{"id":"https://openalex.org/W4387990116","doi":"https://doi.org/10.1002/j.1875-9114.1996.tb02973.x","title":"Effect of Food on the Pharmacokinetics of a New Hydroxypropyl\u2010\u03b2\u2010Cyclodextrin Formulation of Itraconazole","display_name":"Effect of Food on the Pharmacokinetics of a New Hydroxypropyl\u2010\u03b2\u2010Cyclodextrin Formulation of Itraconazole","publication_year":1996,"publication_date":"1996-05-06","ids":{"openalex":"https://openalex.org/W4387990116","doi":"https://doi.org/10.1002/j.1875-9114.1996.tb02973.x","mag":"1497111856","pmid":"https://pubmed.ncbi.nlm.nih.gov/8726601"},"language":"en","primary_location":{"id":"doi:10.1002/j.1875-9114.1996.tb02973.x","doi":"https://doi.org/10.1002/j.1875-9114.1996.tb02973.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1875-9114.1996.tb02973.x","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028858856","display_name":"Vera J.S. Van de Velde","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Vera J.S. Van de Velde","raw_affiliation_strings":["Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042224904","display_name":"Achiel P. Van Peer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Achiel P. Van Peer","raw_affiliation_strings":["Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113762920","display_name":"J. Heykants","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph J.P. Heykants","raw_affiliation_strings":["Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109910846","display_name":"Robert\u00a0J. H. Woestenborghs","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J.H. Woestenborghs","raw_affiliation_strings":["Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109970127","display_name":"P. Van Rooy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia Van Rooy","raw_affiliation_strings":["Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Drug Metabolism and Pharmacokinetics, Clinical Pharmacology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043432216","display_name":"K. De Beule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Karel L. De Beule","raw_affiliation_strings":["Clinical Research and Development, Janssen Research Foundation, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research and Development, Janssen Research Foundation, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110268418","display_name":"Geert F. M. J. Cauwenbergh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Geert F.M.J. Cauwenbergh","raw_affiliation_strings":["Clinical Research and Development, Janssen Research Foundation, Beerse, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research and Development, Janssen Research Foundation, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5028858856"],"corresponding_institution_ids":[],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":4.4621,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.94970329,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"3","first_page":"424","last_page":"428"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.22339999675750732,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1703999936580658,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/itraconazole","display_name":"itraconazole","score":1.0},{"id":"https://openalex.org/keywords/hydroxypropyl-beta-cyclodextrin","display_name":"hydroxypropyl-\u03b2-cyclodextrin","score":0.9570000171661377},{"id":"https://openalex.org/keywords/food-effect","display_name":"food effect","score":0.5879999995231628},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9079999923706055},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pharmaceutical-formulations","display_name":"drug formulation","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C2778199505","wikidata":"https://www.wikidata.org/wiki/Q2992990","display_name":"Postprandial","level":3,"score":0.8881422281265259},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8474664688110352},{"id":"https://openalex.org/C2777071850","wikidata":"https://www.wikidata.org/wiki/Q411229","display_name":"Itraconazole","level":3,"score":0.805307924747467},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7913769483566284},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.6540766954421997},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.5999789237976074},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5560010075569153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5447555184364319},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5048814415931702},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.4892852008342743},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4510882496833801},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.42533737421035767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25401967763900757},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0473480224609375},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.045766621828079224},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D003912","descriptor_name":"Dextrins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004304","descriptor_name":"Dosage