{"id":"https://openalex.org/W4387948396","doi":"https://doi.org/10.1007/s12325-023-02700-0","title":"Treatment-Resistant Depression in Real-World Clinical Practice: A Systematic Literature Review of Data from 2012 to 2022","display_name":"Treatment-Resistant Depression in Real-World Clinical Practice: A Systematic Literature Review of Data from 2012 to 2022","publication_year":2023,"publication_date":"2023-10-26","ids":{"openalex":"https://openalex.org/W4387948396","doi":"https://doi.org/10.1007/s12325-023-02700-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/37882883","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10796703"},"language":"en","primary_location":{"id":"doi:10.1007/s12325-023-02700-0","doi":"https://doi.org/10.1007/s12325-023-02700-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-023-02700-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-023-02700-0.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s12325-023-02700-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032763144","display_name":"Albino Jorge Oliveira-Maia","orcid":"https://orcid.org/0000-0001-5071-3007","observed_orcids":["https://orcid.org/0000-0001-5071-3007"]},"institutions":[{"id":"https://openalex.org/I113358080","display_name":"Champalimaud Foundation","ror":"https://ror.org/03g001n57","country_code":"PT","type":"facility","lineage":["https://openalex.org/I113358080"]},{"id":"https://openalex.org/I83558840","display_name":"Universidade Nova de Lisboa","ror":"https://ror.org/02xankh89","country_code":"PT","type":"education","lineage":["https://openalex.org/I83558840"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Albino J. Oliveira-Maia","raw_affiliation_strings":["Champalimaud Research and Clinical Centre, Champalimaud Foundation, Lisbon, Portugal","Faculdade de Ci\u00eancias M\u00e9dicas, NOVA Medical School, NMS, FCM, Universidade NOVA de Lisboa, Lisbon, Portugal"],"raw_orcid":"https://orcid.org/0000-0001-5071-3007","affiliations":[{"raw_affiliation_string":"Champalimaud Research and Clinical Centre, Champalimaud Foundation, Lisbon, Portugal","institution_ids":["https://openalex.org/I113358080"]},{"raw_affiliation_string":"Faculdade de Ci\u00eancias M\u00e9dicas, NOVA Medical School, NMS, FCM, Universidade NOVA de Lisboa, Lisbon, Portugal","institution_ids":["https://openalex.org/I83558840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063318733","display_name":"Anna Bobrowska","orcid":"https://orcid.org/0000-0002-5001-7981","observed_orcids":["https://orcid.org/0000-0002-5001-7981"]},"institutions":[{"id":"https://openalex.org/I4210157105","display_name":"Costello Medical Consulting (United Kingdom)","ror":"https://ror.org/04pe4vg07","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210157105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ania Bobrowska","raw_affiliation_strings":["Costello Medical, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Costello Medical, Cambridge, UK","institution_ids":["https://openalex.org/I4210157105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073200422","display_name":"\u00c9ric Constant","orcid":"https://orcid.org/0000-0001-8023-1535","observed_orcids":["https://orcid.org/0000-0001-8023-1535"]},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Eric Constant","raw_affiliation_strings":["Centre Hospitalier Sp\u00e9cialis\u00e9 Notre-Dame des Anges, Li\u00e8ge, Belgium","Universit\u00e9 Catholique de Louvain, Brussels, Universit\u00e9 de Li\u00e8ge, Li\u00e8ge, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-8023-1535","affiliations":[{"raw_affiliation_string":"Centre Hospitalier Sp\u00e9cialis\u00e9 Notre-Dame des Anges, Li\u00e8ge, Belgium","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Catholique de Louvain, Brussels, Universit\u00e9 de Li\u00e8ge, Li\u00e8ge, Belgium","institution_ids":["https://openalex.org/I157674565","https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055661024","display_name":"Tetsuro Ito","orcid":"https://orcid.org/0000-0003-0802-638X","observed_orcids":["https://orcid.org/0000-0003-0802-638X"]},"institutions":[{"id":"https://openalex.org/I4210118116","display_name":"Janssen (United Kingdom)","ror":"https://ror.org/02nw6hx08","country_code":"GB","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4210118116"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tetsuro Ito","raw_affiliation_strings":["Janssen EMEA, High Wycombe, UK"],"raw_orcid":"https://orcid.org/0000-0003-0802-638X","affiliations":[{"raw_affiliation_string":"Janssen EMEA, High Wycombe, UK","institution_ids":["https://openalex.org/I4210118116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087681699","display_name":"Yerkebulan Kambarov","orcid":"https://orcid.org/0000-0003-0362-8373","observed_orcids":["https://orcid.org/0000-0003-0362-8373"]},"institutions":[{"id":"https://openalex.org/I137982388","display_name":"Janssen (Belgium)","ror":"https://ror.org/04yzcpd71","country_code":"BE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I137982388"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Yerkebulan Kambarov","raw_affiliation_strings":["Janssen