{"id":"https://openalex.org/W4387979467","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2275","title":"Assessment of five-year emphysema progression in the COPDGene study by Emphysema Severity Index (ESI), a novel spirometry-derived parameter","display_name":"Assessment of five-year emphysema progression in the COPDGene study by Emphysema Severity Index (ESI), a novel spirometry-derived parameter","publication_year":2023,"publication_date":"2023-09-09","ids":{"openalex":"https://openalex.org/W4387979467","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2275"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2023.pa2275","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2275","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa2275","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical respiratory physiology, exercise and functional imaging","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045112331","display_name":"Massimo Pistolesi","orcid":"https://orcid.org/0000-0003-1777-2624","observed_orcids":["https://orcid.org/0000-0003-1777-2624"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Pistolesi","raw_affiliation_strings":["University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083732015","display_name":"Matteo Paoletti","orcid":"https://orcid.org/0000-0002-1221-7747","observed_orcids":["https://orcid.org/0000-0002-1221-7747"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Paoletti","raw_affiliation_strings":["University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029312514","display_name":"Mariaelena Occhipinti","orcid":"https://orcid.org/0000-0003-3324-4063","observed_orcids":["https://orcid.org/0000-0003-3324-4063"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mariaelena Occhipinti","raw_affiliation_strings":["University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065764475","display_name":"Federico Lavorini","orcid":"https://orcid.org/0000-0002-3293-2123","observed_orcids":["https://orcid.org/0000-0002-3293-2123"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federico Lavorini","raw_affiliation_strings":["University of Florence, Florence, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011343670","display_name":"Elizabeth Anne Regan","orcid":"https://orcid.org/0000-0003-0624-9184","observed_orcids":["https://orcid.org/0000-0003-0624-9184"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A Regan","raw_affiliation_strings":["National Jewish Health, Denver, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Health, Denver, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023897162","display_name":"David A. Lynch","orcid":"https://orcid.org/0000-0002-6329-2325","observed_orcids":["https://orcid.org/0000-0002-6329-2325"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Lynch","raw_affiliation_strings":["National Jewish Health, Denver, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Health, Denver, United States","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035524361","display_name":"Edwin K. Silverman","orcid":"https://orcid.org/0000-0002-3641-3822","observed_orcids":["https://orcid.org/0000-0002-3641-3822"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin K Silverman","raw_affiliation_strings":["Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050358373","display_name":"James D. Crapo","orcid":"https://orcid.org/0000-0002-1262-5230","observed_orcids":["https://orcid.org/0000-0002-1262-5230"]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D Crapo","raw_affiliation_strings":["National Jewish Health, Denver, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Health, Denver, United States","institution_ids":["https://openalex.org/I3019586173"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA2275","last_page":"PA2275"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emphysema-progression","display_name":"emphysema progression","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.7540000081062317},{"id":"https://openalex.org/keywords/maximal-expiratory-flow-volume-curve","display_name":"maximal expiratory flow-volume curve","score":0.8840000033378601},{"id":"https://openalex.org/keywords/spirometry","display_name":"spirometry","score":0.8220000267028809},{"id":"https://openalex.org/keywords/quantitative-computed-tomography","display_name":"quantitative computed tomography","score":0.6370000243186951},{"id":"https://openalex.org/keywords/airway-disease","display_name":"airway disease","score":0.5550000071525574},{"id":"https://openalex.org/keywords/fev1-decline","display_name":"FEV1 