{"id":"https://openalex.org/W4387956086","doi":"https://doi.org/10.1016/j.omtm.2023.101143","title":"Multiparametric domain insertional profiling of adeno-associated virus VP1","display_name":"Multiparametric domain insertional profiling of adeno-associated virus VP1","publication_year":2023,"publication_date":"2023-10-26","ids":{"openalex":"https://openalex.org/W4387956086","doi":"https://doi.org/10.1016/j.omtm.2023.101143","pmid":"https://pubmed.ncbi.nlm.nih.gov/37131661","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10153220"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtm.2023.101143","doi":"https://doi.org/10.1016/j.omtm.2023.101143","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtm.2023.101143","pdf_url":null,"source":{"id":"https://openalex.org/S2764588101","display_name":"Molecular Therapy \u2014 Methods & Clinical Development","issn_l":"2329-0501","issn":["2329-0501"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Methods &amp; Clinical Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.omtm.2023.101143","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054973429","display_name":"Mareike Daniela Hoffmann","orcid":"https://orcid.org/0000-0001-8377-1385","observed_orcids":["https://orcid.org/0000-0001-8377-1385"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mareike D. Hoffmann","raw_affiliation_strings":["Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0001-8377-1385","affiliations":[{"raw_affiliation_string":"Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040663742","display_name":"Alina C. Zdechlik","orcid":"https://orcid.org/0000-0002-5365-2745","observed_orcids":["https://orcid.org/0000-0002-5365-2745"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alina C. Zdechlik","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086631720","display_name":"Yungui He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yungui He","raw_affiliation_strings":["Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051720150","display_name":"David M. Nedrud","orcid":"https://orcid.org/0000-0002-2866-3880","observed_orcids":["https://orcid.org/0000-0002-2866-3880"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Nedrud","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041790501","display_name":"George Aslanidi","orcid":"https://orcid.org/0000-0002-2726-8627","observed_orcids":["https://orcid.org/0000-0002-2726-8627"]},"institutions":[{"id":"https://openalex.org/I223919290","display_name":"Hormel (United States)","ror":"https://ror.org/03wnt7k73","country_code":"US","type":"company","lineage":["https://openalex.org/I223919290"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George Aslanidi","raw_affiliation_strings":["The Hormel Institute, Austin, MN 55912, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hormel Institute, Austin, MN 55912, USA","institution_ids":["https://openalex.org/I223919290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022983326","display_name":"Wendy Ryan Gordon","orcid":"https://orcid.org/0000-0001-7696-5560","observed_orcids":["https://orcid.org/0000-0001-7696-5560"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Gordon","raw_affiliation_strings":["Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103057597","display_name":"Daniel Schmidt","orcid":"https://orcid.org/0000-0001-7609-4873","observed_orcids":["https://orcid.org/0000-0001-7609-4873"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel Schmidt","raw_affiliation_strings":["Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA"],"raw_orcid":"https://orcid.org/0000-0001-7609-4873","affiliations":[{"raw_affiliation_string":"Department of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN 55455, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5054973429","https://openalex.org/A5103057597"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":2.9821,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.92769911,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"31","issue":null,"first_page":"101143","last_page":"101143"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adeno-associated-virus","display_name":"adeno-associated virus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vp1-capsid-protein","display_name":"VP1 capsid protein","score":0.8600000143051147},{"id":"https://openalex.org/keywords/capsid-engineering","display_name":"capsid engineering","score":0.8349999785423279},{"id":"https://openalex.org/keywords/aav-tropism","display_name":"AAV tropism","score":0.7609999775886536},{"id":"https://openalex.org/keywords/capsid-stability","display_name":"capsid stability","score":0.6129999756813049},{"id":"https://openalex.org/keywords/infectivity","display_name":"infectivity","score":0.7200000286102295},{"id":"https://openalex.org/keywords/capsid-assembly","display_name":"capsid assembly","score":0.753000020980835},{"id":"https://openalex.org/keywords/gene-therapy-vectors","display_name":"gene therapy vectors","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.9021357297897339},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.7109476327896118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5281170606613159},{"id":"https://openalex.org/C2778107364","wikidata":"https://www.wikidata.org/wiki/Q355989","display_name":"Adeno-associated virus","level":5,"score":0.5251792669296265},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5153283476829529},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4892094135284424},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4300989508628845},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.41969767212867737},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.41793739795684814},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40015357732772827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34839874505996704},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3144712448120117},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.27315574884414673},{"id":"https://openalex.org/C92087593","wikidata":"https://www.wikidata.org/wiki/Q427389","display_name":"Vector (molecular biology)","level":4,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.omtm.2023.101143","doi":"https://doi.org/10.1016/j.omtm.2023.101143","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtm.2023.101143","pdf_url":null,"source":{"id":"https://openalex.org/S2764588101","display_name":"Molecular Therapy \u2014 Methods & Clinical Development","issn_l":"2329-0501","issn":["2329-0501"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Methods &amp; Clinical Development","raw_type":"journal-article"},{"id":"doi:10.1101/2023.04.19.537549","doi":"https://doi.org/10.1101/2023.04.19.537549","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.04.19.537549","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/04/21/2023.04.19.537549.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10661864","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10661864","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10661864/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Methods Clin Dev","raw_type":"Text"},{"id":"pmid:37131661","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37131661","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:38027057","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38027057","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Methods & clinical development","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10153220","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10153220","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.omtm.2023.101143","doi":"https://doi.org/10.1016/j.omtm.2023.101143","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtm.2023.101143","pdf_url":null,"source":{"id":"https://openalex.org/S2764588101","display_name":"Molecular Therapy \u2014 Methods & Clinical Development","issn_l":"2329-0501","issn":["2329-0501"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","ki-jl-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy Methods &amp; Clinical Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1801249269","display_name":null,"funder_award_id":"2025124","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G259601046","display_name":null,"funder_award_id":"ECCS-2025124","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G310967942","display_name":null,"funder_award_id":"ECCS- 2025124","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G403942265","display_name":null,"funder_award_id":"DMR2011401","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G4470453470","display_name":null,"funder_award_id":"DMR-2011401","funder_id":"https://openalex.org/F4320333422","funder_display_name":"Materials Research Science and Engineering Center, Harvard University"},{"id":"https://openalex.org/G5316173330","display_name":null,"funder_award_id":"SCR_020997","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5449242509","display_name":null,"funder_award_id":"SCR_020997","funder_id":"https://openalex.org/F4320332697","funder_display_name":"University of Illinois at Chicago"},{"id":"https://openalex.org/G6917505600","display_name":null,"funder_award_id":"SCR-020997","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G6995829561","display_name":null,"funder_award_id":"2011401","funder_id":"https://openalex.org/F4320337367","funder_display_name":"Division of Materials Research"},{"id":"https://openalex.org/G743970376","display_name":null,"funder_award_id":"DMR-2011401","funder_id":"https://openalex.org/F4320309636","funder_display_name":"University of Minnesota"},{"id":"https://openalex.org/G7573957695","display_name":null,"funder_award_id":"ECCS-2025124","funder_id":"https://openalex.org/F4320333422","funder_display_name":"Materials Research Science and Engineering Center, Harvard University"},{"id":"https://openalex.org/G8552273976","display_name":"University of Minnesota Materials Research Science and Engineering Center","funder_award_id":"2011401","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G878574498","display_name":"NNCI: Midwest Nano Infrastructure Corridor (MINIC)","funder_award_id":"2025124","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000885449","display_name":"Decoding mechanotransduction mechanisms of cell-surface receptors","funder_award_id":"R35GM119483","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000909069","display_name":"Center for Neural Circuits in Addiction","funder_award_id":"P30DA048742","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000920572","display_name":"Viral vector technology for cell type specific gene delivery","funder_award_id":"R01GM141152","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332697","display_name":"University of Illinois at Chicago","ror":"https://ror.org/02mpq6x41"},{"id":"https://openalex.org/F4320333422","display_name":"Materials Research Science and Engineering Center, Harvard University","ror":"https://ror.org/01qa5ep47"},{"id":"https://openalex.org/F4320334165","display_name":"Genomics Center, University of Minnesota","ror":null},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337367","display_name":"Division of Materials