Pharmaceutica NV, Beerse, Belgium. YKambaro@its.jnj.com","Janssen Pharmaceutica NV, Beerse, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-0362-8373","affiliations":[{"raw_affiliation_string":"Janssen Pharmaceutica NV, Beerse, Belgium. YKambaro@its.jnj.com","institution_ids":["https://openalex.org/I137982388"]},{"raw_affiliation_string":"Janssen Pharmaceutica NV, Beerse, Belgium","institution_ids":["https://openalex.org/I137982388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079907731","display_name":"Hannah Luedke","orcid":"https://orcid.org/0009-0006-8290-600X","observed_orcids":["https://orcid.org/0009-0006-8290-600X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah Luedke","raw_affiliation_strings":["Costello Medical, London, UK"],"raw_orcid":"https://orcid.org/0009-0006-8290-600X","affiliations":[{"raw_affiliation_string":"Costello Medical, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031847870","display_name":"Siobh\u00e1n Mulhern-Haughey","orcid":"https://orcid.org/0000-0002-9708-4356","observed_orcids":["https://orcid.org/0000-0002-9708-4356"]},"institutions":[{"id":"https://openalex.org/I4210104516","display_name":"Janssen (Ireland)","ror":"https://ror.org/01dcg9845","country_code":"IE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4210104516"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Siobh\u00e1n Mulhern-Haughey","raw_affiliation_strings":["Janssen EMEA, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-9708-4356","affiliations":[{"raw_affiliation_string":"Janssen EMEA, Dublin, Ireland","institution_ids":["https://openalex.org/I4210104516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114093954","display_name":"Christian von Holt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128934","display_name":"Janssen (Germany)","ror":"https://ror.org/038rd9v60","country_code":"DE","type":"company","lineage":["https://openalex.org/I1330063522","https://openalex.org/I4210128934"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian von Holt","raw_affiliation_strings":["Janssen EMEA, Neuss, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Janssen EMEA, Neuss, Germany","institution_ids":["https://openalex.org/I4210128934"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5087681699"],"corresponding_institution_ids":["https://openalex.org/I137982388"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":1.3741,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.78855721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"41","issue":"1","first_page":"34","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11921","display_name":"Electroconvulsive Therapy Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10272","display_name":"Mental Health Treatment and Access","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.9990000128746033},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.9010000228881836},{"id":"https://openalex.org/keywords/disease-burden","display_name":"disease burden","score":0.8999999761581421},{"id":"https://openalex.org/keywords/remission-rate","display_name":"remission rate","score":0.7829999923706055},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6980000138282776},{"id":"https://openalex.org/keywords/health-related-quality-of-life","display_name":"health-related quality of life","score":0.9700000286102295},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.6019999980926514},{"id":"https://openalex.org/keywords/unmet-needs","display_name":"unmet needs","score":0.39100000262260437},{"id":"https://openalex.org/keywords/antidepressant-treatment-outcome","display_name":"antidepressant treatment outcome","score":0.6079999804496765},{"id":"https://openalex.org/keywords/long-term-depression","display_name":"long-term depression","score":0.4020000100135803},{"id":"https://openalex.org/keywords/access-to-mental-health-care","display_name":"access to mental health care","score":0.3319999873638153},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8574217557907104},{"id":"https://openalex.org/C2779549880","wikidata":"https://www.wikidata.org/wiki/Q5542226","display_name":"PsycINFO","level":3,"score":0.6952285766601562},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.639568567276001},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6343710422515869},{"id":"https://openalex.org/C189708586","wikidata":"https://www.wikidata.org/wiki/Q1504425","display_name":"Systematic review","level":3,"score":0.588379442691803},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5368163585662842},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.534942090511322},{"id":"https://openalex.org/C2777342061","wikidata":"https://www.wikidata.org/wiki/Q7836891","display_name":"Treatment-resistant depression","level":4,"score":0.5174506306648254},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.5093013048171997},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35179591178894043},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.3320157527923584},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.25572192668914795},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.23318690061569214},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061218","descriptor_name":"Depressive Disorder, Treatment-Resistant","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D061218","descriptor_name":"Depressive Disorder, Treatment-Resistant","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1007/s12325-023-02700-0","doi":"https://doi.org/10.1007/s12325-023-02700-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-023-02700-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-023-02700-0.