{"id":"https://openalex.org/W4387981333","doi":"https://doi.org/10.1183/13993003.congress-2023.pa4476","title":"Late Breaking Abstract - Management of RRTIs in children with the Trained Immunity-based Vaccine MV130: A retrospective study","display_name":"Late Breaking Abstract - Management of RRTIs in children with the Trained Immunity-based Vaccine MV130: A retrospective study","publication_year":2023,"publication_date":"2023-09-09","ids":{"openalex":"https://openalex.org/W4387981333","doi":"https://doi.org/10.1183/13993003.congress-2023.pa4476"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2023.pa4476","doi":"https://doi.org/10.1183/13993003.congress-2023.pa4476","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa4476","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatric respiratory infection and immun.","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077185880","display_name":"Laura Conejero","orcid":"https://orcid.org/0000-0001-6515-9221","observed_orcids":["https://orcid.org/0000-0001-6515-9221"]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura Conejero Hall","raw_affiliation_strings":["Inmunotek S.L, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005608288","display_name":"Karla Marina Montalb\u00e1n-Hern\u00e1ndez","orcid":"https://orcid.org/0000-0002-1612-103X","observed_orcids":["https://orcid.org/0000-0002-1612-103X"]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Karla Montalb\u00e1n","raw_affiliation_strings":["Inmunotek S.L, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093133018","display_name":"Ana Cogollo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Cogollo","raw_affiliation_strings":["Inmunotek S.L, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035418482","display_name":"Patricia Gir\u00f3n de Velasco-Sada","orcid":"https://orcid.org/0000-0003-4003-6828","observed_orcids":["https://orcid.org/0000-0003-4003-6828"]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Patricia Gir\u00f3n De Velasco","raw_affiliation_strings":["Inmunotek S.L, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021851311","display_name":"Raquel Caballero","orcid":"https://orcid.org/0000-0001-5012-0340","observed_orcids":["https://orcid.org/0000-0001-5012-0340"]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Caballero","raw_affiliation_strings":["Inmunotek S.L, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007564721","display_name":"Miguel Casanovas","orcid":"https://orcid.org/0000-0003-2330-3963","observed_orcids":["https://orcid.org/0000-0003-2330-3963"]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Casanovas","raw_affiliation_strings":["Inmunotek S.L, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044711362","display_name":"Jos\u00e9 Luis Subiza","orcid":"https://orcid.org/0000-0002-0134-5321","observed_orcids":["https://orcid.org/0000-0002-0134-5321"]},"institutions":[{"id":"https://openalex.org/I4210105381","display_name":"Inmunotek (Spain)","ror":"https://ror.org/01e2spe61","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210105381"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Luis Subiza","raw_affiliation_strings":["Inmunotek S.L, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inmunotek S.L, Madrid, Spain","institution_ids":["https://openalex.org/I4210105381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210105381"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA4476","last_page":"PA4476"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13770","display_name":"Pediatric health and respiratory diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-respiratory-tract-infections","display_name":"recurrent respiratory infections","score":0.9120000004768372},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6790000200271606},{"id":"https://openalex.org/keywords/antibiotic-use","display_name":"antibiotic use","score":0.7760000228881836},{"id":"https://openalex.org/keywords/overuse-of-antibiotics","display_name":"antibiotic overuse","score":0.8489999771118164},{"id":"https://openalex.org/keywords/respiratory-infection-prevention","display_name":"respiratory infection prevention","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C119060515","wikidata":"https://www.wikidata.org/wiki/Q1916617","display_name":"Interquartile