{"id":"https://openalex.org/W4387981050","doi":"https://doi.org/10.1183/13993003.congress-2023.pa3858","title":"Intrapleural use of tissue plasminogen activator and DNase in management of pleural infection.","display_name":"Intrapleural use of tissue plasminogen activator and DNase in management of pleural infection.","publication_year":2023,"publication_date":"2023-09-09","ids":{"openalex":"https://openalex.org/W4387981050","doi":"https://doi.org/10.1183/13993003.congress-2023.pa3858"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2023.pa3858","doi":"https://doi.org/10.1183/13993003.congress-2023.pa3858","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa3858","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory infections and bronchiectasis","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Prashanth Shetty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801905138","display_name":"Luton and Dunstable Hospital","ror":"https://ror.org/05b81av32","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800375139","https://openalex.org/I2801905138"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Prashanth Shetty","raw_affiliation_strings":["Luton and Dunstable University Hospital, Luton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luton and Dunstable University Hospital, Luton, United Kingdom","institution_ids":["https://openalex.org/I2801905138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024039987","display_name":"Alex Francioni","orcid":"https://orcid.org/0009-0005-8495-0306","observed_orcids":["https://orcid.org/0009-0005-8495-0306"]},"institutions":[{"id":"https://openalex.org/I2801905138","display_name":"Luton and Dunstable Hospital","ror":"https://ror.org/05b81av32","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800375139","https://openalex.org/I2801905138"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alex Francioni","raw_affiliation_strings":["Luton and Dunstable University Hospital, Luton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luton and Dunstable University Hospital, Luton, United Kingdom","institution_ids":["https://openalex.org/I2801905138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113032234","display_name":"Adeel Jafri","orcid":"https://orcid.org/0009-0004-1280-8506","observed_orcids":["https://orcid.org/0009-0004-1280-8506"]},"institutions":[{"id":"https://openalex.org/I2801905138","display_name":"Luton and Dunstable Hospital","ror":"https://ror.org/05b81av32","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800375139","https://openalex.org/I2801905138"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Adeel Jafri","raw_affiliation_strings":["Luton and Dunstable University Hospital, Luton, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luton and Dunstable University Hospital, Luton, United Kingdom","institution_ids":["https://openalex.org/I2801905138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801905138"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA3858","last_page":"PA3858"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11738","display_name":"Ultrasound in Clinical Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pleural-infection","display_name":"pleural infection","score":0.9869999885559082},{"id":"https://openalex.org/keywords/alteplase","display_name":"alteplase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/dnase","display_name":"DNase","score":0.7720000147819519},{"id":"https://openalex.org/keywords/thrombolysis","display_name":"thrombolysis","score":0.8270000219345093},{"id":"https://openalex.org/keywords/surgical-referral","display_name":"surgical referral","score":0.5960000157356262},{"id":"https://openalex.org/keywords/30-day-mortality","display_name":"30-day mortality","score":0.7419999837875366},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.49900001287460327}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9471821784973145},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5457356572151184},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.48577621579170227},{"id":"https://openalex.org/C160022790","wikidata":"https://www.wikidata.org/wiki/Q2964004","display_name":"Cardiothoracic