{"id":"https://openalex.org/W4387979341","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2333","title":"Immune dysregulation, Th1/Th2 switch failure and Rheumatological predisposition after COVID-19: Certainty and Reality!!","display_name":"Immune dysregulation, Th1/Th2 switch failure and Rheumatological predisposition after COVID-19: Certainty and Reality!!","publication_year":2023,"publication_date":"2023-09-09","ids":{"openalex":"https://openalex.org/W4387979341","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2333"},"language":"en","primary_location":{"id":"doi:10.1183/13993003.congress-2023.pa2333","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2333","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa2333","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102024558","display_name":"Shital Vishnu Patil","orcid":"https://orcid.org/0000-0003-0502-5904","observed_orcids":["https://orcid.org/0000-0003-0502-5904"]},"institutions":[{"id":"https://openalex.org/I2802663916","display_name":"Maharashtra Institute of Medical Science and Research","ror":"https://ror.org/03szqc633","country_code":"IN","type":"education","lineage":["https://openalex.org/I2802663916"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shital Vishnu Patil","raw_affiliation_strings":["Assistant Professor, Venkatesh chest Hospital Latur, Latur (Maharashtra), India","Pulmonary Medicine, MIMSR Medical college & Venkatesh Chest Hospital Latur, Latur (Maharashtra), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Venkatesh chest Hospital Latur, Latur (Maharashtra), India","institution_ids":[]},{"raw_affiliation_string":"Pulmonary Medicine, MIMSR Medical college & Venkatesh Chest Hospital Latur, Latur (Maharashtra), India","institution_ids":["https://openalex.org/I2802663916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108873308","display_name":"Swati Shital Patil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802663916","display_name":"Maharashtra Institute of Medical Science and Research","ror":"https://ror.org/03szqc633","country_code":"IN","type":"education","lineage":["https://openalex.org/I2802663916"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Swati Shital Patil","raw_affiliation_strings":["Assistant Professor, Venkatesh chest Hospital Latur, Latur (Maharashtra), India","Pulmonary Medicine, MIMSR Medical college & Venkatesh Chest Hospital Latur, Latur (Maharashtra), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Venkatesh chest Hospital Latur, Latur (Maharashtra), India","institution_ids":[]},{"raw_affiliation_string":"Pulmonary Medicine, MIMSR Medical college & Venkatesh Chest Hospital Latur, Latur (Maharashtra), India","institution_ids":["https://openalex.org/I2802663916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032889702","display_name":"Sham Toshniwal","orcid":"https://orcid.org/0000-0001-8048-4006","observed_orcids":["https://orcid.org/0000-0001-8048-4006"]},"institutions":[{"id":"https://openalex.org/I2800157045","display_name":"NIMS University","ror":"https://ror.org/05tw0x522","country_code":"IN","type":"education","lineage":["https://openalex.org/I2800157045"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sham Toshniwal","raw_affiliation_strings":["Professor, Internal Medicine, NIMS Medical college Jaipur, Jaipur Rajasthan India, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Internal Medicine, NIMS Medical college Jaipur, Jaipur Rajasthan India, India","institution_ids":["https://openalex.org/I2800157045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052932441","display_name":"Abhijit Acharya","orcid":"https://orcid.org/0000-0001-9741-4178","observed_orcids":["https://orcid.org/0000-0001-9741-4178"]},"institutions":[{"id":"https://openalex.org/I2802663916","display_name":"Maharashtra Institute of Medical Science and Research","ror":"https://ror.org/03szqc633","country_code":"IN","type":"education","lineage":["https://openalex.org/I2802663916"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Abhijit Acharya","raw_affiliation_strings":["Professor, Pathology, MIMSR Medical college Latur, Latur (Maharashtra), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Pathology, MIMSR Medical college Latur, Latur (Maharashtra), India","institution_ids":["https://openalex.org/I2802663916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058441236","display_name":"Gajanan Gondhali","orcid":"https://orcid.org/0000-0003-1331-8432","observed_orcids":["https://orcid.org/0000-0003-1331-8432"]},"institutions":[{"id":"https://openalex.org/I2802663916","display_name":"Maharashtra Institute of Medical Science and Research","ror":"https://ror.org/03szqc633","country_code":"IN","type":"education","lineage":["https://openalex.org/I2802663916"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gajanan Gondhali","raw_affiliation_strings":["Professor, Internal Medicine, MIMSR Medical college Latur, Latur (Maharashtra), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Internal Medicine, MIMSR Medical college Latur, Latur (Maharashtra), India","institution_ids":["https://openalex.org/I2802663916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102911282","display_name":"Rajesh Patil","orcid":"https://orcid.org/0000-0001-6681-7855","observed_orcids":["https://orcid.org/0000-0001-6681-7855"]},"institutions":[{"id":"https://openalex.org/I2802663916","display_name":"Maharashtra Institute of Medical Science and Research","ror":"https://ror.org/03szqc633","country_code":"IN","type":"education","lineage":["https://openalex.org/I2802663916"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rajesh Patil","raw_affiliation_strings":["Professor, Internal Medicine, MIMSR Medical college Latur, Latur (Maharashtra), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor, Internal Medicine, MIMSR Medical college Latur, Latur (Maharashtra), India","institution_ids":["https://openalex.org/I2802663916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016283426","display_name":"Shubhangi Khule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802663916","display_name":"Maharashtra Institute of Medical Science and Research","ror":"https://ror.org/03szqc633","country_code":"IN","type":"education","lineage":["https://openalex.org/I2802663916"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shubhangi Khule","raw_affiliation_strings":["Assistant Professor, Pathology, MIMSR Medical college Latur, Latur (Maharashtra), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Pathology, MIMSR Medical college Latur, Latur (Maharashtra), India","institution_ids":["https://openalex.org/I2802663916"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5104106651","display_name":"Deepak Patil","orcid":"https://orcid.org/0000-0002-7783-3954","observed_orcids":["https://orcid.org/0000-0002-7783-3954"]},"institutions":[{"id":"https://openalex.org/I2802663916","display_name":"Maharashtra Institute of Medical Science and Research","ror":"https://ror.org/03szqc633","country_code":"IN","type":"education","lineage":["https://openalex.org/I2802663916"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Deepak Patil","raw_affiliation_strings":["Assistant Professor, Internal Medicine, , MIMSR Medical college Latur, Latur (Maharashtra), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Assistant Professor, Internal Medicine, , MIMSR Medical college Latur, Latur (Maharashtra), India","institution_ids":["https://openalex.org/I2802663916"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"PA2333","last_page":"PA2333"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.5303000211715698,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.3073999881744385,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.09390000253915787,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.9330000281333923},{"id":"https://openalex.org/keywords/rheumatic-manifestations","display_name":"rheumatic manifestations","score":0.7929999828338623},{"id":"https://openalex.org/keywords/prolonged-fever","display_name":"persistent fever","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"tuberculosis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/disseminated-tuberculosis","display_name":"disseminated tuberculosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cd4-cd8-ratio","display_name":"CD4/CD8 ratio","score":0.9649999737739563},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.821271538734436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7694072723388672},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6917147636413574},{"id":"https://openalex.org/C2780194698","wikidata":"https://www.wikidata.org/wiki/Q6005429","display_name":"Immune