{"id":"https://openalex.org/W4387968229","doi":"https://doi.org/10.3791/65701","title":"Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities","display_name":"Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities","publication_year":2023,"publication_date":"2023-10-27","ids":{"openalex":"https://openalex.org/W4387968229","doi":"https://doi.org/10.3791/65701","pmid":"https://pubmed.ncbi.nlm.nih.gov/37955389"},"language":"en","primary_location":{"id":"doi:10.3791/65701","doi":"https://doi.org/10.3791/65701","is_oa":true,"landing_page_url":"https://doi.org/10.3791/65701","pdf_url":"https://www.jove.com/pdf/65701/multimodal-cross-device-marker-free-co-registration-preclinical","source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jove.com/pdf/65701/multimodal-cross-device-marker-free-co-registration-preclinical","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070652040","display_name":"Mirko Thamm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mirko Thamm","raw_affiliation_strings":["Institute for Experimental Molecular Imaging, RWTH Aachen University; Gremse-IT GmbH","Gremse-IT GmbH","Institute for Experimental Molecular Imaging, RWTH Aachen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Molecular Imaging, RWTH Aachen University; Gremse-IT GmbH","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Gremse-IT GmbH","institution_ids":[]},{"raw_affiliation_string":"Institute for Experimental Molecular Imaging, RWTH Aachen University","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027244347","display_name":"Justin J. Jeffery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin J. Jeffery","raw_affiliation_strings":["Carbone Cancer Center, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carbone Cancer Center, University of Wisconsin","institution_ids":["https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007261494","display_name":"Yapei Zhang","orcid":"https://orcid.org/0000-0002-1607-8385","observed_orcids":["https://orcid.org/0000-0002-1607-8385"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yapei Zhang","raw_affiliation_strings":["Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063316602","display_name":"Bryan Ronain Smith","orcid":"https://orcid.org/0000-0002-5990-2901","observed_orcids":["https://orcid.org/0000-0002-5990-2901","https://orcid.org/0000-0001-9850-5944"]},"institutions":[{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan R. Smith","raw_affiliation_strings":["Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering and Institute for Quantitative Health Science and Engineering, Michigan State University","institution_ids":["https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075893671","display_name":"Stephen Marchant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Marchant","raw_affiliation_strings":["MediLumine Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MediLumine Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028314781","display_name":"Fabian M. Kiessling","orcid":"https://orcid.org/0000-0002-7341-0399","observed_orcids":["https://orcid.org/0000-0002-7341-0399"]},"institutions":[{"id":"https://openalex.org/I4210137873","display_name":"Fraunhofer Institute for Digital Medicine","ror":"https://ror.org/04farme71","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210137873","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Kiessling","raw_affiliation_strings":["Institute for Experimental Molecular Imaging, RWTH Aachen University; Fraunhofer Institute for Digital Medicine MEVIS","Fraunhofer Institute for Digital Medicine MEVIS","Institute for Experimental Molecular Imaging, RWTH Aachen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Molecular Imaging, RWTH Aachen University; Fraunhofer Institute for Digital Medicine MEVIS","institution_ids":["https://openalex.org/I4210137873","https://openalex.org/I887968799"]},{"raw_affiliation_string":"Fraunhofer Institute for Digital Medicine MEVIS","institution_ids":["https://openalex.org/I4210137873"]},{"raw_affiliation_string":"Institute for Experimental Molecular Imaging, RWTH Aachen University","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069679489","display_name":"Felix Gremse","orcid":"https://orcid.org/0000-0002-6522-9004","observed_orcids":["https://orcid.org/0000-0002-6522-9004"]},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Felix Gremse","raw_affiliation_strings":["Institute for Experimental Molecular Imaging, RWTH Aachen University; Gremse-IT GmbH; fgremse@ukaachen.de","Gremse-IT GmbH","Institute for Experimental Molecular Imaging, RWTH Aachen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Experimental Molecular Imaging, RWTH Aachen University; Gremse-IT GmbH; fgremse@ukaachen.de","institution_ids":["https://openalex.org/I887968799"]},{"raw_affiliation_string":"Gremse-IT GmbH","institution_ids":[]},{"raw_affiliation_string":"Institute for Experimental Molecular Imaging, RWTH Aachen