{"id":"https://openalex.org/W4387950375","doi":"https://doi.org/10.1080/13543784.2023.2274439","title":"Emerging pharmacotherapies for the treatment of pulmonary arterial hypertension","display_name":"Emerging pharmacotherapies for the treatment of pulmonary arterial hypertension","publication_year":2023,"publication_date":"2023-10-26","ids":{"openalex":"https://openalex.org/W4387950375","doi":"https://doi.org/10.1080/13543784.2023.2274439","pmid":"https://pubmed.ncbi.nlm.nih.gov/37881882"},"language":"en","primary_location":{"id":"doi:10.1080/13543784.2023.2274439","doi":"https://doi.org/10.1080/13543784.2023.2274439","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13543784.2023.2274439","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013690153","display_name":"Roger Auth","orcid":"https://orcid.org/0000-0002-1265-6379","observed_orcids":["https://orcid.org/0000-0002-1265-6379"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger Auth","raw_affiliation_strings":["Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071223454","display_name":"James R. Klinger","orcid":"https://orcid.org/0000-0003-2997-5955","observed_orcids":["https://orcid.org/0000-0003-2997-5955"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I2800446032","display_name":"Rhode Island Hospital","ror":"https://ror.org/01aw9fv09","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800446032","https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James R. Klinger","raw_affiliation_strings":["Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary, Sleep and Critical Care Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA","institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071223454"],"corresponding_institution_ids":["https://openalex.org/I27804330","https://openalex.org/I2800446032"],"apc_list":null,"apc_paid":null,"fwci":0.5556,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.53615222,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"32","issue":"11","first_page":"1025","last_page":"1042"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":1.0},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.8820000290870667},{"id":"https://openalex.org/keywords/investigational-drugs","display_name":"investigational drugs","score":0.8489999771118164},{"id":"https://openalex.org/keywords/inhaled-medications","display_name":"inhaled medications","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pulmonary-vasodilation","display_name":"pulmonary vasodilation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pulmonary-vascular-remodeling","display_name":"pulmonary vascular remodeling","score":0.8569999933242798},{"id":"https://openalex.org/keywords/prostacyclin-analogues","display_name":"prostacyclin analogues","score":0.7540000081062317},{"id":"https://openalex.org/keywords/endothelin-receptor-antagonists","display_name":"endothelin receptor antagonists","score":0.8790000081062317},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.906000018119812},{"id":"https://openalex.org/keywords/pulmonary-vasoconstriction","display_name":"pulmonary vasoconstriction","score":0.6840000152587891},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8213702440261841},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5569804310798645},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5204879641532898},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.49619632959365845},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48301705718040466},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.4200170636177063},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4017001986503601},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3371807336807251},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.260037899017334},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000081029","descriptor_name":"Pulmonary Arterial Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000081029","descriptor_name":"Pulmonary Arterial Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015507","descriptor_name":"Drugs, Investigational","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/13543784.2023.2274439","doi":"https://doi.org/10.1080/13543784.2023.2274439","is_oa":false,"landing_page_url":"https://doi.org/10.1080/13543784.2023.2274439","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},{"id":"pmid:37881882","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37881882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on investigational drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":117,"referenced_works":["https://openalex.org/W129609809","https://openalex.org/W163314026","https://openalex.org/W1811208101","https://openalex.org/W1817572790","https://openalex.org/W1888035750","https://openalex.org/W1929000169","https://openalex.org/W1932584694","https://openalex.org/W1941346671","https://openalex.org/W1966465623","https://openalex.org/W1969722648","https://openalex.org/W1971354490","https://openalex.org/W1972623139","https://openalex.org/W1974463975","https://openalex.org/W1979770196","https://openalex.org/W1982015481","https://openalex.org/W1991731724","https://openalex.org/W2008797815","https://openalex.org/W2026469629","https://openalex.org/W2043859884","https://openalex.org/W2046783116","https://openalex.org/W2048964430","https://openalex.org/W2063608650","https://openalex.org/W2065501812","https://openalex.org/W2065781224","https://openalex.org/W2069275891","https://openalex.org/W2071788329","https://openalex.org/W2087141463","https://openalex.org/W2088849545","https://openalex.org/W2090479065","https://openalex.org/W2094975792","https://openalex.org/W2111758472","https://openalex.org/W2112229901","https://openalex.org/W2117339256","https://openalex.org/W2117903697","https://openalex.org/W2120