{"id":"https://openalex.org/W4387965310","doi":"https://doi.org/10.1093/nar/gkad879","title":"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems","display_name":"Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems","publication_year":2023,"publication_date":"2023-10-27","ids":{"openalex":"https://openalex.org/W4387965310","doi":"https://doi.org/10.1093/nar/gkad879","pmid":"https://pubmed.ncbi.nlm.nih.gov/37889040","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10681802"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkad879","doi":"https://doi.org/10.1093/nar/gkad879","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad879","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad879/52632028/gkad879.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad879/52632028/gkad879.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080422008","display_name":"Gianlucca Gon\u00e7alves Nicastro","orcid":"https://orcid.org/0000-0002-3133-2441","observed_orcids":["https://orcid.org/0000-0002-3133-2441"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianlucca G Nicastro","raw_affiliation_strings":["Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004461127","display_name":"Alexander Maxwell Burroughs","orcid":"https://orcid.org/0000-0002-2229-8771","observed_orcids":["https://orcid.org/0000-0002-2229-8771"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Maxwell Burroughs","raw_affiliation_strings":["Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , USA"],"raw_orcid":"https://orcid.org/0000-0002-2229-8771","affiliations":[{"raw_affiliation_string":"Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045663522","display_name":"Lakshminarayan M. Iyer","orcid":"https://orcid.org/0000-0002-4844-2022","observed_orcids":["https://orcid.org/0000-0002-4844-2022"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lakshminarayan\u00a0M Iyer","raw_affiliation_strings":["Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026932356","display_name":"L. Aravind","orcid":"https://orcid.org/0000-0003-0771-253X","observed_orcids":["https://orcid.org/0000-0003-0771-253X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210109390","display_name":"National Center for Biotechnology Information","ror":"https://ror.org/02meqm098","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I2800548410","https://openalex.org/I4210109390"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L Aravind","raw_affiliation_strings":["Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , USA"],"raw_orcid":"https://orcid.org/0000-0003-0771-253X","affiliations":[{"raw_affiliation_string":"Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health , USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026932356"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210109390"],"apc_list":{"value":3630,"currency":"USD","value_usd":3630},"apc_paid":{"value":3630,"currency":"USD","value_usd":3630},"fwci":1.2358,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.78113231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"51","issue":"21","first_page":"11479","last_page":"11503"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.5019999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.22450000047683716,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/effector-domain","display_name":"effector domain","score":0.5929999947547913},{"id":"https://openalex.org/keywords/gtpase-domain","display_name":"GTPase domain","score":0.9120000004768372},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.890789270401001},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.824115514755249},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5351012945175171},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.47657132148742676},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4646202325820923},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4604329466819763},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.29170310497283936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26998162269592285}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009711","descriptor_name":"Nucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011387","descriptor_name":"Prokaryotic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkad879","doi":"https://doi.org/10.1093/nar/gkad879","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad879","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad879/52632028/gkad879.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10681802","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10681802","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10681802/pdf/gkad879.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:37889040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37889040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkad879","doi":"https://doi.org/10.1093/nar/gkad879","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkad879","pdf_url":"https://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkad879/52632028/gkad879.