{"id":"https://openalex.org/W4387974792","doi":"https://doi.org/10.31083/j.jmcm0601002","title":"Genetic Alterations of C-MYC Proto-Oncogene and Their Involvement in the Occurrence and Progression of Oral Cavity Cancers in Senegal","display_name":"Genetic Alterations of C-MYC Proto-Oncogene and Their Involvement in the Occurrence and Progression of Oral Cavity Cancers in Senegal","publication_year":2023,"publication_date":"2023-10-25","ids":{"openalex":"https://openalex.org/W4387974792","doi":"https://doi.org/10.31083/j.jmcm0601002"},"language":"en","primary_location":{"id":"doi:10.31083/j.jmcm0601002","doi":"https://doi.org/10.31083/j.jmcm0601002","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.jmcm0601002","pdf_url":"https://www.imrpress.com/journal/JMCM/6/1/10.31083/j.jmcm0601002/pdf","source":{"id":"https://openalex.org/S4210197488","display_name":"Journal of Molecular and Clinical Medicine","issn_l":"2616-3632","issn":["2616-3632","2617-5282"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular and Clinical Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.imrpress.com/journal/JMCM/6/1/10.31083/j.jmcm0601002/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076722019","display_name":"Diao Ba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":true,"raw_author_name":"Diao Ba","raw_affiliation_strings":["Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110957101","display_name":"Fatimata Binetou Rassoule Mbaye","orcid":"https://orcid.org/0000-0002-1098-9858","observed_orcids":["https://orcid.org/0000-0002-1098-9858"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Fatimata Mbaye","raw_affiliation_strings":["Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076608324","display_name":"Henri Diatta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Henri Diatta","raw_affiliation_strings":["Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014290385","display_name":"Mame Diarra Samb","orcid":"https://orcid.org/0000-0001-8891-8091","observed_orcids":["https://orcid.org/0000-0001-8891-8091"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Mame Diarra Samb","raw_affiliation_strings":["Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114027186","display_name":"Mouhamadou Makhtar Ndiaye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Mouhamadou Makhtar Ndiaye","raw_affiliation_strings":["Department of Maxillofacial Surgery and Stomatology, Faculty of Medicine, Pharmacy and Stomatology, Cheikh Anta Diop University, 5005 Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maxillofacial Surgery and Stomatology, Faculty of Medicine, Pharmacy and Stomatology, Cheikh Anta Diop University, 5005 Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113660720","display_name":"Silly Tour\u00e9","orcid":"https://orcid.org/0009-0003-2688-2291","observed_orcids":["https://orcid.org/0009-0003-2688-2291"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Silly Toure","raw_affiliation_strings":["Department of Maxillofacial Surgery and Stomatology, Faculty of Medicine, Pharmacy and Stomatology, Cheikh Anta Diop University, 5005 Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maxillofacial Surgery and Stomatology, Faculty of Medicine, Pharmacy and Stomatology, Cheikh Anta Diop University, 5005 Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086632304","display_name":"Mback\u00e9 Semb\u00e8ne","orcid":"https://orcid.org/0000-0002-3219-5194","observed_orcids":["https://orcid.org/0000-0002-3219-5194"]},"institutions":[{"id":"https://openalex.org/I96840727","display_name":"Cheikh Anta Diop University","ror":"https://ror.org/04je6yw13","country_code":"SN","type":"education","lineage":["https://openalex.org/I96840727"]}],"countries":["SN"],"is_corresponding":false,"raw_author_name":"Mbacke Sembene","raw_affiliation_strings":["Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics Laboratory, Department of Animal Biology, Faculty of Science and Technology, Cheikh Anta Diop University, 5005 Dakar, Senegal","institution_ids":["https://openalex.org/I96840727"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076722019"],"corresponding_institution_ids":["https://openalex.org/I96840727"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.6664999723434448,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.2709999978542328,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc-proto-oncogene","display_name":"c-myc proto-oncogene","score":0.9459999799728394},{"id":"https://openalex.org/keywords/oral-cancer","display_name":"oral cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/exon-2","display_name":"exon 2","score":0.7279999852180481},{"id":"https://openalex.org/keywords/nonsynonymous-mutations","display_name":"non-synonymous mutations","score":0.8830000162124634},{"id":"https://openalex.org/keywords/synonymous-substitutions","display_name":"synonymous substitutions","score":0.6650000214576721},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.48500001430511475},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.4909999966621399},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4390000104904175},{"id":"https://openalex.org/keywords/senegal","display_name":"Senegal","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.7663260698318481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.668335497379303},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.57328861951828},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5480064749717712},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5402675867080688},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.5400664806365967},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5354964733123779},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5187704563140869},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5164356827735901},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.5041333436965942},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.4914594888687134},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.4854205548763275},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3986572325229645},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.27209651470184326},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31083/j.jmcm0601002","doi":"https://doi.org/10.31083/j.jmcm0601002","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.jmcm0601002","pdf_url":"https://www.imrpress.com/journal/JMCM/6/1/10.31083/j.jmcm0601002/pdf","source":{"id":"https://openalex.org/S4210197488","display_name":"Journal of Molecular and Clinical Medicine","issn_l":"2616-3632","issn":["2616-3632","2617-5282"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular and Clinical Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31083/j.jmcm0601002","doi":"https://doi.org/10.31083/j.jmcm0601002","is_oa":true,"landing_page_url":"https://doi.org/10.31083/j.jmcm0601002","pdf_url":"https://www.imrpress.com/journal/JMCM/6/1/10.31083/j.jmcm0601002/pdf","source":{"id":"https://openalex.org/S4210197488","display_name":"Journal of Molecular and Clinical Medicine","issn_l":"2616-3632","issn":["2616-3632","2617-5282"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310322753","host_organization_name":"IMR Press","host_organization_lineage":["https://openalex.org/P4310322753"],"host_organization_lineage_names":["IMR Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular and Clinical Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387974792.pdf","grobid_xml":"https://content.openalex.org/works/W4387974792.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W69475100","https://openalex.org/W1562753307","https://openalex.org/W1563940013","https://openalex.org/W1975391293","https://openalex.org/W1981989535","https://openalex.org/W1993270595","https://openalex.org/W2005090847","https://openalex.org/W2023350260","https://openalex.org/W2024405748","https://openalex.org/W2031809704","https://openalex.org/W2038556975","https://openalex.org/W2040499525","https://openalex.org/W2074214886","https://openalex.org/W2074534266","https://openalex.org/W2085079187","https://openalex.org/W2093307979","https://openalex.org/W2103551820","https://openalex.org/W2104418738","https://openalex.org/W2106882534","https://openalex.org/W2131389931","https://openalex.org/W2136513422","https://openalex.org/W2144635719","https://openalex.org/W2154845780","https://openalex.org/W2311203695","https://openalex.org/W2346226705","https://openalex.org/W2605336071","https://openalex.org/W2614753460","https://openalex.org/W2965423269","https://openalex.org/W2971331636","https://openalex.org/W3024717664","https://openalex.org/W3033730827","https://openalex.org/W4239149238","https://openalex.org/W4242570503","https://openalex.org/W4295979038","https://openalex.org/W7096257995"],"related_works":["https://openalex.org/W4391204512","https://openalex.org/W4417260664","https://openalex.org/W2971331636","https://openalex.org/W4411779683","https://openalex.org/W2006341712","https://openalex.org/W7097317797","https://openalex.org