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10796703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10796703","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10796703/pdf/12325_2023_Article_2700.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Adv Ther","raw_type":"Text"},{"id":"pmid:37882883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37882883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in therapy","raw_type":"Systematic Review"},{"id":"pmh:oai:frl.publisso.de:frl:6506427","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10796703","pdf_url":null,"source":{"id":"https://openalex.org/S4306402606","display_name":"Informationszentrum Lebenswissenschaften (ZB MED)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210112663","host_organization_name":"ZB MED - Information Centre for Life Sciences","host_organization_lineage":["https://openalex.org/I4210112663"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advances in therapy, 41(1):34-64","raw_type":"Zeitschriftenartikel"},{"id":"pmh:oai:dial.uclouvain.be:boreal:299001","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/299001","pdf_url":null,"source":{"id":"https://openalex.org/S4306400166","display_name":"Digital Access to Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2800384882","host_organization_name":"Harris County Public Library","host_organization_lineage":["https://openalex.org/I2800384882"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advances in therapy, Vol. 41, no.1, p. 34-64 (2024)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:run.unl.pt:10362/160051","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/pages/publications/85174976895","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"review"}],"best_oa_location":{"id":"doi:10.1007/s12325-023-02700-0","doi":"https://doi.org/10.1007/s12325-023-02700-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s12325-023-02700-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s12325-023-02700-0.pdf","source":{"id":"https://openalex.org/S27230875","display_name":"Advances in Therapy","issn_l":"0741-238X","issn":["0741-238X","1865-8652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387948396.pdf","grobid_xml":"https://content.openalex.org/works/W4387948396.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W102833839","https://openalex.org/W190378794","https://openalex.org/W1897872731","https://openalex.org/W1991604982","https://openalex.org/W2010167850","https://openalex.org/W2014360838","https://openalex.org/W2016292245","https://openalex.org/W2017713202","https://openalex.org/W2037227674","https://openalex.org/W2072750060","https://openalex.org/W2084315798","https://openalex.org/W2095852687","https://openalex.org/W2098750661","https://openalex.org/W2111118992","https://openalex.org/W2132322340","https://openalex.org/W2132324173","https://openalex.org/W2157803948","https://openalex.org/W2234395902","https://openalex.org/W2394697357","https://openalex.org/W2598562325","https://openalex.org/W2606796665","https://openalex.org/W2756185629","https://openalex.org/W2770097418","https://openalex.org/W2885418463","https://openalex.org/W2897119380","https://openalex.org/W2914765137","https://openalex.org/W2914894622","https://openalex.org/W2964840460","https://openalex.org/W3044729970","https://openalex.org/W3087322744","https://openalex.org/W3109964933","https://openalex.org/W3113359826","https://openalex.org/W3129740058","https://openalex.org/W3147042728","https://openalex.org/W3190596462","https://openalex.org/W3213354854","https://openalex.org/W4213247170","https://openalex.org/W4220881576","https://openalex.org/W4311432965"],"related_works":["https://openalex.org/W3147042728","https://openalex.org/W2058805315","https://openalex.org/W3176713124","https://openalex.org/W4295900103","https://openalex.org/W3036613458","https://openalex.org/W3213354854","https://openalex.org/W4414181152","https://openalex.org/W1978161441","https://openalex.org/W3112755400","https://openalex.org/W4394976893"],"abstract_inverted_index":{"Real-world":[0,89],"evidence":[1],"in":[2,40,53,56,101,106,237,344,356,366,369,383,394],"treatment-resistant":[3,309],"depression":[4,144,298,310,492],"(TRD;":[5],"commonly":[6],"defined":[7],"as":[8,283,285],"non-response":[9],"to":[10,28,69,84,147,158,191,211,296,333,416],"\u2265":[11],"2":[12,189],"consecutive":[13],"treatments":[14,341,400,421],"at":[15,167],"adequate":[16],"dosage":[17],"and":[18,32,62,78,97,103,116,126,194,214,233,248,256,278,339,407,431,452,477