{"id":"https://openalex.org/W4387949822","doi":"https://doi.org/10.1038/s41598-023-43694-7","title":"Hemoglobin signal network mapping reveals novel indicators for precision medicine","display_name":"Hemoglobin signal network mapping reveals novel indicators for precision medicine","publication_year":2023,"publication_date":"2023-10-25","ids":{"openalex":"https://openalex.org/W4387949822","doi":"https://doi.org/10.1038/s41598-023-43694-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/37880310","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10600136"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-43694-7","doi":"https://doi.org/10.1038/s41598-023-43694-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-43694-7","pdf_url":"https://www.nature.com/articles/s41598-023-43694-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-43694-7.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108402813","display_name":"Randall L. Barbour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall L. Barbour","raw_affiliation_strings":["SUNY Downstate Health Sciences University","Department of Pathology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SUNY Downstate Health Sciences University","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Department of Pathology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058680683","display_name":"Harry L. Graber","orcid":"https://orcid.org/0000-0002-5256-3177","observed_orcids":["https://orcid.org/0000-0002-5256-3177"]},"institutions":[{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harry L. Graber","raw_affiliation_strings":["Photon Migration Technologies Corp. , 15 Cherry Lane , Glen Head , NY 11545","SUNY Downstate Health Sciences University , Department of Pathology , 450 Clarkson Avenue , Brooklyn , NY 11203","Department of Pathology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photon Migration Technologies Corp. , 15 Cherry Lane , Glen Head , NY 11545","institution_ids":[]},{"raw_affiliation_string":"SUNY Downstate Health Sciences University , Department of Pathology , 450 Clarkson Avenue , Brooklyn , NY 11203","institution_ids":["https://openalex.org/I181697535"]},{"raw_affiliation_string":"Department of Pathology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA","institution_ids":["https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":null,"display_name":"San-Lian S. Barbour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"San-Lian S. Barbour","raw_affiliation_strings":["Photon Migration Technologies Corp. , 15 Cherry Lane , Glen Head , NY 11545"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Photon Migration Technologies Corp. , 15 Cherry Lane , Glen Head , NY 11545","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17598944,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"1","first_page":"18257","last_page":"18257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11270","display_name":"Complex Systems and Time Series Analysis","score":0.219200000166893,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11270","display_name":"Complex Systems and Time Series Analysis","score":0.219200000166893,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13283","display_name":"Mental Health Research Topics","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.04670000076293945,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/physiological-time-series","display_name":"physiological time series","score":0.6919999718666077},{"id":"https://openalex.org/keywords/markov-chains","display_name":"Markov chains","score":0.9419999718666077},{"id":"https://openalex.org/keywords/adjacency-matrix","display_name":"adjacency matrix","score":0.6779999732971191},{"id":"https://openalex.org/keywords/non-invasive-cancer-detection","display_name":"non-invasive cancer detection","score":0.6850000023841858},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.6259999871253967},{"id":"https://openalex.org/keywords/molecular-markers","display_name":"molecular markers","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6674004793167114},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.5629382729530334},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4889777898788452},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4886651337146759},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.4637492299079895},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4417327344417572},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.39303141832351685},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.37053319811820984},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25788426399230957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21230235695838928},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17050489783287048}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-023-43694-7","doi":"https://doi.org/10.1038/s41598-023-43694-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-43694-7","pdf_url":"https://www.nature.com/articles/s41598-023-43694-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-2622285/v1","doi":"https://doi.org/10.21203/rs.3.rs-2622285/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-2622285/v1","pdf_url":"https://www.researchsquare.com/article/rs-2622285/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10600136","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10600136","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10600136/pdf/41598_2023_Article_43694.