{"id":"https://openalex.org/W4387979837","doi":"https://doi.org/10.1183/13993003.congress-2023.pa1242","title":"Early detection of lung cancer by metabolomic analysis applied to serum samples before clinical diagnosis in high-risk patients.","display_name":"Early detection of lung cancer by metabolomic analysis applied to serum samples before clinical diagnosis in high-risk patients.","publication_year":2023,"publication_date":"2023-09-09","ids":{"openalex":"https://openalex.org/W4387979837","doi":"https://doi.org/10.1183/13993003.congress-2023.pa1242"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2023.pa1242","doi":"https://doi.org/10.1183/13993003.congress-2023.pa1242","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa1242","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108444421","display_name":"Carolina Gotera","orcid":"https://orcid.org/0000-0002-7349-4078","observed_orcids":["https://orcid.org/0000-0002-7349-4078"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carolina Gotera","raw_affiliation_strings":["IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz. ISCIII-CIBERES, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz. ISCIII-CIBERES, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104188752","display_name":"Antonio Pereira Vega","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129320","display_name":"Hospital Juan Ram\u00f3n Jim\u00e9nez","ror":"https://ror.org/03fpqn433","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210129320"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Antonio Pereira Vega","raw_affiliation_strings":["Hospital Juan Ramon Jim\u00e9nez, Huelva, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Juan Ramon Jim\u00e9nez, Huelva, Spain","institution_ids":["https://openalex.org/I4210129320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072585524","display_name":"Tamara Garc\u00eda\u2010Barrera","orcid":"https://orcid.org/0000-0002-8859-9550","observed_orcids":["https://orcid.org/0000-0002-8859-9550"]},"institutions":[{"id":"https://openalex.org/I78880903","display_name":"Universidad de Huelva","ror":"https://ror.org/03a1kt624","country_code":"ES","type":"education","lineage":["https://openalex.org/I78880903"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Tamara Garc\u00eda Barrera","raw_affiliation_strings":["Departamento de Qu\u00edmica. Universidad de Huelva, Huelva, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica. Universidad de Huelva, Huelva, Spain","institution_ids":["https://openalex.org/I78880903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028810182","display_name":"Jos\u00e9 Mar\u00eda Mar\u00edn","orcid":"https://orcid.org/0000-0001-9096-2294","observed_orcids":["https://orcid.org/0000-0001-9096-2294"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210114530","display_name":"Hospital Universitario Miguel Servet","ror":"https://ror.org/01r13mt55","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210114530"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Mar\u00eda Mar\u00edn Trigo","raw_affiliation_strings":["Hospital Miguel Servet-IISAragon.ISCIII-CIBERES, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Miguel Servet-IISAragon.ISCIII-CIBERES, Zaragoza, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210114530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020331755","display_name":"Ciro Casanova Macario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088232","display_name":"Hospital Universitario Nuestra Se\u00f1ora de Candelaria","ror":"https://ror.org/005a3p084","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210088232"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ciro Casanova Macario","raw_affiliation_strings":["Hospital Ntra. Sra. de la Candelaria, Sta Cruz de Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Ntra. Sra. de la Candelaria, Sta Cruz de Tenerife, Spain","institution_ids":["https://openalex.org/I4210088232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065623766","display_name":"Borja G. Cos\u00edo","orcid":"https://orcid.org/0000-0002-6388-8209","observed_orcids":["https://orcid.org/0000-0002-6388-8209"]},"institutions":[{"id":"https://openalex.org/I4210099160","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias","ror":"https://ror.org/0119pby33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210099160","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210126021","display_name":"Health Research Institute of the Balearic Islands","ror":"https://ror.org/037xbgq12","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210126021"]},{"id":"https://openalex.org/I4210152826","display_name":"Hospital Universitario