{"id":"https://openalex.org/W4387965697","doi":"https://doi.org/10.1038/s41467-023-42255-w","title":"Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization","display_name":"Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization","publication_year":2023,"publication_date":"2023-10-26","ids":{"openalex":"https://openalex.org/W4387965697","doi":"https://doi.org/10.1038/s41467-023-42255-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/37884510"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-42255-w","doi":"https://doi.org/10.1038/s41467-023-42255-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42255-w","pdf_url":"https://www.nature.com/articles/s41467-023-42255-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-42255-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011005127","display_name":"Yanxiang Meng","orcid":"https://orcid.org/0000-0001-7447-9788","observed_orcids":["https://orcid.org/0000-0001-7447-9788"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yanxiang Meng","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0001-7447-9788","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022176959","display_name":"Sarah E. Garnish","orcid":"https://orcid.org/0000-0002-9415-1517","observed_orcids":["https://orcid.org/0000-0002-9415-1517"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Sarah E. Garnish","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102870041","display_name":"Katherine A. Davies","orcid":"https://orcid.org/0000-0002-4423-4664","observed_orcids":["https://orcid.org/0000-0002-4423-4664"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Katherine A. Davies","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4423-4664","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066070723","display_name":"Katrina A. Black","orcid":"https://orcid.org/0000-0002-4094-6170","observed_orcids":["https://orcid.org/0000-0002-4094-6170"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Katrina A. Black","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0002-4094-6170","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073733069","display_name":"Andrew P. Leis","orcid":"https://orcid.org/0000-0003-4905-9401","observed_orcids":["https://orcid.org/0000-0003-4905-9401"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Andrew P. Leis","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028698788","display_name":"Christopher R. Horne","orcid":"https://orcid.org/0000-0003-1318-514X","observed_orcids":["https://orcid.org/0000-0003-1318-514X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Christopher R. Horne","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0003-1318-514X","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001610383","display_name":"Joanne M. Hildebrand","orcid":"https://orcid.org/0000-0002-1456-2042","observed_orcids":["https://orcid.org/0000-0002-1456-2042"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Joanne M. Hildebrand","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0002-1456-2042","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009492090","display_name":"Hanadi Hoblos","orcid":"https://orcid.org/0009-0007-1712-9213","observed_orcids":["https://orcid.org/0009-0007-1712-9213"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hanadi Hoblos","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013054442","display_name":"Cheree Fitzgibbon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Cheree Fitzgibbon","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047676306","display_name":"Samuel N. Young","orcid":"https://orcid.org/0009-0001-6543-1851","observed_orcids":["https://orcid.org/0009-0001-6543-1851"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Samuel N. Young","raw_affiliation_strings":["Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051173642","display_name":"Toby A. Dite","orcid":"https://orcid.org/0000-0001-8001-3634","observed_orcids":["https://orcid.org/0000-0001-8001-3634"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Toby Dite","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018298796","display_name":"Laura F. Dagley","orcid":"https://orcid.org/0000-0003-4171-3712","observed_orcids":["https://orcid.org/0000-0003-4171-3712"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Laura F. Dagley","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0003-4171-3712","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089553328","display_name":"Aarya Venkat","orcid":"https://orcid.org/0000-0002-8793-4097","observed_orcids":["https://orcid.org/0000-0002-8793-4097"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aarya Venkat","raw_affiliation_strings":["Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033384464","display_name":"Natarajan Kannan","orcid":"https://orcid.org/0000-0002-2833-8375","observed_orcids":["https://orcid.org/0000-0002-2833-8375"]},"institutions":[{"id":"https://openalex.org/I165733156","display_name":"University of