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37880310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37880310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:468ba4cb213c41659a2ccf6279bf9413","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/468ba4cb213c41659a2ccf6279bf9413","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-43694-7","doi":"https://doi.org/10.1038/s41598-023-43694-7","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-43694-7","pdf_url":"https://www.nature.com/articles/s41598-023-43694-7.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387949822.pdf","grobid_xml":"https://content.openalex.org/works/W4387949822.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1948848271","https://openalex.org/W1972481679","https://openalex.org/W1982499849","https://openalex.org/W2024405977","https://openalex.org/W2042400809","https://openalex.org/W2045866331","https://openalex.org/W2098524049","https://openalex.org/W2123487311","https://openalex.org/W2149659501","https://openalex.org/W2163105084","https://openalex.org/W2327202751","https://openalex.org/W2513408092","https://openalex.org/W2620777624","https://openalex.org/W2742400585","https://openalex.org/W2765216222","https://openalex.org/W2772704314","https://openalex.org/W2774217687","https://openalex.org/W2774742000","https://openalex.org/W2778189383","https://openalex.org/W2805397465","https://openalex.org/W2906107882","https://openalex.org/W2945262871","https://openalex.org/W3003192283","https://openalex.org/W3015266960","https://openalex.org/W3090143721","https://openalex.org/W3173839039","https://openalex.org/W3195285310","https://openalex.org/W4211146340","https://openalex.org/W4224284075","https://openalex.org/W4282935008","https://openalex.org/W4306964096","https://openalex.org/W4317718028","https://openalex.org/W6807828861"],"related_works":["https://openalex.org/W2020621047","https://openalex.org/W7154510777","https://openalex.org/W4285987711","https://openalex.org/W2571107035","https://openalex.org/W2511712066","https://openalex.org/W2767021407","https://openalex.org/W6922616254","https://openalex.org/W2566311349","https://openalex.org/W2768645605","https://openalex.org/W2173780949"],"abstract_inverted_index":{"Precision":[0],"medicine":[1],"currently":[2],"relies":[3],"on":[4],"a":[5,29,69,78,83,95,157,179],"mix":[6],"of":[7,67,73,104,110,113,117,127,131,145,156,164,182,190,201],"deep":[8],"phenotyping":[9],"strategies":[10],"to":[11,31,46,90,101,135,141,174,187,198],"guide":[12],"more":[13,70,162],"individualized":[14],"healthcare.":[15],"Despite":[16],"being":[17],"widely":[18],"available":[19],"and":[20,60,119,139,194],"information-rich,":[21],"physiological":[22,191],"time-series":[23,192],"measures":[24,44,92],"are":[25,133,171],"often":[26],"overlooked":[27],"as":[28],"resource":[30],"extend":[32],"insights":[33],"gained":[34],"from":[35,77],"such":[36],"measures.":[37],"Here":[38],"we":[39],"have":[40],"explored":[41],"resting-state":[42],"hemoglobin":[43],"applied":[45,89],"intact":[47],"whole":[48],"breasts":[49],"for":[50],"two":[51],"subject":[52],"groups":[53],"-":[54,63],"women":[55],"with":[56,64],"confirmed":[57],"breast":[58],"cancer":[59,75],"control":[61],"subjects":[62],"the":[65,74,108,154],"goal":[66],"achieving":[68],"detailed":[71],"assessment":[72],"phenotype":[76],"non-invasive":[79],"measure.":[80],"Invoked":[81],"is":[82],"novel":[84],"ordinal":[85],"partition":[86],"network":[87],"method":[88],"multivariate":[91],"that":[93,152,177],"generates":[94],"Markov":[96],"chain,":[97],"thereby":[98],"providing":[99],"access":[100],"quantitative":[102],"descriptions":[103],"short-term":[105],"dynamics":[106],"in":[107],"form":[109],"several":[111],"classes":[112],"adjacency":[114],"matrices.":[115],"Exploration":[116],"these":[118],"their":[120],"associated":[121],"co-dependent":[122],"behaviors":[123,138],"unexpectedly":[124],"reveals":[125],"features":[126,161],"structured":[128],"dynamics,":[129],"some":[130],"which":[132],"shown":[134],"exhibit":[136],"enzyme-like":[137],"sensitivity":[140],"recognized":[142],"molecular":[143],"markers":[144],"disease.":[146],"Thus,":[147],"findings":[148],"obtained":[149],"strongly":[150],"indicate":[151],"despite":[153],"use":[155],"macroscale":[158],"sensing":[159],"method,":[160],"typical":[163],"molecular-cellular":[165],"processes":[166],"can":[167],"be":[168],"identified.":[169],"Discussed":[170],"factors":[172],"unique":[173],"our":[175],"approach":[176],"favor":[178],"deeper":[180],"depiction":[181],"tissue":[183],"phenotypes,":[184],"its":[185,195],"extension":[186],"other":[188],"forms":[189],"measures,":[193],"expected":[196],"utility":[197],"advance":[199],"goals":[200],"precision":[202],"medicine.":[203]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-27T00:00:00"}