{"id":"https://openalex.org/W4387976050","doi":"https://doi.org/10.58838/2075-1230-2023-101-1s-51-56","title":"Efficacy of photodynamic therapy in an experimental mice tuberculosis model","display_name":"Efficacy of photodynamic therapy in an experimental mice tuberculosis model","publication_year":2023,"publication_date":"2023-10-27","ids":{"openalex":"https://openalex.org/W4387976050","doi":"https://doi.org/10.58838/2075-1230-2023-101-1s-51-56"},"language":"en","primary_location":{"id":"doi:10.58838/2075-1230-2023-101-1s-51-56","doi":"https://doi.org/10.58838/2075-1230-2023-101-1s-51-56","is_oa":true,"landing_page_url":"http://dx.doi.org/10.58838/2075-1230-2023-101-1s-51-56","pdf_url":"https://www.tibl-journal.com/jour/article/download/1756/1764","source":{"id":"https://openalex.org/S4210212927","display_name":"Tuberculosis and lung diseases","issn_l":"1728-2993","issn":["1728-2993","2075-1230","2542-1506"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312615","host_organization_name":"NEW TERRA Publishing House","host_organization_lineage":["https://openalex.org/P4310312615"],"host_organization_lineage_names":["NEW TERRA Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis and Lung Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.tibl-journal.com/jour/article/download/1756/1764","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111022712","display_name":"\u0421. \u041d. \u0411\u0435\u043b\u043e\u0433\u043e\u0440\u043e\u0434\u0446\u0435\u0432","orcid":"https://orcid.org/0000-0002-3481-3793","observed_orcids":["https://orcid.org/0000-0002-3481-3793"]},"institutions":[{"id":"https://openalex.org/I4210094961","display_name":"Novosibirsk Tuberculosis Research Institute","ror":"https://ror.org/00mcf6y06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210094961"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. N. Belogorodtsev","raw_affiliation_strings":["Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health"],"raw_orcid":"https://orcid.org/0000-0002-3481-3793","affiliations":[{"raw_affiliation_string":"Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health","institution_ids":["https://openalex.org/I4210094961","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075747070","display_name":"Alexander P. Lykov","orcid":"https://orcid.org/0000-0003-4897-8676","observed_orcids":["https://orcid.org/0000-0003-4897-8676"]},"institutions":[{"id":"https://openalex.org/I4210094961","display_name":"Novosibirsk Tuberculosis Research Institute","ror":"https://ror.org/00mcf6y06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210094961"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. P. Lykov","raw_affiliation_strings":["Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health"],"raw_orcid":"https://orcid.org/0000-0003-4897-8676","affiliations":[{"raw_affiliation_string":"Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health","institution_ids":["https://openalex.org/I4210094961","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010520127","display_name":"\u0421. \u0414. \u041d\u0438\u043a\u043e\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-4319-3717","observed_orcids":["https://orcid.org/0000-0002-4319-3717"]},"institutions":[{"id":"https://openalex.org/I145597306","display_name":"Novosibirsk State Medical University","ror":"https://ror.org/00d167n54","country_code":"RU","type":"education","lineage":["https://openalex.org/I145597306"]},{"id":"https://openalex.org/I4210094961","display_name":"Novosibirsk Tuberculosis Research Institute","ror":"https://ror.org/00mcf6y06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210094961"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. D. Nikonov","raw_affiliation_strings":["Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health; Novosibirsk State Medical University V. Zelman Institute of Medicine and Psychology"],"raw_orcid":"https://orcid.org/0000-0002-4319-3717","affiliations":[{"raw_affiliation_string":"Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health; Novosibirsk State Medical University V. Zelman Institute of Medicine and Psychology","institution_ids":["https://openalex.org/I145597306","https://openalex.org/I4210094961","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110957295","display_name":"D. \u0410. Bredikhin","orcid":"https://orcid.org/0000-0001-8047-8765","observed_orcids":["https://orcid.org/0000-0001-8047-8765"]},"institutions":[{"id":"https://openalex.org/I145597306","display_name":"Novosibirsk