{"id":"https://openalex.org/W4387979871","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2222","title":"CD4+ T cells from EBUS/TBNA samples express different immunomodulatory molecules in patients with sarcoidosis.","display_name":"CD4+ T cells from EBUS/TBNA samples express different immunomodulatory molecules in patients with sarcoidosis.","publication_year":2023,"publication_date":"2023-09-09","ids":{"openalex":"https://openalex.org/W4387979871","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2222"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2023.pa2222","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2222","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa2222","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sarcoidosis and other granulomatous ILD/DPLD","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049208576","display_name":"Agata Raniszewska","orcid":"https://orcid.org/0000-0003-3917-6030","observed_orcids":["https://orcid.org/0000-0003-3917-6030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agata Raniszewska","raw_affiliation_strings":["Military Institute of Medicine, Department of Internal Medicine and Hematology Laboratory of Flow Cytometry, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Institute of Medicine, Department of Internal Medicine and Hematology Laboratory of Flow Cytometry, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055038501","display_name":"El\u017cbieta Rutkowska","orcid":"https://orcid.org/0000-0002-2172-3609","observed_orcids":["https://orcid.org/0000-0002-2172-3609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"El\u017cbieta Rutkowska","raw_affiliation_strings":["Military Institute of Medicine, Department of Internal Medicine and Hematology Laboratory of Flow Cytometry, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Institute of Medicine, Department of Internal Medicine and Hematology Laboratory of Flow Cytometry, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063169593","display_name":"Iwona Kwiecie\u0144","orcid":"https://orcid.org/0000-0003-2266-971X","observed_orcids":["https://orcid.org/0000-0003-2266-971X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iwona Kwiecie\u0144","raw_affiliation_strings":["Military Institute of Medicine, Department of Internal Medicine and Hematology Laboratory of Flow Cytometry, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Institute of Medicine, Department of Internal Medicine and Hematology Laboratory of Flow Cytometry, Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093132977","display_name":"Piotr Miklusz","orcid":"https://orcid.org/0009-0002-3706-1985","observed_orcids":["https://orcid.org/0009-0002-3706-1985"]},"institutions":[{"id":"https://openalex.org/I4210146974","display_name":"Wojskowy Instytut Medyczny","ror":"https://ror.org/04zvqhj72","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210146974"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Miklusz","raw_affiliation_strings":["Military Institute of Medicine, Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Institute of Medicine, Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210146974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042164149","display_name":"Karina Jahnz\u2010R\u00f3\u017cyk","orcid":"https://orcid.org/0000-0002-3505-1858","observed_orcids":["https://orcid.org/0000-0002-3505-1858"]},"institutions":[{"id":"https://openalex.org/I4210146974","display_name":"Wojskowy Instytut Medyczny","ror":"https://ror.org/04zvqhj72","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210146974"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Karina Jahnz-R\u00f3\u017cyk","raw_affiliation_strings":["Military Institute of Medicine, Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Institute of Medicine, Department of Internal Medicine, Pulmonology, Allergology and Clinical Immunology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210146974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078285983","display_name":"Piotr Rzepecki","orcid":"https://orcid.org/0000-0003-0694-390X","observed_orcids":["https://orcid.org/0000-0003-0694-390X"]},"institutions":[{"id":"https://openalex.org/I4210146974","display_name":"Wojskowy Instytut Medyczny","ror":"https://ror.org/04zvqhj72","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210146974"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Piotr Rzepecki","raw_affiliation_strings":["Military Institute of Medicine, Department of Internal Medicine and Hematology, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Military Institute of Medicine, Department of Internal Medicine and Hematology, Warsaw, Poland","institution_ids":["https://openalex.org/I4210146974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA2222","last_page":"PA2222"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11571","display_name":"Sarcoidosis and Beryllium Toxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcoidosis","display_name":"sarcoidosis","score":1.0},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.7770000100135803},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/ctla-4","display_name":"CTLA-4","score":1.0},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.7860000133514404},{"id":"https://openalex.org/keywords/immunomodulatory-molecules","display_name":"immunomodulatory molecules","score":0.8960000276565552},{"id":"https://openalex.org/keywords/t-cell-dysfunction","display_name":"T cell dysfunction","score":0.781000018119812},{"id":"https://openalex.org/keywords/lymph-node-granulomas","display_name":"lymph node granulomas","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lung-granulomas","display_name":"lung granulomas","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ebus-tbna","display_name":"EBUS-TBNA","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.7609999775886536},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.8351932764053345},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6829672455787659},{"id":"https://openalex.org/C2781301800","wikidata":"https://www.wikidata.org/wiki/Q193894","display_name":"Sarcoidosis","level":2,"score":0.6718817353248596},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6514126658439636},{"id":"https://openalex.org/C21705690","wikidata":"https://www.wikidata.org/wiki/Q2907609","display_name":"CTLA-4","level":4,"score":0.5790671110153198},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5360984802246094},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5325018167495728},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4820307493209839},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47496888041496277},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4734729826450348},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.45496827363967896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44251203536987305},{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.4304659962654114},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40403592586517334},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35484036803245544},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32340872287750244},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3150453567504883},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14825686812400818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2023.pa2222","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2222","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa2222","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sarcoidosis and other granulomatous ILD/DPLD","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3216668351","https://openalex.org/W4312946789","https://openalex.org/W4229363825","https://openalex.org/W4283575455","https://openalex.org/W2413225757","https://openalex.org/W4404100464","https://openalex.org/W2900787410","https://openalex.org/W3217731570","https://openalex.org/W3096604845","https://openalex.org/W4387979140"],"abstract_inverted_index":{"Sarcoidosis":[0],"(SA)":[1],"is":[2],"a":[3,114],"systemic":[4],"disease":[5],"that":[6],"affects":[7],"different":[8],"organs":[9],"including":[10],"lymph":[11],"nodes":[12],"(LNs).":[13],"Lymphocytes":[14],"play":[15],"an":[16],"important":[17],"role":[18,194],"in":[19,24,34,40,75,101,122,126,130,153,160,175,201],"the":[20,47,52,85,166,180,192],"formation":[21],"of":[22,28,46,54,117,138,146,168,172,195,203],"granulomas":[23,100,125],"SA.":[25,78,204],"Enhanced":[26],"expression":[27,39,53,116,137,145],"inhibitory":[29],"molecules":[30],"has":[31],"been":[32],"described":[33],"lung":[35],"cancer.":[36],"However,":[37],"their":[38],"SA":[41,186],"remains":[42],"unknown.":[43],"The":[44],"aim":[45],"study":[48,164],"was":[49],"to":[50],"investigate":[51],"immunomodulatory":[55],"molecules:":[56],"CD28,":[57,111,196],"Tim3,":[58],"PD-1,":[59],"CTLA-4,":[60],"Lag3":[61],"on":[62],"CD4":[63,103,132,181],"and":[64,70,119,140,142,159,198],"CD8":[65,154],"T":[66,87,104,133,155,182],"cells":[67,88,105,134,156,174,183],"from":[68,84,106,157],"EBUS/TBNA":[69,107,176],"peripheral":[71],"blood":[72],"(PB)":[73],"samples":[74,108],"patients":[76,97,123],"with":[77,80,98,124],"Patients":[79],"cancer":[81],"were":[82,90,150],"excluded":[83],"study.":[86],"characteristics":[89],"determined":[91],"by":[92],"multiparameter":[93],"flow":[94,169],"cytometry.":[95],"In":[96],"confirmed":[99,165],"LNs":[102,131,158],"expressed":[109],"more":[110],"but":[112,128],"had":[113,135,143],"lower":[115,144],"PD-1":[118,139,197],"CTLA-4.":[120],"Contrariwise,":[121],"lungs,":[127],"not":[129,151],"higher":[136],"CTLA-4":[141,199],"CD28.":[147],"Such":[148],"differences":[149],"observed":[152],"PB":[161],"samples.":[162,177],"Recent":[163],"advantage":[167],"cytometric":[170],"analysis":[171],"immune":[173],"We":[178],"demonstrated":[179],"dysfunction":[184],"among":[185],"patients.":[187],"Finally,":[188],"our":[189],"results":[190],"suggest":[191],"potential":[193],"pathways":[200],"development":[202]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-28T00:00:00"}