{"id":"https://openalex.org/W4387940171","doi":"https://doi.org/10.1038/s41598-023-45534-0","title":"Age and severity-dependent gut microbiota alterations in Tunisian children with autism spectrum disorder","display_name":"Age and severity-dependent gut microbiota alterations in Tunisian children with autism spectrum disorder","publication_year":2023,"publication_date":"2023-10-25","ids":{"openalex":"https://openalex.org/W4387940171","doi":"https://doi.org/10.1038/s41598-023-45534-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/37880312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10600251"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-45534-0","doi":"https://doi.org/10.1038/s41598-023-45534-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-45534-0","pdf_url":"https://www.nature.com/articles/s41598-023-45534-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-45534-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046453340","display_name":"Mariem Chamtouri","orcid":"https://orcid.org/0000-0002-7839-6784","observed_orcids":["https://orcid.org/0000-0002-7839-6784"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]},{"id":"https://openalex.org/I4210091402","display_name":"Instituto de Productos L\u00e1cteos de Asturias","ror":"https://ror.org/00bnagp43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]}],"countries":["ES","TN"],"is_corresponding":false,"raw_author_name":"Mariem Chamtouri","raw_affiliation_strings":["Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain","Laboratory of Transmissible Diseases and Biologically Active Substances LR99ES27, Faculty of Pharmacy, University of Monastir, 5000, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]},{"raw_affiliation_string":"Laboratory of Transmissible Diseases and Biologically Active Substances LR99ES27, Faculty of Pharmacy, University of Monastir, 5000, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069151422","display_name":"Naoufel Gaddour","orcid":"https://orcid.org/0000-0002-7219-9376","observed_orcids":["https://orcid.org/0000-0002-7219-9376"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Naoufel Gaddour","raw_affiliation_strings":["Unit of Child Psychiatry, Monastir University Hospital, 5000, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Child Psychiatry, Monastir University Hospital, 5000, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022815201","display_name":"Abderrahmen Merghni","orcid":"https://orcid.org/0000-0003-4427-0208","observed_orcids":["https://orcid.org/0000-0003-4427-0208"]},"institutions":[{"id":"https://openalex.org/I108714496","display_name":"Tunis University","ror":"https://ror.org/02q1spa57","country_code":"TN","type":"education","lineage":["https://openalex.org/I108714496"]},{"id":"https://openalex.org/I4403386600","display_name":"Facult\u00e9 de m\u00e9decine de Tunis","ror":"https://ror.org/03pyhhg10","country_code":"TN","type":"education","lineage":["https://openalex.org/I4403386600","https://openalex.org/I63596082"]},{"id":"https://openalex.org/I63596082","display_name":"Tunis El Manar University","ror":"https://ror.org/029cgt552","country_code":"TN","type":"education","lineage":["https://openalex.org/I63596082"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Abderrahmen Merghni","raw_affiliation_strings":["Laboratory of Antimicrobial Resistance LR99ES09, Faculty of Medicine of Tunis, University of Tunis El Manar, 1068, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Antimicrobial Resistance LR99ES09, Faculty of Medicine of Tunis, University of Tunis El Manar, 1068, Tunis, Tunisia","institution_ids":["https://openalex.org/I108714496","https://openalex.org/I4403386600","https://openalex.org/I63596082"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052128544","display_name":"Maha Mastouri","orcid":"https://orcid.org/0000-0003-3630-5255","observed_orcids":["https://orcid.org/0000-0003-3630-5255"]},"institutions":[{"id":"https://openalex.org/I166928557","display_name":"University of Monastir","ror":"https://ror.org/00nhtcg76","country_code":"TN","type":"education","lineage":["https://openalex.org/I166928557"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Maha Mastouri","raw_affiliation_strings":["Laboratory of Transmissible Diseases and Biologically Active Substances LR99ES27, Faculty of Pharmacy, University of Monastir, 5000, Monastir, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Transmissible Diseases and Biologically Active Substances LR99ES27, Faculty of Pharmacy, University of Monastir, 