Georgia","ror":"https://ror.org/00te3t702","country_code":"US","type":"education","lineage":["https://openalex.org/I165733156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natarajan Kannan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA","Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA"],"raw_orcid":"https://orcid.org/0000-0002-2833-8375","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]},{"raw_affiliation_string":"Institute of Bioinformatics, University of Georgia, Athens, GA, 30602, USA","institution_ids":["https://openalex.org/I165733156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071333092","display_name":"Akiko Koide","orcid":"https://orcid.org/0000-0003-1796-7077","observed_orcids":["https://orcid.org/0000-0003-1796-7077"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akiko Koide","raw_affiliation_strings":["Department of Medicine, New York University School of Medicine, New York, NY, 10016, USA","Perlmutter Cancer Center, New York University Langone Health, New York, NY, 10016, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York University School of Medicine, New York, NY, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Perlmutter Cancer Center, New York University Langone Health, New York, NY, 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026366958","display_name":"Shohei Koide","orcid":"https://orcid.org/0000-0001-5473-4358","observed_orcids":["https://orcid.org/0000-0001-5473-4358"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shohei Koide","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, 10016, USA","Perlmutter Cancer Center, New York University Langone Health, New York, NY, 10016, USA"],"raw_orcid":"https://orcid.org/0000-0001-5473-4358","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, 10016, USA","institution_ids":["https://openalex.org/I57206974"]},{"raw_affiliation_string":"Perlmutter Cancer Center, New York University Langone Health, New York, NY, 10016, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047533207","display_name":"Alisa Glukhova","orcid":"https://orcid.org/0000-0003-4146-965X","observed_orcids":["https://orcid.org/0000-0003-4146-965X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alisa Glukhova","raw_affiliation_strings":["Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, VIC, 3052, Australia","Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0003-4146-965X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063424737","display_name":"Peter E. Czabotar","orcid":"https://orcid.org/0000-0002-2594-496X","observed_orcids":["https://orcid.org/0000-0002-2594-496X"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Peter E. Czabotar","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. czabotar@wehi.edu.au","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia. czabotar@wehi.edu.au","Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0002-2594-496X","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. czabotar@wehi.edu.au","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia. czabotar@wehi.edu.au","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029275926","display_name":"James M. Murphy","orcid":"https://orcid.org/0000-0003-0195-3949","observed_orcids":["https://orcid.org/0000-0003-0195-3949"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"James M. Murphy","raw_affiliation_strings":["Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au","Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au","Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au","Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia"],"raw_orcid":"https://orcid.org/0000-0003-0195-3949","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia. jamesm@wehi.edu.au","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5029275926","https://openalex.org/A5063424737"],"corresponding_institution_ids":["https://openalex.org/I165779595","https://openalex.org/I196021976","https://openalex.org/I56590836"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":2.9153,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.93105156,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"6804","last_page":"6804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/necroptosis","display_name":"necroptosis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/mlkl","display_name":"MLKL","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ripk3","display_name":"RIPK3","score":0.8840000033378601},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"phosphorylation","score":0.6589999794960022},{"id":"https://openalex.org/keywords/pseudokinase-domain","display_name":"pseudokinase domain","score":0.9729999899864197},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.9150000214576721},{"id":"https://openalex.org/keywords/coiled-coil","display_name":"coiled coil","score":0.7020000219345093},{"id":"https://openalex.org/keywords/four-helix-bundle","display_name":"four-helix bundle","score":0.9490000009536743},{"id":"https://openalex.org/keywords/membrane-permeabilization","display_name":"membrane