{"id":"https://openalex.org/W4387948765","doi":"https://doi.org/10.1007/s00213-023-06480-x","title":"Oral ketamine may offer a solution to the ketamine conundrum","display_name":"Oral ketamine may offer a solution to the ketamine conundrum","publication_year":2023,"publication_date":"2023-10-26","ids":{"openalex":"https://openalex.org/W4387948765","doi":"https://doi.org/10.1007/s00213-023-06480-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/37882811"},"language":"en","primary_location":{"id":"doi:10.1007/s00213-023-06480-x","doi":"https://doi.org/10.1007/s00213-023-06480-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-023-06480-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-023-06480-x.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00213-023-06480-x.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Megan Dutton","orcid":"https://orcid.org/0000-0003-4331-7457","observed_orcids":["https://orcid.org/0000-0003-4331-7457"]},"institutions":[{"id":"https://openalex.org/I174025329","display_name":"University of the Sunshine Coast","ror":"https://ror.org/016gb9e15","country_code":"AU","type":"education","lineage":["https://openalex.org/I174025329"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Megan Dutton","raw_affiliation_strings":["Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia. mdutton@usc.edu.au","Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia"],"raw_orcid":"https://orcid.org/0000-0003-4331-7457","affiliations":[{"raw_affiliation_string":"Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia. mdutton@usc.edu.au","institution_ids":["https://openalex.org/I174025329"]},{"raw_affiliation_string":"Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia","institution_ids":["https://openalex.org/I174025329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051802152","display_name":"Adem Can","orcid":"https://orcid.org/0000-0001-7686-8840","observed_orcids":["https://orcid.org/0000-0001-7686-8840"]},"institutions":[{"id":"https://openalex.org/I174025329","display_name":"University of the Sunshine Coast","ror":"https://ror.org/016gb9e15","country_code":"AU","type":"education","lineage":["https://openalex.org/I174025329"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Adem T. Can","raw_affiliation_strings":["Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia","institution_ids":["https://openalex.org/I174025329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041201452","display_name":"Jim Lagopoulos","orcid":"https://orcid.org/0000-0002-5684-8583","observed_orcids":["https://orcid.org/0000-0002-5684-8583"]},"institutions":[{"id":"https://openalex.org/I174025329","display_name":"University of the Sunshine Coast","ror":"https://ror.org/016gb9e15","country_code":"AU","type":"education","lineage":["https://openalex.org/I174025329"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jim Lagopoulos","raw_affiliation_strings":["Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia","institution_ids":["https://openalex.org/I174025329"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039492331","display_name":"Daniel Francis Hermens","orcid":"https://orcid.org/0000-0002-8570-2663","observed_orcids":["https://orcid.org/0000-0002-8570-2663"]},"institutions":[{"id":"https://openalex.org/I174025329","display_name":"University of the Sunshine Coast","ror":"https://ror.org/016gb9e15","country_code":"AU","type":"education","lineage":["https://openalex.org/I174025329"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Daniel F. Hermens","raw_affiliation_strings":["Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thompson Institute, University of the Sunshine Coast, 12 Innovation Parkway, Birtinya, QLD, 4575, Australia","institution_ids":["https://openalex.org/I174025329"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I174025329"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":2.464,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.90140144,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"240","issue":"12","first_page":"2483","last_page":"2497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-ketamine","display_name":"oral ketamine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/antidepressant-effects","display_name":"antidepressant effects","score":0.6859999895095825},{"id":"https://openalex.org/keywords/norketamine","display_name":"norketamine","score":0.9449999928474426},{"id":"https://openalex.org/keywords/first-pass-metabolism","display_name":"first-pass metabolism","score":0.8730000257492065},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9190000295639038},{"id":"https://openalex.org/keywords/psychotomimetic-side-effects","display_name":"psychotomimetic