surgery","level":2,"score":0.4436783492565155},{"id":"https://openalex.org/C195910791","wikidata":"https://www.wikidata.org/wiki/Q1324077","display_name":"Medical record","level":2,"score":0.41906973719596863},{"id":"https://openalex.org/C3019730217","wikidata":"https://www.wikidata.org/wiki/Q3631290","display_name":"Pulmonary infection","level":2,"score":0.4153212010860443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35378700494766235}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2023.pa3858","doi":"https://doi.org/10.1183/13993003.congress-2023.pa3858","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa3858","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Respiratory infections and bronchiectasis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2154565989","https://openalex.org/W2029095790","https://openalex.org/W2133581405","https://openalex.org/W2133023987","https://openalex.org/W7097599173","https://openalex.org/W2082965965","https://openalex.org/W2115372900","https://openalex.org/W2990249619","https://openalex.org/W1840463562","https://openalex.org/W2906474437"],"abstract_inverted_index":{"Introduction:":[0],"Pleural":[1],"infection":[2,71,130],"is":[3,41,236],"associated":[4],"with":[5,16,69],"considerable":[6],"morbidity":[7],"and":[8,18,38,64,76,83,109,115,120,133,142,155,170,189,203,233,259],"mortality,":[9],"20":[10],"to":[11,54],"30%":[12],"fail":[13],"initial":[14,47],"treatment":[15,202],"antibiotics":[17],"chest":[19],"drain":[20],"who":[21,72],"may":[22],"require":[23,187],"surgery.":[24,62,195,208],"MIST":[25],"2":[26],"trial":[27],"showed":[28,250],"that":[29],"use":[30],"of":[31,46,177,210,243,253],"intrapleural":[32,74,139],"t-PA(t-PA)":[33],"&":[34],"DNase":[35],"was":[36,92,221],"effective":[37,238],"safe.":[39],"It":[40],"often":[42],"used":[43],"on":[44],"failure":[45],"medical":[48],"management":[49,242],"as":[50],"an":[51,180,237],"adjunct":[52],"prior":[53],"surgery":[55],"or":[56],"in":[57,87,150,153,157,182,240,247],"patients":[58,68,149,178,212],"not":[59,186,199],"fit":[60],"for":[61,84,102,128,207],"Aims":[63],"objectives:":[65],"We":[66],"reviewed":[67,119],"pleural":[70,103,129,244],"had":[73,179,193,213],"t-PA":[75,232],"Dnase":[77,144,234],"-":[78,161],"their":[79,183],"outcomes,":[80],"surgical":[81,254],"referral":[82],"any":[85,214],"complications":[86,215,258],"our":[88,211,248],"centre.":[89],"Methods:":[90],"This":[91],"a":[93],"retrospective":[94],"study,":[95],"examined":[96],"data":[97,121],"from":[98,216,227],"adult":[99],"inpatients":[100,125],"treated":[101,127],"infection,":[104],"between":[105,131],"1st":[106],"January":[107],"2018":[108,132],"31st":[110],"December":[111],"2020.":[112,134],"Inpatient":[113],"notes":[114],"outpatient":[116],"letters":[117],"were":[118,126,168,173,204],"collated.":[122],"Results:":[123],"83":[124],"Of":[135],"these,":[136],"18":[137],"received":[138],"10mg":[140],"Alteplase":[141],"5mg":[143],"over":[145],"3":[146],"days":[147],"(6":[148],"2018,":[151],"5":[152],"2019":[154],"7":[156],"2020).":[158],"Average":[159],"age":[160],"64":[162],"years":[163],"old":[164],"(33-94).":[165],"61%":[166],"(n=11)":[167],"male":[169],"39%":[171],"(n=7)":[172],"female.":[174],"72.2%":[175],"(n=13)":[176],"improvement":[181],"imaging,":[184],"did":[185,198],"surgery,":[188],"discharged.":[190],"15.8%":[191],"(n=3)":[192],"cardiothoracic":[194],"11.1%":[196],"(n=2)":[197],"improve":[200],"after":[201],"deemed":[205],"unsuitable":[206],"None":[209],"above":[217],"treatment.":[218],"30-day":[219],"mortality":[220],"5.6%":[222],"(n=1)-":[223],"this":[224],"patient":[225],"dying":[226],"unrelated":[228],"causes.":[229],"Conclusions:":[230],"Intrapleural":[231],"therapy":[235],"tool":[239],"the":[241],"infection;":[245],"experience":[246],"centre":[249],"reduced":[251],"frequency":[252],"referral,":[255],"no":[256],"major":[257],"good":[260],"outcomes.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2023-10-28T00:00:00"}