5000, Monastir, Tunisia","institution_ids":["https://openalex.org/I166928557"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084156178","display_name":"Silvia Arboleya","orcid":"https://orcid.org/0000-0002-6155-5822","observed_orcids":["https://orcid.org/0000-0002-6155-5822"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210091402","display_name":"Instituto de Productos L\u00e1cteos de Asturias","ror":"https://ror.org/00bnagp43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]},{"id":"https://openalex.org/I4210166274","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias","ror":"https://ror.org/05xzb7x97","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210166274"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Silvia Arboleya","raw_affiliation_strings":["Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain. silvia.arboleya@ipla.csic.es","Diet, Microbiota, and Health Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain. silvia.arboleya@ipla.csic.es","Diet, Microbiota, and Health Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain. silvia.arboleya@ipla.csic.es","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]},{"raw_affiliation_string":"Diet, Microbiota, and Health Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain. silvia.arboleya@ipla.csic.es","institution_ids":["https://openalex.org/I4210166274"]},{"raw_affiliation_string":"Diet, Microbiota, and Health Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain","institution_ids":["https://openalex.org/I4210166274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031547823","display_name":"Clara G. de los Reyes\u2010Gavil\u00e1n","orcid":"https://orcid.org/0000-0001-9396-6311","observed_orcids":["https://orcid.org/0000-0001-9396-6311"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210091402","display_name":"Instituto de Productos L\u00e1cteos de Asturias","ror":"https://ror.org/00bnagp43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]},{"id":"https://openalex.org/I4210166274","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias","ror":"https://ror.org/05xzb7x97","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210166274"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Clara G. de los Reyes-Gavil\u00e1n","raw_affiliation_strings":["Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain. greyes_gavilan@ipla.csic.es","Diet, Microbiota, and Health Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain. greyes_gavilan@ipla.csic.es","Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain. greyes_gavilan@ipla.csic.es","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]},{"raw_affiliation_string":"Diet, Microbiota, and Health Group, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA), 33011, Oviedo, Spain. greyes_gavilan@ipla.csic.es","institution_ids":["https://openalex.org/I4210166274"]},{"raw_affiliation_string":"Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos L\u00e1cteos de Asturias (IPLA-CSIC), 33300, Villaviciosa, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091402"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5031547823","https://openalex.org/A5084156178"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210091402","https://openalex.org/I4210166274"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":2.0023,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.87676778,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"18218","last_page":"18218"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9959999918937683},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.9160000085830688},{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.8579999804496765},{"id":"https://openalex.org/keywords/collinsella","display_name":"Collinsella","score":0.9980000257492065},{"id":"https://openalex.org/keywords/propionic-acid","display_name":"propionic acid","score":0.8299999833106995},{"id":"https://openalex.org/keywords/valeric-acid","display_name":"valeric acid","score":1.0},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.6700000166893005},{"id":"https://openalex.org/keywords/autism-severity","display_name":"autism severity","score":0.734000027179718},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.6570000052452087},{"id":"https://openalex.org/keywords/tunisian-children","display_name":"Tunisian children","score":0.7250000238418579},{"id":"https://openalex.org/keywords/sibling-comparison","display_name":"sibling