permeabilization","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cell-death","display_name":"cell death","score":0.7149999737739563},{"id":"https://openalex.org/keywords/protein-oligomerization","display_name":"protein oligomerization","score":0.6919999718666077}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7183308601379395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6246439814567566},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6131947040557861},{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.555609941482544},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5134454965591431},{"id":"https://openalex.org/C2778886173","wikidata":"https://www.wikidata.org/wiki/Q53832","display_name":"Tetramer","level":3,"score":0.4961157739162445},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.48243531584739685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2709096670150757},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1468469202518463},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0907352864742279}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053422","descriptor_name":"Receptor-Interacting Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053422","descriptor_name":"Receptor-Interacting Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053422","descriptor_name":"Receptor-Interacting Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41467-023-42255-w","doi":"https://doi.org/10.1038/s41467-023-42255-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42255-w","pdf_url":"https://www.nature.com/articles/s41467-023-42255-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmid:37884510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37884510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10603135","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10603135","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10603135/pdf/41467_2023_Article_42255.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42255-w","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-42255-w","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:3125421e28064554a4a1522779b6993c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3125421e28064554a4a1522779b6993c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-42255-w","doi":"https://doi.org/10.1038/s41467-023-42255-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42255-w","pdf_url":"https://www.nature.com/articles/s41467-023-42255-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7400000095367432}],"study_designs":[],"awards":[{"id":"https://openalex.org/G113576957","display_name":null,"funder_award_id":"IRIISS (9000719)","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G1231490504","display_name":null,"funder_award_id":"R35 GM139656","funder_id":"https://openalex.org/F4320306085","funder_display_name":"U.S. Department of Health and Human Services"},{"id":"https://openalex.org/G187672687","display_name":null,"funder_award_id":"9000719","funder_id":"https://openalex.org/F4320322858","funder_display_name":"State Government of Victoria"},{"id":"https://openalex.org/G2307925652","display_name":"Targeting necroptosis in the race to treat acute and chronic inflammation","funder_award_id":"2011584","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G437209489","display_name":"IRIISS - 2021","funder_award_id":"9000719","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G5021709376","display_name":"The necroptosis cell death pathway as a therapeutic target in human disease","funder_award_id":"1172929","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G5610352411","display_name":"Mining the Molecular Machinery of Cell Death for Novel Drug Targets","funder_award_id":"2009062","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G9000902437","display_name":"Unlocking sequence-structure-function-disease relationships in large protein super-families","funder_award_id":"R35GM139656","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320320435","display_name":"Australian Institute of Nuclear Science and Engineering","ror":"https://ror.org/03p711j77"},{"id":"https://openalex.org/F4320320540","display_name":"Australian Synchrotron","ror":"https://ror.org/03vk18a84"},{"id":"https://openalex.org/F4320322858","display_name":"State Government of Victoria","ror":"https://ror.org/02xvc5r05"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387965697.pdf","grobid_xml":"https://content.openalex.org/works/W4387965697.