Son Espases","ror":"https://ror.org/05jmd4043","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210152826"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Borja Garc\u00eda-Cos\u00edo Piqueras","raw_affiliation_strings":["Hospital Son Espases.IdISBa. ISCIII-CIBERES, Palma de Mallorca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Son Espases.IdISBa. ISCIII-CIBERES, Palma de Mallorca, Spain","institution_ids":["https://openalex.org/I4210099160","https://openalex.org/I4210126021","https://openalex.org/I4210152826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012189091","display_name":"Isabel Mir Viladrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087626","display_name":"Hospital Son Llatzer","ror":"https://ror.org/003ez4w63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210087626"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel Mir Viladrich","raw_affiliation_strings":["Hospital Son Ll\u00e0tzer, Palma de Mallorca, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Son Ll\u00e0tzer, Palma de Mallorca, Spain","institution_ids":["https://openalex.org/I4210087626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030724148","display_name":"Ingrid Solanes","orcid":"https://orcid.org/0000-0001-8506-908X","observed_orcids":["https://orcid.org/0000-0001-8506-908X"]},"institutions":[{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ingrid Solanes Garc\u00eda","raw_affiliation_strings":["Hospital Santa Creu i Sant Pau, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Santa Creu i Sant Pau, Barcelona, Spain","institution_ids":["https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025095426","display_name":"Jos\u00e9 Luis G\u00f3mez\u2010Ariza","orcid":"https://orcid.org/0000-0001-7997-7444","observed_orcids":["https://orcid.org/0000-0001-7997-7444"]},"institutions":[{"id":"https://openalex.org/I78880903","display_name":"Universidad de Huelva","ror":"https://ror.org/03a1kt624","country_code":"ES","type":"education","lineage":["https://openalex.org/I78880903"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Luis G\u00f3mez Ariza","raw_affiliation_strings":["Departamento de Qu\u00edmica. Universidad de Huelva, Huelva, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica. Universidad de Huelva, Huelva, Spain","institution_ids":["https://openalex.org/I78880903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033314276","display_name":"Jos\u00e9 Lu\u00eds L\u00f3pez-Campos","orcid":"https://orcid.org/0000-0003-1703-1367","observed_orcids":["https://orcid.org/0000-0003-1703-1367"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Luis L\u00f3pez-Campos Bodineau","raw_affiliation_strings":["Hospital Virgen del Roc\u00edo. Instituto de Biomedicina de Sevilla (IBiS). ISCIII-CIBERES, Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Virgen del Roc\u00edo. Instituto de Biomedicina de Sevilla (IBiS). ISCIII-CIBERES, Sevilla, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006970392","display_name":"Luis Miguel Seijo","orcid":"https://orcid.org/0000-0001-9344-728X","observed_orcids":["https://orcid.org/0000-0001-9344-728X"]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Seijo Maceiras","raw_affiliation_strings":["Clinica Universidad de Navarra, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Universidad de Navarra, Madrid, Spain","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109109731","display_name":"Nuria Feu Collado","orcid":"https://orcid.org/0000-0003-4439-4243","observed_orcids":["https://orcid.org/0000-0003-4439-4243"]},"institutions":[{"id":"https://openalex.org/I4210093628","display_name":"Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba","ror":"https://ror.org/00j9b6f88","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210093628"]},{"id":"https://openalex.org/I4210123675","display_name":"Hospital Universitario Reina Sof\u00eda","ror":"https://ror.org/02vtd2q19","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210123675"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nuria Feu Collado","raw_affiliation_strings":["Hospital Reina Sof\u00eda. Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, C\u00f3rdoba, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Reina Sof\u00eda. Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba, C\u00f3rdoba, Spain","institution_ids":["https://openalex.org/I4210093628","https://openalex.org/I4210123675"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078565688","display_name":"Carlos Cabrera L\u00f3pez","orcid":"https://orcid.org/0000-0002-6251-4854","observed_orcids":["https://orcid.org/0000-0002-6251-4854"]},"institutions":[{"id":"https://openalex.org/I4210098027","display_name":"Hospital Universitario de Gran Canaria Doctor Negr\u00edn","ror":"https://ror.org/00s4vhs88","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210098027"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Cabrera L\u00f3pez","raw_affiliation_strings":["Hospital Doctor Negr\u00edn, Las Palmas De Gran Canarias, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Doctor Negr\u00edn, Las Palmas De Gran Canarias, Spain","institution_ids":["https://openalex.org/I4210098027"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035086833","display_name":"Carlos Antonio Amado Diago","orcid":"https://orcid.org/0000-0002-5598-1753","observed_orcids":["https://orcid.org/0000-0002-5598-1753"]},"institutions":[{"id":"https://openalex.org/I4210099858","display_name":"Marqu\u00e9s de Valdecilla University Hospital","ror":"https://ror.org/01w4yqf75","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210099858"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Amado Diago","raw_affiliation_strings":["Hospital Marqu\u00e9s de Valdecilla, Santander, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Marqu\u00e9s de Valdecilla, Santander, Spain","institution_ids":["https://openalex.org/I4210099858"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052883631","display_name":"Amparo Romero Plaza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104708","display_name":"Fundaci\u00f3n Hospital Manacor","ror":"https://ror.org/01dmnvb64","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210104708"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Amparo Romero Plaza","raw_affiliation_strings":["Hospital de Manacor, Manacor, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Manacor, Manacor, Spain","institution_ids":["https://openalex.org/I4210104708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069057018","display_name":"Luis Alejandro Padr\u00f3n Fraysse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129320","display_name":"Hospital Juan Ram\u00f3n Jim\u00e9nez","ror":"https://ror.org/03fpqn433","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210129320"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Alejandro Padr\u00f3n Fraysse","raw_affiliation_strings":["Hospital Juan Ramon Jim\u00e9nez, Huelva, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Juan Ramon Jim\u00e9nez, Huelva, Spain","institution_ids":["https://openalex.org/I4210129320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091462975","display_name":"Bel\u00e9n Callej\u00f3n Leblic","orcid":"https://orcid.org/0000-0001-8100-3358","observed_orcids":["https://orcid.org/0000-0001-8100-3358"]},"institutions":[{"id":"https://openalex.org/I78880903","display_name":"Universidad de Huelva","ror":"https://ror.org/03a1kt624","country_code":"ES","type":"education","lineage":["https://openalex.org/I78880903"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Belen Callej\u00f3n Leblic","raw_affiliation_strings":["Departamento de Qu\u00edmica. Universidad de Huelva, Huelva, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica. Universidad de Huelva, Huelva, Spain","institution_ids":["https://openalex.org/I78880903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049758158","display_name":"Eduardo M\u00e1rquez Mart\u00edn","orcid":"https://orcid.org/0000-0001-5715-7613","observed_orcids":["https://orcid.org/0000-0001-5715-7613"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eduardo M\u00e1rquez Mart\u00edn","raw_affiliation_strings":["Hospital Virgen del Roc\u00edo. Instituto de Biomedicina de Sevilla (IBiS). ISCIII-CIBERES, Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Virgen del Roc\u00edo. Instituto de Biomedicina de Sevilla (IBiS). ISCIII-CIBERES, Sevilla, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110721393","display_name":"Margarita Mar\u00edn Royo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margarita Mar\u00edn Royo","raw_affiliation_strings":["Hospital de Castell\u00f3n, Castell\u00f3n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Castell\u00f3n, Castell\u00f3n, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007347458","display_name":"Antonia Llunell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonia Llunell Casanovas","raw_affiliation_strings":["Hospital de Terrasa, Terrasa, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Terrasa, Terrasa, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005202076","display_name":"Eva Balcells","orcid":"https://orcid.org/0000-0001-5334-549X","observed_orcids":["https://orcid.org/0000-0001-5334-549X"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210099160","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias","ror":"https://ror.org/0119pby33","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210099160","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Eva