University","institution_ids":["https://openalex.org/I887968799"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4945,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59523751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":"200","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.6187000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.2766000032424927,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preclinical-imaging","display_name":"small animal imaging","score":0.8309999704360962},{"id":"https://openalex.org/keywords/fiducial-markers","display_name":"fiducial markers","score":0.7570000290870667},{"id":"https://openalex.org/keywords/coordinate-transformation","display_name":"coordinate transformation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/pet-ct","display_name":"PET/CT","score":0.7519999742507935},{"id":"https://openalex.org/keywords/optical-tomography","display_name":"optical tomography","score":0.8389999866485596},{"id":"https://openalex.org/keywords/x-ray-microtomography","display_name":"X-ray microtomography","score":0.9860000014305115},{"id":"https://openalex.org/keywords/image-fusion","display_name":"image fusion","score":0.4569999873638153}],"concepts":[{"id":"https://openalex.org/C173974348","wikidata":"https://www.wikidata.org/wiki/Q1469893","display_name":"Fiducial marker","level":2,"score":0.9570482969284058},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6866974234580994},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.5981879234313965},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5838402509689331},{"id":"https://openalex.org/C166704113","wikidata":"https://www.wikidata.org/wiki/Q861092","display_name":"Image registration","level":3,"score":0.5707302093505859},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5566370487213135},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5410946011543274},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5300517082214355},{"id":"https://openalex.org/C2780226545","wikidata":"https://www.wikidata.org/wiki/Q6888030","display_name":"Modality (human\u2013computer interaction)","level":2,"score":0.5299221873283386},{"id":"https://openalex.org/C104293457","wikidata":"https://www.wikidata.org/wiki/Q28324852","display_name":"Imaging phantom","level":2,"score":0.49601754546165466},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.4803955852985382},{"id":"https://openalex.org/C69744172","wikidata":"https://www.wikidata.org/wiki/Q860822","display_name":"Image fusion","level":3,"score":0.46168628334999084},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.45083582401275635},{"id":"https://openalex.org/C163716698","wikidata":"https://www.wikidata.org/wiki/Q841267","display_name":"Tomography","level":2,"score":0.42375773191452026},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.41995108127593994},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.4173971712589264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2723976969718933},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2546676993370056},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2288409173488617},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.15794184803962708},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.11400496959686279},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019047","descriptor_name":"Phantoms, Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057918","descriptor_name":"Fiducial Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3791/65701","doi":"https://doi.org/10.3791/65701","is_oa":true,"landing_page_url":"https://doi.org/10.3791/65701","pdf_url":"https://www.jove.com/pdf/65701/multimodal-cross-device-marker-free-co-registration-preclinical","source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},{"id":"pmid:37955389","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37955389","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of visualized experiments : JoVE","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/506286","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/506286","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:publications.rwth-aachen.de:983087","doi":null,"is_oa":false,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-253143%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JoVE / Video journal (200), e65701 (2023). doi:10.3791/65701","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3791/65701","doi":"https://doi.org/10.3791/65701","is_oa":true,"landing_page_url":"https://doi.org/10.3791/65701","pdf_url":"https://www.jove.com/pdf/65701/multimodal-cross-device-marker-free-co-registration-preclinical","source":{"id":"https://openalex.org/S199738284","display_name":"Journal of Visualized Experiments","issn_l":"1940-087X","issn":["1940-087X","2834-8400"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320416","host_organization_name":"MyJOVE","host_organization_lineage":["https://openalex.org/P4310320416"],"host_organization_lineage_names":["MyJOVE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Visualized Experiments","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3570765224","display_name":null,"funder_award_id":"SFB 1382","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7155641737","display_name":null,"funder_award_id":"CRC 1382","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8023386771","display_name":"SFB 1382: Die DarmLeber Achse \u2013 Funktionelle Zusammenh\u00e4nge und therapeutische Strategien","funder_award_id":"403224013","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387968229.pdf","grobid_xml":"https://content.openalex.org/works/W4387968229.