/W2580395163","https://openalex.org/W4416142423","https://openalex.org/W6940119632","https://openalex.org/W1024040872"],"abstract_inverted_index":{"Background:":[0],"Oral":[1],"cancer":[2,8],"is":[3,39,42,382],"the":[4,30,36,50,73,76,81,90,167,192,195,201,240,243,259,283,290,327,356,368,371,379,386,398,408],"17th":[5],"most":[6,291],"common":[7],"worldwide,":[9],"with":[10,20,57,98,104,275,315,332],"a":[11,21,43,46,65,339],"mortality":[12,31,66],"rate":[13,32,67,322],"of":[14,35,49,54,68,75,83,135,150,163,166,187,194,209,218,236,242,253,268,277,286,297,326,370,390,412],"1.8%.":[15],"Their":[16],"incidence":[17],"varies":[18],"considerably,":[19],"clear":[22],"prevalence":[23],"in":[24,62,80,86,89,95,323,338,355,385,394,401],"South":[25],"Asian":[26],"countries.":[27],"In":[28],"Africa,":[29],"for":[33,64,407],"cancers":[34,101,393],"oral":[37,99,391,413],"cavity":[38,100,392],"1.3%.":[40],"Senegal":[41],"perfect":[44,47],"illustration":[45,48],"seriousness":[51],"and":[52,102,114,146,157,204,225,250,279,282,302,343,352,363,365,388],"scale":[53],"this":[55],"disease,":[56],"177":[58],"new":[59,405],"cases":[60],"recorded":[61],"2020,":[63],"1.4%.":[69],"To":[70],"add":[71],"to":[72,360],"knowledge":[74],"molecular":[77],"mechanisms":[78],"involved":[79,384],"carcinogenesis":[82],"these":[84],"pathologies":[85],"Senegal,":[87],"mutations":[88,211,399],"C-MYC":[91,168,328,380],"proto-oncogene":[92,329],"were":[93,119,138,263,299,304,358],"examined":[94],"22":[96,143],"patients":[97,269,298,307],"compared":[103],"samples":[105,137],"from":[106,121,129,141,144,148],"32":[107,140],"control":[108,130],"individuals.":[109,152],"Methods:":[110],"Cancerous":[111],"tissue":[112,117],"(CT)":[113],"adjacent":[115],"normal":[116],"(ANT)":[118],"sampled":[120],"diseased":[122,151,340],"individuals,":[123],"whereas":[124],"whole":[125],"blood":[126],"was":[127,155,170,178,198,214,246,270,330],"obtained":[128],"individuals":[131],"(C).":[132],"A":[133,319],"total":[134],"67":[136],"collected:":[139],"controls,":[142],"CTs,":[145],"13":[147,273],"ANTs":[149],"Total":[153],"DNA":[154],"extracted":[156],"polymerase":[158],"chain":[159],"reaction":[160],"(PCR)":[161],"amplification":[162],"exon":[164,324],"2":[165,325],"gene":[169],"performed,":[171],"followed":[172],"by":[173],"Sanger":[174],"sequencing.":[175],"Mutation":[176,181],"analysis":[177,252],"performed":[179],"using":[180,200,216,230,248],"Surveyor":[182],"Software":[183],"v5.0.1.":[184],"The":[185,207,234,265,345],"effect":[186],"each":[188],"non-synonymous":[189,210,237,346],"mutation":[190],"on":[191,239],"function":[193],"encoded":[196,244,372],"protein":[197,245],"determined":[199,247],"POLYPHEN-2,":[202],"PANTHER-PSEP,":[203],"PROVEAN":[205],"algorithms.":[206],"probability":[208],"causing":[212],"diseases":[213],"predicted":[215,359],"Prediction":[217],"human":[219],"Deleterious":[220],"Single":[221],"Nucleotide":[222],"Polymorphism":[223],"(PhD-SNP)":[224],"Predicting":[226],"disease":[227],"associated":[228],"variations":[229,238],"GO":[231],"terms":[232],"(SNP&GO).":[233],"impact":[235],"stability":[241,369],"I-Mutant2":[249],"In-silico":[251],"Protein":[254],"Stability":[255],"(INPS).":[256],"Results:":[257],"Of":[258],"study":[260],"participants,":[261],"63%":[262],"females.":[264],"mean":[266],"age":[267,284,293],"46.43":[271],"\u00b1":[272],"years,":[274],"extremes":[276],"14":[278],"83":[280],"years":[281,288],"range":[285],"40\u201370":[287],"as":[289],"representative":[292],"group.":[294],"Only":[295],"5%":[296],"alcohol":[300],"drinkers":[301],"15%":[303],"smokers.":[305],"Most":[306],"(80%)":[308],"had":[309],"stage":[310],"III":[311],"or":[312],"IV":[313],"tumors":[314],"lymph":[316],"node":[317],"invasion.":[318],"low":[320],"polymorphism":[321],"identified,":[331],"one":[333],"synonymous":[334],"substitution":[335],"(Q48Q)":[336],"found":[337,354,400],"individual":[341],"(CT":[342],"ANT).":[344],"substitutions":[347],"(D31N,":[348],"D31E,":[349],"V33G,":[350],"Y36N,":[351],"Y36D)":[353],"controls":[357,402],"be":[361],"damaging":[362],"pathogenic,":[364],"might":[366],"decrease":[367],"protein.":[373],"Conclusions:":[374],"Our":[375],"results":[376],"indicate":[377],"that":[378],"protooncogene":[381],"not":[383],"occurrence":[387],"progression":[389],"Senegalese":[395],"patients.":[396],"However,":[397],"could":[403],"provide":[404],"markers":[406],"early":[409],"clinical":[410],"diagnosis":[411],"cancer.":[414]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-28T00:00:00"}