comparison","score":0.43299999833106995},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.8407974243164062},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.7380717992782593},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.7247679233551025},{"id":"https://openalex.org/C2780305828","wikidata":"https://www.wikidata.org/wiki/Q132656","display_name":"Bifidobacterium","level":4,"score":0.6579546928405762},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.5759388208389282},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4898809790611267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.433156818151474},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3802526891231537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3347482681274414},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2961578667163849},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.21217447519302368},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.11930957436561584},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.09097746014595032},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.08171594142913818},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08047065138816833},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06433048844337463}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001644","descriptor_name":"Bifidobacterium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005232","descriptor_name":"Fatty Acids, Volatile","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1038/s41598-023-45534-0","doi":"https://doi.org/10.1038/s41598-023-45534-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-45534-0","pdf_url":"https://www.nature.com/articles/s41598-023-45534-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10600251","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10600251","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10600251/pdf/41598_2023_Article_45534.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37880312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37880312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/347143","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/347143","pdf_url":"https://digital.csic.es/bitstream/10261/347143/1/s41598-023-45534-0.pdf","source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:232a73e9bf28430992308d0694a0f21b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/232a73e9bf28430992308d0694a0f21b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)","raw_type":"article"},{"id":"doi:10.60692/g0xfs-00j80","doi":"https://doi.org/10.60692/g0xfs-00j80","is_oa":true,"landing_page_url":"https://doi.org/10.60692/g0xfs-00j80","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/t4mnj-c0h55","doi":"https://doi.org/10.60692/t4mnj-c0h55","is_oa":true,"landing_page_url":"https://doi.org/10.60692/t4mnj-c0h55","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-45534-0","doi":"https://doi.org/10.1038/s41598-023-45534-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-45534-0","pdf_url":"https://www.nature.com/articles/s41598-023-45534-0.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1732097490","display_name":null,"funder_award_id":"COOPA2022","funder_id":"https://openalex.org/F4320334857","funder_display_name":"Consejo Superior de Investigaciones Cient\u00edficas"},{"id":"https://openalex.org/G8576845922","display_name":null,"funder_award_id":"AYUD/2021/50981","funder_id":"https://openalex.org/F4320313141","funder_display_name":"Gobierno del Principado de Asturias"}],"funders":[{"id":"https://openalex.org/F4320313141","display_name":"Gobierno del Principado de Asturias","ror":"https://ror.org/05mj4yh71"},{"id":"https://openalex.org/F4320317243","display_name":"Universit\u00e9 Monastir","ror":"https://ror.org/00nhtcg76"},{"id":"https://openalex.org/F4320334857","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387940171.pdf","grobid_xml":"https://content.openalex.org/works/W4387940171.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W39259094","https://openalex.org/W1832427420","https://openalex.org/W1860290282","https://openalex.org/W1975228824","https://openalex.org/W1980309199","https://openalex.org/W1993694478","https://openalex.org/W1996441448","https://openalex.org/W2005365566","https://openalex.org/W2026473386","https://openalex.org/W2034285706","https://openalex.org/W2035612381","https://openalex.org/W2072970694","https://openalex.org/W2077095925","https://openalex.org/W2086865963","https://openalex.org/W2088758516","https://openalex.org/W2088833470","https://openalex.org/W2091358560","https://openalex.org/W2099390528","https://openalex.org/W2100746158","https://openalex.org/W2101120467","https