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W1523845694","https://openalex.org/W1970858396","https://openalex.org/W1979032223","https://openalex.org/W1985231277","https://openalex.org/W1985831101","https://openalex.org/W1986283558","https://openalex.org/W1986656413","https://openalex.org/W1993613360","https://openalex.org/W1998983498","https://openalex.org/W2000390423","https://openalex.org/W2007303185","https://openalex.org/W2016466447","https://openalex.org/W2026477080","https://openalex.org/W2035503835","https://openalex.org/W2036321220","https://openalex.org/W2041738154","https://openalex.org/W2049587638","https://openalex.org/W2056303166","https://openalex.org/W2069800916","https://openalex.org/W2077317536","https://openalex.org/W2080752012","https://openalex.org/W2087232320","https://openalex.org/W2091363184","https://openalex.org/W2110808180","https://openalex.org/W2114559206","https://openalex.org/W2124026197","https://openalex.org/W2132161879","https://openalex.org/W2138887185","https://openalex.org/W2147874841","https://openalex.org/W2152326664","https://openalex.org/W2154714625","https://openalex.org/W2163341755","https://openalex.org/W2261153787","https://openalex.org/W2265728551","https://openalex.org/W2323927982","https://openalex.org/W2329801438","https://openalex.org/W2509943971","https://openalex.org/W2547118804","https://openalex.org/W2547911415","https://openalex.org/W2550336164","https://openalex.org/W2559036050","https://openalex.org/W2560438292","https://openalex.org/W2573286366","https://openalex.org/W2618633434","https://openalex.org/W2749909301","https://openalex.org/W2782020850","https://openalex.org/W2792417102","https://openalex.org/W2795830099","https://openalex.org/W2802914881","https://openalex.org/W2808059176","https://openalex.org/W2898649585","https://openalex.org/W2903516075","https://openalex.org/W2908089242","https://openalex.org/W2921397389","https://openalex.org/W2937724828","https://openalex.org/W2940752472","https://openalex.org/W2945463821","https://openalex.org/W2976299346","https://openalex.org/W3014714615","https://openalex.org/W3035828086","https://openalex.org/W3035955336","https://openalex.org/W3035966325","https://openalex.org/W3040698871","https://openalex.org/W3044264283","https://openalex.org/W3049118667","https://openalex.org/W3083406432","https://openalex.org/W3083962220","https://openalex.org/W3109413273","https://openalex.org/W3112170103","https://openalex.org/W3119610650","https://openalex.org/W3121368050","https://openalex.org/W3127684143","https://openalex.org/W3131133065","https://openalex.org/W3153931909","https://openalex.org/W3165534117","https://openalex.org/W3167630409","https://openalex.org/W3177235230","https://openalex.org/W3207460977","https://openalex.org/W3216965974","https://openalex.org/W4210521569","https://openalex.org/W4210586598","https://openalex.org/W4220682851","https://openalex.org/W4221009600","https://openalex.org/W4221062575","https://openalex.org/W4226144004","https://openalex.org/W4226175427","https://openalex.org/W4229032987","https://openalex.org/W4281790889","https://openalex.org/W4283215706","https://openalex.org/W4283323915","https://openalex.org/W4286750111","https://openalex.org/W4289886798","https://openalex.org/W4313488675","https://openalex.org/W4372202584","https://openalex.org/W4387136895"],"related_works":["https://openalex.org/W2621136438","https://openalex.org/W1952688415","https://openalex.org/W2020112528","https://openalex.org/W2071430672","https://openalex.org/W10561809","https://openalex.org/W2991355330","https://openalex.org/W3143577155","https://openalex.org/W243056473","https://openalex.org/W4287092123","https://openalex.org/W2087666519"],"abstract_inverted_index":{"The":[0,26],"necroptosis":[1],"pathway":[2,51],"is":[3,12],"a":[4,43,70,101],"lytic,":[5],"pro-inflammatory":[6],"mode":[7],"of":[8,29,48,63,84,95,138],"cell":[9,146],"death":[10],"that":[11,113],"widely":[13],"implicated":[14],"in":[15,33],"human":[16,65],"disease,":[17],"including":[18],"renal,":[19],"pulmonary,":[20],"gut":[21],"and":[22,41,46,91,117,136,145],"skin":[23],"inflammatory":[24],"pathologies.":[25],"precise":[27],"mechanism":[28],"the":[30,34,37,49,64,96,107,115,134],"terminal":[31,50],"steps":[32],"pathway,":[35],"where":[36],"RIPK3":[38],"kinase":[39],"phosphorylates":[40],"triggers":[42],"conformation":[44],"change":[45],"oligomerization":[47],"effector,":[52],"MLKL,":[53],"are":[54],"only":[55],"emerging.":[56],"Here,":[57],"we":[58],"structurally":[59],"identify":[60],"RIPK3-mediated":[61],"phosphorylation":[62],"MLKL":[66,73,77,97,125],"activation":[67],"loop":[68],"as":[69,127],"cue":[71],"for":[72,142],"pseudokinase":[74,78,116],"domain":[75,79],"dimerization.":[76],"dimerization":[80],"subsequently":[81],"drives":[82],"formation":[83],"elongated":[85],"homotetramers.":[86],"Negative":[87],"stain":[88],"electron":[89],"microscopy":[90],"modelling":[92],"support":[93],"nucleation":[94],"tetramer":[98],"assembly":[99],"by":[100,106],"central":[102],"coiled":[103],"coil":[104],"formed":[105],"extended,":[108],"~80":[109],"\u00c5":[110],"brace":[111],"helix":[112],"connects":[114],"executioner":[118],"four-helix":[119,139],"bundle":[120,140],"domains.":[121],"Mutational":[122],"data":[123],"assert":[124],"tetramerization":[126],"an":[128],"essential":[129],"prerequisite":[130],"step":[131],"to":[132],"enable":[133],"release":[135],"reorganization":[137],"domains":[141],"membrane":[143],"permeabilization":[144],"death.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":7}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}