State Medical University","ror":"https://ror.org/00d167n54","country_code":"RU","type":"education","lineage":["https://openalex.org/I145597306"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"D. A. Bredikhin","raw_affiliation_strings":["Novosibirsk State Medical University V. Zelman Institute of Medicine and Psychology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novosibirsk State Medical University V. Zelman Institute of Medicine and Psychology","institution_ids":["https://openalex.org/I145597306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048302833","display_name":"Ya. Sh. Schwartz","orcid":"https://orcid.org/0000-0002-3036-9795","observed_orcids":["https://orcid.org/0000-0002-3036-9795"]},"institutions":[{"id":"https://openalex.org/I4210094961","display_name":"Novosibirsk Tuberculosis Research Institute","ror":"https://ror.org/00mcf6y06","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210094961"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ya. Sh. Schwartz","raw_affiliation_strings":["Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health","Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health, Novosibirsk, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3036-9795","affiliations":[{"raw_affiliation_string":"Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health","institution_ids":["https://openalex.org/I4210094961","https://openalex.org/I4210117042"]},{"raw_affiliation_string":"Novosibirsk Tuberculosis Research Institute, Russian Ministry of Health, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210094961","https://openalex.org/I4210117042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1873,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.38811538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"101","issue":"1S","first_page":"51","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.020999999716877937,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial-photodynamic-therapy","display_name":"antimicrobial photodynamic therapy","score":0.9739999771118164},{"id":"https://openalex.org/keywords/photosensitizers","display_name":"photosensitizers","score":0.9319999814033508},{"id":"https://openalex.org/keywords/multidrug-resistant-tuberculosis","display_name":"multidrug-resistant tuberculosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/red-laser-irradiation","display_name":"red laser irradiation","score":0.6819999814033508},{"id":"https://openalex.org/keywords/mycobacterial-load","display_name":"mycobacterial load","score":0.9269999861717224},{"id":"https://openalex.org/keywords/granulomatous-inflammation","display_name":"granulomatous inflammation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/optical-absorption","display_name":"optical absorption","score":0.453000009059906},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.7860495448112488},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.7676607370376587},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7178401350975037},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5103279948234558},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.47751370072364807},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4728850722312927},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4677595794200897},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.42706090211868286},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3378266394138336},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2706795632839203},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.19652292132377625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13425210118293762},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09445956349372864},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.58838/2075-1230-2023-101-1s-51-56","doi":"https://doi.org/10.58838/2075-1230-2023-101-1s-51-56","is_oa":true,"landing_page_url":"http://dx.doi.org/10.58838/2075-1230-2023-101-1s-51-56","pdf_url":"https://www.tibl-journal.com/jour/article/download/1756/1764","source":{"id":"https://openalex.org/S4210212927","display_name":"Tuberculosis and lung diseases","issn_l":"1728-2993","issn":["1728-2993","2075-1230","2542-1506"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312615","host_organization_name":"NEW TERRA Publishing House","host_organization_lineage":["https://openalex.org/P4310312615"],"host_organization_lineage_names":["NEW TERRA Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis and Lung Diseases","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:ce5871436a15438dbb60f26cae13459a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ce5871436a15438dbb60f26cae13459a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0422\u0443\u0431\u0435\u0440\u043a\u0443\u043b\u0435\u0437 \u0438 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043b\u0451\u0433\u043a\u0438\u0445, Vol 101, Iss 1S, Pp 51-56 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.58838/2075-1230-2023-101-1s-51-56","doi":"https://doi.org/10.58838/2075-1230-2023-101-1s-51-56","is_oa":true,"landing_page_url":"http://dx.doi.org/10.58838/2075-1230-2023-101-1s-51-56","pdf_url":"https://www.tibl-journal.com/jour/article/download/1756/1764","source":{"id":"https://openalex.org/S4210212927","display_name":"Tuberculosis and lung diseases","issn_l":"1728-2993","issn":["1728-2993","2075-1230","2542-1506"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312615","host_organization_name":"NEW TERRA Publishing House","host_organization_lineage":["https://openalex.org/P4310312615"],"host_organization_lineage_names":["NEW TERRA Publishing House"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tuberculosis and Lung Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387976050.pdf","grobid_xml":"https://content.openalex.org/works/W4387976050.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2026889493","https://openalex.org/W2060944383","https://openalex.org/W2337398547","https://openalex.org/W2772947739","https://openalex.org/W2785899953","https://openalex.org/W2952932872","https://openalex.org/W2966974768","https://openalex.org/W3009426500","https://openalex.org/W3048996356","https://openalex.org/W3119049079","https://openalex.org/W3153713346","https://openalex.org/W3160712519","https://openalex.org/W3167118986","https://openalex.org/W4385725366"],"related_works":["https://openalex.org/W1981731800","https://openalex.org/W4385725366","https://openalex.org/W4416828621","https://openalex.org/W1978186060","https://openalex.org/W2948531130","https://openalex.org/W4317826667","https://openalex.org/W2319268528","https://openalex.org/W3167118986","https://openalex.org/W2137609107","https://openalex.org/W3138770230"],"abstract_inverted_index":{"The":[0,105,135],"objective:":[1],"to":[2,157,190],"study":[3],"the":[4,19,34,67,80,100,114,138,149,179],"efficacy":[5],"of":[6,22,40,61,64,69,84,90,92,107,110,123,137,145,152,170,194],"antimicrobial":[7],"photodynamic":[8],"therapy":[9],"(APDT)":[10],"using":[11,132],"hydroxyaluminum":[12,47],"phthalocyanine":[13,48],"(Photosens)":[14],"as":[15,119,121,166],"a":[16,142,159,167],"photosensitizer":[17],"in":[18,25,99,177],"experimental":[20,139],"model":[21],"tuberculosis":[23,42,202],"infection":[24,196],"mice.":[26],"Subjects":[27],"and":[28,49,73,95,103,116,126,173],"Methods.":[29],"Balb/cmice":[30],"were":[31,54,75],"infected":[32],"with":[33,46,203],"multiple":[35],"drug":[36],"resistant":[37],"(MDR)":[38],"strain":[39],"M.":[41,201],"Beijing":[43],"BO/W148.":[44],"APDT":[45,65,85,184],"red":[50],"laser":[51,111],"light":[52,108,146,153],"exposure":[53],"started":[55],"on":[56,66],"Day":[57,78],"45.":[58],"A":[59],"total":[60],"4":[62],"sessions":[63],"projection":[68],"both":[70],"lungs,":[71,101,124],"liver":[72,102,125],"spleen":[74,127],"performed.":[76],"On":[77],"60,":[79],"therapeutic":[81,161],"eff":[82],"ect":[83],"was":[86,128],"assessed":[87],"by":[88,113,130,200],"evaluation":[89],"severity":[91],"mycobacterial":[93,171],"load":[94,172],"specific":[96,174],"granulomatous":[97],"infiltration":[98],"spleen.":[104],"absorption":[106],"energy":[109],"radiation":[112],"chest":[115],"abdominal":[117],"walls,":[118],"well":[120],"tissues":[122,136],"determined":[129],"photometry":[131],"afluovisor.":[133],"Results.":[134],"animal":[140],"retain":[141],"significant":[143,168],"amount":[144],"energy,":[147],"however,":[148],"residual":[150],"value":[151],"transmission":[154],"is":[155],"sufficient":[156],"provide":[158],"pronounced":[160],"effect":[162],"which":[163],"manifests":[164],"itself":[165],"decrease":[169],"inflammatory":[175],"process":[176],"all":[178],"studied":[180],"internal":[181],"organs.":[182],"Conclusion.":[183],"may":[185],"be":[186],"an":[187],"effective":[188],"tool":[189],"treat":[191],"some":[192],"forms":[193],"tuberculous":[195],"including":[197],"those":[198],"caused":[199],"MDR.":[204]},"counts_by_year":[{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-28T00:00:00"}