decline","score":0.7960000038146973},{"id":"https://openalex.org/keywords/respiratory-mortality","display_name":"respiratory mortality","score":0.44699999690055847},{"id":"https://openalex.org/keywords/copdgene","display_name":"COPDGene","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C2780333948","wikidata":"https://www.wikidata.org/wiki/Q653305","display_name":"Spirometry","level":3,"score":0.7480905055999756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7224488258361816},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6040045619010925},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.542238175868988},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.4779001474380493},{"id":"https://openalex.org/C2992836489","wikidata":"https://www.wikidata.org/wiki/Q188605","display_name":"Pulmonary emphysema","level":3,"score":0.4471467137336731},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.3275025486946106},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.32700833678245544},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.18919667601585388},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.12799131870269775}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2023.pa2275","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2275","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa2275","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical respiratory physiology, exercise and functional imaging","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3022738567","https://openalex.org/W4387980378","https://openalex.org/W2947683949","https://openalex.org/W4200502480","https://openalex.org/W4410277367","https://openalex.org/W4282944484","https://openalex.org/W7152561765","https://openalex.org/W3082283539","https://openalex.org/W4220830629","https://openalex.org/W7214300077"],"abstract_inverted_index":{"Background":[0],"Emphysema":[1],"severity":[2,48],"on":[3,104],"CT":[4,42,94,105,142,232],"predicts":[5,111],"five-year":[6,35,133,156,189,222],"functional":[7],"impairment":[8],"and":[9,75,89,93,110,139,149,160,171,180,194,205],"reduced":[10],"survival":[11],"in":[12,79,114],"the":[13,46,60,83,118],"COPDGene":[14,84],"study":[15,85],"Aim":[16],"We":[17,44,126],"ascertain":[18],"whether":[19],"mathematical":[20],"modeling":[21],"of":[22,82,117,135,144,191,207,228],"airway":[23,146,192],"biomechanical":[24],"properties":[25],"by":[26,40,58,64,128],"maximal":[27],"expiratory":[28],"flow/volume":[29],"curve":[30],"(MEFV)":[31],"data":[32,95,137],"could":[33],"predict":[34],"emphysema":[36,47,102,150,181,195,223],"progression":[37,134,157,173,190,201,224],"as":[38,68],"assessed":[39],"quantitative":[41],"Methods":[43],"measured":[45],"index":[49],"(ESI),":[50],"a":[51,115],"parameter":[52],"ranging":[53],"from":[54],"0":[55],"to":[56,226],"10,":[57],"fitting":[59],"MEFV":[61],"descending":[62],"limb":[63],"an":[65],"algorithm":[66],"using":[67],"input":[69],"variables":[70],"PEF,":[71],"FEF25,":[72],"FEF50,":[73],"FEF75,":[74],"FVC":[76],"absolute":[77],"values":[78],"4884":[80],"subjects":[81],"who":[86],"had":[87,162,202],"enrollment":[88],"5-year":[90],"follow-up":[91],"spirometry":[92],"available.":[96],"ESI":[97,199,217],"is":[98],"significantly":[99],"related":[100],"with":[101],"quantitated":[103],"(Occhipinti,":[106],"Respir":[107,123],"Res":[108],"2020)":[109],"respiratory":[112],"mortality":[113],"sample":[116],"Swedish":[119],"general":[120],"population":[121],"(Luoto,":[122],"Med":[124],"2022).":[125],"evaluated":[127],"principal":[129],"component":[130],"analysis":[131],"(PCA)":[132],"spirometric":[136],"(FEV1,ESI)":[138],"co-registered":[140],"inspiratory-expiratory":[141],"metrics":[143],"small":[145],"disease":[147,178,193],"(%fSAD)":[148],"(%pLDA)":[151,182],"Results":[152],"PCA":[153],"vectors":[154,183],"indicating":[155,168,187],"for":[158],"FEV1":[159,170],"%fSAD":[161,172],"same":[163,203],"direction":[164,204],"but":[165],"opposite":[166],"versus":[167,206],"that":[169,188,210,227],"have":[174],"negative":[175],"relationship.":[176],"Airway":[177],"(FEV1,%fSAD)":[179],"were":[184],"90\u00b0":[185],"rotated":[186],"are":[196,212],"independent.":[197],"Conversely,":[198],"vector":[200],"%pLDA,":[208],"suggesting":[209],"they":[211],"capturing":[213],"similar":[214],"information":[215,220],"Conclusions":[216],"can":[218],"derive":[219],"about":[221],"comparable":[225],"%pLDA":[229],"obtained":[230],"at":[231]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2023-10-28T00:00:00"}