139621","https://openalex.org/W2121376498","https://openalex.org/W2132001965","https://openalex.org/W2134915108","https://openalex.org/W2143241675","https://openalex.org/W2144090991","https://openalex.org/W2146264128","https://openalex.org/W2148225708","https://openalex.org/W2154568166","https://openalex.org/W2158657788","https://openalex.org/W2158862125","https://openalex.org/W2161370807","https://openalex.org/W2163585396","https://openalex.org/W2168595762","https://openalex.org/W2178413825","https://openalex.org/W2194585464","https://openalex.org/W2410230392","https://openalex.org/W2492672367","https://openalex.org/W2512905153","https://openalex.org/W2560835818","https://openalex.org/W2589551254","https://openalex.org/W2737389832","https://openalex.org/W2746297077","https://openalex.org/W2755040977","https://openalex.org/W2758208370","https://openalex.org/W2798060402","https://openalex.org/W2801818213","https://openalex.org/W2809966069","https://openalex.org/W2888881199","https://openalex.org/W2888972782","https://openalex.org/W2890378137","https://openalex.org/W2900760553","https://openalex.org/W2904180601","https://openalex.org/W2904847674","https://openalex.org/W2905257285","https://openalex.org/W2905582258","https://openalex.org/W2913206873","https://openalex.org/W2942931819","https://openalex.org/W2943788550","https://openalex.org/W2952074557","https://openalex.org/W2965586691","https://openalex.org/W2973241128","https://openalex.org/W2974260792","https://openalex.org/W2980987186","https://openalex.org/W3001829806","https://openalex.org/W3009862159","https://openalex.org/W3016504452","https://openalex.org/W3024330048","https://openalex.org/W3048455630","https://openalex.org/W3081830235","https://openalex.org/W3093467643","https://openalex.org/W3096447447","https://openalex.org/W3106985941","https://openalex.org/W3111458410","https://openalex.org/W3126168449","https://openalex.org/W3133955216","https://openalex.org/W3137567872","https://openalex.org/W3139219071","https://openalex.org/W3152050105","https://openalex.org/W3196901088","https://openalex.org/W3201735854","https://openalex.org/W3203914588","https://openalex.org/W3207757913","https://openalex.org/W4220835467","https://openalex.org/W4223504984","https://openalex.org/W4223542003","https://openalex.org/W4224879000","https://openalex.org/W4225316868","https://openalex.org/W4229335505","https://openalex.org/W4255412302","https://openalex.org/W4282937720","https://openalex.org/W4285490537","https://openalex.org/W4286592267","https://openalex.org/W4293217384","https://openalex.org/W4298393580","https://openalex.org/W4310137383","https://openalex.org/W4312095670","https://openalex.org/W4321108076","https://openalex.org/W4321377628","https://openalex.org/W4323293924","https://openalex.org/W4367599705","https://openalex.org/W4376872385","https://openalex.org/W4384282523"],"related_works":["https://openalex.org/W3036356353","https://openalex.org/W6925031555","https://openalex.org/W4410207013","https://openalex.org/W2164261898","https://openalex.org/W7159792550","https://openalex.org/W4304014559","https://openalex.org/W1756483023","https://openalex.org/W2138428172","https://openalex.org/W4288045505","https://openalex.org/W2185294827"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Pulmonary":[1],"arterial":[2],"hypertension":[3],"(PAH)":[4],"is":[5],"a":[6,89],"progressive":[7],"and":[8,24,35,46,72,94,98,114,170,181],"life-threatening":[9],"disease.":[10,204],"Approved":[11,125],"treatment":[12,200],"options":[13,161],"currently":[14,51,103],"primarily":[15,137],"target":[16,129],"abnormal":[17],"cell":[18],"signaling":[19,189],"pathways":[20,64,134,190],"involved":[21,65],"in":[22,66,76,131,192],"vasoconstriction":[23],"proliferation,":[25],"such":[26],"as":[27],"those":[28],"mediated":[29],"by":[30],"prostacyclin,":[31],"cyclic":[32],"guanosine":[33],"monophosphate,":[34],"endothelin.":[36],"AREAS":[37],"COVERED:":[38],"Recent":[39],"advancements":[40],"have":[41,69,118],"led":[42],"to":[43,197],"new":[44,111],"applications":[45],"modes":[47],"of":[48,50,152,167,201],"delivery":[49,169],"approved":[52,104],"PAH":[53,67,86,128,193],"medications.":[54],"At":[55],"the":[56,165,187,199],"same":[57],"time,":[58],"novel":[59],"drugs":[60,116],"targeting":[61],"specific":[62],"molecular":[63],"pathogenesis":[68],"been":[70,121],"developed":[71],"are":[73],"being":[74],"investigated":[75],"clinical":[77],"trials.":[78],"This":[79],"review":[80],"summarizes":[81],"investigational":[82],"drug":[83,168],"trials":[84],"for":[85,127],"gathered":[87],"from":[88],"comprehensive":[90],"search":[91],"using":[92],"PubMed":[93],"ClinicalTrials.gov":[95],"between":[96],"2003":[97],"2023.":[99],"It":[100],"includes":[101],"both":[102],"medications":[105,157],"studied":[106],"at":[107],"different":[108],"doses":[109],"or":[110],"administration":[112],"forms":[113],"experimental":[115],"that":[117,135,162,184],"not":[119],"yet":[120],"approved.":[122],"EXPERT":[123],"OPINION:":[124],"treatments":[126],"imbalances":[130],"pulmonary":[132,140,147],"vasoactive":[133],"work":[136],"on":[138,146,179],"enhancing":[139],"vasodilation":[141],"with":[142],"less":[143],"salient":[144],"effects":[145],"vascular":[148],"remodeling.":[149],"The":[150,175],"advent":[151],"more":[153,176,195],"locally":[154],"acting":[155],"inhaled":[156],"offers":[158],"additional":[159],"therapeutic":[160],"may":[163],"improve":[164],"ease":[166],"reduce":[171],"adverse":[172],"systemic":[173],"effects.":[174],"recent":[177],"emphasis":[178],"developing":[180],"applying":[182],"therapeutics":[183],"directly":[185],"impact":[186],"aberrant":[188],"implicated":[191],"appears":[194],"likely":[196],"advance":[198],"this":[202],"devastating":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-27T00:00:00"}