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1337871145","display_name":"Evolutionary Analysis and Comparative Genomics of Protein Superfamilies","funder_award_id":"Z01LM594244","funder_id":"https://openalex.org/F4320337372","funder_display_name":"U.S. National Library of Medicine"},{"id":"https://openalex.org/G9000120959","display_name":null,"funder_award_id":"LM594244","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387965310.pdf","grobid_xml":"https://content.openalex.org/works/W4387965310.grobid-xml"},"referenced_works_count":205,"referenced_works":["https://openalex.org/W122556128","https://openalex.org/W288150766","https://openalex.org/W1511292457","https://openalex.org/W1515366468","https://openalex.org/W1521207244","https://openalex.org/W1530003583","https://openalex.org/W1571439356","https://openalex.org/W1586135756","https://openalex.org/W1591163699","https://openalex.org/W1777525352","https://openalex.org/W1802567635","https://openalex.org/W1805101080","https://openalex.org/W1848301660","https://openalex.org/W1864325817","https://openalex.org/W1870388044","https://openalex.org/W1875835053","https://openalex.org/W1890597695","https://openalex.org/W1890914571","https://openalex.org/W1964979713","https://openalex.org/W1967663492","https://openalex.org/W1969003508","https://openalex.org/W1970877539","https://openalex.org/W1971507610","https://openalex.org/W1974784632","https://openalex.org/W1977331125","https://openalex.org/W1979289218","https://openalex.org/W1980421520","https://openalex.org/W1981138564","https://openalex.org/W1981382847","https://openalex.org/W1981888730","https://openalex.org/W1984046437","https://openalex.org/W1986703858","https://openalex.org/W1991008498","https://openalex.org/W1992007798","https://openalex.org/W1993525477","https://openalex.org/W1993683428","https://openalex.org/W1994415899","https://openalex.org/W2003789674","https://openalex.org/W2005935812","https://openalex.org/W2006346753","https://openalex.org/W2010043198","https://openalex.org/W2011718165","https://openalex.org/W2011879414","https://openalex.org/W2012919786","https://openalex.org/W2018024025","https://openalex.org/W2020815519","https://openalex.org/W2026674427","https://openalex.org/W2027853473","https://openalex.org/W2028904598","https://openalex.org/W2030075085","https://openalex.org/W2030711495","https://openalex.org/W2030974598","https://openalex.org/W2031386057","https://openalex.org/W2031611770","https://openalex.org/W2032893777","https://openalex.org/W2037913221","https://openalex.org/W2038174431","https://openalex.org/W2038724843","https://openalex.org/W2039122956","https://openalex.org/W2041074318","https://openalex.org/W2042221984","https://openalex.org/W2049898530","https://openalex.org/W2055960791","https://openalex.org/W2056876004","https://openalex.org/W2059970735","https://openalex.org/W2062197402","https://openalex.org/W2065206097","https://openalex.org/W2069458148","https://openalex.org/W2069554621","https://openalex.org/W2069866716","https://openalex.org/W2071415155","https://openalex.org/W2075139535","https://openalex.org/W2079391939","https://openalex.org/W2082667898","https://openalex.org/W2093814623","https://openalex.org/W2094025485","https://openalex.org/W2095162524","https://openalex.org/W2096525273","https://openalex.org/W2098891503","https://openalex.org/W2099299706","https://openalex.org/W2099610218","https://openalex.org/W2099976574","https://openalex.org/W2100262865","https://openalex.org/W2104812091","https://openalex.org/W2107986672","https://openalex.org/W2109872885","https://openalex.org/W2110162745","https://openalex.org/W2110389552","https://openalex.org/W2112671289","https://openalex.org/W2121453804","https://openalex.org/W2121571048","https://openalex.org/W2129004089","https://openalex.org/W2131172232","https://openalex.org/W2133312664","https://openalex.org/W2133821029","https://openalex.org/W2133830966","https://openalex.org/W2138122982","https://openalex.org/W2139621307","https://openalex.org/W2142388331","https://openalex.org/W2146271614","https://openalex.org/W2147020223","https://openalex.org/W2148478714","https://openalex.org/W2154802584","https://openalex.org/W2156826925","https://openalex.org/W2160378127","https://openalex.org/W2160521062","https://openalex.org/W2163241233","https://openalex.org/W2163374339","https://openalex.org/W2167370287","https://openalex.org/W2167790255","https://openalex.org/W2169187392","https://openalex.org/W2176123637","https://openalex.org/W2178130253","https://openalex.org/W2181797758","https://openalex.org/W2224056471","https://openalex.org/W2259046624","https://openalex.org/W2288272959","https://openalex.org/W2303521084","https://openalex.org/W2321778368","https://openalex.org/W2329428957","https://openalex.org/W2427806340","https://openalex.org/W2517638694","https://openalex.org/W2528984149","https://openalex.org/W2532347595","https://openalex.org/W2558438718","https://openalex.org/W2565616863","https://openalex.org/W2568598703","https://openalex.org/W2613163105","https://openalex.org/W2620505555","https://openalex.org/W2732924043","https://openalex.org/W2734470795","https://openalex.org/W2784532673","https://openalex.org/W2785101149","https://openalex.org/W2808457005","https://openalex.org/W2883825889","https://openalex.org/W2889985201","https://openalex.org/W2902800597","https://openalex.org/W2917815849","https://openalex.org/W2924932674","https://openalex.org/W2946064840","https://openalex.org/W2946394399","https://openalex.org/W2946853949","https://openalex.org/W2950684512","https://openalex.org/W2961387473","https://openalex.org/W2980170804","https://openalex.org/W2983062606","https://openalex.org/W2999070159","https://openalex.org/W3005235420","https://openalex.org/W3006567658","https://openalex.org/W3007412071","https://openalex.org/W3007480931","https://openalex.org/W3014161378","https://openalex.org/W3033444158","https://openalex.org/W3041183043","https://openalex.org/W3046638151","https://openalex.org/W3081228941","https://openalex.org/W3082970947","https://openalex.org/W3084056065","https://openalex.org/W3096234081","https://openalex.org/W3101667854","https://openalex.org/W3106948039","https://openalex.org/W3119247605","https://openalex.org/W3127222994","https://openalex.org/W3127405188","https://openalex.org/W3152994696","https://openalex.org/W3155106744","https://openalex.org/W3159719254","https://openalex.org/W3160734557","https://openalex.org/W3164683859","https://openalex.org/W3174255068","https://openalex.org/W3177828909","https://openalex.org/W3186179742","https://openalex.org/W3199367313","https://openalex.org/W3200469881","https://openalex.org/W3203405076","https://openalex.org/W3204044460","https://openalex.org/W3216692711","https://openalex.org/W4200379711","https://openalex.org/W4205440119","https://openalex.org/W4214926555","https://openalex.org/W4220838810","https://openalex.org/W4220997118","https://openalex.org/W4221028808","https://openalex.org/W4229333976","https://openalex.org/W4281485691","https://openalex.org/W4281790889","https://openalex.org/W4281999294","https://openalex.org/W4285006928","https://openalex.org/W4285013775","https://openalex.org/W4285727841","https://openalex.org/W4289274885","https://openalex.org/W4293298428","https://openalex.org/W4294818102","https://openalex.org/W4295094744","https://openalex.org/W4296381497","https://openalex.org/W4297218063","https://openalex.org/W4311931795","https://openalex.org/W4319728686","https://openalex.org/W4375858802","https://openalex.org/W4376121990","https://openalex.org/W4378781273","https://openalex.org/W4378839880","https://openalex.org/W4385949307","https://openalex.org/W4387737550","https://openalex.org/W6769843042"],"related_works":["https://openalex.org/W3082970947","https://openalex.org/W4401162222","https://openalex.org/W4385949307","https://openalex.org/W3008442039","https://openalex.org/W2329428957","https://openalex.org/W4407764705","https://openalex.org/W2178130253","https://openalex.org/W7156221238","https://openalex.org/W7223270104","https://openalex.org/W4412184551"],"abstract_inverted_index":{"While":[0,149],"nucleic":[1],"acid-targeting":[2],"effectors":[3,21,159,177],"are":[4,64,73,140],"known":[5],"to":[6,9,75,142,168,188],"be":[7],"central":[8],"biological":[10],"conflicts":[11],"and":[12,27,36,50,61,72,129,136,183],"anti-selfish":[13],"element":[14],"immunity,":[15],"recent":[16],"findings":[17,85],"have":[18],"revealed":[19],"immune":[20,70,89,164,181],"that":[22,139],"target":[23],"their":[24,185],"building":[25],"blocks":[26],"the":[28,59],"cellular":[29],"energy":[30],"currency-free":[31],"nucleotides.":[32,119],"Through":[33],"comparative":[34],"genomics":[35],"sequence-structure":[37],"analysis,":[38],"we":[39,46],"identified":[40],"several":[41],"distinct":[42],"effector":[43],"domains,":[44,53,63],"which":[45],"named":[47],"Calcineurin-CE,":[48],"HD-CE,":[49],"PRTase-CE.":[51],"These":[52],"along":[54],"with":[55,92],"specific":[56],"versions":[57],"of":[58,103,114,125,134,157],"ParB":[60],"MazG":[62],"widely":[65],"present":[66],"in":[67,151,191],"diverse":[68],"prokaryotic":[69],"systems":[71,90,105,126],"predicted":[74],"degrade":[76],"nucleotides":[77],"by":[78],"targeting":[79],"phosphate":[80],"or":[81,111,145],"glycosidic":[82],"linkages.":[83],"Our":[84],"unveil":[86],"multiple":[87],"potential":[88],"associated":[91],"at":[93],"least":[94],"17":[95],"different":[96],"functional":[97],"themes":[98],"featuring":[99],"these":[100,104,143],"effectors.":[101,148],"Some":[102],"sense":[106],"modified":[107],"DNA/nucleotides":[108],"from":[109],"phages":[110],"operate":[112],"downstream":[113],"novel":[115],"enzymes":[116],"generating":[117],"signaling":[118],"We":[120],"also":[121],"uncovered":[122],"a":[123,154],"class":[124],"utilizing":[127],"HSP90-":[128],"HSP70-related":[130],"modules":[131],"as":[132,178],"analogs":[133],"STAND":[135],"GTPase":[137],"domains":[138,190],"coupled":[141],"nucleotide-targeting-":[144],"proteolysis-induced":[146],"complex-forming":[147],"widespread":[150],"bacteria,":[152],"only":[153],"limited":[155],"subset":[156],"nucleotide-targeting":[158],"was":[160],"integrated":[161],"into":[162],"eukaryotic":[163],"systems,":[165],"suggesting":[166],"barriers":[167],"interoperability":[169],"across":[170],"subcellular":[171],"contexts.":[172],"This":[173],"work":[174],"establishes":[175],"nucleotide-degrading":[176],"an":[179],"emerging":[180],"paradigm":[182],"traces":[184],"origins":[186],"back":[187],"homologous":[189],"housekeeping":[192],"systems.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-10-28T00:00:00"}