,522],"duration)":[19],"is":[20,223,250,307,331],"lacking.":[21],"A":[22,48],"systematic":[23,76],"literature":[24,49],"review":[25,96],"was":[26,51,219,397,480],"conducted":[27,52],"understand":[29,262,334],"disease":[30,118,153,166],"burden":[31,164,245,265],"treatment":[33,120,122,281],"outcomes":[34,105,125],"for":[35,136,254,362,434,449,504,520],"patients":[36,140],"with":[37,108,177,442,447],"TRD,":[38,109,513],"studied":[39],"a":[41,162,224,243,357,426,435,505],"real-world":[42,238,367,384],"setting":[43],"over":[44],"the":[45,182,230,263,314,335,370,399,524],"last":[46,371],"decade.":[47],"search":[50],"May":[54],"2022":[55,85],"MEDLINE,":[57],"Embase,":[58],"The":[59],"Cochrane":[60],"Libraries":[61],"PsycINFO,":[63],"comprising":[64],"studies":[65,132,270,363,381,424,461,471,483,501,515],"published":[66,100],"from":[67,82,273,321],"2012":[68],"2022.":[70],"Bibliographies":[71],"of":[72,129,165,184,217,226,235,246,266,275,280,288,291,313,337,429,475,486,491,512,527],"all":[73],"relevant":[74,79,377],"identified":[75],"reviews":[77],"conference":[80],"proceedings":[81],"2020":[83],"were":[86,110,133,171,202,382,387,405,410,455],"manually":[87],"hand-searched.":[88],"studies,":[90,99,151],"including":[91,392],"cohort,":[92],"cross-sectional,":[93],"case\u2013control,":[94],"chart":[95],"registry":[98],"English":[102],"reporting":[104],"adults":[107],"included.":[111,134],"Extracted":[112],"data":[113],"included":[114,425],"study":[115],"baseline":[117],"characteristics,":[119],"type,":[121],"response,":[123],"clinical":[124,227,322],"health-related":[127,215,289,473],"quality":[128,216,290,474],"life.":[130,292],"Twenty":[131],"Criteria":[135],"TRD":[137,236,241,319,338,340,396,443,465,535],"varied,":[138],"but":[139,174],"typically":[141,172,497],"experienced":[142],"long-lasting":[143],"(range":[145,188,209],"1.4":[146],"16.5":[148],"years).":[149],"Across":[150],"mean":[152],"severity":[154,276],"scores":[155],"demonstrated":[156],"moderate":[157,456],"severe":[159],"depression,":[160],"reflecting":[161],"high":[163,244],"baseline.":[168],"Remission":[169],"rates":[170],"low":[173,206],"generally":[175],"increased":[176],"longer":[178,506,521],"follow-up":[179,186],"durations.":[180],"However,":[181,495],"heterogeneity":[183],"interventions,":[185],"durations":[187],"weeks":[190],"9.4":[192],"years)":[193],"assessment":[195,232,277],"tools":[196],"precluded":[197],"their":[198,345,453,467],"quantitative":[199],"synthesis.":[200],"Studies":[201],"frequently":[203],"limited":[204],"by":[205],"sample":[207],"size":[208],"14":[210],"411":[212],"patients)":[213],"life":[218,476],"infrequently":[220],"assessed.":[221],"There":[222],"lack":[225],"consensus":[228],"regarding":[229],"definition,":[231],"monitoring":[234],"practice.":[239],"Nevertheless,":[240],"carries":[242],"illness":[247],"there":[249,386],"an":[251],"unmet":[252],"need":[253],"faster":[255],"more":[257,304,499,518],"effective":[258],"treatments.":[259],"To":[260,508],"better":[261],"personal":[264],"affected":[267,466],"patients,":[268],"future":[269,514],"would":[271],"benefit":[272],"standardisation":[274],"measures":[279],"effectiveness,":[282],"well":[284],"greater":[286],"consideration":[287],"Many":[293],"people":[294,343,404,430,441,463,487,503,519],"continue":[295],"experience":[297],"even":[299],"after":[300,493],"trying":[301],"two":[302,460,470],"or":[303,457],"medications.":[305],"This":[306,412],"called":[308],"(TRD).":[311],"Most":[312,423,482],"information":[315],"we":[316],"have":[317],"on":[318,342],"comes":[320],"trials,":[323],"which":[324],"take":[325],"place":[326],"under":[327],"tightly-controlled":[328],"conditions.":[329],"It":[330],"important":[332],"effects":[336],"day-to-day":[346,351],"lives.":[347,468,539],"Researchers":[348],"studying":[349],"people\u2019s":[350,537],"lives":[352],"call":[353],"this":[354],"researching":[355],"\u201creal-world":[358],"setting\u201d.":[359],"We":[360,374,439],"searched":[361],"carried":[364],"out":[365],"settings":[368],"10":[372],"years.":[373],"found":[375,440,472,484],"20":[376],"studies.":[378],"As":[379],"these":[380],"settings,":[385],"many":[388,450],"differences":[389,393],"between":[390],"them,":[391],"how":[395,402,408,418,464,534],"diagnosed,":[398],"used,":[401],"long":[403],"monitored":[406,432,502],"results":[409],"measured.":[411],"made":[413],"it":[414,448],"difficult":[415],"compare":[417],"successful":[419],"different":[420],"were.":[422],"small":[427],"number":[428],"them":[433],"relatively":[436],"short":[437],"time.":[438,507],"had":[444,489],"usually":[445],"lived":[446],"years":[451],"symptoms":[454,490,496],"severe.":[458],"Only":[459],"asked":[462],"These":[469],"work":[478],"productivity":[479],"low.":[481],"lots":[485],"still":[488],"treatment.":[494],"improved":[498],"when":[500],"improve":[509],"our":[510],"knowledge":[511],"should":[516,531],"monitor":[517],"use":[523],"same":[525],"ways":[526],"measuring":[528],"results.":[529],"They":[530],"also":[532],"ask":[533],"affects":[536],"daily":[538]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-27T00:00:00"}