Research","ror":"https://ror.org/01pc7k308"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W1517847098","https://openalex.org/W1518729035","https://openalex.org/W1598111769","https://openalex.org/W1601268295","https://openalex.org/W1934162206","https://openalex.org/W1964668661","https://openalex.org/W1964959966","https://openalex.org/W1965727113","https://openalex.org/W1965786463","https://openalex.org/W1969538192","https://openalex.org/W1973362947","https://openalex.org/W1973733861","https://openalex.org/W1976672416","https://openalex.org/W1981130347","https://openalex.org/W1990700578","https://openalex.org/W1995854207","https://openalex.org/W1996745685","https://openalex.org/W2001738143","https://openalex.org/W2002565864","https://openalex.org/W2006244553","https://openalex.org/W2008235836","https://openalex.org/W2009455163","https://openalex.org/W2009681413","https://openalex.org/W2010666698","https://openalex.org/W2012551702","https://openalex.org/W2015426350","https://openalex.org/W2016667239","https://openalex.org/W2021928977","https://openalex.org/W2022161423","https://openalex.org/W2033689077","https://openalex.org/W2042928389","https://openalex.org/W2051072233","https://openalex.org/W2051159468","https://openalex.org/W2053937911","https://openalex.org/W2057761603","https://openalex.org/W2059470894","https://openalex.org/W2060588922","https://openalex.org/W2064524294","https://openalex.org/W2071404720","https://openalex.org/W2071854673","https://openalex.org/W2078547670","https://openalex.org/W2090256568","https://openalex.org/W2090661761","https://openalex.org/W2099707172","https://openalex.org/W2119043113","https://openalex.org/W2123260147","https://openalex.org/W2137572138","https://openalex.org/W2139964006","https://openalex.org/W2141236766","https://openalex.org/W2141797403","https://openalex.org/W2147193337","https://openalex.org/W2147844196","https://openalex.org/W2149501736","https://openalex.org/W2149644622","https://openalex.org/W2149678280","https://openalex.org/W2156683693","https://openalex.org/W2157464327","https://openalex.org/W2160986529","https://openalex.org/W2164625869","https://openalex.org/W2256579886","https://openalex.org/W2266837556","https://openalex.org/W2486597359","https://openalex.org/W2520782926","https://openalex.org/W2554762375","https://openalex.org/W2587189647","https://openalex.org/W2613406214","https://openalex.org/W2708579841","https://openalex.org/W2736065260","https://openalex.org/W2736159391","https://openalex.org/W2744336424","https://openalex.org/W2770879058","https://openalex.org/W2786672974","https://openalex.org/W2801716316","https://openalex.org/W2889326414","https://openalex.org/W2910753534","https://openalex.org/W2911513195","https://openalex.org/W2913212173","https://openalex.org/W2938803199","https://openalex.org/W2946762521","https://openalex.org/W2949706399","https://openalex.org/W2952214667","https://openalex.org/W2955699452","https://openalex.org/W2974137843","https://openalex.org/W2989663382","https://openalex.org/W2989766830","https://openalex.org/W2990259661","https://openalex.org/W2991022372","https://openalex.org/W2994588979","https://openalex.org/W3004887743","https://openalex.org/W3016724860","https://openalex.org/W3033188494","https://openalex.org/W3108171657","https://openalex.org/W3120773077","https://openalex.org/W3127426316","https://openalex.org/W3133555598","https://openalex.org/W3134311741","https://openalex.org/W3186179742","https://openalex.org/W3202031789","https://openalex.org/W3208686740","https://openalex.org/W4200295183","https://openalex.org/W4253384929","https://openalex.org/W4280492873","https://openalex.org/W4283811747","https://openalex.org/W4312196022","https://openalex.org/W4319984362","https://openalex.org/W6653436041"],"related_works":["https://openalex.org/W7167243758","https://openalex.org/W1964959966","https://openalex.org/W2149501736","https://openalex.org/W2801388024","https://openalex.org/W2987216513","https://openalex.org/W2991022372","https://openalex.org/W7164484916","https://openalex.org/W4254237775","https://openalex.org/W6998354850","https://openalex.org/W2791913869"],"abstract_inverted_index":{"Evolved":[0],"properties":[1,25],"of":[2,55,86,103,131,138],"Adeno-Associated":[3],"Virus":[4],"(AAV),":[5],"such":[6],"as":[7],"broad":[8],"tropism":[9],"and":[10,35,71,99,123],"immunogenicity":[11],"in":[12,119],"humans,":[13],"are":[14],"barriers":[15],"to":[16,22,78,89,116,147],"AAV-based":[17],"gene":[18],"therapy.":[19],"Previous":[20],"efforts":[21],"re-engineer":[23],"these":[24],"have":[26],"focused":[27],"on":[28],"variable":[29],"regions":[30],"near":[31],"AAV\u2019s":[32],"3-fold":[33],"protrusions":[34],"capsid":[36,64],"protein":[37,58,65],"termini.":[38],"To":[39],"comprehensively":[40],"survey":[41],"AAV":[42,50,74,87,120,132,149],"capsids":[43,88],"for":[44],"engineerable":[45,129],"hotspots,":[46],"we":[47,113],"determined":[48],"multiple":[49],"fitness":[51,100],"phenotypes":[52],"upon":[53],"insertion":[54,76,104],"large,":[56],"structured":[57],"domains":[59],"into":[60,108],"the":[61,69,135],"entire":[62],"AAV-DJ":[63],"VP1.":[66],"This":[67],"is":[68],"largest":[70],"most":[72],"comprehensive":[73],"domain":[75,92],"dataset":[77],"date.":[79],"Our":[80],"data":[81],"revealed":[82],"a":[83],"surprising":[84],"robustness":[85],"accommodate":[90],"large":[91],"insertions.":[93],"There":[94],"was":[95],"strong":[96],"positional,":[97],"domain-type,":[98],"phenotype":[101],"dependence":[102],"permissibility,":[105],"which":[106,141],"clustered":[107],"correlated":[109],"structural":[110],"units":[111],"that":[112,133],"could":[114],"link":[115],"distinct":[117],"roles":[118],"assembly,":[121],"stability,":[122],"infectivity.":[124],"We":[125],"also":[126],"identified":[127],"new":[128],"hotspots":[130],"facilitate":[134],"covalent":[136],"attachment":[137],"binding":[139],"scaffolds,":[140],"may":[142],"represent":[143],"an":[144],"alternative":[145],"approach":[146],"re-direct":[148],"tropism.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":6}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-10-27T00:00:00"}