Balcells Vilarnau","raw_affiliation_strings":["Hospital del Mar.ISCIII-CIBERES, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital del Mar.ISCIII-CIBERES, Barcelona, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210099160","https://openalex.org/I4210130874"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078930451","display_name":"Cristina Mart\u00ednez Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-0369-4920","observed_orcids":["https://orcid.org/0000-0002-0369-4920"]},"institutions":[{"id":"https://openalex.org/I4210133994","display_name":"Hospital Universitario Central de Asturias","ror":"https://ror.org/03v85ar63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210133994","https://openalex.org/I4405258403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Mart\u00ednez Gonz\u00e1lez","raw_affiliation_strings":["Hospital Central de Asturias, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Central de Asturias, Oviedo, Spain","institution_ids":["https://openalex.org/I4210133994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024513196","display_name":"Juan Bautista G\u00e1ldiz Iturri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210137412","display_name":"Hospital de Cruces","ror":"https://ror.org/03nzegx43","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210125364","https://openalex.org/I4210137412"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Bautista Gald\u00edz Iturri","raw_affiliation_strings":["Hospital Universitario de Cruces.ISCIII-CIBERES, Baracaldo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Cruces.ISCIII-CIBERES, Baracaldo, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210137412"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026638655","display_name":"Celia Lac\u00e1rcel Bautista","orcid":"https://orcid.org/0009-0008-7694-133X","observed_orcids":["https://orcid.org/0009-0008-7694-133X"]},"institutions":[{"id":"https://openalex.org/I4210117781","display_name":"Complejo Hospitalario de Ja\u00e9n","ror":"https://ror.org/02ecxgj38","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210117781"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Celia Lac\u00e1rcel Bautista","raw_affiliation_strings":["Hospital Universitario de Ja\u00e9n, Ja\u00e9n, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Universitario de Ja\u00e9n, Ja\u00e9n, Spain","institution_ids":["https://openalex.org/I4210117781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5141602156","display_name":"Juan Pablo De Torres Tajes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Pablo De Torres Tajes","raw_affiliation_strings":["Clinica Universidad de Navarra, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinica Universidad de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093132969","display_name":"Isabel D\u00edaz Olivarez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129320","display_name":"Hospital Juan Ram\u00f3n Jim\u00e9nez","ror":"https://ror.org/03fpqn433","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210129320"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Isabel D\u00edaz Olivarez","raw_affiliation_strings":["Hospital Juan Ramon Jim\u00e9nez, Huelva, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Juan Ramon Jim\u00e9nez, Huelva, Spain","institution_ids":["https://openalex.org/I4210129320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024467694","display_name":"Germ\u00e1n Peces-Barba Romero","orcid":"https://orcid.org/0000-0002-7543-1812","observed_orcids":["https://orcid.org/0000-0002-7543-1812"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Germ\u00e1n Peces-Barba Romero","raw_affiliation_strings":["IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz. ISCIII-CIBERES, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz. ISCIII-CIBERES, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":22,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA1242","last_page":"PA1242"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.953000009059906},{"id":"https://openalex.org/keywords/serum-metabolomics","display_name":"serum metabolomics","score":0.796999990940094},{"id":"https://openalex.org/keywords/blood-metabolites","display_name":"blood metabolites","score":0.5659999847412109},{"id":"https://openalex.org/keywords/high-risk-patients","display_name":"high-risk patients","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pre-diagnostic-biomarkers","display_name":"pre-diagnostic