side effects","score":0.7850000262260437},{"id":"https://openalex.org/keywords/pain-management","display_name":"pain management","score":0.515999972820282},{"id":"https://openalex.org/keywords/depression-treatment","display_name":"depression treatment","score":0.3529999852180481},{"id":"https://openalex.org/keywords/route-of-administration","display_name":"route of administration","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2780795376","wikidata":"https://www.wikidata.org/wiki/Q243547","display_name":"Ketamine","level":2,"score":0.880683422088623},{"id":"https://openalex.org/C2781065190","wikidata":"https://www.wikidata.org/wiki/Q7256512","display_name":"Psychotomimetic","level":4,"score":0.7500835657119751},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6987435817718506},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.6874082684516907},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5846281051635742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5796399712562561},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5317004919052124},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.4696361720561981},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.46544942259788513},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4175513982772827},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3765918016433716},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3426237404346466},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3008292317390442},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.21208536624908447},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.20631346106529236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15555551648139954},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10080045461654663},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007649","descriptor_name":"Ketamine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00213-023-06480-x","doi":"https://doi.org/10.1007/s00213-023-06480-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-023-06480-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-023-06480-x.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:37882811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37882811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10640543","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10640543","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10640543/pdf/213_2023_Article_6480.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Psychopharmacology (Berl)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s00213-023-06480-x","doi":"https://doi.org/10.1007/s00213-023-06480-x","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00213-023-06480-x","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00213-023-06480-x.pdf","source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7699999809265137}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320986","display_name":"University of the Sunshine Coast","ror":"https://ror.org/016gb9e15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387948765.pdf","grobid_xml":"https://content.openalex.org/works/W4387948765.grobid-xml"},"referenced_works_count":96,"referenced_works":["https://openalex.org/W892371344","https://openalex.org/W1549246370","https://openalex.org/W1603603884","https://openalex.org/W1774380774","https://openalex.org/W1885564923","https://openalex.org/W1963822402","https://openalex.org/W1989188733","https://openalex.org/W1990792515","https://openalex.org/W2002143520","https://openalex.org/W2003960536","https://openalex.org/W2004678922","https://openalex.org/W2011239975","https://openalex.org/W2020235530","https://openalex.org/W2020935675","https://openalex.org/W2023081218","https://openalex.org/W2028423021","https://openalex.org/W2028884770","https://openalex.org/W2032836087","https://openalex.org/W2035312998","https://openalex.org/W2044440339","https://openalex.org/W2045893995","https://openalex.org/W2047276596","https://openalex.org/W2066655743","https://openalex.org/W2072055545","https://openalex.org/W2082299145","https://openalex.org/W2084774621","https://openalex.org/W2094496261","https://openalex.org/W2095919616","https://openalex.org/W2108466731","https://openalex.org/W2109334244","https://openalex.org/W2123090955","https://openalex.org/W2128918664","https://openalex.org/W2130624894","https://openalex.org/W2138830589","https://openalex.org/W2141110896","https://openalex.org/W2144645267","https://openalex.org/W2151821353","https://openalex.org/W2154822242","https://openalex.org/W2156342513","https://openalex.org/W2158691492","https://openalex.org/W2163389233","