dysregulation","level":3,"score":0.5374411344528198},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4882343113422394},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47324854135513306},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.41998153924942017},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3592776656150818},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10729053616523743},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1183/13993003.congress-2023.pa2333","doi":"https://doi.org/10.1183/13993003.congress-2023.pa2333","is_oa":false,"landing_page_url":"https://doi.org/10.1183/13993003.congress-2023.pa2333","pdf_url":null,"source":{"id":"https://openalex.org/S4210207896","display_name":"European Respiratory Journal","issn_l":"0903-1936","issn":["0903-1936","1399-3003"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317833","host_organization_name":"European Respiratory Society","host_organization_lineage":["https://openalex.org/P4310317833"],"host_organization_lineage_names":["European Respiratory Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pathology and functional genomics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4387249578","https://openalex.org/W4387707003","https://openalex.org/W4412694159","https://openalex.org/W4366974975","https://openalex.org/W4206683529","https://openalex.org/W4383264895","https://openalex.org/W4404100821","https://openalex.org/W4321438710","https://openalex.org/W4353094827","https://openalex.org/W4390750996"],"abstract_inverted_index":{"Background:":[0],"Immune":[1,195],"dysregulation":[2],"during":[3],"and":[4,65,71,174,181],"after":[5,199],"COVID-19":[6],"is":[7,16,197,210,222],"known":[8],"with":[9,43,48,60,77,87,97,149,154,156,169,187],"deleterious":[10],"effects.":[11],"Role":[12],"of":[13,29,204],"reboot":[14],"system":[15],"unknown":[17],"Methods:":[18],"Prospective,":[19],"observational":[20],"study,":[21],"included":[22],"300":[23],"cases":[24,42,47,59,76,89,104,148,153,155,168,186],"in":[25,31,63,68,80,84,143,172,177,190,206],"four":[26,145],"different":[27],"groups":[28,86],"patients":[30],"post":[32,69,124,178],"covid":[33,78,92,125,179,188],"care":[34],"setting":[35],"to":[36,107,219],"assess":[37],"immune":[38,230],"dysregulation.":[39],"Groups":[40],"includes":[41],"rheumatological":[44,150],"manifestations":[45,151],"post-covid,":[46],"recurrent":[49,157],"seasonal":[50,158],"viral":[51,159],"infections":[52,160],"post-covid":[53,161],"(never":[54,162],"experienced":[55,163],"before":[56,164],"covid-19":[57,98,165],"infection),":[58],"persistent":[61,170],"fever":[62,171],"TB":[64,67,173,176],"disseminated":[66,175],"covid,":[70],"asymptomatic":[72,88,182],"or":[73,94,183,216],"minimally":[74,184],"symptomatic":[75,185],"vaccination":[79,189,205],"recent":[81,191],"past.":[82],"Comparison":[83],"all":[85,144],"not":[90,95,211],"received":[91],"vaccine":[93],"infected":[96],"measured":[99],"by":[100,111],"antibody":[101],"test.":[102],"All":[103],"were":[105],"subjected":[106],"TH1/TH2":[108],"balance":[109],"measurement":[110],"CD4,":[112],"CD8,":[113],"CD4/CD8":[114],"ratio,":[115],"INF-\u03b3,":[116],"&":[117,202],"IL-4,":[118],"IL-5,":[119],"IL-13":[120],"respectively":[121],"Results:":[122],"In":[123],"setting,":[126],"Th1/Th2":[127,132,208],"homeostasis":[128],"desynchrony":[129],"(categorised":[130],"as":[131,226,228],"normal,":[133],"Th1":[134],"hyperactive/Th2":[135],"suppressed,":[136],"Th1Supressed":[137],"andTh2":[138],"hyperactive)":[139],"has":[140],"been":[141],"documented":[142,198,227],"study":[146],"groups,":[147],"(p<0.00001),":[152,167,180],"infection)":[166],"past":[192],"(p<0.00001)":[193],"Conclusion:":[194],"alteration":[196],"natural":[200],"infection":[201],"effect":[203],"restoring":[207],"interplay":[209],"known.":[212],"The":[213],"\u2018reboot":[214],"system\u2019":[215],"time":[217],"required":[218],"restore":[220],"9normalcy9":[221],"a":[223],"real":[224],"concern":[225],"our":[229],"phenomenon":[231]},"counts_by_year":[{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-28T00:00:00"}