biomarkers","score":0.628000020980835},{"id":"https://openalex.org/keywords/oxalic-acid","display_name":"oxalic acid","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glyceric-acid","display_name":"glyceric acid","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2779349466","wikidata":"https://www.wikidata.org/wiki/Q181619","display_name":"Glutamine","level":3,"score":0.7120994329452515},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6727662086486816},{"id":"https://openalex.org/C2776655898","wikidata":"https://www.wikidata.org/wiki/Q424906","display_name":"Glyceric acid","level":3,"score":0.6652954816818237},{"id":"https://openalex.org/C2781346138","wikidata":"https://www.wikidata.org/wiki/Q184832","display_name":"Oxalic acid","level":2,"score":0.598162055015564},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.47633200883865356},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4577109217643738},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4451022148132324},{"id":"https://openalex.org/C2777573094","wikidata":"https://www.wikidata.org/wiki/Q483752","display_name":"Valine","level":3,"score":0.4334821105003357},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.43241047859191895},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4177599251270294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3711611032485962},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3021236062049866},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.29082998633384705},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.26848137378692627},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2023.pa1242","doi":"https://doi.org/10.1183/13993003.congress-2023.pa1242","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa1242","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7127241162","https://openalex.org/W4297543245","https://openalex.org/W4225252360","https://openalex.org/W3194259836","https://openalex.org/W7214099267","https://openalex.org/W2095583778","https://openalex.org/W1846033450","https://openalex.org/W2889658094","https://openalex.org/W2564788885","https://openalex.org/W2898094534"],"abstract_inverted_index":{"To":[0],"analyse":[1],"the":[2,12,36,46,58,61,87,105,120,187,203,227,240,245],"metabolomic":[3,71,224],"profile":[4,72],"in":[5,11,35,119,128,210,226],"high-risk":[6],"subjects":[7,22,94],"before":[8,38,53,64,108,229,247],"LC":[9,24,39,65,248],"diagnosis":[10,26,54,66,109],"CHAIN":[13],"and":[14,30,56,79,111,162,170,174,217,234,236],"DEPRECAP":[15],"cohort.":[16],"M&M:":[17],"Blood":[18],"samples":[19,138,167],"(BS)":[20],"from":[21,57,92],"with":[23,32,102,141,186,202],"at":[25,98,104,139,168],"(t0)":[27],"were":[28,42,95,100,117,145,213],"selected":[29],"compared":[31,101],"BS":[33,49,91,97,103],"obtained":[34],"years":[37,52,228],"diagnosis.":[40],"These":[41],"classified":[43],"according":[44],"to":[45,60,68,85,113,132,172,176],"time":[47,246],"of":[48,244],"collection:":[50],"three":[51],"(t-3)":[55],"4th":[59],"7th":[62],"year":[63],"(t-4":[67],"t-7).":[69],"A":[70],"was":[73,83],"analysed":[74],"using":[75],"advanced":[76],"mass":[77],"spectrometry":[78],"chromatography":[80],"techniques.":[81],"PLS-DA":[82],"used":[84],"compare":[86],"groups.":[88],"Results:":[89],"72":[90],"38":[93],"analysed.":[96],"t0":[99,140,169,173],"two":[106],"periods":[107],"[(t-3":[110],"t-4":[112,171,175],"7)].":[114],"Significant":[115],"differences":[116,183],"found":[118,181,222],"analysis":[121],"identifying":[122,148],"14":[123,149],"altered":[124,151,200],"metabolites":[125,201],"potentially":[126,150],"implicated":[127],"developing":[129],"LC,":[130],"belonging":[131],"8":[133],"metabolic":[134],"pathways.":[135],"When":[136,164],"comparing":[137,165],"t-3,":[142],"both":[143,211],"groups":[144],"significantly":[146],"different,":[147],"metabolites,":[152],"mostly":[153],"Oxalic":[154,195,231],"acid;":[155,158,191,196],"Valine;":[156],"Stearic":[157],"Cholesterol;":[159],"Phosphoric":[160],"acid":[161],"Glutamine.":[163],"blood":[166],"-7":[177],"beforehand,":[178],"we":[179],"also":[180],"significant":[182,205],"(Figure":[184],"2)":[185],"following":[188],"metabolites:":[189],"Glyceric":[190,237],"Acetamide;":[192],"Glycine;":[193],"Glutamine;":[194],"Isocitric":[197],"acid.":[198,219],"The":[199],"most":[204,241],"impact":[206],"on":[207],"ROC":[208],"curves":[209],"analyses":[212],"oxalic":[214],"acid,":[215],"glutamine":[216],"glyceric":[218],"Conclusions:":[220],"We":[221],"changing":[223],"profiles":[225],"CP.":[230],"Acid,":[232],"Glutamine":[233,235],"Acid":[238],"are":[239],"relevant,":[242],"regardless":[243]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2023-10-28T00:00:00"}