Forms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D017964","descriptor_name":"Itraconazole","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D018565","descriptor_name":"Food-Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/j.1875-9114.1996.tb02973.x","doi":"https://doi.org/10.1002/j.1875-9114.1996.tb02973.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1875-9114.1996.tb02973.x","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},{"id":"pmid:8726601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8726601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy","raw_type":"Clinical Trial"},{"id":"mag:1497111856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8726601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1989617949","https://openalex.org/W2036171561","https://openalex.org/W2037698344","https://openalex.org/W2054862228","https://openalex.org/W2056863521","https://openalex.org/W2069193583","https://openalex.org/W2085792620","https://openalex.org/W2138866540","https://openalex.org/W2143982445","https://openalex.org/W2502670554","https://openalex.org/W3215454188"],"related_works":["https://openalex.org/W1497111856","https://openalex.org/W2170290676","https://openalex.org/W2122658253","https://openalex.org/W1672347066","https://openalex.org/W2138866540","https://openalex.org/W2085792620","https://openalex.org/W7097639485","https://openalex.org/W2608726960","https://openalex.org/W2151464620","https://openalex.org/W13726000"],"abstract_inverted_index":{"STUDY":[0],"OBJECTIVE:":[1],"To":[2],"compare":[3],"the":[4,84,87,124,143,164,194,214],"pharmacokinetics":[5],"of":[6,12,18,86,98,167,171,175,189,217],"a":[7,19],"single":[8],"100-mg":[9],"oral":[10],"dose":[11],"itraconazole":[13,21,100,172],"administered":[14],"as":[15],"10":[16],"ml":[17],"10-mg/ml":[20],"solution":[22,195],"in":[23,177,208],"hydroxypropyl-beta-cyclodextrin":[24],"under":[25,109,113,133,136,142,153,156],"fasting":[26,110,134,154],"versus":[27],"postprandial":[28,114,157],"conditions.":[29,115,138,158],"DESIGN:":[30],"Open-label,":[31],"two-way,":[32],"randomized,":[33],"crossover":[34],"study.":[35,88],"SETTING:":[36],"Janssen":[37],"Research":[38],"Foundation,":[39],"Belgium.":[40],"PATIENTS:":[41],"Twelve":[42],"healthy":[43],"volunteers.":[44],"INTERVENTIONS:":[45],"Blood":[46,67],"samples":[47,70],"were":[48,71,106,130,149],"obtained":[49,72],"for":[50,73,122],"pharmacokinetic":[51],"analyses":[52,79],"immediately":[53],"before":[54],"dosing":[55,219],"and":[56,68,76,82,101,127,146,200],"at":[57,80,83],"regular":[58],"intervals":[59],"up":[60],"to":[61,119,185],"96":[62],"hours":[63],"after":[64],"each":[65],"dose.":[66],"urine":[69],"hematologic,":[74],"biochemical,":[75],"urinary":[77],"safety":[78],"baseline":[81],"end":[85],"MEASUREMENTS":[89],"AND":[90],"MAIN":[91],"RESULTS:":[92],"The":[93,116,139,191],"mean":[94,117,140],"peak":[95,120],"plasma":[96],"concentrations":[97],"both":[99,123],"its":[102,128],"active":[103],"metabolite":[104,129],"hydroxy-itraconazole":[105],"significantly":[107,131,151],"higher":[108,152,165],"conditions":[111],"than":[112,135,155],"times":[118],"concentration":[121],"parent":[125],"compound":[126],"shorter":[132],"nonfasting":[137],"areas":[141],"curve":[144],"(AUC0-infinity":[145],"AUC0-24":[147],"hrs)":[148],"also":[150,197],"CONCLUSIONS:":[159],"Our":[160],"findings":[161],"suggest":[162],"that":[163,193],"bioavailability":[166],"this":[168,218],"new":[169],"formulation":[170],"may":[173],"be":[174],"benefit":[176],"seriously":[178],"ill":[179],"patients":[180],"who":[181],"are":[182],"not":[183,202],"able":[184],"ingest":[186],"adequate":[187],"quantities":[188],"food.":[190],"fact":[192],"was":[196,201],"well":[198],"tolerated":[199],"associated":[203],"with":[204],"clinically":[205],"significant":[206],"changes":[207],"any":[209],"laboratory":[210],"value":[211],"further":[212],"underscores":[213],"potential":[215],"utility":[216],"form.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-10-28T00:00:00"}
