{"id":"https://openalex.org/W4387982055","doi":"https://doi.org/10.1183/13993003.congress-2023.pa4760","title":"Doctors Clinical-Decision making Algorithm for Allergy to Anti-Tuberculosis Drugs in Tunisia","display_name":"Doctors Clinical-Decision making Algorithm for Allergy to Anti-Tuberculosis Drugs in Tunisia","publication_year":2023,"publication_date":"2023-09-09","ids":{"openalex":"https://openalex.org/W4387982055","doi":"https://doi.org/10.1183/13993003.congress-2023.pa4760"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2023.pa4760","doi":"https://doi.org/10.1183/13993003.congress-2023.pa4760","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa4760","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and immunology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075955563","display_name":"A. Saidane","orcid":"https://orcid.org/0009-0003-6810-1908","observed_orcids":["https://orcid.org/0009-0003-6810-1908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ASMA SAIDANE","raw_affiliation_strings":["Pneumology, TUNIS, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology, TUNIS, Tunisia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063974418","display_name":"Selsebil Daboussi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Selsebil Daboussi","raw_affiliation_strings":["Pneumology, TUNIS, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology, TUNIS, Tunisia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067135593","display_name":"Meriem Chaabane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meriem Chaabane","raw_affiliation_strings":["Pneumology, TUNIS, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology, TUNIS, Tunisia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027936893","display_name":"Marwa Kacem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marwa Kacem","raw_affiliation_strings":["Pneumology, TUNIS, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology, TUNIS, Tunisia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022105863","display_name":"N. Boubaker","orcid":"https://orcid.org/0000-0002-9095-5729","observed_orcids":["https://orcid.org/0000-0002-9095-5729"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nouha Boubaker","raw_affiliation_strings":["Pneumology, TUNIS, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology, TUNIS, Tunisia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050713275","display_name":"Chiraz Aichaouia","orcid":"https://orcid.org/0009-0005-5174-4872","observed_orcids":["https://orcid.org/0009-0005-5174-4872"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiraz Aichaouia","raw_affiliation_strings":["Pneumology, TUNIS, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology, TUNIS, Tunisia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114094358","display_name":"Samira Mhamedi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samira Mhamedi","raw_affiliation_strings":["Pneumology, TUNIS, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology, TUNIS, Tunisia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078026916","display_name":"Zied Moatameri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zied Moatameri","raw_affiliation_strings":["Pneumology, TUNIS, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology, TUNIS, Tunisia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA4760","last_page":"PA4760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-hypersensitivity","display_name":"drug hypersensitivity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.9929999709129333},{"id":"https://openalex.org/keywords/clinical-decision-algorithm","display_name":"clinical decision algorithm","score":0.7409999966621399},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/drug-reaction-with-eosinophilia-and-systemic-symptoms","display_name":"DRESS syndrome","score":0.640999972820282},{"id":"https://openalex.org/keywords/anaphylactic-shock","display_name":"anaphylactic shock","score":0.8669999837875366},{"id":"https://openalex.org/keywords/rifampicin","display_name":"rifampicin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"pyrazinamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/isoniazid","display_name":"isoniazid","score":1.0},{"id":"https://openalex.org/keywords/oral-desensitization","display_name":"oral desensitization","score":0.8460000157356262},{"id":"https://openalex.org/keywords/prick-testing","display_name":"prick testing","score":0.5659999847412109},{"id":"https://openalex.org/keywords/physician-survey","display_name":"physician