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W2008117298","https://openalex.org/W2050049213","https://openalex.org/W2052890798","https://openalex.org/W2057069782","https://openalex.org/W2066273530","https://openalex.org/W2081083350","https://openalex.org/W2106666760","https://openalex.org/W2121526802","https://openalex.org/W2289785863","https://openalex.org/W2298535816","https://openalex.org/W2580514243","https://openalex.org/W2748141155","https://openalex.org/W2808325895","https://openalex.org/W2809530635","https://openalex.org/W2921439049","https://openalex.org/W2962087643","https://openalex.org/W2966698813","https://openalex.org/W2972575578","https://openalex.org/W2992581850","https://openalex.org/W3041855720","https://openalex.org/W3043636152","https://openalex.org/W3201932903","https://openalex.org/W4223909723","https://openalex.org/W4307883147","https://openalex.org/W4382678086"],"related_works":["https://openalex.org/W1981385642","https://openalex.org/W2021410853","https://openalex.org/W2105259578","https://openalex.org/W250896160","https://openalex.org/W4404745270","https://openalex.org/W2067211914","https://openalex.org/W2054843394","https://openalex.org/W2160272860","https://openalex.org/W1995250675","https://openalex.org/W4231459672"],"abstract_inverted_index":{"Integrated":[0],"preclinical":[1],"multimodal":[2,71],"imaging":[3,20,101,222,257],"systems,":[4],"such":[5,69,171],"as":[6,70,138],"X-ray":[7,59],"computed":[8],"tomography":[9,15,56],"(CT)":[10],"combined":[11,22],"with":[12,23,45,242,253],"positron":[13],"emission":[14],"(PET)":[16],"or":[17,49,57,109,118,168],"magnetic":[18],"resonance":[19],"(MRI)":[21],"PET,":[24],"are":[25,37,142,173,193],"widely":[26],"available":[27,240,246],"and":[28,80,125,185,199],"typically":[29],"provide":[30],"robustly":[31],"co-registered":[32],"volumes.":[33],"However,":[34],"separate":[35],"devices":[36],"often":[38,86],"needed":[39],"to":[40,50,94,211,228],"combine":[41],"a":[42,151,159,213],"standalone":[43],"MRI":[44],"an":[46],"existing":[47,146],"PET-CT":[48],"incorporate":[51],"additional":[52],"data":[53,92,184],"from":[54,116],"optical":[55],"high-resolution":[58],"microtomography.":[60],"This":[61,148,224],"necessitates":[62],"image":[63,78,82,132],"co-registration,":[64,133],"which":[65],"involves":[66],"complex":[67],"aspects":[68],"mouse":[72],"bed":[73],"design,":[74],"fiducial":[75,166,233],"marker":[76,107,110],"inclusion,":[77],"reconstruction,":[79],"software-based":[81],"fusion.":[83],"Fiducial":[84],"markers":[85,167,172],"pose":[87],"problems":[88],"for":[89,181,203,244],"in":[90,106,135,145,176],"vivo":[91],"due":[93],"dynamic":[95],"range":[96],"issues,":[97],"limitations":[98],"on":[99],"the":[100,139,182,186,190,217],"field":[102],"of":[103,220,250,256],"view,":[104],"difficulties":[105],"placement,":[108],"signal":[111],"loss":[112],"over":[113],"time":[114],"(e.g.,":[115],"drying":[117],"decay).":[119],"These":[120],"challenges":[121],"must":[122],"be":[123],"understood":[124],"addressed":[126],"by":[127,189],"each":[128,204],"research":[129],"group":[130],"requiring":[131],"resulting":[134],"repeated":[136],"efforts,":[137],"relevant":[140],"details":[141],"rarely":[143],"described":[144,210],"publications.":[147],"protocol":[149],"outlines":[150],"general":[152],"workflow":[153],"that":[154],"overcomes":[155],"these":[156],"issues.":[157],"Although":[158],"differential":[160,214],"transformation":[161,215],"is":[162,209,237,263],"initially":[163],"created":[164],"using":[165,239],"visual":[169],"structures,":[170],"not":[174],"required":[175],"production":[177,230],"scans.":[178],"The":[179,195,248],"requirements":[180,201],"volume":[183],"metadata":[187],"generated":[188],"reconstruction":[191],"software":[192],"detailed.":[194],"discussion":[196],"covers":[197],"achieving":[198],"verifying":[200],"separately":[202],"modality.":[205],"A":[206],"phantom-based":[207],"approach":[208,252],"generate":[212],"between":[216],"coordinate":[218],"systems":[219],"two":[221],"modalities.":[223],"method":[225],"showcases":[226],"how":[227],"co-register":[229],"scans":[231],"without":[232],"markers.":[234],"Each":[235],"step":[236],"illustrated":[238],"software,":[241],"recommendations":[243],"commercially":[245],"phantoms.":[247],"feasibility":[249],"this":[251],"different":[254],"combinations":[255],"modalities":[258],"installed":[259],"at":[260],"various":[261],"sites":[262],"showcased.":[264]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-28T00:00:00"}