https://openalex.org/W2170862369","https://openalex.org/W2289004134","https://openalex.org/W2322548405","https://openalex.org/W2328324756","https://openalex.org/W2330587564","https://openalex.org/W2410279573","https://openalex.org/W2412461974","https://openalex.org/W2571047716","https://openalex.org/W2608506675","https://openalex.org/W2608847325","https://openalex.org/W2614321752","https://openalex.org/W2615030723","https://openalex.org/W2752700145","https://openalex.org/W2755528490","https://openalex.org/W2770540120","https://openalex.org/W2771797851","https://openalex.org/W2785770559","https://openalex.org/W2789775639","https://openalex.org/W2794064701","https://openalex.org/W2796261668","https://openalex.org/W2796494601","https://openalex.org/W2803958441","https://openalex.org/W2811304329","https://openalex.org/W2889166554","https://openalex.org/W2894395548","https://openalex.org/W2910925824","https://openalex.org/W2911747652","https://openalex.org/W2921561928","https://openalex.org/W2938982352","https://openalex.org/W2964225567","https://openalex.org/W2967193400","https://openalex.org/W2990917747","https://openalex.org/W2999453539","https://openalex.org/W3015053440","https://openalex.org/W3016264041","https://openalex.org/W3026895695","https://openalex.org/W3037344949","https://openalex.org/W3088001093","https://openalex.org/W3101120017","https://openalex.org/W3121350448","https://openalex.org/W3121560609","https://openalex.org/W3128492039","https://openalex.org/W3157093408","https://openalex.org/W3187758358","https://openalex.org/W3194748817","https://openalex.org/W3202661650","https://openalex.org/W4212826549","https://openalex.org/W4225421510","https://openalex.org/W4286567499","https://openalex.org/W4301188094","https://openalex.org/W4309412689","https://openalex.org/W4312071407","https://openalex.org/W4317207262","https://openalex.org/W4322730794","https://openalex.org/W4353055898"],"related_works":["https://openalex.org/W3183055727","https://openalex.org/W2404592296","https://openalex.org/W3041749296","https://openalex.org/W2473510258","https://openalex.org/W2491637274","https://openalex.org/W2600461805","https://openalex.org/W2589198547","https://openalex.org/W3138142958","https://openalex.org/W2962200731","https://openalex.org/W3030480099"],"abstract_inverted_index":{"Ketamine":[0],"has":[1,64,132],"received":[2],"considerable":[3],"attention":[4],"for":[5],"its":[6,187],"rapid":[7],"and":[8,42,85,113,152,185],"robust":[9],"antidepressant":[10],"response":[11],"over":[12],"the":[13,54,83,111,127,181,190],"past":[14],"decade.":[15],"Current":[16],"evidence,":[17],"in":[18,117,172,196],"clinical":[19],"populations,":[20],"predominantly":[21],"relates":[22],"to":[23,30,46,51,69,103,126,135,147,180,189],"parenterally":[24],"administered":[25,62,71,161],"ketamine,":[26,52,72],"which":[27,131],"is":[28,169,194],"reported":[29],"produce":[31,47],"significant":[32],"undesirable":[33],"side":[34,56],"effects,":[35,57,108],"with":[36],"additional":[37],"concerns":[38],"regarding":[39,82],"long-term":[40],"safety":[41],"abuse":[43],"potential.":[44],"Attempts":[45],"a":[48,65,77,95],"similar":[49],"drug":[50],"without":[53,110],"psychotomimetic":[55],"have":[58],"proved":[59],"elusive.":[60],"Orally":[61],"ketamine":[63,89,168],"different":[66],"pharmacological":[67,121],"profile":[68],"parentally":[70],"suggesting":[73],"it":[74,92,101],"may":[75,93,123,176],"be":[76,94,124,136,178],"viable":[78],"alternative.":[79],"Emerging":[80],"evidence":[81,163],"efficacy":[84],"tolerability":[86],"of":[87,98,183],"oral":[88,142,167],"suggests":[90,164],"that":[91,165],"favourable":[96],"route":[97],"administration,":[99],"as":[100],"appears":[102],"obtain":[104],"similarly":[105],"beneficial":[106],"treatment":[107],"but":[109],"cost":[112],"medical":[114],"resources":[115],"required":[116],"parenteral":[118],"dosing.":[119],"The":[120],"effects":[122],"due":[125,146,179],"active":[128],"metabolite":[129],"norketamine,":[130],"been":[133],"found":[134],"at":[137],"substantially":[138],"higher":[139],"levels":[140],"via":[141],"dosing,":[143],"most":[144],"likely":[145],"first-pass":[148],"clearance.":[149],"Despite":[150],"bioavailability":[151],"peak":[153],"plasma":[154],"concentrations":[155],"both":[156],"being":[157],"lower":[158],"than":[159],"when":[160],"parenterally,":[162],"low-dose":[166],"clinically":[170],"effective":[171],"treating":[173],"pain.":[174],"This":[175],"also":[177],"actions":[182],"norketamine":[184],"therefore,":[186],"relevance":[188],"mental":[191],"health":[192],"context":[193],"explored":[195],"this":[197],"narrative":[198],"review.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}