex.org/W4416199638","https://openalex.org/W4404214358","https://openalex.org/W4287511598","https://openalex.org/W7163592943","https://openalex.org/W3145485668","https://openalex.org/W4387780992","https://openalex.org/W4407233730"],"abstract_inverted_index":{"The":[0],"pharmaceutical":[1,42],"industry":[2],"has":[3],"entered":[4],"an":[5],"era":[6],"of":[7,12,34,41,66,84,91,117,128,134,149],"transformation":[8],"with":[9,114],"the":[10,28,64,81,89,115,126,147],"emergence":[11],"Pharma":[13,68],"4.0,":[14],"which":[15],"leverages":[16],"cutting-edge":[17],"technologies":[18,119],"in":[19,74,80,131],"manufacturing":[20,55,82,151],"processes.":[21,152],"These":[22],"hold":[23],"tremendous":[24],"potential":[25,122],"for":[26,146],"enhancing":[27],"overall":[29],"efficiency,":[30],"safety,":[31],"and":[32,53,77,106,120],"quality":[33],"non-biological":[35],"complex":[36,54],"drugs":[37],"(NBCDs),":[38],"a":[39,141],"category":[40],"products":[43],"that":[44],"pose":[45],"unique":[46],"challenges":[47,112],"due":[48],"to":[49,60,139],"their":[50],"intricate":[51],"composition":[52],"requirements.":[56],"This":[57],"review":[58],"attempts":[59],"provide":[61],"insight":[62],"into":[63],"application":[65],"select":[67],"4.0":[69],"technologies,":[70],"namely":[71,145],"machine":[72],"learning,":[73],"silico":[75],"modeling,":[76],"3D":[78],"printing,":[79],"process":[83],"NBCDs.":[85],"Specifically,":[86],"it":[87,137],"reviews":[88],"impact":[90],"these":[92,118],"tools":[93],"on":[94],"NBCDs":[95,150],"such":[96],"as":[97,136],"liposomes,":[98],"polymeric":[99],"micelles,":[100],"glatiramer":[101],"acetate,":[102],"iron":[103],"carbohydrate":[104],"complexes,":[105],"nanocrystals.":[107],"It":[108],"also":[109],"addresses":[110],"regulatory":[111],"associated":[113],"implementation":[116],"presents":[121],"future":[123],"perspectives,":[124],"highlighting":[125],"incorporation":[127],"digital":[129],"twins":[130],"this":[132],"field":[133],"research":[135],"seems":[138],"be":[140],"very":[142],"promising":[143],"approach,":[144],"optimization":[148]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":11}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-11-01T00:00:00"}