range","level":2,"score":0.8232768774032593},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7259699702262878},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.6278476119041443},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5779678821563721},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5558748245239258},{"id":"https://openalex.org/C2776012195","wikidata":"https://www.wikidata.org/wiki/Q754447","display_name":"Respiratory tract infections","level":3,"score":0.4880274832248688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46424636244773865},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.4626425504684448},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.43933340907096863},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3925849199295044},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3792625367641449},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.21212825179100037},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.19239512085914612},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.16811567544937134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16044774651527405}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2023.pa4476","doi":"https://doi.org/10.1183/13993003.congress-2023.pa4476","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa4476","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Paediatric respiratory infection and immun.","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387979997","https://openalex.org/W4391600173","https://openalex.org/W7116729689","https://openalex.org/W7117090083","https://openalex.org/W2892308401","https://openalex.org/W70646192","https://openalex.org/W2001178580","https://openalex.org/W3119654520","https://openalex.org/W2999328076","https://openalex.org/W2011013142"],"abstract_inverted_index":{"Background:":[0],"Respiratory":[1],"infections":[2,106,165],"are":[3,15,31],"the":[4,16,38,44,57,100,162,168,184,207,237,242],"most":[5,9],"common":[6],"and":[7,29,73,89,143,149,183,241],"potentially":[8],"severe":[10],"type":[11],"of":[12,21,24,40,46,60,69,85,102,131,140,164,173,189,220,239,244],"infections.":[13],"Antibiotics":[14],"mainstay":[17],"treatment,":[18],"despite":[19],"many":[20],"them":[22],"being":[23],"viral":[25],"aetiology.":[26],"Antibiotic":[27,211],"overuse":[28],"misuse":[30],"posing":[32],"a":[33,51,82,171,187,218],"global":[34],"threat":[35],"due":[36],"to":[37,77,128,179,193,224],"generation":[39],"multidrug":[41],"resistance.":[42],"Thus,":[43],"development":[45],"alternative":[47],"strategies":[48],"has":[49,74],"become":[50],"priority.":[52],"Aim:":[53],"MV130":[54,97,153,159,231],"falls":[55],"within":[56],"new":[58],"concept":[59],"mucosal":[61],"Trained":[62],"Immunity-based":[63],"Vaccine":[64],"(TIbV).":[65],"It":[66],"is":[67,232],"composed":[68],"heat-inactivated":[70],"whole-cell":[71],"bacteria":[72],"been":[75],"shown":[76],"confer":[78],"heterologous":[79],"protections":[80],"against":[81],"broad":[83],"range":[84,176],"pathogens,":[86],"including":[87,122],"viruses":[88],"bacteria,":[90],"through":[91],"trained":[92],"immunity.":[93],"We":[94],"hypothesised":[95],"that":[96],"could":[98],"reduce":[99],"number":[101,139,163],"recurrent":[103],"respiratory":[104],"tract":[105],"(RRTIs)":[107],"and,":[108],"therefore,":[109],"antibiotic":[110,144,245],"consumption":[111,212],"in":[112,167,205,236,247],"children":[113,124],"suffering":[114,133],"from":[115,125,134,217],"RRTIs.":[116],"Methods:":[117],"A":[118],"retrospective":[119],"multicentre":[120],"study":[121],"186":[123],"6":[126],"months":[127,147,151],"17":[129],"years":[130],"age":[132],"RRTIs":[135,240],"was":[136,156,213],"conducted.":[137],"The":[138],"infectious":[141],"episodes":[142,200],"courses":[145,228],"12":[146,150],"prior":[148],"following":[152],"sublingual":[154],"immunisation":[155],"assessed.":[157],"Results:":[158],"significantly":[160,215],"reduced":[161,216],"both":[166],"upper":[169],"(from":[170,186],"median":[172,188,219],"5.0":[174,190],"[interquartile":[175],"(IQR),":[177],"4.0-6.0]":[178,192],"1.0":[180],"[IQR,":[181,191,195],"0.0-2.0]),":[182],"lower":[185],"2.0":[194],"1.0-3.0])":[196],"airways":[197],"(p<0.0001).":[198,229],"Infectious":[199],"decreased":[201],"more":[202],"than":[203],"50%":[204],"all":[206],"assessed":[208],"aged":[209],"groups.":[210],"also":[214],"4.0":[221],"(IQR,":[222,226],"3.0-5.0)":[223],"0.0":[225],"0.0-1.0)":[227],"Conclusion:":[230],"an":[233],"effective":[234],"strategy":[235],"prevention":[238],"reduction":[243],"uptake":[246],"children.":[248]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-10-28T00:00:00"}