survey","score":0.4269999861717224},{"id":"https://openalex.org/keywords/tunisia","display_name":"Tunisia","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9030919075012207},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.700905978679657},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6058691740036011},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.5814203023910522},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5802319645881653},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.524486243724823},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.5094292759895325},{"id":"https://openalex.org/C2780459521","wikidata":"https://www.wikidata.org/wiki/Q417571","display_name":"Pyrazinamide","level":4,"score":0.47260600328445435},{"id":"https://openalex.org/C2993280485","wikidata":"https://www.wikidata.org/wiki/Q5958765","display_name":"Hypersensitivity reaction","level":2,"score":0.46982526779174805},{"id":"https://openalex.org/C2775933838","wikidata":"https://www.wikidata.org/wiki/Q168800","display_name":"Anaphylaxis","level":3,"score":0.4322492182254791},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.4227522611618042},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.35178500413894653},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3494943678379059},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3469901978969574},{"id":"https://openalex.org/C2776967927","wikidata":"https://www.wikidata.org/wiki/Q423169","display_name":"Isoniazid","level":3,"score":0.3446264863014221},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25815922021865845},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2566438317298889},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24790793657302856},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07433006167411804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2023.pa4760","doi":"https://doi.org/10.1183/13993003.congress-2023.pa4760","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa4760","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Allergy and immunology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3006173792","https://openalex.org/W4416637159","https://openalex.org/W2905616498","https://openalex.org/W2006005480","https://openalex.org/W3170011763","https://openalex.org/W2162236201","https://openalex.org/W2786689674","https://openalex.org/W2070424186","https://openalex.org/W1913791334","https://openalex.org/W1982120315"],"abstract_inverted_index":{"The":[0,80,114],"prevalence":[1],"of":[2,73,126,133,199,205,225],"the":[3,40,131,153,166,170,180,197],"allergic":[4,88,100,154,201,212],"reactions":[5,213],"dur":[6],"to":[7,13,22,29,38,45,86,135,151,193,214],"anti-tuberculosis":[8,41,136,167,185,206,215],"treatment":[9,81,168,207,216],"varies":[10],"from":[11],"(4%)":[12],"(5%)":[14],"in":[15,24,60,84,191,229],"exposed":[16],"patients":[17,97,226],"and":[18,34,122,220],"can":[19],"increase":[20],"up":[21],"(25%)":[23],"HIV":[25],"patients.":[26],"We":[27,63],"aimed":[28],"find":[30],"out":[31],"an":[32],"optimal":[33],"a":[35,51,65,127,157,174,183],"rational":[36],"approach":[37],"manage":[39],"drugs":[42,117,137],"allergy":[43,134,181],"according":[44],"our":[46],"socio-economic":[47],"context.":[48],"This":[49],"is":[50,138,143,160,177,227],"prospective,":[52],"cross-sectional":[53],"study":[54],"including":[55],"physicians":[56],"(pulmonologists,":[57],"dermatologists\u2026)":[58],"experienced":[59],"this":[61],"field.":[62],"created":[64],"semi-structured":[66],"questionnaire":[67],"on":[68],"\"Google":[69],"Forms":[70],"\u00bb.":[71],"Most":[72,102],"them":[74],"(61.6%)":[75],"reported":[76,104,118],"delayed":[77],"hypersensitivity":[78],"reactions.":[79,101],"may":[82],"result":[83],"mild":[85],"moderate":[87],"reaction":[89],"such":[90],"as":[91],"pruritus,":[92],"urticaria,":[93],"skin":[94],"rash.(44.4%)":[95],"treated":[96],"with":[98],"severe":[99,200],"experts":[103,147],"Dress":[105],"syndrome":[106],"(66%).":[107],"Anaphylactic":[108],"shock":[109],"was":[110],"also":[111],"noted":[112],"(13%).":[113],"most":[115],"common":[116],"were":[119],"rifampin,":[120],"pyrazinamide":[121],"isoniazid.":[123],"In":[124,196],"case":[125,198],"strong":[128],"clinical":[129],"suspicion,":[130],"diagnosis":[132],"retained.":[139],"No":[140],"additional":[141],"examination":[142],"currently":[144],"recommended.":[145],"Some":[146],"use":[148],"prick":[149],"tests":[150],"document":[152],"reaction.":[155],"Then,":[156,173],"decision":[158],"algorithm":[159],"established.":[161],"They":[162],"start":[163],"by":[164],"stopping":[165],"until":[169],"symptoms":[171],"disappear.":[172],"reintroduction":[175],"test":[176],"performed.":[178],"If":[179],"concerns":[182],"major":[184],"treatment,":[186],"they":[187],"recommend":[188],"oral":[189],"desensitization":[190],"order":[192],"induce":[194],"tolerance.":[195],"reactions,":[202],"permanent":[203],"discontinuation":[204],"seems":[208],"reasonable.":[209],"To":[210],"conclude,":[211],"are":[217],"often":[218],"unpredictable":[219],"potentially":[221],"serious.":[222],"Rigorous":[223],"monitoring":[224],"necessary":[228],"routine":[230],"practice.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-28T00:00:00"}