://openalex.org/W2101147266","https://openalex.org/W2103294794","https://openalex.org/W2104037158","https://openalex.org/W2133856765","https://openalex.org/W2136879569","https://openalex.org/W2144133378","https://openalex.org/W2148546434","https://openalex.org/W2149756110","https://openalex.org/W2152885278","https://openalex.org/W2157107905","https://openalex.org/W2162088497","https://openalex.org/W2168887663","https://openalex.org/W2267973470","https://openalex.org/W2343713965","https://openalex.org/W2400607720","https://openalex.org/W2401857311","https://openalex.org/W2589674438","https://openalex.org/W2756485101","https://openalex.org/W2768282074","https://openalex.org/W2769544142","https://openalex.org/W2781422490","https://openalex.org/W2789794205","https://openalex.org/W2809253616","https://openalex.org/W2858069613","https://openalex.org/W2891956880","https://openalex.org/W2904339023","https://openalex.org/W2914809023","https://openalex.org/W2921695936","https://openalex.org/W2924578805","https://openalex.org/W2946372752","https://openalex.org/W2952990209","https://openalex.org/W2963327097","https://openalex.org/W2967392987","https://openalex.org/W2969167159","https://openalex.org/W2971621396","https://openalex.org/W2980733351","https://openalex.org/W2981275956","https://openalex.org/W2982520321","https://openalex.org/W3003912482","https://openalex.org/W3016963629","https://openalex.org/W3032030481","https://openalex.org/W3042237022","https://openalex.org/W3080939274","https://openalex.org/W3092672783","https://openalex.org/W3101824430","https://openalex.org/W3112267312","https://openalex.org/W3127826052","https://openalex.org/W3153746339","https://openalex.org/W3203514468","https://openalex.org/W3207106718","https://openalex.org/W3208454676","https://openalex.org/W3211039389","https://openalex.org/W4200614723","https://openalex.org/W4213012461","https://openalex.org/W4247665917","https://openalex.org/W4306673374","https://openalex.org/W4362666328"],"related_works":["https://openalex.org/W2924578805","https://openalex.org/W2904339023","https://openalex.org/W4288096083","https://openalex.org/W3183779267","https://openalex.org/W3080939274","https://openalex.org/W3005689456","https://openalex.org/W4200156845","https://openalex.org/W1993694478","https://openalex.org/W3042237022","https://openalex.org/W4223624106"],"abstract_inverted_index":{"Alterations":[0],"in":[1,13,26,69,77,172],"gut":[2,21,59,146,163,190],"microbiota":[3,22,60,104,147,164],"and":[4,23,35,48,65,74,82,118,192,194],"short":[5],"chain":[6],"fatty":[7],"acids":[8,120],"(SCFA)":[9],"have":[10],"been":[11],"reported":[12],"autism":[14],"spectrum":[15],"disorder":[16],"(ASD).":[17],"We":[18],"analysed":[19],"the":[20,51,70,99,103,134,141,145],"fecal":[24],"SCFA":[25],"Tunisian":[27,150],"autistic":[28,151],"children":[29,49,79,152],"from":[30,42,50],"4":[31],"to":[32,39,63,85,198],"10":[33],"years,":[34,125],"results":[36],"were":[37],"compared":[38,62],"those":[40],"obtained":[41],"a":[43,154],"group":[44],"of":[45,72,96,102,116,136,149],"siblings":[46],"(SIB)":[47],"general":[52],"population":[53],"(GP).":[54],"ASD":[55,110],"patients":[56,111],"presented":[57,112],"different":[58],"profiles":[61],"SIB":[64],"GP,":[66],"with":[67,107],"differences":[68,128],"levels":[71,115],"Bifidobacterium":[73,97],"Collinsella":[75],"occurring":[76],"younger":[78],"(4-7":[80],"years)":[81],"that":[83,185],"tend":[84],"be":[86],"attenuated":[87],"at":[88,123,130,166,169],"older":[89],"ages":[90,171],"(8-10":[91],"years).":[92],"The":[93],"lower":[94],"abundance":[95],"is":[98,140],"key":[100],"feature":[101],"composition":[105],"associated":[106,197],"severe":[108],"autism.":[109],"significantly":[113],"higher":[114],"propionic":[117],"valeric":[119],"than":[121,168],"GP":[122],"4-7":[124],"but":[126],"these":[127],"disappeared":[129],"8-10":[131],"years.":[132],"To":[133],"best":[135],"our":[137,182],"knowledge,":[138],"this":[139],"first":[142],"study":[143,159],"on":[144],"profile":[148],"using":[153],"metataxonomic":[155],"approach.":[156],"This":[157],"exploratory":[158],"reveals":[160],"more":[161],"pronounced":[162],"alterations":[165],"early":[167,186],"advanced":[170],"ASD.":[173,199],"Although":[174],"we":[175],"did":[176],"not":[177],"account":[178],"for":[179],"multiple":[180],"testing,":[181],"findings":[183],"suggest":[184],"interventions":[187],"might":[188],"mitigate":[189],"disorders":[191],"cognitive":[193],"neurodevelopment":[195],"impairment":[196]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-26T00:00:00"}